FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 16584

FusionGeneSummary for HNRNPH1_RNF130

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPH1_RNF130
Fusion gene ID: 16584
HgeneTgene
Gene symbol

HNRNPH1

RNF130

Gene ID

3187

55819

Gene nameheterogeneous nuclear ribonucleoprotein H1ring finger protein 130
SynonymsHNRPH|HNRPH1|hnRNPHG1RZFP|GOLIATH|GP
Cytomap

5q35.3

5q35.3

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein Hheterogeneous nuclear ribonucleoprotein H1 (H)E3 ubiquitin-protein ligase RNF130RING-type E3 ubiquitin transferase RNF130g1-related zinc finger proteingoliath homolog
Modification date2018052420180523
UniProtAcc

P31943

Q86XS8

Ensembl transtripts involved in fusion geneENST00000393432, ENST00000442819, 
ENST00000356731, ENST00000329433, 
ENST00000510411, ENST00000511300, 
ENST00000524180, 
ENST00000522208, 
ENST00000521389, ENST00000261947, 
ENST00000520564, 
Fusion gene scores* DoF score11 X 13 X 4=57210 X 7 X 6=420
# samples 1210
** MAII scorelog2(12/572*10)=-2.25298074116987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HNRNPH1 [Title/Abstract] AND RNF130 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHNRNPH1

GO:0043484

regulation of RNA splicing

16946708


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A1LE-01AHNRNPH1chr5

179042547

-RNF130chr5

179382669

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000393432ENST00000522208HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000393432ENST00000521389HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000393432ENST00000261947HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-5UTRENST00000393432ENST00000520564HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000442819ENST00000522208HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000442819ENST00000521389HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000442819ENST00000261947HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-5UTRENST00000442819ENST00000520564HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000356731ENST00000522208HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000356731ENST00000521389HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000356731ENST00000261947HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-5UTRENST00000356731ENST00000520564HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
intron-intronENST00000329433ENST00000522208HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
intron-intronENST00000329433ENST00000521389HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
intron-intronENST00000329433ENST00000261947HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
intron-5UTRENST00000329433ENST00000520564HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000510411ENST00000522208HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000510411ENST00000521389HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000510411ENST00000261947HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-5UTRENST00000510411ENST00000520564HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000511300ENST00000522208HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000511300ENST00000521389HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-intronENST00000511300ENST00000261947HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
5CDS-5UTRENST00000511300ENST00000520564HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
intron-intronENST00000524180ENST00000522208HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
intron-intronENST00000524180ENST00000521389HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
intron-intronENST00000524180ENST00000261947HNRNPH1chr5

179042547

-RNF130chr5

179382669

-
intron-5UTRENST00000524180ENST00000520564HNRNPH1chr5

179042547

-RNF130chr5

179382669

-

Top

FusionProtFeatures for HNRNPH1_RNF130


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPH1

P31943

RNF130

Q86XS8

This protein is a component of the heterogeneous nuclearribonucleoprotein (hnRNP) complexes which provide the substratefor the processing events that pre-mRNAs undergo before becomingfunctional, translatable mRNAs in the cytoplasm. Mediates pre-mRNAalternative splicing regulation. Inhibits, together with CUGBP1,insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast.Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644,ECO:0000269|PubMed:16946708}. May have a role during the programmed cell death ofhematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase. {ECO:0000250, ECO:0000269|PubMed:16549277}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for HNRNPH1_RNF130


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for HNRNPH1_RNF130


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HNRNPH1TCERG1, CRMP1, NCBP1, NCBP2, KHSRP, HNRNPF, MEPCE, CDK9, HNRNPA1, CCT4, DDX17, DDX5, KPNA2, HNRNPA2B1, HNRNPD, HNRNPK, SYNCRIP, KHDRBS2, GPN1, CCT5, RQCD1, HNRNPH2, HNRNPU, YTHDF2, HNRNPM, CPNE1, YKT6, HSPD1, MYSM1, SRRM2, UBC, SMN1, CD4, DGCR8, YWHAG, ZWINT, VHL, SMARCAD1, SREK1, NDRG1, MBNL1, ELAVL1, ARRB1, ARRB2, NFX1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, PRAME, HIPK3, SHC1, EGFR, HNRNPR, RBMX, HNRNPUL1, HNRNPA3, U2AF2, SNRNP70, HNRNPA0, HNRNPL, RALY, ILF2, HNRNPDL, HNRNPH3, RAB5C, IKBIP, YES1, TPP1, RBM4, PGRMC1, NUPL1, RANBP2, USP7, LSM14A, RBM14, EEF2, HADHA, PTRF, GTF2I, MAGOH, EIF4A3, SMURF1, NPM1, FN1, VCAM1, SF3B4, SF1, ATF2, MAP1LC3A, UBL4A, ITGA4, PAN2, CD81, IGSF8, ICAM1, ADRB2, TARDBP, YWHAQ, FBXO6, PARP1, PARK2, APBB1, PIN1, AASDHPPT, IPO11, PEG10, PPP3CA, PSMD9, TNPO3, PPP2CA, RPA3, RPA2, RPA1, ERG, ASB2, HSPA5, UBASH3B, STAU1, CEP250, CEP76, TP53, TUBGCP3, VCP, HUWE1, FUS, CUL7, OBSL1, CCDC8, EED, SUMO2, SIRT6, TYK2, FBXW11, UNK, BASP1, HNRNPAB, AHNAK, C21orf59, C9orf78, CPNE3, CPS1, DDX43, ELAC2, HIBCH, HNRNPA1L2, HSPB1, IARS2, KIAA0368, RTCA, RTCB, SAR1B, TSTA3, NAMPT, PDCD6, RPS6KA3, SCOC, NTRK1, SCARNA22, AHSA1, MATR3, GAN, CRY1, ALKBH3, MCM2, SNW1, CDC5L, ERBB3, ESRRB, AIRE, PLOD1, NAGK, MTNR1A, CYLD, TRIM25, HEY1, BRCA1, LMNA, MTF1RNF130FGFR3, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2N, UBE2Z, MYC, UBC, CD1B, TSPAN18, NRG1, TMEM231, MCOLN3, TSPAN17, BTNL8, PTCH1, ZACN, HTR3C, PON2, CDC5L, SCGB1D4, GGT7, MANSC1, HTR3A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for HNRNPH1_RNF130


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for HNRNPH1_RNF130


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHNRNPH1C0033578Prostatic Neoplasms1CTD_human
TgeneRNF130C0033578Prostatic Neoplasms1CTD_human