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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16556

FusionGeneSummary for HNRNPC_WRN

check button Fusion gene summary
Fusion gene informationFusion gene name: HNRNPC_WRN
Fusion gene ID: 16556
HgeneTgene
Gene symbol

HNRNPC

WRN

Gene ID

3183

7486

Gene nameheterogeneous nuclear ribonucleoprotein C (C1/C2)Werner syndrome RecQ like helicase
SynonymsC1|C2|HNRNP|HNRPC|SNRPCRECQ3|RECQL2|RECQL3
Cytomap

14q11.2

8p12

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoproteins C1/C2hnRNP C1/C2nuclear ribonucleoprotein particle C1 proteinnuclear ribonucleoprotein particle C2 proteinWerner syndrome ATP-dependent helicaseDNA helicase, RecQ-like type 3Werner syndrome, RecQ helicase-likeexonuclease WRNrecQ protein-like 2
Modification date2018052320180523
UniProtAcc

P07910

Q14191

Ensembl transtripts involved in fusion geneENST00000449098, ENST00000320084, 
ENST00000336053, ENST00000554969, 
ENST00000556142, ENST00000554455, 
ENST00000430246, ENST00000553753, 
ENST00000555914, ENST00000555309, 
ENST00000556628, ENST00000555883, 
ENST00000556513, ENST00000557201, 
ENST00000553300, ENST00000556897, 
ENST00000420743, 
ENST00000298139, 
Fusion gene scores* DoF score7 X 6 X 6=2526 X 5 X 5=150
# samples 86
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HNRNPC [Title/Abstract] AND WRN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWRN

GO:0000731

DNA synthesis involved in DNA repair

17563354

TgeneWRN

GO:0006259

DNA metabolic process

16622405

TgeneWRN

GO:0006284

base-excision repair

17611195

TgeneWRN

GO:0006974

cellular response to DNA damage stimulus

18203716

TgeneWRN

GO:0006979

response to oxidative stress

17611195

TgeneWRN

GO:0009267

cellular response to starvation

11420665

TgeneWRN

GO:0010225

response to UV-C

17563354

TgeneWRN

GO:0031297

replication fork processing

17115688

TgeneWRN

GO:0032508

DNA duplex unwinding

11735402|26420422

TgeneWRN

GO:0044806

G-quadruplex DNA unwinding

11735402

TgeneWRN

GO:0051345

positive regulation of hydrolase activity

17611195

TgeneWRN

GO:0061820

telomeric D-loop disassembly

15200954|19734539|26420422

TgeneWRN

GO:0071480

cellular response to gamma radiation

21639834

TgeneWRN

GO:0098530

positive regulation of strand invasion

26420422

TgeneWRN

GO:1902570

protein localization to nucleolus

11420665


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-J9-A8CK-01AHNRNPCchr14

21698478

-WRNchr8

31030511

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000449098ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
In-frameENST00000320084ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shitENST00000336053ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shitENST00000554969ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shitENST00000556142ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shitENST00000554455ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
In-frameENST00000430246ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shitENST00000553753ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shitENST00000555914ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shitENST00000555309ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shitENST00000556628ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shitENST00000555883ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shitENST00000556513ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shitENST00000557201ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shitENST00000553300ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
In-frameENST00000556897ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+
Frame-shitENST00000420743ENST00000298139HNRNPCchr14

21698478

-WRNchr8

31030511

+

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FusionProtFeatures for HNRNPC_WRN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPC

P07910

WRN

Q14191

Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activitytowards double-stranded DNA with a 5'-overhang. Has no nucleaseactivity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containingalternate secondary structures, such as replication forks andHolliday junctions. May play an important role in the dissociationof joint DNA molecules that can arise as products of homologousrecombination, at stalled replication forks or during DNA repair.Alleviates stalling of DNA polymerases at the site of DNA lesions.Important for genomic integrity. Plays a role in the formation ofDNA replication focal centers; stably associates with focielements generating binding sites for RP-A (By similarity). Playsa role in double-strand break repair after gamma-irradiation.{ECO:0000250, ECO:0000269|PubMed:11863428,ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042,ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551,ECO:0000269|PubMed:21639834}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HNRNPC_WRN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HNRNPC_ENST00000320084_chr14_21698478_-_WRN_ENST00000298139_chr8_31030511_+_170aa
MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKTGKIVGCSVHKGFAFVQTVNERNARAAVAGEDGRMIAGQVLDINLAAEPKV

>In-frame_HNRNPC_ENST00000430246_chr14_21698478_-_WRN_ENST00000298139_chr8_31030511_+_157aa
MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKTGKIVGCSVHKGFAFVQTVNERNARAAVAGEDGRMIAGQVLDINLAAEPKV

>In-frame_HNRNPC_ENST00000556897_chr14_21698478_-_WRN_ENST00000298139_chr8_31030511_+_157aa
MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKTGKIVGCSVHKGFAFVQTVNERNARAAVAGEDGRMIAGQVLDINLAAEPKV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HNRNPC_ENST00000320084_chr14_21698478_-_WRN_ENST00000298139_chr8_31030511_+_512nt
ATGGCCAGCAACGTTACCAACAAGACAGATCCTCGCTCCATGAACTCCCGTGTATTCATTGGGAATCTCAACACTCTTGTGGTCAAGAAA
TCTGATGTGGAGGCAATCTTTTCGAAGTATGGCAAAATTGTGGGCTGCTCTGTTCATAAGGGCTTTGCCTTCGTTCAGTATGTTAATGAG
AGAAATGCCCGGGCTGCTGTAGCAGGAGAGGATGGCAGAATGATTGCTGGCCAGGTTTTAGATATTAACCTGGCTGCAGAGCCAAAAGTG
AACCGAGGAAAAGCAGGTGTGAAACGATCTGCAGCGGAGATGTACGGGTCAGTAACAGAACACCCTTCTCCGTCCCCTCTACTCAGCTCC
TCTTTTGACTTGGACTATGACTTTCAACGGGACTATTATGATAGACTTCATCTGCAGAGAGAAAGAGACGATTACCTGTGTGGTTTGCCA

>In-frame_HNRNPC_ENST00000430246_chr14_21698478_-_WRN_ENST00000298139_chr8_31030511_+_473nt
ATGGCCAGCAACGTTACCAACAAGACAGATCCTCGCTCCATGAACTCCCGTGTATTCATTGGGAATCTCAACACTCTTGTGGTCAAGAAA
TCTGATGTGGAGGCAATCTTTTCGAAGTATGGCAAAATTGTGGGCTGCTCTGTTCATAAGGGCTTTGCCTTCGTTCAGTATGTTAATGAG
AGAAATGCCCGGGCTGCTGTAGCAGGAGAGGATGGCAGAATGATTGCTGGCCAGGTTTTAGATATTAACCTGGCTGCAGAGCCAAAAGTG
AACCGAGGAAAAGCAGGTGTGAAACGATCTGCAGCGGAGATGTACGGCTCCTCTTTTGACTTGGACTATGACTTTCAACGGGACTATTAT
GATAGACTTCATCTGCAGAGAGAAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCAGCAAGAAATTAATGGACAAAACGA

>In-frame_HNRNPC_ENST00000556897_chr14_21698478_-_WRN_ENST00000298139_chr8_31030511_+_473nt
ATGGCCAGCAACGTTACCAACAAGACAGATCCTCGCTCCATGAACTCCCGTGTATTCATTGGGAATCTCAACACTCTTGTGGTCAAGAAA
TCTGATGTGGAGGCAATCTTTTCGAAGTATGGCAAAATTGTGGGCTGCTCTGTTCATAAGGGCTTTGCCTTCGTTCAGTATGTTAATGAG
AGAAATGCCCGGGCTGCTGTAGCAGGAGAGGATGGCAGAATGATTGCTGGCCAGGTTTTAGATATTAACCTGGCTGCAGAGCCAAAAGTG
AACCGAGGAAAAGCAGGTGTGAAACGATCTGCAGCGGAGATGTACGGCTCCTCTTTTGACTTGGACTATGACTTTCAACGGGACTATTAT
GATAGACTTCATCTGCAGAGAGAAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCAGCAAGAAATTAATGGACAAAACGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_HNRNPC_ENST00000320084_chr14_21698478_-_WRN_ENST00000298139_chr8_31030511_+_1419nt
AGGAATGGGGCGGGGACTAGGCCTTCGCCTCGGCGGCAGAGGAGACTCGGGGGCCATTTTGTGAAGAGACGAAGACTGAGCGGTTGTGGC
CGCGTTGCCGACCTCCAGCAGCAGTCGGCTTCTCTACGCAGAACCCGGGAGTAGGAGACTCAGAATCGAATCTCTTCTCCCTCCCCTTCT
TGTATACTTTTTTTTGCTTTACAGTTTTCGGCTTTGTGAGAAACCTTACCATCAAACACGATGGCCAGCAACGTTACCAACAAGACAGAT
CCTCGCTCCATGAACTCCCGTGTATTCATTGGGAATCTCAACACTCTTGTGGTCAAGAAATCTGATGTGGAGGCAATCTTTTCGAAGTAT
GGCAAAATTGTGGGCTGCTCTGTTCATAAGGGCTTTGCCTTCGTTCAGTATGTTAATGAGAGAAATGCCCGGGCTGCTGTAGCAGGAGAG
GATGGCAGAATGATTGCTGGCCAGGTTTTAGATATTAACCTGGCTGCAGAGCCAAAAGTGAACCGAGGAAAAGCAGGTGTGAAACGATCT
GCAGCGGAGATGTACGGGTCAGTAACAGAACACCCTTCTCCGTCCCCTCTACTCAGCTCCTCTTTTGACTTGGACTATGACTTTCAACGG
GACTATTATGATAGACTTCATCTGCAGAGAGAAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCAGCAAGAAATTAATGG
ACAAAACGAAAAGGGGAGGTCTTTTTAGTTAAGCTGGCAATTACCAGAACAATTATGTTTCTTGCTGTATTATAAGAGGATAGCTATATT
TTATTTCTGAAGAGTAAGGAGTAGTATTTTGGCTTAAAAATCATTCTAATTACAAAGTTCACTGTTTATTGAAGAACTGGCATCTTAAAT
CAGCCTTCCGCAATTCATGTAGTTTCTGGGTCTTCTGGGAGCCTACGTGAGTACATCACCTAACAGAATATTAAATTAGACTTCCTGTAA
GATTGCTTTAAGAAACTGTTACTGTCCTGTTTTCTAATCTCTTTATTAAAACAGTGTATTTGGAAAATGTTATGTGCTCTGATTTGATAT
AGATAACAGATTAGTAGTTACATGGTAATTATGTGATATAAAATATTCATATATTATCAAAATTCTGTTTTGTAAATGTAAGAAAGCATA
GTTATTTTACAAATTGTTTTTACTGTCTTTTGAAGAAGTTCTTAAATACGTTGTTAAATGGTATTAGTTGACCAGGGCAGTGAAAATGAA
ACCGCATTTTGGGTGCCATTAAATAGGGAAAAAACATGTAAAAAATGTAAAATGGAGACCAATTGCACTAGGCAAGTGTATATTTTGTAT

>In-frame_HNRNPC_ENST00000430246_chr14_21698478_-_WRN_ENST00000298139_chr8_31030511_+_4092nt
TTCTTGATTGAAAATGGTGCTAAAGTTGGTCTTTTTATGAGTGGTAGCTCTTCAGTTTAACATAAATAACATCTTGGGAGATACTGAGCT
TTTTGATATTGAAAGATAGAATTGGTTTCTTTTCACATTTTTCTTTATTTTTAAGCTTATGTCTTGTGGCACCTGTACAAAGGACTTGGT
TGTGGTTGAGCTATAAAGTTATGTATCTTGAAAATTGATTACCAGGTTTGGGCTGTGGCTCCAAATAAGAAAATGAAATGTTTCACCATA
ACTGTATTTCATAAACAGGAAAAGAACATTCAGATGTATATTTCTTACAATTCTTCACAAACTTTTTCCGCAATTTGTACATTCATACAG
TTTTCACACATCAAATGTAAAAATTAACTGTCATTCCTACACTGTTCTTTTTAAAAATGTATGGTACTTGTTGCTGCTGTAGTCATTCAT
GTATAGTTGGCTCAAGGAACACTTCTAAAAGCTCAATTAAAAATTTTTTTTTTGAGACAGGGTCTCTCTCTGGCCTGGCTGAAGTGCAGT
GGCGTGATCAGAGCTCACTGCAGCCTCGAACTCCTGGGCTCAAGTGATCCTCGCTCCTCAGACTGCTAAGTAGCTGGGATTTCAGGCTAC
CACACCCTGCTAATGTTTTTTGTTTTTAATAAAGTCTCGTCATGTTTCCCAGGCTGGTCTCAAACTACTGAGCTCAAGCCGTGCTCTACC
CTGGCCTCCCAAAGTGTTGGGATTACAGGTGTGAGCCACCACACTTGGCCTTAAAATATTTTAATTTCCTCAAATTTACAAAGGAGAATA
AGACCTCATGGCTAAATTGAACAGTGAGTGCAGCTAGTTCATTGTTTGCACAAGGAACTACAGTCTAATTGCAGTTCCTATTTTAGCTGA
TGAAACAACCAGTTTGTCATGGAAATTATTTTAGTGTGGTATTATGTACCAGATTTTTAGAATCCATAACTTGAAATTAGCTTTACACGC
TACATAGTAAATAGTGGACTACAGAAACAAAAGTATTAACATAAGGACCTTAATTTTTTTCACCTATTTTATGACCTTAAATATTCAGTA
TTTTTTTAATTCCATCTGTATTTTCGTTTTGTCAGTGAGTGGAATAATGTGCTCCTTATTTAAAACATCTTTTCCCCTAACAGTAGAACC
TATTAGGTCTTGTGGTTTGATCACTCACTGGTTTTGAGAATAGATGAGTCATCTCTAGTATAGATCTTCATGGTAGGCCATTCACCTTCA
GTCTATTACTCATAGCAAAAACTCCACGGACTTTTTTAAGTTTAAAACCCATGAATCTGCTTAGGTTTTATAATCTCAGTATTTGACATT
TGCTCACTATTTCATCTCTATTTGTTGGCCCGGTTTTTCTGTATTTTCTTTGCCCAAACTGCTCATTATCAAGATGAACATTTGGGATAT
ACTCTTTTTGAGACCCTCAAGGGCATATTGACATGAATTTAGTTAATTTTAGTCATCTATTGATGTTGAAGAATTGTGAAGACAGTCACT
GGTAGAGGTGATTCTATGGAGGCTATCCCATCCCAGTGGAATGTTAATGCTTTACCAAAATGTGTTAGCTGCAGTAGACAGATGTTTCTG
TCTTGGGGGTTTAGGGCACAACATTTCTGAGGAACTCTGACTCAATCTGTCCCTTCTCCTTTCACAGGGCAGCAAGGCGAACCCCATCCC
TACTCACTGGAGCTCAGCTTTGATTTTTAACCTCCCTTCCCCACCCTTCCAGAACACACACATTCCATTCCAAAACTGATTTTATAAAGA
CATTTTAAACATAATGATGCAACTTGGTGTGCACTACAGCAAATGTACAGGTGTTTTTTTTTTAATTGTTTCCAAAACCGGGACCTGGAT
TTAAGATGTAATTTTTAAAATTTCTATTTCTATTTTTTCTGCAGCAGTTGGGTTAGAGGAGGAGGAGCCTTTTAGCCTCTCATAAACTGA
CCTCTCTACTTCCTCGTGTATTTTTAAGATTGATTGATGATGTGGAAAGGGCTTTGCTTGTCTGCTACTGAAAACTTTATCCTTGCGGTT
TTTGTGGAAACTGCTTTTGGAAAGAGAAAAGAAATGAACTTTACTGACTTGACATTTTTGCACCTCCCGTTTTTCTAATCTGGGCTATTT
TTATTTTTGTTTTTTTACAGTGAGATTTTTTTGATCTTCAGCTACAGTAAGTTATTCCAATTTTTTTTTAACATTTTTCCTGACTTTCCG
CTGATTTCCTTTTTATTGTTGTTACTAGTTACTATTACTTATTATTATTATATTAATACTTATGATGGTGATGATGATGATGATAATGAC
ACTGATGATTTTTAACCGGATTAAAATCGAGTTTTTCTGAATGTTTCTAAGAATTTCTCCGGCCTCCTGATTGACTTTGGAGTTTTGCAT
CTTGGGAGAGAAAGCGAAGGCATTAGTATTTTTAAGTGGTTTGATCACGTAAACCTTTTCTCTCCCAACCCCACCCTTGCCCTCATCCCC
TTCCCCACACTGAAAAGAATTTTACTGGCTGTTAAGTCTATGACCTTATTTTTCCTGATCTTTAACTTAACTGTTTTAGAGCATCTCTGG
ACGTCTGTATTTTTAATTTTTTTTATTTTTGTTTTTTTATTTTTAATCTTTCATTTGTTAAATTTTTAAACTGTGCTGCAATAAAATGTG
TGTGGTACTACTTAACACTTATGATCGTGATGGCATTTTCCCTGAAAGCCATCTTCCTCCTGTTTCCCTTGAAATCCCATCCTGCTTTTC
CTGTACACTACCCCTCACAAACCACAAGCTGCAGCAACATGGATGCCCAGCCTGGAGCAGCAGCAGCCAGGATGACCTGGAGCCAGGGGG
GCCTTCGGAACAGATGCACACCCTTCCTGGGTGATGTTTTCGGCTTTGTGAGAAACCTTACCATCAAACACGATGGCCAGCAACGTTACC
AACAAGACAGATCCTCGCTCCATGAACTCCCGTGTATTCATTGGGAATCTCAACACTCTTGTGGTCAAGAAATCTGATGTGGAGGCAATC
TTTTCGAAGTATGGCAAAATTGTGGGCTGCTCTGTTCATAAGGGCTTTGCCTTCGTTCAGTATGTTAATGAGAGAAATGCCCGGGCTGCT
GTAGCAGGAGAGGATGGCAGAATGATTGCTGGCCAGGTTTTAGATATTAACCTGGCTGCAGAGCCAAAAGTGAACCGAGGAAAAGCAGGT
GTGAAACGATCTGCAGCGGAGATGTACGGCTCCTCTTTTGACTTGGACTATGACTTTCAACGGGACTATTATGATAGACTTCATCTGCAG
AGAGAAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCAGCAAGAAATTAATGGACAAAACGAAAAGGGGAGGTCTTTTTA
GTTAAGCTGGCAATTACCAGAACAATTATGTTTCTTGCTGTATTATAAGAGGATAGCTATATTTTATTTCTGAAGAGTAAGGAGTAGTAT
TTTGGCTTAAAAATCATTCTAATTACAAAGTTCACTGTTTATTGAAGAACTGGCATCTTAAATCAGCCTTCCGCAATTCATGTAGTTTCT
GGGTCTTCTGGGAGCCTACGTGAGTACATCACCTAACAGAATATTAAATTAGACTTCCTGTAAGATTGCTTTAAGAAACTGTTACTGTCC
TGTTTTCTAATCTCTTTATTAAAACAGTGTATTTGGAAAATGTTATGTGCTCTGATTTGATATAGATAACAGATTAGTAGTTACATGGTA
ATTATGTGATATAAAATATTCATATATTATCAAAATTCTGTTTTGTAAATGTAAGAAAGCATAGTTATTTTACAAATTGTTTTTACTGTC
TTTTGAAGAAGTTCTTAAATACGTTGTTAAATGGTATTAGTTGACCAGGGCAGTGAAAATGAAACCGCATTTTGGGTGCCATTAAATAGG
GAAAAAACATGTAAAAAATGTAAAATGGAGACCAATTGCACTAGGCAAGTGTATATTTTGTATTTTATATACAATTTCTATTATTTTTCA

>In-frame_HNRNPC_ENST00000556897_chr14_21698478_-_WRN_ENST00000298139_chr8_31030511_+_1253nt
GCCTGGAGCAGCAGCAGCCAGGATGACCTGGAGCCAGGGGGGCCTTCGGAACAGATGCACACCCTTCCTGGGTGATGTTTTCGGCTTTGT
GAGAAACCTTACCATCAAACACGATGGCCAGCAACGTTACCAACAAGACAGATCCTCGCTCCATGAACTCCCGTGTATTCATTGGGAATC
TCAACACTCTTGTGGTCAAGAAATCTGATGTGGAGGCAATCTTTTCGAAGTATGGCAAAATTGTGGGCTGCTCTGTTCATAAGGGCTTTG
CCTTCGTTCAGTATGTTAATGAGAGAAATGCCCGGGCTGCTGTAGCAGGAGAGGATGGCAGAATGATTGCTGGCCAGGTTTTAGATATTA
ACCTGGCTGCAGAGCCAAAAGTGAACCGAGGAAAAGCAGGTGTGAAACGATCTGCAGCGGAGATGTACGGCTCCTCTTTTGACTTGGACT
ATGACTTTCAACGGGACTATTATGATAGACTTCATCTGCAGAGAGAAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCAG
CAAGAAATTAATGGACAAAACGAAAAGGGGAGGTCTTTTTAGTTAAGCTGGCAATTACCAGAACAATTATGTTTCTTGCTGTATTATAAG
AGGATAGCTATATTTTATTTCTGAAGAGTAAGGAGTAGTATTTTGGCTTAAAAATCATTCTAATTACAAAGTTCACTGTTTATTGAAGAA
CTGGCATCTTAAATCAGCCTTCCGCAATTCATGTAGTTTCTGGGTCTTCTGGGAGCCTACGTGAGTACATCACCTAACAGAATATTAAAT
TAGACTTCCTGTAAGATTGCTTTAAGAAACTGTTACTGTCCTGTTTTCTAATCTCTTTATTAAAACAGTGTATTTGGAAAATGTTATGTG
CTCTGATTTGATATAGATAACAGATTAGTAGTTACATGGTAATTATGTGATATAAAATATTCATATATTATCAAAATTCTGTTTTGTAAA
TGTAAGAAAGCATAGTTATTTTACAAATTGTTTTTACTGTCTTTTGAAGAAGTTCTTAAATACGTTGTTAAATGGTATTAGTTGACCAGG
GCAGTGAAAATGAAACCGCATTTTGGGTGCCATTAAATAGGGAAAAAACATGTAAAAAATGTAAAATGGAGACCAATTGCACTAGGCAAG


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FusionGenePPI for HNRNPC_WRN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HNRNPCKPNA3, RBM41, CCDC85B, KRAS, HNRNPC, RALYL, ZNF581, FXR2, PHKB, PIN1, AP1M1, UBE2I, LMO3, CNBP, PUF60, MYC, GRB2, KHDRBS2, HNRNPA1, MEPCE, BANF1, MGMT, SMARCA4, CHD4, SMARCC1, SRRM2, DHX9, TADA2A, H2AFX, UBC, AGO4, YWHAQ, TOP1, EIF2AK2, PSMA3, VHL, SREK1, CEBPA, ELAVL1, SF3A2, ARRB2, BRINP1, SH3KBP1, XRCC5, PRKDC, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, PRAME, XIAP, FBXO6, HNRNPR, EFTUD2, SNRNP200, RBMX, SF3A1, HNRNPM, NHP2L1, RNPS1, U2AF2, SFPQ, SART1, RALY, SAP18, USP39, SMU1, KHDRBS1, WDR18, MYBBP1A, TRIM55, SEPT7, RRP7A, TPBG, RRS1, TRA2A, ILVBL, UTP14A, VAPB, KRT14, MRPS9, ZC3H18, SSR3, MRPL40, MRPL42, HNRNPCL1, LMBRD1, NXF1, ILF3, BARD1, ECT2, MDC1, MAGOH, EIF4A3, YWHAE, FN1, VCAM1, SF3B2, HNRNPD, PTBP2, CELF1, CSNK2A1, IFIT1, SRPK1, IL7R, UBL4A, ITGA4, KHDRBS3, PAN2, CSNK1A1, BTRC, FAS, KPNA2, SMARCD1, CLK3, SRPK2, TARDBP, PARK2, CDKN2A, ERG, IVNS1ABP, STAU1, CEP250, PALB2, BRCA1, BRCA2, RAD51, BRIP1, EPS8, KPNA4, LMO2, SDCBP, SUMO1, ZFYVE26, SUMO1P1, PHF6, CUL7, OBSL1, EED, RNF2, ESR1, ILF2, GNL1, RPL6, MED1, RANBP2, NTRK1, SCARNA22, XPO1, HNRNPU, MATR3, CCDC93, NLRP3, ENTHD2, GAN, MCM2, MCM5, USP37, SNW1, CDC5L, CRBN, ELAVL2, GSPT2, MTMR7, APOBEC3D, FBXW11, C11orf57, CYLD, TRIM25, UBE2A, LMNA, MTF1, TRAF3WRNMDC1, TERF2, BLM, ATM, ATR, PRKDC, FEN1, PCNA, WRNIP1, POLR1C, XRCC5, XRCC6, TP53, WDR48, CHAF1A, POLB, POT1, H2AFX, NBN, DHX9, RAD51, RAD52, ATRX, RAD54B, SIRT1, WRN, PARP1, VCP, CDKN2A, CDC5L, PML, SUMO1, SUMO2, RPA1, RPA2, RPA3, CREBBP, KIAA0930, SKAP1, NTRK1, MUS81, PTTG1, TINF2, POLK, POLL, SUPT16H, ARL3, CHEK2, CHEK1, WEE1, TUBA1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HNRNPC_WRN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HNRNPC_WRN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWRNC0043119Werner Syndrome3CTD_human;ORPHANET;UNIPROT
TgeneWRNC0231341Premature aging syndrome1CTD_human