|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 16510 |
FusionGeneSummary for HNF1B_ANAPC16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HNF1B_ANAPC16 | Fusion gene ID: 16510 | Hgene | Tgene | Gene symbol | HNF1B | ANAPC16 | Gene ID | 6928 | 119504 |
| Gene name | HNF1 homeobox B | anaphase promoting complex subunit 16 | |
| Synonyms | FJHN|HNF-1-beta|HNF-1B|HNF1beta|HNF2|HPC11|LF-B3|LFB3|MODY5|TCF-2|TCF2|VHNF1 | APC16|C10orf104|CENP-27|MSAG|bA570G20.3 | |
| Cytomap | 17q12 | 10q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | hepatocyte nuclear factor 1-betaHNF1 beta Ahomeoprotein LFB3transcription factor 2, hepatic | anaphase-promoting complex subunit 16centromere protein 27cyclosome subunit 16metabolic syndrome-associated protein | |
| Modification date | 20180528 | 20180522 | |
| UniProtAcc | P35680 | Q96DE5 | |
| Ensembl transtripts involved in fusion gene | ENST00000225893, ENST00000561193, ENST00000560016, ENST00000427275, | ENST00000299381, ENST00000470481, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 8 X 7 X 5=280 |
| # samples | 4 | 11 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/280*10)=-1.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HNF1B [Title/Abstract] AND ANAPC16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HNF1B | GO:0001822 | kidney development | 21281489 |
| Hgene | HNF1B | GO:0045893 | positive regulation of transcription, DNA-templated | 16297991|21281489 |
| Hgene | HNF1B | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter | 15355349 |
| Tgene | ANAPC16 | GO:0016567 | protein ubiquitination | 20360068 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-CJ-4920-01A | HNF1B | chr17 | 36091586 | - | ANAPC16 | chr10 | 73990124 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000225893 | ENST00000299381 | HNF1B | chr17 | 36091586 | - | ANAPC16 | chr10 | 73990124 | + |
| 5CDS-3UTR | ENST00000225893 | ENST00000470481 | HNF1B | chr17 | 36091586 | - | ANAPC16 | chr10 | 73990124 | + |
| In-frame | ENST00000561193 | ENST00000299381 | HNF1B | chr17 | 36091586 | - | ANAPC16 | chr10 | 73990124 | + |
| 5CDS-3UTR | ENST00000561193 | ENST00000470481 | HNF1B | chr17 | 36091586 | - | ANAPC16 | chr10 | 73990124 | + |
| In-frame | ENST00000560016 | ENST00000299381 | HNF1B | chr17 | 36091586 | - | ANAPC16 | chr10 | 73990124 | + |
| 5CDS-3UTR | ENST00000560016 | ENST00000470481 | HNF1B | chr17 | 36091586 | - | ANAPC16 | chr10 | 73990124 | + |
| In-frame | ENST00000427275 | ENST00000299381 | HNF1B | chr17 | 36091586 | - | ANAPC16 | chr10 | 73990124 | + |
| 5CDS-3UTR | ENST00000427275 | ENST00000470481 | HNF1B | chr17 | 36091586 | - | ANAPC16 | chr10 | 73990124 | + |
Top |
FusionProtFeatures for HNF1B_ANAPC16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HNF1B | ANAPC16 |
| Transcription factor, probably binds to the invertedpalindrome 5'-GTTAATNATTAAC-3'. | Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle.The APC/C complex acts by mediating ubiquitination and subsequentdegradation of target proteins: it mainly mediates the formationof 'Lys-11'-linked polyubiquitin chains and, to a lower extent,the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains. {ECO:0000269|PubMed:20360068}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HNF1B | chr17:36091586 | chr10:73990124 | ENST00000225893 | - | 4 | 9 | 231_311 | 348 | 558 | DNA binding | Homeobox%3B HNF1-type |
| Hgene | HNF1B | chr17:36091586 | chr10:73990124 | ENST00000427275 | - | 4 | 7 | 231_311 | 322 | 458 | DNA binding | Homeobox%3B HNF1-type |
| Hgene | HNF1B | chr17:36091586 | chr10:73990124 | ENST00000561193 | - | 4 | 9 | 231_311 | 322 | 532 | DNA binding | Homeobox%3B HNF1-type |
| Hgene | HNF1B | chr17:36091586 | chr10:73990124 | ENST00000225893 | - | 4 | 9 | 1_31 | 348 | 558 | Region | Dimerization |
| Hgene | HNF1B | chr17:36091586 | chr10:73990124 | ENST00000427275 | - | 4 | 7 | 1_31 | 322 | 458 | Region | Dimerization |
| Hgene | HNF1B | chr17:36091586 | chr10:73990124 | ENST00000561193 | - | 4 | 9 | 1_31 | 322 | 532 | Region | Dimerization |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ANAPC16 | chr17:36091586 | chr10:73990124 | ENST00000299381 | + | 1 | 4 | 4_26 | 47 | 111 | Compositional bias | Note=Ser-rich |
Top |
FusionGeneSequence for HNF1B_ANAPC16 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HNF1B_ENST00000225893_chr17_36091586_-_ANAPC16_ENST00000299381_chr10_73990124_+_412aa MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPP ILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREIL RQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNR AECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSDGSERFLCESVF >In-frame_HNF1B_ENST00000561193_chr17_36091586_-_ANAPC16_ENST00000299381_chr10_73990124_+_386aa MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPP ILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREIL RQFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRV YNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSDGSERFLCESVFSYQVASTLKQVKHDQQVARMEKLAGL >In-frame_HNF1B_ENST00000560016_chr17_36091586_-_ANAPC16_ENST00000299381_chr10_73990124_+_412aa MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPP ILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREIL RQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNR AECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSDGSERFLCESVF >In-frame_HNF1B_ENST00000427275_chr17_36091586_-_ANAPC16_ENST00000299381_chr10_73990124_+_386aa MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPP ILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREIL RQFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRV YNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSDGSERFLCESVFSYQVASTLKQVKHDQQVARMEKLAGL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HNF1B_ENST00000225893_chr17_36091586_-_ANAPC16_ENST00000299381_chr10_73990124_+_1236nt ATGGTGTCCAAGCTCACGTCGCTCCAGCAAGAACTCCTGAGCGCCCTGCTGAGCTCCGGGGTCACCAAGGAGGTGCTGGTTCAGGCCTTG GAGGAGTTGCTGCCATCCCCGAACTTCGGGGTGAAGCTGGAGACGCTGCCCCTGTCCCCTGGCAGCGGGGCCGAGCCCGACACCAAGCCG GTCTTCCATACTCTCACCAACGGCCACGCCAAGGGCCGCTTGTCCGGCGACGAGGGCTCCGAGGACGGCGACGACTATGACACACCTCCC ATCCTCAAGGAGCTGCAGGCGCTCAACACCGAGGAGGCGGCGGAGCAGCGGGCGGAGGTGGACCGGATGCTCAGTGAGGACCCTTGGAGG GCTGCTAAAATGATCAAGGGTTACATGCAGCAACACAACATCCCCCAGAGGGAGGTGGTCGATGTCACCGGCCTGAACCAGTCGCACCTC TCCCAGCATCTCAACAAGGGCACCCCTATGAAGACCCAGAAGCGTGCCGCTCTGTACACCTGGTACGTCAGAAAGCAACGAGAGATCCTC CGACAATTCAACCAGACAGTCCAGAGTTCTGGAAATATGACAGACAAAAGCAGTCAGGATCAGCTGCTGTTTCTCTTTCCAGAGTTCAGT CAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAACCGGTTCAAATGGGGGCCC GCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAGGAATGCAACAGG GCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGTCCGTGTCTACAACTGGTTT GCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCACAGCCTGAACCCTCTGCTC TCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGATGGCTCTGAGAGATTCCTCTGCGAATCTGTTTTT AGCTATCAAGTGGCATCCACGCTTAAACAGGTGAAACATGATCAGCAAGTTGCTCGGATGGAAAAACTAGCTGGTTTGGTAGAAGAGCTG >In-frame_HNF1B_ENST00000561193_chr17_36091586_-_ANAPC16_ENST00000299381_chr10_73990124_+_1158nt ATGGTGTCCAAGCTCACGTCGCTCCAGCAAGAACTCCTGAGCGCCCTGCTGAGCTCCGGGGTCACCAAGGAGGTGCTGGTTCAGGCCTTG GAGGAGTTGCTGCCATCCCCGAACTTCGGGGTGAAGCTGGAGACGCTGCCCCTGTCCCCTGGCAGCGGGGCCGAGCCCGACACCAAGCCG GTCTTCCATACTCTCACCAACGGCCACGCCAAGGGCCGCTTGTCCGGCGACGAGGGCTCCGAGGACGGCGACGACTATGACACACCTCCC ATCCTCAAGGAGCTGCAGGCGCTCAACACCGAGGAGGCGGCGGAGCAGCGGGCGGAGGTGGACCGGATGCTCAGTGAGGACCCTTGGAGG GCTGCTAAAATGATCAAGGGTTACATGCAGCAACACAACATCCCCCAGAGGGAGGTGGTCGATGTCACCGGCCTGAACCAGTCGCACCTC TCCCAGCATCTCAACAAGGGCACCCCTATGAAGACCCAGAAGCGTGCCGCTCTGTACACCTGGTACGTCAGAAAGCAACGAGAGATCCTC CGACAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAACCGGTTC AAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAG GAATGCAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGTCCGTGTC TACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCACAGCCTG AACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGATGGCTCTGAGAGATTCCTCTGC GAATCTGTTTTTAGCTATCAAGTGGCATCCACGCTTAAACAGGTGAAACATGATCAGCAAGTTGCTCGGATGGAAAAACTAGCTGGTTTG >In-frame_HNF1B_ENST00000560016_chr17_36091586_-_ANAPC16_ENST00000299381_chr10_73990124_+_1236nt ATGGTGTCCAAGCTCACGTCGCTCCAGCAAGAACTCCTGAGCGCCCTGCTGAGCTCCGGGGTCACCAAGGAGGTGCTGGTTCAGGCCTTG GAGGAGTTGCTGCCATCCCCGAACTTCGGGGTGAAGCTGGAGACGCTGCCCCTGTCCCCTGGCAGCGGGGCCGAGCCCGACACCAAGCCG GTCTTCCATACTCTCACCAACGGCCACGCCAAGGGCCGCTTGTCCGGCGACGAGGGCTCCGAGGACGGCGACGACTATGACACACCTCCC ATCCTCAAGGAGCTGCAGGCGCTCAACACCGAGGAGGCGGCGGAGCAGCGGGCGGAGGTGGACCGGATGCTCAGTGAGGACCCTTGGAGG GCTGCTAAAATGATCAAGGGTTACATGCAGCAACACAACATCCCCCAGAGGGAGGTGGTCGATGTCACCGGCCTGAACCAGTCGCACCTC TCCCAGCATCTCAACAAGGGCACCCCTATGAAGACCCAGAAGCGTGCCGCTCTGTACACCTGGTACGTCAGAAAGCAACGAGAGATCCTC CGACAATTCAACCAGACAGTCCAGAGTTCTGGAAATATGACAGACAAAAGCAGTCAGGATCAGCTGCTGTTTCTCTTTCCAGAGTTCAGT CAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAACCGGTTCAAATGGGGGCCC GCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAGGAATGCAACAGG GCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGTCCGTGTCTACAACTGGTTT GCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCACAGCCTGAACCCTCTGCTC TCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGATGGCTCTGAGAGATTCCTCTGCGAATCTGTTTTT AGCTATCAAGTGGCATCCACGCTTAAACAGGTGAAACATGATCAGCAAGTTGCTCGGATGGAAAAACTAGCTGGTTTGGTAGAAGAGCTG >In-frame_HNF1B_ENST00000427275_chr17_36091586_-_ANAPC16_ENST00000299381_chr10_73990124_+_1158nt ATGGTGTCCAAGCTCACGTCGCTCCAGCAAGAACTCCTGAGCGCCCTGCTGAGCTCCGGGGTCACCAAGGAGGTGCTGGTTCAGGCCTTG GAGGAGTTGCTGCCATCCCCGAACTTCGGGGTGAAGCTGGAGACGCTGCCCCTGTCCCCTGGCAGCGGGGCCGAGCCCGACACCAAGCCG GTCTTCCATACTCTCACCAACGGCCACGCCAAGGGCCGCTTGTCCGGCGACGAGGGCTCCGAGGACGGCGACGACTATGACACACCTCCC ATCCTCAAGGAGCTGCAGGCGCTCAACACCGAGGAGGCGGCGGAGCAGCGGGCGGAGGTGGACCGGATGCTCAGTGAGGACCCTTGGAGG GCTGCTAAAATGATCAAGGGTTACATGCAGCAACACAACATCCCCCAGAGGGAGGTGGTCGATGTCACCGGCCTGAACCAGTCGCACCTC TCCCAGCATCTCAACAAGGGCACCCCTATGAAGACCCAGAAGCGTGCCGCTCTGTACACCTGGTACGTCAGAAAGCAACGAGAGATCCTC CGACAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAACCGGTTC AAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAG GAATGCAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGTCCGTGTC TACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCACAGCCTG AACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGATGGCTCTGAGAGATTCCTCTGC GAATCTGTTTTTAGCTATCAAGTGGCATCCACGCTTAAACAGGTGAAACATGATCAGCAAGTTGCTCGGATGGAAAAACTAGCTGGTTTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HNF1B_ENST00000225893_chr17_36091586_-_ANAPC16_ENST00000299381_chr10_73990124_+_4342nt GAGTACAATGGACCCTGGCAAAGCCCCGCTCCCGGCCCAGGTCTTCTGCTCTCCAGGTCTGCCCCTCCGGCTCTCCCTCTCTCCGGGTTT CCCCCTCCCCACCATCATTTGCATCCAGCCGAAAGCTGGGCCCTTCCCACTAATTTGCATATCTTATATGGCCTAATGGTGGCGATCATG GCAAGTTAGAAGTTTTCTGACTCCTTTCGGAGGAGCCTCCGGGACCCCGGGGAGTAACAGGTGTCTGGAGGCTGAAGGGTGGAGGGGTTC CTGGATTTGGGGTTTGCTTGTGAAACTCCCCTCCACCCTCCTCTCTCGCACCCACCCACCCCCTCACCCCCTTCTTTTTCCGTCCTTGGA AAATGGTGTCCAAGCTCACGTCGCTCCAGCAAGAACTCCTGAGCGCCCTGCTGAGCTCCGGGGTCACCAAGGAGGTGCTGGTTCAGGCCT TGGAGGAGTTGCTGCCATCCCCGAACTTCGGGGTGAAGCTGGAGACGCTGCCCCTGTCCCCTGGCAGCGGGGCCGAGCCCGACACCAAGC CGGTCTTCCATACTCTCACCAACGGCCACGCCAAGGGCCGCTTGTCCGGCGACGAGGGCTCCGAGGACGGCGACGACTATGACACACCTC CCATCCTCAAGGAGCTGCAGGCGCTCAACACCGAGGAGGCGGCGGAGCAGCGGGCGGAGGTGGACCGGATGCTCAGTGAGGACCCTTGGA GGGCTGCTAAAATGATCAAGGGTTACATGCAGCAACACAACATCCCCCAGAGGGAGGTGGTCGATGTCACCGGCCTGAACCAGTCGCACC TCTCCCAGCATCTCAACAAGGGCACCCCTATGAAGACCCAGAAGCGTGCCGCTCTGTACACCTGGTACGTCAGAAAGCAACGAGAGATCC TCCGACAATTCAACCAGACAGTCCAGAGTTCTGGAAATATGACAGACAAAAGCAGTCAGGATCAGCTGCTGTTTCTCTTTCCAGAGTTCA GTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAACCGGTTCAAATGGGGGC CCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAGGAATGCAACA GGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGTCCGTGTCTACAACTGGT TTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCACAGCCTGAACCCTCTGC TCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGATGGCTCTGAGAGATTCCTCTGCGAATCTGTTT TTAGCTATCAAGTGGCATCCACGCTTAAACAGGTGAAACATGATCAGCAAGTTGCTCGGATGGAAAAACTAGCTGGTTTGGTAGAAGAGC TGGAGGCTGACGAGTGGCGGTTTAAGCCCATCGAGCAGCTGCTGGGATTCACCCCCTCTTCAGGTTGATACTGCCTGGATGGTCACCTCT GGTGCGCAGCAAGTGCAAAGCCAGTGGGGGACTTTCTCACAGCTTACATAGCCATCCAGAGATCCACAGCTACGTCACTGAATTGTTAAT GCACATTTGTACTTGGTTTCTCTGTATCTATTCACAGGCAACAAATACTTATATGTGTGATCTTTCAGGGAATGTTTTGTTTATTTGTTT TTAAAAGTATTGGGAATCAGATTAAGACAATCAGTTTCAGAGAACCAGGAGGTTTGGGGTTAAGAGATACTCAAAAATTTTCACAAGCCA AGTAGGGCATATATCAGATTTGGCCAACTGAATGGCGTCTGTCCTGTCATCCATATGGTGCCTGGAAATATTTACCAGTCAAGGTCAAGG TCAGCATCTGTGGTTAAAAATATAGCATTCTGACCTAAAAAAGTTATTTTGCAGATGAATGTGTTTTCAACTCAGGACCTATCCAAATGA GGAATTTTTAAATATTCTTTTTTTTTTCCTATTTTTAGACATCAATTCTATAGATTCTGACTTTTTCTAACCTCTTATAGACATGCCAAA TGCTGGCAAAAAGAAGTGCTTTTTGGATATGGCAGCACTTGTAAAAATAAAGCAGTAAGCAAAATCCTTTTAAACACAGAAATCCTGAGT TCTTCTCATTGGTGGACTCAAGCAATTCTGTAGCAAATAAATCCTTTGAAAGAGCTCCAAATTGGTGGCATTATCCTTTCAAAATCTCAG GGATTTGGGATGAAGTGAAGAGGTCAAATTACTTTTTAGAAGAAGGGAATCTAAAAACCATCTCTCCTAAACAAATGGTAGACTGGCTTT ACTTAAGGGATATTTGTCTTTATAGGAGTACATAAATTTATCTTAATGATATTTAAGTAGTTTTTTTTTTTTTTTGAGACGAAGTTTTGC TCTTGTTGCCCAGGCTGTATCGCAATGGCGCGATCTCTGCTCACTGCAACATCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCT CCCAAGTAGCTGGGATTACAGGCACCCGCCACCACACCCAGCTAATTTTTTGTATATTTAGTAGAGACGGGGTTTCACCATGTTGACCAG GCTAGTCTCGAACTTCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAATTGCTGGGATTACAGGCGTGAGCCACCTTGCCCAGCCA ATTTTTTTTTAAAGAGACATGGTCTTGCTATGTTGCCCAGGTTGGTCTTGAACTCCTGGCCTCAAGAGATCCCCCCAACCTTGGCCTCCA AAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCTCAAGTAAGTTTTTATACCATGATAGGGGAAAACCTGGAAGGCTAAGAGAT GTGCTGTTTTCCTTCATGGGACCCCACTTTCCACAGTAAACAACTGGTATAATCATTTATTACGTTGTATGCAAATTTTGCCTTAGACAA CATTTGTCTGGTTCCTTATTAATAACTTGCATCTGATCTGCTTAGAGTTGCTTAATTATAAGTAAATATAATCCCAGTAGCATTTAGCCT TAATCTCAAGAGTTCAAAATGTTTAACACATTCTACCTGACGGGAGGTGGTGACCTCATTCAGTCGGTTAAGAGCCTGAGCCCTGTGAAG TTAAACACCTGCTCATGGTCACATAGCCCAGGCAGAAGAAAATCTCGGACTTGGAATAGATCCCAGTTGCCTGATAATTCATCTCATTAT TGCCTCTAAAGCAAATTGGAGACTGGGCACAGTGGCTCCCACCTTTAATCCCAGCACCTGGGGAGGCTGAGGTGAGTGGATCACTAGAGG TCAGGAGTTCAAGACCAGTCTGGCCGACATGGTGAAACTCAGTCTCTATTGAAAATACAAAAATTAGCTCAGTGTGGTGGCACACACTTG TAATCCCAGCTACTCAGGAGGCTGAGGCATGAGAATCGCTTAAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCACACCATTGCACT CTAGTCTGGGTGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAATAAAGCCGGGCGTGGTGGCTCACGCCTGTAATCCCGGCACTTTGG GAGGCTGAGGCAGGCGGATTGCCTGAGATCGGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCTTGTCTCTACTAAAACTACAAAA AAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGCAGAATCGTTTGAACCCGGGAGGCGGAGG TTGCAGTGAGTGGAGATCGTGCCTGTGTGCTCCAGCCTGAGCAACAAGAGCGAAACTGTCTCAAAAAAAAGAAGAAAATAAATAAATAAA AATCAGAGCACAAGAAGTACCAGTCCACCAACTCACATTTTCTATATTAATAATTCTTAACTAAAAGAAGTTCCATATTCGACAGCATTT TAGTTTTTTAATAGTACTTATTAGCATCAACCATCTTGATAATCACCAAGGGAAAAATTAAAAATACCTAGACTGCAATAAACCTTTAAA TTGGATTTTCAGTGAGAATTTAGAAGCAATCACTACCTTTCTCGTTTCATTTGTGTAACCATGCAGCATAGGCACTGTGTTACATCATCT TTACGCTTTGGTATTTGAACTTATTACAGAATTTTTTCTCTAAATTGGATGTTTCTTTATATGACCTTGGAAACTGAAGTGATCTTAGCA >In-frame_HNF1B_ENST00000561193_chr17_36091586_-_ANAPC16_ENST00000299381_chr10_73990124_+_4077nt AGAAGTTTTCTGACTCCTTTCGGAGGAGCCTCCGGGACCCCGGGGAGTAACAGGTGTCTGGAGGCTGAAGGGTGGAGGGGTTCCTGGATT TGGGGTTTGCTTGTGAAACTCCCCTCCACCCTCCTCTCTCGCACCCACCCACCCCCTCACCCCCTTCTTTTTCCGTCCTTGGAAAATGGT GTCCAAGCTCACGTCGCTCCAGCAAGAACTCCTGAGCGCCCTGCTGAGCTCCGGGGTCACCAAGGAGGTGCTGGTTCAGGCCTTGGAGGA GTTGCTGCCATCCCCGAACTTCGGGGTGAAGCTGGAGACGCTGCCCCTGTCCCCTGGCAGCGGGGCCGAGCCCGACACCAAGCCGGTCTT CCATACTCTCACCAACGGCCACGCCAAGGGCCGCTTGTCCGGCGACGAGGGCTCCGAGGACGGCGACGACTATGACACACCTCCCATCCT CAAGGAGCTGCAGGCGCTCAACACCGAGGAGGCGGCGGAGCAGCGGGCGGAGGTGGACCGGATGCTCAGTGAGGACCCTTGGAGGGCTGC TAAAATGATCAAGGGTTACATGCAGCAACACAACATCCCCCAGAGGGAGGTGGTCGATGTCACCGGCCTGAACCAGTCGCACCTCTCCCA GCATCTCAACAAGGGCACCCCTATGAAGACCCAGAAGCGTGCCGCTCTGTACACCTGGTACGTCAGAAAGCAACGAGAGATCCTCCGACA GTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAACCGGTTCAAATG GGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAGGAATG CAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGTCCGTGTCTACAA CTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCACAGCCTGAACCC TCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACAAGCTGTCAGATGGCTCTGAGAGATTCCTCTGCGAATC TGTTTTTAGCTATCAAGTGGCATCCACGCTTAAACAGGTGAAACATGATCAGCAAGTTGCTCGGATGGAAAAACTAGCTGGTTTGGTAGA AGAGCTGGAGGCTGACGAGTGGCGGTTTAAGCCCATCGAGCAGCTGCTGGGATTCACCCCCTCTTCAGGTTGATACTGCCTGGATGGTCA CCTCTGGTGCGCAGCAAGTGCAAAGCCAGTGGGGGACTTTCTCACAGCTTACATAGCCATCCAGAGATCCACAGCTACGTCACTGAATTG TTAATGCACATTTGTACTTGGTTTCTCTGTATCTATTCACAGGCAACAAATACTTATATGTGTGATCTTTCAGGGAATGTTTTGTTTATT TGTTTTTAAAAGTATTGGGAATCAGATTAAGACAATCAGTTTCAGAGAACCAGGAGGTTTGGGGTTAAGAGATACTCAAAAATTTTCACA AGCCAAGTAGGGCATATATCAGATTTGGCCAACTGAATGGCGTCTGTCCTGTCATCCATATGGTGCCTGGAAATATTTACCAGTCAAGGT CAAGGTCAGCATCTGTGGTTAAAAATATAGCATTCTGACCTAAAAAAGTTATTTTGCAGATGAATGTGTTTTCAACTCAGGACCTATCCA AATGAGGAATTTTTAAATATTCTTTTTTTTTTCCTATTTTTAGACATCAATTCTATAGATTCTGACTTTTTCTAACCTCTTATAGACATG CCAAATGCTGGCAAAAAGAAGTGCTTTTTGGATATGGCAGCACTTGTAAAAATAAAGCAGTAAGCAAAATCCTTTTAAACACAGAAATCC TGAGTTCTTCTCATTGGTGGACTCAAGCAATTCTGTAGCAAATAAATCCTTTGAAAGAGCTCCAAATTGGTGGCATTATCCTTTCAAAAT CTCAGGGATTTGGGATGAAGTGAAGAGGTCAAATTACTTTTTAGAAGAAGGGAATCTAAAAACCATCTCTCCTAAACAAATGGTAGACTG GCTTTACTTAAGGGATATTTGTCTTTATAGGAGTACATAAATTTATCTTAATGATATTTAAGTAGTTTTTTTTTTTTTTTGAGACGAAGT TTTGCTCTTGTTGCCCAGGCTGTATCGCAATGGCGCGATCTCTGCTCACTGCAACATCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTC AGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCACCACACCCAGCTAATTTTTTGTATATTTAGTAGAGACGGGGTTTCACCATGTTG ACCAGGCTAGTCTCGAACTTCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAATTGCTGGGATTACAGGCGTGAGCCACCTTGCCC AGCCAATTTTTTTTTAAAGAGACATGGTCTTGCTATGTTGCCCAGGTTGGTCTTGAACTCCTGGCCTCAAGAGATCCCCCCAACCTTGGC CTCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCTCAAGTAAGTTTTTATACCATGATAGGGGAAAACCTGGAAGGCTAA GAGATGTGCTGTTTTCCTTCATGGGACCCCACTTTCCACAGTAAACAACTGGTATAATCATTTATTACGTTGTATGCAAATTTTGCCTTA GACAACATTTGTCTGGTTCCTTATTAATAACTTGCATCTGATCTGCTTAGAGTTGCTTAATTATAAGTAAATATAATCCCAGTAGCATTT AGCCTTAATCTCAAGAGTTCAAAATGTTTAACACATTCTACCTGACGGGAGGTGGTGACCTCATTCAGTCGGTTAAGAGCCTGAGCCCTG TGAAGTTAAACACCTGCTCATGGTCACATAGCCCAGGCAGAAGAAAATCTCGGACTTGGAATAGATCCCAGTTGCCTGATAATTCATCTC ATTATTGCCTCTAAAGCAAATTGGAGACTGGGCACAGTGGCTCCCACCTTTAATCCCAGCACCTGGGGAGGCTGAGGTGAGTGGATCACT AGAGGTCAGGAGTTCAAGACCAGTCTGGCCGACATGGTGAAACTCAGTCTCTATTGAAAATACAAAAATTAGCTCAGTGTGGTGGCACAC ACTTGTAATCCCAGCTACTCAGGAGGCTGAGGCATGAGAATCGCTTAAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCACACCATT GCACTCTAGTCTGGGTGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAATAAAGCCGGGCGTGGTGGCTCACGCCTGTAATCCCGGCAC TTTGGGAGGCTGAGGCAGGCGGATTGCCTGAGATCGGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCTTGTCTCTACTAAAACTA CAAAAAAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGCAGAATCGTTTGAACCCGGGAGGC GGAGGTTGCAGTGAGTGGAGATCGTGCCTGTGTGCTCCAGCCTGAGCAACAAGAGCGAAACTGTCTCAAAAAAAAGAAGAAAATAAATAA ATAAAAATCAGAGCACAAGAAGTACCAGTCCACCAACTCACATTTTCTATATTAATAATTCTTAACTAAAAGAAGTTCCATATTCGACAG CATTTTAGTTTTTTAATAGTACTTATTAGCATCAACCATCTTGATAATCACCAAGGGAAAAATTAAAAATACCTAGACTGCAATAAACCT TTAAATTGGATTTTCAGTGAGAATTTAGAAGCAATCACTACCTTTCTCGTTTCATTTGTGTAACCATGCAGCATAGGCACTGTGTTACAT CATCTTTACGCTTTGGTATTTGAACTTATTACAGAATTTTTTCTCTAAATTGGATGTTTCTTTATATGACCTTGGAAACTGAAGTGATCT >In-frame_HNF1B_ENST00000560016_chr17_36091586_-_ANAPC16_ENST00000299381_chr10_73990124_+_4114nt GGGGAGTAACAGGTGTCTGGAGGCTGAAGGGTGGAGGGGTTCCTGGATTTGGGGTTTGCTTGTGAAACTCCCCTCCACCCTCCTCTCTCG CACCCACCCACCCCCTCACCCCCTTCTTTTTCCGTCCTTGGAAAATGGTGTCCAAGCTCACGTCGCTCCAGCAAGAACTCCTGAGCGCCC TGCTGAGCTCCGGGGTCACCAAGGAGGTGCTGGTTCAGGCCTTGGAGGAGTTGCTGCCATCCCCGAACTTCGGGGTGAAGCTGGAGACGC TGCCCCTGTCCCCTGGCAGCGGGGCCGAGCCCGACACCAAGCCGGTCTTCCATACTCTCACCAACGGCCACGCCAAGGGCCGCTTGTCCG GCGACGAGGGCTCCGAGGACGGCGACGACTATGACACACCTCCCATCCTCAAGGAGCTGCAGGCGCTCAACACCGAGGAGGCGGCGGAGC AGCGGGCGGAGGTGGACCGGATGCTCAGTGAGGACCCTTGGAGGGCTGCTAAAATGATCAAGGGTTACATGCAGCAACACAACATCCCCC AGAGGGAGGTGGTCGATGTCACCGGCCTGAACCAGTCGCACCTCTCCCAGCATCTCAACAAGGGCACCCCTATGAAGACCCAGAAGCGTG CCGCTCTGTACACCTGGTACGTCAGAAAGCAACGAGAGATCCTCCGACAATTCAACCAGACAGTCCAGAGTTCTGGAAATATGACAGACA AAAGCAGTCAGGATCAGCTGCTGTTTCTCTTTCCAGAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATGCCTGCTCTGAGC CCACCAACAAGAAGATGCGCCGCAACCGGTTCAAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATCGGCAAAAGAACC CCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAGGAATGCAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCAAAGCCCACGGCC TGGGCTCCAACTTGGTCACTGAGGTCCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAAAGCTGGCCATGG ACGCCTATAGCTCCAACCAGACTCACAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCTCTCCTCCAAACA AGCTGTCAGATGGCTCTGAGAGATTCCTCTGCGAATCTGTTTTTAGCTATCAAGTGGCATCCACGCTTAAACAGGTGAAACATGATCAGC AAGTTGCTCGGATGGAAAAACTAGCTGGTTTGGTAGAAGAGCTGGAGGCTGACGAGTGGCGGTTTAAGCCCATCGAGCAGCTGCTGGGAT TCACCCCCTCTTCAGGTTGATACTGCCTGGATGGTCACCTCTGGTGCGCAGCAAGTGCAAAGCCAGTGGGGGACTTTCTCACAGCTTACA TAGCCATCCAGAGATCCACAGCTACGTCACTGAATTGTTAATGCACATTTGTACTTGGTTTCTCTGTATCTATTCACAGGCAACAAATAC TTATATGTGTGATCTTTCAGGGAATGTTTTGTTTATTTGTTTTTAAAAGTATTGGGAATCAGATTAAGACAATCAGTTTCAGAGAACCAG GAGGTTTGGGGTTAAGAGATACTCAAAAATTTTCACAAGCCAAGTAGGGCATATATCAGATTTGGCCAACTGAATGGCGTCTGTCCTGTC ATCCATATGGTGCCTGGAAATATTTACCAGTCAAGGTCAAGGTCAGCATCTGTGGTTAAAAATATAGCATTCTGACCTAAAAAAGTTATT TTGCAGATGAATGTGTTTTCAACTCAGGACCTATCCAAATGAGGAATTTTTAAATATTCTTTTTTTTTTCCTATTTTTAGACATCAATTC TATAGATTCTGACTTTTTCTAACCTCTTATAGACATGCCAAATGCTGGCAAAAAGAAGTGCTTTTTGGATATGGCAGCACTTGTAAAAAT AAAGCAGTAAGCAAAATCCTTTTAAACACAGAAATCCTGAGTTCTTCTCATTGGTGGACTCAAGCAATTCTGTAGCAAATAAATCCTTTG AAAGAGCTCCAAATTGGTGGCATTATCCTTTCAAAATCTCAGGGATTTGGGATGAAGTGAAGAGGTCAAATTACTTTTTAGAAGAAGGGA ATCTAAAAACCATCTCTCCTAAACAAATGGTAGACTGGCTTTACTTAAGGGATATTTGTCTTTATAGGAGTACATAAATTTATCTTAATG ATATTTAAGTAGTTTTTTTTTTTTTTTGAGACGAAGTTTTGCTCTTGTTGCCCAGGCTGTATCGCAATGGCGCGATCTCTGCTCACTGCA ACATCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCACCACACCCAGCTAATTT TTTGTATATTTAGTAGAGACGGGGTTTCACCATGTTGACCAGGCTAGTCTCGAACTTCTGACCTCAGGTGATCCACCTGCCTCAGCCTCC CAAATTGCTGGGATTACAGGCGTGAGCCACCTTGCCCAGCCAATTTTTTTTTAAAGAGACATGGTCTTGCTATGTTGCCCAGGTTGGTCT TGAACTCCTGGCCTCAAGAGATCCCCCCAACCTTGGCCTCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCTCAAGTAAG TTTTTATACCATGATAGGGGAAAACCTGGAAGGCTAAGAGATGTGCTGTTTTCCTTCATGGGACCCCACTTTCCACAGTAAACAACTGGT ATAATCATTTATTACGTTGTATGCAAATTTTGCCTTAGACAACATTTGTCTGGTTCCTTATTAATAACTTGCATCTGATCTGCTTAGAGT TGCTTAATTATAAGTAAATATAATCCCAGTAGCATTTAGCCTTAATCTCAAGAGTTCAAAATGTTTAACACATTCTACCTGACGGGAGGT GGTGACCTCATTCAGTCGGTTAAGAGCCTGAGCCCTGTGAAGTTAAACACCTGCTCATGGTCACATAGCCCAGGCAGAAGAAAATCTCGG ACTTGGAATAGATCCCAGTTGCCTGATAATTCATCTCATTATTGCCTCTAAAGCAAATTGGAGACTGGGCACAGTGGCTCCCACCTTTAA TCCCAGCACCTGGGGAGGCTGAGGTGAGTGGATCACTAGAGGTCAGGAGTTCAAGACCAGTCTGGCCGACATGGTGAAACTCAGTCTCTA TTGAAAATACAAAAATTAGCTCAGTGTGGTGGCACACACTTGTAATCCCAGCTACTCAGGAGGCTGAGGCATGAGAATCGCTTAAACCCA GGAGGCGGAGGTTGCAGTGAGCTGAGATCACACCATTGCACTCTAGTCTGGGTGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAATAA AGCCGGGCGTGGTGGCTCACGCCTGTAATCCCGGCACTTTGGGAGGCTGAGGCAGGCGGATTGCCTGAGATCGGGAGTTCGAGACCAGCC TGGCCAACATGGTGAAACCTTGTCTCTACTAAAACTACAAAAAAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAATCCCAGCTACTCAG GAGGCTGAGGCAGCAGAATCGTTTGAACCCGGGAGGCGGAGGTTGCAGTGAGTGGAGATCGTGCCTGTGTGCTCCAGCCTGAGCAACAAG AGCGAAACTGTCTCAAAAAAAAGAAGAAAATAAATAAATAAAAATCAGAGCACAAGAAGTACCAGTCCACCAACTCACATTTTCTATATT AATAATTCTTAACTAAAAGAAGTTCCATATTCGACAGCATTTTAGTTTTTTAATAGTACTTATTAGCATCAACCATCTTGATAATCACCA AGGGAAAAATTAAAAATACCTAGACTGCAATAAACCTTTAAATTGGATTTTCAGTGAGAATTTAGAAGCAATCACTACCTTTCTCGTTTC ATTTGTGTAACCATGCAGCATAGGCACTGTGTTACATCATCTTTACGCTTTGGTATTTGAACTTATTACAGAATTTTTTCTCTAAATTGG >In-frame_HNF1B_ENST00000427275_chr17_36091586_-_ANAPC16_ENST00000299381_chr10_73990124_+_4036nt GGGGAGTAACAGGTGTCTGGAGGCTGAAGGGTGGAGGGGTTCCTGGATTTGGGGTTTGCTTGTGAAACTCCCCTCCACCCTCCTCTCTCG CACCCACCCACCCCCTCACCCCCTTCTTTTTCCGTCCTTGGAAAATGGTGTCCAAGCTCACGTCGCTCCAGCAAGAACTCCTGAGCGCCC TGCTGAGCTCCGGGGTCACCAAGGAGGTGCTGGTTCAGGCCTTGGAGGAGTTGCTGCCATCCCCGAACTTCGGGGTGAAGCTGGAGACGC TGCCCCTGTCCCCTGGCAGCGGGGCCGAGCCCGACACCAAGCCGGTCTTCCATACTCTCACCAACGGCCACGCCAAGGGCCGCTTGTCCG GCGACGAGGGCTCCGAGGACGGCGACGACTATGACACACCTCCCATCCTCAAGGAGCTGCAGGCGCTCAACACCGAGGAGGCGGCGGAGC AGCGGGCGGAGGTGGACCGGATGCTCAGTGAGGACCCTTGGAGGGCTGCTAAAATGATCAAGGGTTACATGCAGCAACACAACATCCCCC AGAGGGAGGTGGTCGATGTCACCGGCCTGAACCAGTCGCACCTCTCCCAGCATCTCAACAAGGGCACCCCTATGAAGACCCAGAAGCGTG CCGCTCTGTACACCTGGTACGTCAGAAAGCAACGAGAGATCCTCCGACAGTTCAGTCAACAGAGCCATGGGCCTGGGCAGTCCGATGATG CCTGCTCTGAGCCCACCAACAAGAAGATGCGCCGCAACCGGTTCAAATGGGGGCCCGCGTCCCAGCAAATCTTGTACCAGGCCTACGATC GGCAAAAGAACCCCAGCAAGGAAGAGAGAGAGGCCTTAGTGGAGGAATGCAACAGGGCAGAATGTTTGCAGCGAGGGGTGTCCCCCTCCA AAGCCCACGGCCTGGGCTCCAACTTGGTCACTGAGGTCCGTGTCTACAACTGGTTTGCAAACCGCAGGAAGGAGGAGGCATTCCGGCAAA AGCTGGCCATGGACGCCTATAGCTCCAACCAGACTCACAGCCTGAACCCTCTGCTCTCCCACGGCTCCCCCCACCACCAGCCCAGCTCCT CTCCTCCAAACAAGCTGTCAGATGGCTCTGAGAGATTCCTCTGCGAATCTGTTTTTAGCTATCAAGTGGCATCCACGCTTAAACAGGTGA AACATGATCAGCAAGTTGCTCGGATGGAAAAACTAGCTGGTTTGGTAGAAGAGCTGGAGGCTGACGAGTGGCGGTTTAAGCCCATCGAGC AGCTGCTGGGATTCACCCCCTCTTCAGGTTGATACTGCCTGGATGGTCACCTCTGGTGCGCAGCAAGTGCAAAGCCAGTGGGGGACTTTC TCACAGCTTACATAGCCATCCAGAGATCCACAGCTACGTCACTGAATTGTTAATGCACATTTGTACTTGGTTTCTCTGTATCTATTCACA GGCAACAAATACTTATATGTGTGATCTTTCAGGGAATGTTTTGTTTATTTGTTTTTAAAAGTATTGGGAATCAGATTAAGACAATCAGTT TCAGAGAACCAGGAGGTTTGGGGTTAAGAGATACTCAAAAATTTTCACAAGCCAAGTAGGGCATATATCAGATTTGGCCAACTGAATGGC GTCTGTCCTGTCATCCATATGGTGCCTGGAAATATTTACCAGTCAAGGTCAAGGTCAGCATCTGTGGTTAAAAATATAGCATTCTGACCT AAAAAAGTTATTTTGCAGATGAATGTGTTTTCAACTCAGGACCTATCCAAATGAGGAATTTTTAAATATTCTTTTTTTTTTCCTATTTTT AGACATCAATTCTATAGATTCTGACTTTTTCTAACCTCTTATAGACATGCCAAATGCTGGCAAAAAGAAGTGCTTTTTGGATATGGCAGC ACTTGTAAAAATAAAGCAGTAAGCAAAATCCTTTTAAACACAGAAATCCTGAGTTCTTCTCATTGGTGGACTCAAGCAATTCTGTAGCAA ATAAATCCTTTGAAAGAGCTCCAAATTGGTGGCATTATCCTTTCAAAATCTCAGGGATTTGGGATGAAGTGAAGAGGTCAAATTACTTTT TAGAAGAAGGGAATCTAAAAACCATCTCTCCTAAACAAATGGTAGACTGGCTTTACTTAAGGGATATTTGTCTTTATAGGAGTACATAAA TTTATCTTAATGATATTTAAGTAGTTTTTTTTTTTTTTTGAGACGAAGTTTTGCTCTTGTTGCCCAGGCTGTATCGCAATGGCGCGATCT CTGCTCACTGCAACATCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCACCACA CCCAGCTAATTTTTTGTATATTTAGTAGAGACGGGGTTTCACCATGTTGACCAGGCTAGTCTCGAACTTCTGACCTCAGGTGATCCACCT GCCTCAGCCTCCCAAATTGCTGGGATTACAGGCGTGAGCCACCTTGCCCAGCCAATTTTTTTTTAAAGAGACATGGTCTTGCTATGTTGC CCAGGTTGGTCTTGAACTCCTGGCCTCAAGAGATCCCCCCAACCTTGGCCTCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTG GCCTCAAGTAAGTTTTTATACCATGATAGGGGAAAACCTGGAAGGCTAAGAGATGTGCTGTTTTCCTTCATGGGACCCCACTTTCCACAG TAAACAACTGGTATAATCATTTATTACGTTGTATGCAAATTTTGCCTTAGACAACATTTGTCTGGTTCCTTATTAATAACTTGCATCTGA TCTGCTTAGAGTTGCTTAATTATAAGTAAATATAATCCCAGTAGCATTTAGCCTTAATCTCAAGAGTTCAAAATGTTTAACACATTCTAC CTGACGGGAGGTGGTGACCTCATTCAGTCGGTTAAGAGCCTGAGCCCTGTGAAGTTAAACACCTGCTCATGGTCACATAGCCCAGGCAGA AGAAAATCTCGGACTTGGAATAGATCCCAGTTGCCTGATAATTCATCTCATTATTGCCTCTAAAGCAAATTGGAGACTGGGCACAGTGGC TCCCACCTTTAATCCCAGCACCTGGGGAGGCTGAGGTGAGTGGATCACTAGAGGTCAGGAGTTCAAGACCAGTCTGGCCGACATGGTGAA ACTCAGTCTCTATTGAAAATACAAAAATTAGCTCAGTGTGGTGGCACACACTTGTAATCCCAGCTACTCAGGAGGCTGAGGCATGAGAAT CGCTTAAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCACACCATTGCACTCTAGTCTGGGTGACAGAGCGAGACTCTGTCTCAAAA AAAAAAAAATAAAGCCGGGCGTGGTGGCTCACGCCTGTAATCCCGGCACTTTGGGAGGCTGAGGCAGGCGGATTGCCTGAGATCGGGAGT TCGAGACCAGCCTGGCCAACATGGTGAAACCTTGTCTCTACTAAAACTACAAAAAAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAATC CCAGCTACTCAGGAGGCTGAGGCAGCAGAATCGTTTGAACCCGGGAGGCGGAGGTTGCAGTGAGTGGAGATCGTGCCTGTGTGCTCCAGC CTGAGCAACAAGAGCGAAACTGTCTCAAAAAAAAGAAGAAAATAAATAAATAAAAATCAGAGCACAAGAAGTACCAGTCCACCAACTCAC ATTTTCTATATTAATAATTCTTAACTAAAAGAAGTTCCATATTCGACAGCATTTTAGTTTTTTAATAGTACTTATTAGCATCAACCATCT TGATAATCACCAAGGGAAAAATTAAAAATACCTAGACTGCAATAAACCTTTAAATTGGATTTTCAGTGAGAATTTAGAAGCAATCACTAC CTTTCTCGTTTCATTTGTGTAACCATGCAGCATAGGCACTGTGTTACATCATCTTTACGCTTTGGTATTTGAACTTATTACAGAATTTTT |
Top |
FusionGenePPI for HNF1B_ANAPC16 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HNF1B | CREB1, ATF1, HNF1A, PCBD1, HIST1H3A | ANAPC16 | RBBP6, CDC27, ELAVL1, MDC1, TP53BP1, ANAPC4, CDC20, PENK, BUB3, GRAP2, MAGIX, TTLL1, ANAPC7, ANAPC1, ANAPC5, CDC23, CDC26, CDC16, ANAPC15, CFAP97, USP37, ANAPC13, C16orf87, KIF2B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HNF1B_ANAPC16 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HNF1B_ANAPC16 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HNF1B | C0431693 | Renal cysts and diabetes syndrome | 9 | CTD_human;ORPHANET;UNIPROT |
| Hgene | HNF1B | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | CTD_human;HPO;UNIPROT |
| Hgene | HNF1B | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|