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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 16490

FusionGeneSummary for HMGXB3_PAM

check button Fusion gene summary
Fusion gene informationFusion gene name: HMGXB3_PAM
Fusion gene ID: 16490
HgeneTgene
Gene symbol

HMGXB3

PAM

Gene ID

22993

23077

Gene nameHMG-box containing 3MYC binding protein 2, E3 ubiquitin protein ligase
SynonymsHMGX3|SMFMyc-bp2|PAM|Phr
Cytomap

5q32

13q22.3

Type of geneprotein-codingprotein-coding
DescriptionHMG domain-containing protein 3HMG box domain containing 3E3 ubiquitin-protein ligase MYCBP2HighwireRING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Myc
Modification date2018052220180523
UniProtAcc

Q12766

P19021

Ensembl transtripts involved in fusion geneENST00000503427, ENST00000502717, 
ENST00000438793, ENST00000346918, 
ENST00000379787, ENST00000348126, 
ENST00000304400, ENST00000274392, 
ENST00000455264, ENST00000513648, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 6 X 2=60
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HMGXB3 [Title/Abstract] AND PAM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EB-A5KH-06AHMGXB3chr5

149386210

+PAMchr5

102201527

+
TCGALDSKCMTCGA-EB-A5KH-06AHMGXB3chr5

149386210

+PAMchr5

102237060

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000503427ENST00000438793HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-5UTRENST00000503427ENST00000346918HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-5UTRENST00000503427ENST00000379787HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-5UTRENST00000503427ENST00000348126HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-intronENST00000503427ENST00000304400HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-intronENST00000503427ENST00000274392HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-intronENST00000503427ENST00000455264HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-intronENST00000503427ENST00000513648HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-5UTRENST00000502717ENST00000438793HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-5UTRENST00000502717ENST00000346918HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-5UTRENST00000502717ENST00000379787HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-5UTRENST00000502717ENST00000348126HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-intronENST00000502717ENST00000304400HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-intronENST00000502717ENST00000274392HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-intronENST00000502717ENST00000455264HMGXB3chr5

149386210

+PAMchr5

102201527

+
5CDS-intronENST00000502717ENST00000513648HMGXB3chr5

149386210

+PAMchr5

102201527

+
In-frameENST00000503427ENST00000438793HMGXB3chr5

149386210

+PAMchr5

102237060

+
In-frameENST00000503427ENST00000346918HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-5UTRENST00000503427ENST00000379787HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-5UTRENST00000503427ENST00000348126HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-5UTRENST00000503427ENST00000304400HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-intronENST00000503427ENST00000274392HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-intronENST00000503427ENST00000455264HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-intronENST00000503427ENST00000513648HMGXB3chr5

149386210

+PAMchr5

102237060

+
In-frameENST00000502717ENST00000438793HMGXB3chr5

149386210

+PAMchr5

102237060

+
In-frameENST00000502717ENST00000346918HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-5UTRENST00000502717ENST00000379787HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-5UTRENST00000502717ENST00000348126HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-5UTRENST00000502717ENST00000304400HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-intronENST00000502717ENST00000274392HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-intronENST00000502717ENST00000455264HMGXB3chr5

149386210

+PAMchr5

102237060

+
5CDS-intronENST00000502717ENST00000513648HMGXB3chr5

149386210

+PAMchr5

102237060

+

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FusionProtFeatures for HMGXB3_PAM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HMGXB3

Q12766

PAM

P19021


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePAMchr5:149386210chr5:102237060ENST00000304400+125495_81770975RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:149386210chr5:102237060ENST00000346918+123495_81770888RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:149386210chr5:102237060ENST00000348126+124495_81770867RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:149386210chr5:102237060ENST00000438793+125495_81770974RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:149386210chr5:102237060ENST00000455264+124495_81770906RegionPeptidyl-alpha-hydroxyglycine alpha-amidating lyase
TgenePAMchr5:149386210chr5:102237060ENST00000304400+125498_54170975RepeatNote=NHL 1
TgenePAMchr5:149386210chr5:102237060ENST00000304400+125567_60870975RepeatNote=NHL 2
TgenePAMchr5:149386210chr5:102237060ENST00000304400+125617_66270975RepeatNote=NHL 3
TgenePAMchr5:149386210chr5:102237060ENST00000304400+125670_71470975RepeatNote=NHL 4
TgenePAMchr5:149386210chr5:102237060ENST00000304400+125766_80970975RepeatNote=NHL 5
TgenePAMchr5:149386210chr5:102237060ENST00000346918+123498_54170888RepeatNote=NHL 1
TgenePAMchr5:149386210chr5:102237060ENST00000346918+123567_60870888RepeatNote=NHL 2
TgenePAMchr5:149386210chr5:102237060ENST00000346918+123617_66270888RepeatNote=NHL 3
TgenePAMchr5:149386210chr5:102237060ENST00000346918+123670_71470888RepeatNote=NHL 4
TgenePAMchr5:149386210chr5:102237060ENST00000346918+123766_80970888RepeatNote=NHL 5
TgenePAMchr5:149386210chr5:102237060ENST00000348126+124498_54170867RepeatNote=NHL 1
TgenePAMchr5:149386210chr5:102237060ENST00000348126+124567_60870867RepeatNote=NHL 2
TgenePAMchr5:149386210chr5:102237060ENST00000348126+124617_66270867RepeatNote=NHL 3
TgenePAMchr5:149386210chr5:102237060ENST00000348126+124670_71470867RepeatNote=NHL 4
TgenePAMchr5:149386210chr5:102237060ENST00000348126+124766_80970867RepeatNote=NHL 5
TgenePAMchr5:149386210chr5:102237060ENST00000438793+125498_54170974RepeatNote=NHL 1
TgenePAMchr5:149386210chr5:102237060ENST00000438793+125567_60870974RepeatNote=NHL 2
TgenePAMchr5:149386210chr5:102237060ENST00000438793+125617_66270974RepeatNote=NHL 3
TgenePAMchr5:149386210chr5:102237060ENST00000438793+125670_71470974RepeatNote=NHL 4
TgenePAMchr5:149386210chr5:102237060ENST00000438793+125766_80970974RepeatNote=NHL 5
TgenePAMchr5:149386210chr5:102237060ENST00000455264+124498_54170906RepeatNote=NHL 1
TgenePAMchr5:149386210chr5:102237060ENST00000455264+124567_60870906RepeatNote=NHL 2
TgenePAMchr5:149386210chr5:102237060ENST00000455264+124617_66270906RepeatNote=NHL 3
TgenePAMchr5:149386210chr5:102237060ENST00000455264+124670_71470906RepeatNote=NHL 4
TgenePAMchr5:149386210chr5:102237060ENST00000455264+124766_80970906RepeatNote=NHL 5
TgenePAMchr5:149386210chr5:102237060ENST00000304400+125888_97370975Topological domainCytoplasmic
TgenePAMchr5:149386210chr5:102237060ENST00000346918+123888_97370888Topological domainCytoplasmic
TgenePAMchr5:149386210chr5:102237060ENST00000348126+124888_97370867Topological domainCytoplasmic
TgenePAMchr5:149386210chr5:102237060ENST00000438793+125888_97370974Topological domainCytoplasmic
TgenePAMchr5:149386210chr5:102237060ENST00000455264+124888_97370906Topological domainCytoplasmic
TgenePAMchr5:149386210chr5:102237060ENST00000304400+125864_88770975TransmembraneHelical
TgenePAMchr5:149386210chr5:102237060ENST00000346918+123864_88770888TransmembraneHelical
TgenePAMchr5:149386210chr5:102237060ENST00000348126+124864_88770867TransmembraneHelical
TgenePAMchr5:149386210chr5:102237060ENST00000438793+125864_88770974TransmembraneHelical
TgenePAMchr5:149386210chr5:102237060ENST00000455264+124864_88770906TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHMGXB3chr5:149386210chr5:102237060ENST00000502717+3201523_15321041293Compositional biasNote=Poly-Glu
HgeneHMGXB3chr5:149386210chr5:102237060ENST00000502717+320276_2821041293Compositional biasNote=Poly-Lys
HgeneHMGXB3chr5:149386210chr5:102237060ENST00000502717+320518_5241041293Compositional biasNote=Poly-Ser
HgeneHMGXB3chr5:149386210chr5:102237060ENST00000502717+32062_2391041293Compositional biasNote=Arg-rich
HgeneHMGXB3chr5:149386210chr5:102237060ENST00000502717+320288_3561041293DNA bindingHMG box
TgenePAMchr5:149386210chr5:102237060ENST00000304400+1251_49470975RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:149386210chr5:102237060ENST00000346918+1231_49470888RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:149386210chr5:102237060ENST00000348126+1241_49470867RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:149386210chr5:102237060ENST00000438793+1251_49470974RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:149386210chr5:102237060ENST00000455264+1241_49470906RegionPeptidylglycine alpha-hydroxylating monooxygenase
TgenePAMchr5:149386210chr5:102237060ENST00000304400+12531_86370975Topological domainIntragranular
TgenePAMchr5:149386210chr5:102237060ENST00000346918+12331_86370888Topological domainIntragranular
TgenePAMchr5:149386210chr5:102237060ENST00000348126+12431_86370867Topological domainIntragranular
TgenePAMchr5:149386210chr5:102237060ENST00000438793+12531_86370974Topological domainIntragranular
TgenePAMchr5:149386210chr5:102237060ENST00000455264+12431_86370906Topological domainIntragranular


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FusionGeneSequence for HMGXB3_PAM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HMGXB3_ENST00000503427_chr5_149386210_+_PAM_ENST00000438793_chr5_102237060_+_1008aa
MDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKKYKIHGEKTKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSY
YLEKAKLEKEGLDPSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLP
KGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRV
HTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSF
MTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHEHHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKA
ESESDLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQPPPGEGTWEPEHTGDFHMEEALDWPG
VYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTD
VALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVP
HSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVR
KHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEAEAVVETKMENKPTSSELQKMQEKQKLIKEPGSGVPV
VLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEHKLETSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSE

>In-frame_HMGXB3_ENST00000503427_chr5_149386210_+_PAM_ENST00000346918_chr5_102237060_+_922aa
MDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKKYKIHGEKTKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSY
YLEKAKLEKEGLDPSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLP
KGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRV
HTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSF
MTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHEHHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKA
ESESDLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQPPPGEGTWEPEHTGDFHMEEALDWPG
VYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTD
VALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVP
HSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVR
KHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKED

>In-frame_HMGXB3_ENST00000502717_chr5_149386210_+_PAM_ENST00000438793_chr5_102237060_+_1008aa
MDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKKYKIHGEKTKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSY
YLEKAKLEKEGLDPSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLP
KGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRV
HTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSF
MTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHEHHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKA
ESESDLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQPPPGEGTWEPEHTGDFHMEEALDWPG
VYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTD
VALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVP
HSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVR
KHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEAEAVVETKMENKPTSSELQKMQEKQKLIKEPGSGVPV
VLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEHKLETSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSE

>In-frame_HMGXB3_ENST00000502717_chr5_149386210_+_PAM_ENST00000346918_chr5_102237060_+_922aa
MDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKKYKIHGEKTKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSY
YLEKAKLEKEGLDPSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLP
KGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRV
HTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSF
MTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHEHHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKA
ESESDLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQPPPGEGTWEPEHTGDFHMEEALDWPG
VYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTD
VALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVP
HSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVR
KHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKED


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HMGXB3_ENST00000503427_chr5_149386210_+_PAM_ENST00000438793_chr5_102237060_+_3024nt
ATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTGATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTCCTGGGCCACCCAAG
AAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAGAAACCCAGGTCTGCTTACCTTCTGTACTATTACGACATCTACCTGAAAGTG
CAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAATAAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGGCCGAGAGGAGTTAC
TACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGATCCTTCCGATACATACTTCTGCATGTCTATGCGAATACCAGTGGATGAGGAA
GCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGATACTGTCCATCACATGTTACTTTTTGGATGCAATATGCCTTCATCCACTGGA
AGTTACTGGTTTTGTGATGAAGGAACCTGTACAGATAAAGCCAATATTCTGTATGCCTGGGCGAGAAATGCTCCCCCTACCCGGCTCCCC
AAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGTAAATACTTTGTACTACAGGTACACTATGGGGATATTAGTGCTTTTAGAGAT
AATAACAAGGACTGTTCTGGTGTGTCCTTACACCTCACACGTCTGCCACAGCCTTTAATTGCTGGCATGTACCTTATGATGTCTGTTGAC
ACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGACATTTCATGCCATTATAAAAATTATCCAATGCATGTCTTTGCCTATAGAGTT
CACACTCACCATTTAGGTAAGGTAGTAAGTGGATACAGAGTAAGAAATGGACAGTGGACACTGATTGGACGGCAGAGCCCTCAGCTGCCA
CAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGTTTTGGTGACCTACTGGCTGCAAGATGTGTATTCACTGGTGAAGGAAGGACA
GAAGCCACACACATTGGTGGCACGTCTAGTGATGAAATGTGCAACTTATACATTATGTATTACATGGAAGCCAAGCATGCAGTTTCTTTC
ATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGAACCATACCACCAGAGGCCAACATTCCAATTCCCGTGAAGTCTGATATGGTT
ATGATGCATGAACATCATAAAGAAACAGAATATAAAGATAAGATTCCTTTACTACAGCAGCCAAAACGAGAAGAAGAAGAAGTGTTAGAC
CAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGAGAAAGGGAAGATGTTGTTCATGTGCACAAATATAATCCTACAGAAAAGGCA
GAATCAGAGTCAGACCTGGTAGCTGAGATTGCAAATGTAGTCCAAAAAAAGGATCTTGGTCGATCTGATGCCAGAGAGGGTGCAGAACAT
GAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCACAAATTCCACAGACTAGTATCTACCTTGAGGCCACCAGAGAGCAGAGTTTTC
TCATTACAGCAGCCCCCACCTGGTGAAGGCACCTGGGAACCAGAACACACAGGAGATTTCCACATGGAAGAGGCACTGGATTGGCCTGGA
GTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTAGACCCTAAGAATAACCTGGTGATTTTCCACAGAGGTGACCATGTCTGGGAT
GGAAACTCGTTTGACAGCAAGTTTGTTTACCAGCAAATAGGACTCGGACCAATTGAAGAAGACACTATTCTTGTCATAGATCCAAATAAT
GCTGCAGTACTCCAGTCCAGTGGAAAAAATCTGTTTTACTTGCCACATGGCTTGAGTATAGATAAAGATGGGAATTATTGGGTCACAGAC
GTGGCTCTCCATCAGGTGTTCAAACTGGATCCAAACAATAAAGAAGGCCCTGTATTAATCCTGGGAAGGAGCATGCAACCAGGCAGTGAC
CAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGATCCAGGCACTGGAGCCATTTATGTATCAGATGGTTACTGCAACAGCAGGATT
GTGCAGTTTTCACCAAGTGGAAAGTTCATCACACAGTGGGGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCAGGCCAGTTCACTGTTCCT
CACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGTGTGGCAGACCGGGAAAATGGTCGGATCCAGTGTTTTAAAACTGACACCAAA
GAATTTGTGAGAGAGATTAAGCATTCATCATTTGGAAGAAATGTATTTGCAATTTCATATATACCAGGCTTGCTCTTTGCAGTGAATGGG
AAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTTGTGATGAACTTTTCCAATGGGGAAATTATAGACATCTTCAAGCCAGTGCGC
AAGCACTTTGATATGCCTCATGATATTGTTGCATCTGAAGATGGGACTGTGTACATTGGAGATGCTCATACCAACACCGTGTGGAAGTTC
ACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAGGCTGGCATTGAGGTCCAGGAAATCAAAGAAGCCGAGGCAGTTGTTGAAACC
AAAATGGAGAACAAACCCACCTCCTCAGAATTGCAGAAGATGCAAGAGAAACAGAAACTGATCAAAGAGCCAGGCTCGGGAGTGCCTGTT
GTTCTCATTACAACCCTTCTGGTTATTCCGGTGGTTGTCCTGCTGGCCATTGCCATATTTATTCGGTGGAAAAAATCAAGGGCCTTTGGA
GATTCTGAACACAAACTCGAGACGAGTTCAGGAAGAGTACTGGGAAGATTTAGAGGAAAGGGAAGTGGAGGCTTAAACCTTGGTAATTTC
TTTGCAAGCCGTAAGGGCTACAGTCGAAAAGGGTTTGACCGGCTTAGCACTGAGGGCAGTGACCAAGAGAAAGAGGATGATGGAAGTGAA

>In-frame_HMGXB3_ENST00000503427_chr5_149386210_+_PAM_ENST00000346918_chr5_102237060_+_2766nt
ATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTGATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTCCTGGGCCACCCAAG
AAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAGAAACCCAGGTCTGCTTACCTTCTGTACTATTACGACATCTACCTGAAAGTG
CAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAATAAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGGCCGAGAGGAGTTAC
TACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGATCCTTCCGATACATACTTCTGCATGTCTATGCGAATACCAGTGGATGAGGAA
GCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGATACTGTCCATCACATGTTACTTTTTGGATGCAATATGCCTTCATCCACTGGA
AGTTACTGGTTTTGTGATGAAGGAACCTGTACAGATAAAGCCAATATTCTGTATGCCTGGGCGAGAAATGCTCCCCCTACCCGGCTCCCC
AAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGTAAATACTTTGTACTACAGGTACACTATGGGGATATTAGTGCTTTTAGAGAT
AATAACAAGGACTGTTCTGGTGTGTCCTTACACCTCACACGTCTGCCACAGCCTTTAATTGCTGGCATGTACCTTATGATGTCTGTTGAC
ACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGACATTTCATGCCATTATAAAAATTATCCAATGCATGTCTTTGCCTATAGAGTT
CACACTCACCATTTAGGTAAGGTAGTAAGTGGATACAGAGTAAGAAATGGACAGTGGACACTGATTGGACGGCAGAGCCCTCAGCTGCCA
CAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGTTTTGGTGACCTACTGGCTGCAAGATGTGTATTCACTGGTGAAGGAAGGACA
GAAGCCACACACATTGGTGGCACGTCTAGTGATGAAATGTGCAACTTATACATTATGTATTACATGGAAGCCAAGCATGCAGTTTCTTTC
ATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGAACCATACCACCAGAGGCCAACATTCCAATTCCCGTGAAGTCTGATATGGTT
ATGATGCATGAACATCATAAAGAAACAGAATATAAAGATAAGATTCCTTTACTACAGCAGCCAAAACGAGAAGAAGAAGAAGTGTTAGAC
CAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGAGAAAGGGAAGATGTTGTTCATGTGCACAAATATAATCCTACAGAAAAGGCA
GAATCAGAGTCAGACCTGGTAGCTGAGATTGCAAATGTAGTCCAAAAAAAGGATCTTGGTCGATCTGATGCCAGAGAGGGTGCAGAACAT
GAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCACAAATTCCACAGACTAGTATCTACCTTGAGGCCACCAGAGAGCAGAGTTTTC
TCATTACAGCAGCCCCCACCTGGTGAAGGCACCTGGGAACCAGAACACACAGGAGATTTCCACATGGAAGAGGCACTGGATTGGCCTGGA
GTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTAGACCCTAAGAATAACCTGGTGATTTTCCACAGAGGTGACCATGTCTGGGAT
GGAAACTCGTTTGACAGCAAGTTTGTTTACCAGCAAATAGGACTCGGACCAATTGAAGAAGACACTATTCTTGTCATAGATCCAAATAAT
GCTGCAGTACTCCAGTCCAGTGGAAAAAATCTGTTTTACTTGCCACATGGCTTGAGTATAGATAAAGATGGGAATTATTGGGTCACAGAC
GTGGCTCTCCATCAGGTGTTCAAACTGGATCCAAACAATAAAGAAGGCCCTGTATTAATCCTGGGAAGGAGCATGCAACCAGGCAGTGAC
CAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGATCCAGGCACTGGAGCCATTTATGTATCAGATGGTTACTGCAACAGCAGGATT
GTGCAGTTTTCACCAAGTGGAAAGTTCATCACACAGTGGGGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCAGGCCAGTTCACTGTTCCT
CACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGTGTGGCAGACCGGGAAAATGGTCGGATCCAGTGTTTTAAAACTGACACCAAA
GAATTTGTGAGAGAGATTAAGCATTCATCATTTGGAAGAAATGTATTTGCAATTTCATATATACCAGGCTTGCTCTTTGCAGTGAATGGG
AAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTTGTGATGAACTTTTCCAATGGGGAAATTATAGACATCTTCAAGCCAGTGCGC
AAGCACTTTGATATGCCTCATGATATTGTTGCATCTGAAGATGGGACTGTGTACATTGGAGATGCTCATACCAACACCGTGTGGAAGTTC
ACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAGGCTGGCATTGAGGTCCAGGAAATCAAAGGAAAGGGAAGTGGAGGCTTAAAC
CTTGGTAATTTCTTTGCAAGCCGTAAGGGCTACAGTCGAAAAGGGTTTGACCGGCTTAGCACTGAGGGCAGTGACCAAGAGAAAGAGGAT

>In-frame_HMGXB3_ENST00000502717_chr5_149386210_+_PAM_ENST00000438793_chr5_102237060_+_3024nt
ATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTGATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTCCTGGGCCACCCAAG
AAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAGAAACCCAGGTCTGCTTACCTTCTGTACTATTACGACATCTACCTGAAAGTG
CAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAATAAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGGCCGAGAGGAGTTAC
TACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGATCCTTCCGATACATACTTCTGCATGTCTATGCGAATACCAGTGGATGAGGAA
GCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGATACTGTCCATCACATGTTACTTTTTGGATGCAATATGCCTTCATCCACTGGA
AGTTACTGGTTTTGTGATGAAGGAACCTGTACAGATAAAGCCAATATTCTGTATGCCTGGGCGAGAAATGCTCCCCCTACCCGGCTCCCC
AAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGTAAATACTTTGTACTACAGGTACACTATGGGGATATTAGTGCTTTTAGAGAT
AATAACAAGGACTGTTCTGGTGTGTCCTTACACCTCACACGTCTGCCACAGCCTTTAATTGCTGGCATGTACCTTATGATGTCTGTTGAC
ACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGACATTTCATGCCATTATAAAAATTATCCAATGCATGTCTTTGCCTATAGAGTT
CACACTCACCATTTAGGTAAGGTAGTAAGTGGATACAGAGTAAGAAATGGACAGTGGACACTGATTGGACGGCAGAGCCCTCAGCTGCCA
CAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGTTTTGGTGACCTACTGGCTGCAAGATGTGTATTCACTGGTGAAGGAAGGACA
GAAGCCACACACATTGGTGGCACGTCTAGTGATGAAATGTGCAACTTATACATTATGTATTACATGGAAGCCAAGCATGCAGTTTCTTTC
ATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGAACCATACCACCAGAGGCCAACATTCCAATTCCCGTGAAGTCTGATATGGTT
ATGATGCATGAACATCATAAAGAAACAGAATATAAAGATAAGATTCCTTTACTACAGCAGCCAAAACGAGAAGAAGAAGAAGTGTTAGAC
CAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGAGAAAGGGAAGATGTTGTTCATGTGCACAAATATAATCCTACAGAAAAGGCA
GAATCAGAGTCAGACCTGGTAGCTGAGATTGCAAATGTAGTCCAAAAAAAGGATCTTGGTCGATCTGATGCCAGAGAGGGTGCAGAACAT
GAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCACAAATTCCACAGACTAGTATCTACCTTGAGGCCACCAGAGAGCAGAGTTTTC
TCATTACAGCAGCCCCCACCTGGTGAAGGCACCTGGGAACCAGAACACACAGGAGATTTCCACATGGAAGAGGCACTGGATTGGCCTGGA
GTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTAGACCCTAAGAATAACCTGGTGATTTTCCACAGAGGTGACCATGTCTGGGAT
GGAAACTCGTTTGACAGCAAGTTTGTTTACCAGCAAATAGGACTCGGACCAATTGAAGAAGACACTATTCTTGTCATAGATCCAAATAAT
GCTGCAGTACTCCAGTCCAGTGGAAAAAATCTGTTTTACTTGCCACATGGCTTGAGTATAGATAAAGATGGGAATTATTGGGTCACAGAC
GTGGCTCTCCATCAGGTGTTCAAACTGGATCCAAACAATAAAGAAGGCCCTGTATTAATCCTGGGAAGGAGCATGCAACCAGGCAGTGAC
CAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGATCCAGGCACTGGAGCCATTTATGTATCAGATGGTTACTGCAACAGCAGGATT
GTGCAGTTTTCACCAAGTGGAAAGTTCATCACACAGTGGGGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCAGGCCAGTTCACTGTTCCT
CACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGTGTGGCAGACCGGGAAAATGGTCGGATCCAGTGTTTTAAAACTGACACCAAA
GAATTTGTGAGAGAGATTAAGCATTCATCATTTGGAAGAAATGTATTTGCAATTTCATATATACCAGGCTTGCTCTTTGCAGTGAATGGG
AAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTTGTGATGAACTTTTCCAATGGGGAAATTATAGACATCTTCAAGCCAGTGCGC
AAGCACTTTGATATGCCTCATGATATTGTTGCATCTGAAGATGGGACTGTGTACATTGGAGATGCTCATACCAACACCGTGTGGAAGTTC
ACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAGGCTGGCATTGAGGTCCAGGAAATCAAAGAAGCCGAGGCAGTTGTTGAAACC
AAAATGGAGAACAAACCCACCTCCTCAGAATTGCAGAAGATGCAAGAGAAACAGAAACTGATCAAAGAGCCAGGCTCGGGAGTGCCTGTT
GTTCTCATTACAACCCTTCTGGTTATTCCGGTGGTTGTCCTGCTGGCCATTGCCATATTTATTCGGTGGAAAAAATCAAGGGCCTTTGGA
GATTCTGAACACAAACTCGAGACGAGTTCAGGAAGAGTACTGGGAAGATTTAGAGGAAAGGGAAGTGGAGGCTTAAACCTTGGTAATTTC
TTTGCAAGCCGTAAGGGCTACAGTCGAAAAGGGTTTGACCGGCTTAGCACTGAGGGCAGTGACCAAGAGAAAGAGGATGATGGAAGTGAA

>In-frame_HMGXB3_ENST00000502717_chr5_149386210_+_PAM_ENST00000346918_chr5_102237060_+_2766nt
ATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTGATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTCCTGGGCCACCCAAG
AAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAGAAACCCAGGTCTGCTTACCTTCTGTACTATTACGACATCTACCTGAAAGTG
CAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAATAAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGGCCGAGAGGAGTTAC
TACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGATCCTTCCGATACATACTTCTGCATGTCTATGCGAATACCAGTGGATGAGGAA
GCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGATACTGTCCATCACATGTTACTTTTTGGATGCAATATGCCTTCATCCACTGGA
AGTTACTGGTTTTGTGATGAAGGAACCTGTACAGATAAAGCCAATATTCTGTATGCCTGGGCGAGAAATGCTCCCCCTACCCGGCTCCCC
AAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGTAAATACTTTGTACTACAGGTACACTATGGGGATATTAGTGCTTTTAGAGAT
AATAACAAGGACTGTTCTGGTGTGTCCTTACACCTCACACGTCTGCCACAGCCTTTAATTGCTGGCATGTACCTTATGATGTCTGTTGAC
ACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGACATTTCATGCCATTATAAAAATTATCCAATGCATGTCTTTGCCTATAGAGTT
CACACTCACCATTTAGGTAAGGTAGTAAGTGGATACAGAGTAAGAAATGGACAGTGGACACTGATTGGACGGCAGAGCCCTCAGCTGCCA
CAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGTTTTGGTGACCTACTGGCTGCAAGATGTGTATTCACTGGTGAAGGAAGGACA
GAAGCCACACACATTGGTGGCACGTCTAGTGATGAAATGTGCAACTTATACATTATGTATTACATGGAAGCCAAGCATGCAGTTTCTTTC
ATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGAACCATACCACCAGAGGCCAACATTCCAATTCCCGTGAAGTCTGATATGGTT
ATGATGCATGAACATCATAAAGAAACAGAATATAAAGATAAGATTCCTTTACTACAGCAGCCAAAACGAGAAGAAGAAGAAGTGTTAGAC
CAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGAGAAAGGGAAGATGTTGTTCATGTGCACAAATATAATCCTACAGAAAAGGCA
GAATCAGAGTCAGACCTGGTAGCTGAGATTGCAAATGTAGTCCAAAAAAAGGATCTTGGTCGATCTGATGCCAGAGAGGGTGCAGAACAT
GAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCACAAATTCCACAGACTAGTATCTACCTTGAGGCCACCAGAGAGCAGAGTTTTC
TCATTACAGCAGCCCCCACCTGGTGAAGGCACCTGGGAACCAGAACACACAGGAGATTTCCACATGGAAGAGGCACTGGATTGGCCTGGA
GTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTAGACCCTAAGAATAACCTGGTGATTTTCCACAGAGGTGACCATGTCTGGGAT
GGAAACTCGTTTGACAGCAAGTTTGTTTACCAGCAAATAGGACTCGGACCAATTGAAGAAGACACTATTCTTGTCATAGATCCAAATAAT
GCTGCAGTACTCCAGTCCAGTGGAAAAAATCTGTTTTACTTGCCACATGGCTTGAGTATAGATAAAGATGGGAATTATTGGGTCACAGAC
GTGGCTCTCCATCAGGTGTTCAAACTGGATCCAAACAATAAAGAAGGCCCTGTATTAATCCTGGGAAGGAGCATGCAACCAGGCAGTGAC
CAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGATCCAGGCACTGGAGCCATTTATGTATCAGATGGTTACTGCAACAGCAGGATT
GTGCAGTTTTCACCAAGTGGAAAGTTCATCACACAGTGGGGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCAGGCCAGTTCACTGTTCCT
CACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGTGTGGCAGACCGGGAAAATGGTCGGATCCAGTGTTTTAAAACTGACACCAAA
GAATTTGTGAGAGAGATTAAGCATTCATCATTTGGAAGAAATGTATTTGCAATTTCATATATACCAGGCTTGCTCTTTGCAGTGAATGGG
AAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTTGTGATGAACTTTTCCAATGGGGAAATTATAGACATCTTCAAGCCAGTGCGC
AAGCACTTTGATATGCCTCATGATATTGTTGCATCTGAAGATGGGACTGTGTACATTGGAGATGCTCATACCAACACCGTGTGGAAGTTC
ACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAGGCTGGCATTGAGGTCCAGGAAATCAAAGGAAAGGGAAGTGGAGGCTTAAAC
CTTGGTAATTTCTTTGCAAGCCGTAAGGGCTACAGTCGAAAAGGGTTTGACCGGCTTAGCACTGAGGGCAGTGACCAAGAGAAAGAGGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_HMGXB3_ENST00000503427_chr5_149386210_+_PAM_ENST00000438793_chr5_102237060_+_5925nt
ATGAGAGGGAAAGACTGAGACAGGCTGAGGTCAGGCCTTGAACGTCGTGCTGAGGAGAGGGTGGTATTGTAGGCTTCCCAGCGCCCGACG
TGGCTCTGAAAGGTGAGGCGGGGCCTAGATCCCTCACGCTCAGCACAGCCCCGCCCCTGTTACCTGAACGCCCCACAGCAGTGCCCGGGG
GCTGAGCGGCCGGGGCGTCCCACCGCCGGCAGCCACAGCTTCCTCCTCCGCCCGGGACCTCTGGCCGGAAGCAGTCCGTTCGCCTTACTA
GACCCGCTCCAAGCCTTTGAGCAGTTCGTGTGGGTCCGCTCCCAAGCTAGGGCTGGGCTGTTGCGCTTGCGCCAGGGGTCGCATGCAGTC
ACGCGCTGCCGACCGCTTCCGGTGCGCCGCGAGGGCCGCCGGGACGGGTCTCCCTGGCGATCCGTGGTGTGCCGCTACTGCCGGTGCAGC
CGCCAAACCGGTGCCTCGGTGACGACCGTGTCCCTGCCGTCTTCCTCGAGCTCCCCGGGGCTTGACCCCCGGGGCCCTCGGCAGGCATCG
GTGAGGAGCCTGCGGAGCGAACCTGTGCTCCTATTCTTGCCCTTCAGGACCCCATATCGCGACTCCGAGGAGGGGAAGCGAGAGGGGCTG
TCGCGACTCCGCGCCGTGTGTCGCCGGGCGGGGCCGCGGGGCCGGGGCTCCTTCAGCCCCCGGGATGCGCGCGCGAGCCCTCGCCTCCAC
TTCCTTGTTGCTGCTGTCACGACTGGAGCCGCCTCTCGCCGACAGCGGGGAGCGCGAGTGCGCCAGCCATCCCCCTCGTCCAGCCGCCGG
GCCAAGCGCCTCCGGGAATGTGAGCGGCGCAGCTTGCACGCTCCTCCGGCCATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTG
ATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTCCTGGGCCACCCAAGAAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAG
AAACCCAGGTCTGCTTACCTTCTGTACTATTACGACATCTACCTGAAAGTGCAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAAT
AAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGGCCGAGAGGAGTTACTACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGAT
CCTTCCGATACATACTTCTGCATGTCTATGCGAATACCAGTGGATGAGGAAGCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGAT
ACTGTCCATCACATGTTACTTTTTGGATGCAATATGCCTTCATCCACTGGAAGTTACTGGTTTTGTGATGAAGGAACCTGTACAGATAAA
GCCAATATTCTGTATGCCTGGGCGAGAAATGCTCCCCCTACCCGGCTCCCCAAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGT
AAATACTTTGTACTACAGGTACACTATGGGGATATTAGTGCTTTTAGAGATAATAACAAGGACTGTTCTGGTGTGTCCTTACACCTCACA
CGTCTGCCACAGCCTTTAATTGCTGGCATGTACCTTATGATGTCTGTTGACACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGAC
ATTTCATGCCATTATAAAAATTATCCAATGCATGTCTTTGCCTATAGAGTTCACACTCACCATTTAGGTAAGGTAGTAAGTGGATACAGA
GTAAGAAATGGACAGTGGACACTGATTGGACGGCAGAGCCCTCAGCTGCCACAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGT
TTTGGTGACCTACTGGCTGCAAGATGTGTATTCACTGGTGAAGGAAGGACAGAAGCCACACACATTGGTGGCACGTCTAGTGATGAAATG
TGCAACTTATACATTATGTATTACATGGAAGCCAAGCATGCAGTTTCTTTCATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGA
ACCATACCACCAGAGGCCAACATTCCAATTCCCGTGAAGTCTGATATGGTTATGATGCATGAACATCATAAAGAAACAGAATATAAAGAT
AAGATTCCTTTACTACAGCAGCCAAAACGAGAAGAAGAAGAAGTGTTAGACCAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGA
GAAAGGGAAGATGTTGTTCATGTGCACAAATATAATCCTACAGAAAAGGCAGAATCAGAGTCAGACCTGGTAGCTGAGATTGCAAATGTA
GTCCAAAAAAAGGATCTTGGTCGATCTGATGCCAGAGAGGGTGCAGAACATGAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCAC
AAATTCCACAGACTAGTATCTACCTTGAGGCCACCAGAGAGCAGAGTTTTCTCATTACAGCAGCCCCCACCTGGTGAAGGCACCTGGGAA
CCAGAACACACAGGAGATTTCCACATGGAAGAGGCACTGGATTGGCCTGGAGTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTA
GACCCTAAGAATAACCTGGTGATTTTCCACAGAGGTGACCATGTCTGGGATGGAAACTCGTTTGACAGCAAGTTTGTTTACCAGCAAATA
GGACTCGGACCAATTGAAGAAGACACTATTCTTGTCATAGATCCAAATAATGCTGCAGTACTCCAGTCCAGTGGAAAAAATCTGTTTTAC
TTGCCACATGGCTTGAGTATAGATAAAGATGGGAATTATTGGGTCACAGACGTGGCTCTCCATCAGGTGTTCAAACTGGATCCAAACAAT
AAAGAAGGCCCTGTATTAATCCTGGGAAGGAGCATGCAACCAGGCAGTGACCAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGAT
CCAGGCACTGGAGCCATTTATGTATCAGATGGTTACTGCAACAGCAGGATTGTGCAGTTTTCACCAAGTGGAAAGTTCATCACACAGTGG
GGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCAGGCCAGTTCACTGTTCCTCACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGT
GTGGCAGACCGGGAAAATGGTCGGATCCAGTGTTTTAAAACTGACACCAAAGAATTTGTGAGAGAGATTAAGCATTCATCATTTGGAAGA
AATGTATTTGCAATTTCATATATACCAGGCTTGCTCTTTGCAGTGAATGGGAAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTT
GTGATGAACTTTTCCAATGGGGAAATTATAGACATCTTCAAGCCAGTGCGCAAGCACTTTGATATGCCTCATGATATTGTTGCATCTGAA
GATGGGACTGTGTACATTGGAGATGCTCATACCAACACCGTGTGGAAGTTCACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAG
GCTGGCATTGAGGTCCAGGAAATCAAAGAAGCCGAGGCAGTTGTTGAAACCAAAATGGAGAACAAACCCACCTCCTCAGAATTGCAGAAG
ATGCAAGAGAAACAGAAACTGATCAAAGAGCCAGGCTCGGGAGTGCCTGTTGTTCTCATTACAACCCTTCTGGTTATTCCGGTGGTTGTC
CTGCTGGCCATTGCCATATTTATTCGGTGGAAAAAATCAAGGGCCTTTGGAGATTCTGAACACAAACTCGAGACGAGTTCAGGAAGAGTA
CTGGGAAGATTTAGAGGAAAGGGAAGTGGAGGCTTAAACCTTGGTAATTTCTTTGCAAGCCGTAAGGGCTACAGTCGAAAAGGGTTTGAC
CGGCTTAGCACTGAGGGCAGTGACCAAGAGAAAGAGGATGATGGAAGTGAATCAGAAGAGGAGTATTCAGCACCTCTGCCTGCGCTCGCA
CCTTCCTCCTCCTGAAAACCAAGCTTTGATTTAGATTGAGTAAGATTTACCCAGAATGTCAGATTCCTTTCCCTTTAGCACGTTTAAAGT
TCTGTGTATTTAATTGTAAACTGTACTAGTCTGTGTGGGACTGTACACACTTTATTTACTTCGTTTTGGTTAAGTTGGCTTCTGTTTCTA
GTTGAGGAGTTTCCTAAAAGTTCATAACAGTGCCATTGTCTTTATATGAACATAGACTAGAGAAACCGTCCTCTTTTTCCATCATAATTC
TAATCTAACAATGGAAGATTTGCCCATTTACACTTTTGAGACTTTTTGGTGGATGTAAATAACCCCATTCTTTGCTTGAACACAGTATTT
TCCCAATAGCACTTTCATTGCCAGTGTCTTTCTTTGGTGCCTTTCCTGTTCAGCATTCTTAGCCTGTGGCAGTAAAGAGAAACTTTGTGC
TACATGACGACAAAGCTGCTAAATCTCCTATTTTTTTAAAATCACTAACATTATATTGCAATGAAGGAAATAAAAAAGTCTCTATTTAAA
TTCTTTTTTAAATTTTCTTCAGTTGGTGTGTTTTTGGGATGTCTTATTTTTAGATGGTTACACTGTTAGAACACTATTTTCAGAATCTGA
ATGTAATTTGTGTAATAAAGTGTTTTCAGAGCATTAGCTGTCAGTGTATTTTCCAGTTTTTGCGTATTTGCAGATTTTACATACAACTTT
TATAATAATTACACAAACCCACAAATATTAGTGAAACTTACTCGATGTCTTCAACTAAAAGAAATGTGTGTATTGTACAAAATTTAGAAG
ATACTTTAGCCAATATAAATTAAAAACCAGCCTGAGTTTACATAAATTTGTAAAGTCAGGCTCTTCTAAAATCCAAAGAGGGTTTTTGCC
TATATATCAATCAGAGGATAAATACTTTAATAAAAGGTAATCACAGCTAAGTGGATACCTGTGTCTCAAATTACATATGCAAATGATCCA
TCAGTAGGGATCACTAATAATAGTTTTCCTTTTAAAAAATAATTTCAGGGCAGGTACAGTGGCTCAAGCCTATACTTCCAGGACTTTGGG
AGGCCAAGCAGAAGGATTGTGGGAGGCCAAGCAGAAGGATTGTTTGAGCCCAGAAATTCAAGGCTGCAGTGAGCTATGATCAATCCACTG
TACTCCAGCCTAGGCTACAGAGTGAGATCCTTTCTCTAAAATAAAATACAATTTCCATGTATCCATAGGAATATATTCATCTTTTACAGT
GATTGCAGATTAGTTTTAAAACGTCTTTTTCGTAATTCGTCAATGCAAGTTAGTAAGAACCAGATAATTTTCCATTTTAAAATGATAGGA
ATCTAAAACTCTTTTTCAAAAATGCCAACCTGTTTTTCCGGCATCATAGTAGTTGGAATAATACAGATATAATTGACTAATCATAAAGTA
CATGAGAGTACAGAAGGGAAATTTGGAAACGGTAAGTCTGCTAGGGCATTACAATCCTGTCCTAGCACTCCACCTTTATTCTGCCAACCT
GGGTTAATTAAAGATGGTAGCCTGGAAAGTAATGAATGACATTGACTTCAGGCAATCTTTCCACTGATTATTCTTGGCTGAACTTCATTT
ATCGAGTCAGAGAATGCACTGCCTGAGAAATGTCCCAGAGGAGTGAATCCTAGGCCTGGCCACAGTAGAATCGCCTGGAGAATTTAAGAA
AAAAATTGTTGGGCACTCACTCTTTCCAGTGATCTTTATTTAGTTGGCTTACAATGGAATACAGGTATGGTTCATGTTTTTAAATTTGTC
CAGGTGTTTCTATTGTGCAGTCACAGTTGAAAACCATTGTCTTCGAGAATAGCTATTCTATCTTGCCAGTTACAATAAGTGGATAGCTAT
ATTTTCACATAAATTATAGTTTACAGATGTTTGGAGGGGGAAGACAGGATCTGAGGTGTTTTGATATGACTGTTAGCACCAAAATCTGAA

>In-frame_HMGXB3_ENST00000503427_chr5_149386210_+_PAM_ENST00000346918_chr5_102237060_+_3806nt
ATGAGAGGGAAAGACTGAGACAGGCTGAGGTCAGGCCTTGAACGTCGTGCTGAGGAGAGGGTGGTATTGTAGGCTTCCCAGCGCCCGACG
TGGCTCTGAAAGGTGAGGCGGGGCCTAGATCCCTCACGCTCAGCACAGCCCCGCCCCTGTTACCTGAACGCCCCACAGCAGTGCCCGGGG
GCTGAGCGGCCGGGGCGTCCCACCGCCGGCAGCCACAGCTTCCTCCTCCGCCCGGGACCTCTGGCCGGAAGCAGTCCGTTCGCCTTACTA
GACCCGCTCCAAGCCTTTGAGCAGTTCGTGTGGGTCCGCTCCCAAGCTAGGGCTGGGCTGTTGCGCTTGCGCCAGGGGTCGCATGCAGTC
ACGCGCTGCCGACCGCTTCCGGTGCGCCGCGAGGGCCGCCGGGACGGGTCTCCCTGGCGATCCGTGGTGTGCCGCTACTGCCGGTGCAGC
CGCCAAACCGGTGCCTCGGTGACGACCGTGTCCCTGCCGTCTTCCTCGAGCTCCCCGGGGCTTGACCCCCGGGGCCCTCGGCAGGCATCG
GTGAGGAGCCTGCGGAGCGAACCTGTGCTCCTATTCTTGCCCTTCAGGACCCCATATCGCGACTCCGAGGAGGGGAAGCGAGAGGGGCTG
TCGCGACTCCGCGCCGTGTGTCGCCGGGCGGGGCCGCGGGGCCGGGGCTCCTTCAGCCCCCGGGATGCGCGCGCGAGCCCTCGCCTCCAC
TTCCTTGTTGCTGCTGTCACGACTGGAGCCGCCTCTCGCCGACAGCGGGGAGCGCGAGTGCGCCAGCCATCCCCCTCGTCCAGCCGCCGG
GCCAAGCGCCTCCGGGAATGTGAGCGGCGCAGCTTGCACGCTCCTCCGGCCATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTG
ATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTCCTGGGCCACCCAAGAAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAG
AAACCCAGGTCTGCTTACCTTCTGTACTATTACGACATCTACCTGAAAGTGCAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAAT
AAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGGCCGAGAGGAGTTACTACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGAT
CCTTCCGATACATACTTCTGCATGTCTATGCGAATACCAGTGGATGAGGAAGCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGAT
ACTGTCCATCACATGTTACTTTTTGGATGCAATATGCCTTCATCCACTGGAAGTTACTGGTTTTGTGATGAAGGAACCTGTACAGATAAA
GCCAATATTCTGTATGCCTGGGCGAGAAATGCTCCCCCTACCCGGCTCCCCAAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGT
AAATACTTTGTACTACAGGTACACTATGGGGATATTAGTGCTTTTAGAGATAATAACAAGGACTGTTCTGGTGTGTCCTTACACCTCACA
CGTCTGCCACAGCCTTTAATTGCTGGCATGTACCTTATGATGTCTGTTGACACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGAC
ATTTCATGCCATTATAAAAATTATCCAATGCATGTCTTTGCCTATAGAGTTCACACTCACCATTTAGGTAAGGTAGTAAGTGGATACAGA
GTAAGAAATGGACAGTGGACACTGATTGGACGGCAGAGCCCTCAGCTGCCACAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGT
TTTGGTGACCTACTGGCTGCAAGATGTGTATTCACTGGTGAAGGAAGGACAGAAGCCACACACATTGGTGGCACGTCTAGTGATGAAATG
TGCAACTTATACATTATGTATTACATGGAAGCCAAGCATGCAGTTTCTTTCATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGA
ACCATACCACCAGAGGCCAACATTCCAATTCCCGTGAAGTCTGATATGGTTATGATGCATGAACATCATAAAGAAACAGAATATAAAGAT
AAGATTCCTTTACTACAGCAGCCAAAACGAGAAGAAGAAGAAGTGTTAGACCAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGA
GAAAGGGAAGATGTTGTTCATGTGCACAAATATAATCCTACAGAAAAGGCAGAATCAGAGTCAGACCTGGTAGCTGAGATTGCAAATGTA
GTCCAAAAAAAGGATCTTGGTCGATCTGATGCCAGAGAGGGTGCAGAACATGAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCAC
AAATTCCACAGACTAGTATCTACCTTGAGGCCACCAGAGAGCAGAGTTTTCTCATTACAGCAGCCCCCACCTGGTGAAGGCACCTGGGAA
CCAGAACACACAGGAGATTTCCACATGGAAGAGGCACTGGATTGGCCTGGAGTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTA
GACCCTAAGAATAACCTGGTGATTTTCCACAGAGGTGACCATGTCTGGGATGGAAACTCGTTTGACAGCAAGTTTGTTTACCAGCAAATA
GGACTCGGACCAATTGAAGAAGACACTATTCTTGTCATAGATCCAAATAATGCTGCAGTACTCCAGTCCAGTGGAAAAAATCTGTTTTAC
TTGCCACATGGCTTGAGTATAGATAAAGATGGGAATTATTGGGTCACAGACGTGGCTCTCCATCAGGTGTTCAAACTGGATCCAAACAAT
AAAGAAGGCCCTGTATTAATCCTGGGAAGGAGCATGCAACCAGGCAGTGACCAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGAT
CCAGGCACTGGAGCCATTTATGTATCAGATGGTTACTGCAACAGCAGGATTGTGCAGTTTTCACCAAGTGGAAAGTTCATCACACAGTGG
GGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCAGGCCAGTTCACTGTTCCTCACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGT
GTGGCAGACCGGGAAAATGGTCGGATCCAGTGTTTTAAAACTGACACCAAAGAATTTGTGAGAGAGATTAAGCATTCATCATTTGGAAGA
AATGTATTTGCAATTTCATATATACCAGGCTTGCTCTTTGCAGTGAATGGGAAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTT
GTGATGAACTTTTCCAATGGGGAAATTATAGACATCTTCAAGCCAGTGCGCAAGCACTTTGATATGCCTCATGATATTGTTGCATCTGAA
GATGGGACTGTGTACATTGGAGATGCTCATACCAACACCGTGTGGAAGTTCACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAG
GCTGGCATTGAGGTCCAGGAAATCAAAGGAAAGGGAAGTGGAGGCTTAAACCTTGGTAATTTCTTTGCAAGCCGTAAGGGCTACAGTCGA
AAAGGGTTTGACCGGCTTAGCACTGAGGGCAGTGACCAAGAGAAAGAGGATGATGGAAGTGAATCAGAAGAGGAGTATTCAGCACCTCTG
CCTGCGCTCGCACCTTCCTCCTCCTGAAAACCAAGCTTTGATTTAGATTGAGTAAGATTTACCCAGAATGTCAGATTCCTTTCCCTTTAG
CACGTTTAAAGTTCTGTGTATTTAATTGTAAACTGTACTAGTCTGTGTGGGACTGTACACACTTTATTTACTTCGTTTTGGTTAAGTTGG

>In-frame_HMGXB3_ENST00000502717_chr5_149386210_+_PAM_ENST00000438793_chr5_102237060_+_5528nt
GCCGGGACGGGTCTCCCTGGCGATCCGTGGTGTGCCGCTACTGCCGGTGCAGCCGCCAAACCGGTGCCTCGGTGACGACCGTGTCCCTGC
CGTCTTCCTCGAGCTCCCCGGGGCTTGACCCCCGGGGCCCTCGGCAGGCATCGGTGAGGAGCCTGCGGAGCGAACCTGTGCTCCTATTCT
TGCCCTTCAGGACCCCATATCGCGACTCCGAGGAGGGGAAGCGAGAGGGGCTGTCGCGACTCCGCGCCGTGTGTCGCCGGGCGGGGCCGC
GGGGCCGGGGCTCCTTCAGCCCCCGGGATGCGCGCGCGAGCCCTCGCCTCCACTTCCTTGTTGCTGCTGTCACGACTGGAGCCGCCTCTC
GCCGACAGCGGGGAGCGCGAGTGCGCCAGCCATCCCCCTCGTCCAGCCGCCGGGCCAAGCGCCTCCGGGAATGTGAGCGGCGCAGCTTGC
ACGCTCCTCCGGCCATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTGATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTC
CTGGGCCACCCAAGAAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAGAAACCCAGGTCTGCTTACCTTCTGTACTATTACGACA
TCTACCTGAAAGTGCAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAATAAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGG
CCGAGAGGAGTTACTACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGATCCTTCCGATACATACTTCTGCATGTCTATGCGAATAC
CAGTGGATGAGGAAGCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGATACTGTCCATCACATGTTACTTTTTGGATGCAATATGC
CTTCATCCACTGGAAGTTACTGGTTTTGTGATGAAGGAACCTGTACAGATAAAGCCAATATTCTGTATGCCTGGGCGAGAAATGCTCCCC
CTACCCGGCTCCCCAAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGTAAATACTTTGTACTACAGGTACACTATGGGGATATTA
GTGCTTTTAGAGATAATAACAAGGACTGTTCTGGTGTGTCCTTACACCTCACACGTCTGCCACAGCCTTTAATTGCTGGCATGTACCTTA
TGATGTCTGTTGACACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGACATTTCATGCCATTATAAAAATTATCCAATGCATGTCT
TTGCCTATAGAGTTCACACTCACCATTTAGGTAAGGTAGTAAGTGGATACAGAGTAAGAAATGGACAGTGGACACTGATTGGACGGCAGA
GCCCTCAGCTGCCACAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGTTTTGGTGACCTACTGGCTGCAAGATGTGTATTCACTG
GTGAAGGAAGGACAGAAGCCACACACATTGGTGGCACGTCTAGTGATGAAATGTGCAACTTATACATTATGTATTACATGGAAGCCAAGC
ATGCAGTTTCTTTCATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGAACCATACCACCAGAGGCCAACATTCCAATTCCCGTGA
AGTCTGATATGGTTATGATGCATGAACATCATAAAGAAACAGAATATAAAGATAAGATTCCTTTACTACAGCAGCCAAAACGAGAAGAAG
AAGAAGTGTTAGACCAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGAGAAAGGGAAGATGTTGTTCATGTGCACAAATATAATC
CTACAGAAAAGGCAGAATCAGAGTCAGACCTGGTAGCTGAGATTGCAAATGTAGTCCAAAAAAAGGATCTTGGTCGATCTGATGCCAGAG
AGGGTGCAGAACATGAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCACAAATTCCACAGACTAGTATCTACCTTGAGGCCACCAG
AGAGCAGAGTTTTCTCATTACAGCAGCCCCCACCTGGTGAAGGCACCTGGGAACCAGAACACACAGGAGATTTCCACATGGAAGAGGCAC
TGGATTGGCCTGGAGTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTAGACCCTAAGAATAACCTGGTGATTTTCCACAGAGGTG
ACCATGTCTGGGATGGAAACTCGTTTGACAGCAAGTTTGTTTACCAGCAAATAGGACTCGGACCAATTGAAGAAGACACTATTCTTGTCA
TAGATCCAAATAATGCTGCAGTACTCCAGTCCAGTGGAAAAAATCTGTTTTACTTGCCACATGGCTTGAGTATAGATAAAGATGGGAATT
ATTGGGTCACAGACGTGGCTCTCCATCAGGTGTTCAAACTGGATCCAAACAATAAAGAAGGCCCTGTATTAATCCTGGGAAGGAGCATGC
AACCAGGCAGTGACCAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGATCCAGGCACTGGAGCCATTTATGTATCAGATGGTTACT
GCAACAGCAGGATTGTGCAGTTTTCACCAAGTGGAAAGTTCATCACACAGTGGGGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCAGGCC
AGTTCACTGTTCCTCACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGTGTGGCAGACCGGGAAAATGGTCGGATCCAGTGTTTTA
AAACTGACACCAAAGAATTTGTGAGAGAGATTAAGCATTCATCATTTGGAAGAAATGTATTTGCAATTTCATATATACCAGGCTTGCTCT
TTGCAGTGAATGGGAAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTTGTGATGAACTTTTCCAATGGGGAAATTATAGACATCT
TCAAGCCAGTGCGCAAGCACTTTGATATGCCTCATGATATTGTTGCATCTGAAGATGGGACTGTGTACATTGGAGATGCTCATACCAACA
CCGTGTGGAAGTTCACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAGGCTGGCATTGAGGTCCAGGAAATCAAAGAAGCCGAGG
CAGTTGTTGAAACCAAAATGGAGAACAAACCCACCTCCTCAGAATTGCAGAAGATGCAAGAGAAACAGAAACTGATCAAAGAGCCAGGCT
CGGGAGTGCCTGTTGTTCTCATTACAACCCTTCTGGTTATTCCGGTGGTTGTCCTGCTGGCCATTGCCATATTTATTCGGTGGAAAAAAT
CAAGGGCCTTTGGAGATTCTGAACACAAACTCGAGACGAGTTCAGGAAGAGTACTGGGAAGATTTAGAGGAAAGGGAAGTGGAGGCTTAA
ACCTTGGTAATTTCTTTGCAAGCCGTAAGGGCTACAGTCGAAAAGGGTTTGACCGGCTTAGCACTGAGGGCAGTGACCAAGAGAAAGAGG
ATGATGGAAGTGAATCAGAAGAGGAGTATTCAGCACCTCTGCCTGCGCTCGCACCTTCCTCCTCCTGAAAACCAAGCTTTGATTTAGATT
GAGTAAGATTTACCCAGAATGTCAGATTCCTTTCCCTTTAGCACGTTTAAAGTTCTGTGTATTTAATTGTAAACTGTACTAGTCTGTGTG
GGACTGTACACACTTTATTTACTTCGTTTTGGTTAAGTTGGCTTCTGTTTCTAGTTGAGGAGTTTCCTAAAAGTTCATAACAGTGCCATT
GTCTTTATATGAACATAGACTAGAGAAACCGTCCTCTTTTTCCATCATAATTCTAATCTAACAATGGAAGATTTGCCCATTTACACTTTT
GAGACTTTTTGGTGGATGTAAATAACCCCATTCTTTGCTTGAACACAGTATTTTCCCAATAGCACTTTCATTGCCAGTGTCTTTCTTTGG
TGCCTTTCCTGTTCAGCATTCTTAGCCTGTGGCAGTAAAGAGAAACTTTGTGCTACATGACGACAAAGCTGCTAAATCTCCTATTTTTTT
AAAATCACTAACATTATATTGCAATGAAGGAAATAAAAAAGTCTCTATTTAAATTCTTTTTTAAATTTTCTTCAGTTGGTGTGTTTTTGG
GATGTCTTATTTTTAGATGGTTACACTGTTAGAACACTATTTTCAGAATCTGAATGTAATTTGTGTAATAAAGTGTTTTCAGAGCATTAG
CTGTCAGTGTATTTTCCAGTTTTTGCGTATTTGCAGATTTTACATACAACTTTTATAATAATTACACAAACCCACAAATATTAGTGAAAC
TTACTCGATGTCTTCAACTAAAAGAAATGTGTGTATTGTACAAAATTTAGAAGATACTTTAGCCAATATAAATTAAAAACCAGCCTGAGT
TTACATAAATTTGTAAAGTCAGGCTCTTCTAAAATCCAAAGAGGGTTTTTGCCTATATATCAATCAGAGGATAAATACTTTAATAAAAGG
TAATCACAGCTAAGTGGATACCTGTGTCTCAAATTACATATGCAAATGATCCATCAGTAGGGATCACTAATAATAGTTTTCCTTTTAAAA
AATAATTTCAGGGCAGGTACAGTGGCTCAAGCCTATACTTCCAGGACTTTGGGAGGCCAAGCAGAAGGATTGTGGGAGGCCAAGCAGAAG
GATTGTTTGAGCCCAGAAATTCAAGGCTGCAGTGAGCTATGATCAATCCACTGTACTCCAGCCTAGGCTACAGAGTGAGATCCTTTCTCT
AAAATAAAATACAATTTCCATGTATCCATAGGAATATATTCATCTTTTACAGTGATTGCAGATTAGTTTTAAAACGTCTTTTTCGTAATT
CGTCAATGCAAGTTAGTAAGAACCAGATAATTTTCCATTTTAAAATGATAGGAATCTAAAACTCTTTTTCAAAAATGCCAACCTGTTTTT
CCGGCATCATAGTAGTTGGAATAATACAGATATAATTGACTAATCATAAAGTACATGAGAGTACAGAAGGGAAATTTGGAAACGGTAAGT
CTGCTAGGGCATTACAATCCTGTCCTAGCACTCCACCTTTATTCTGCCAACCTGGGTTAATTAAAGATGGTAGCCTGGAAAGTAATGAAT
GACATTGACTTCAGGCAATCTTTCCACTGATTATTCTTGGCTGAACTTCATTTATCGAGTCAGAGAATGCACTGCCTGAGAAATGTCCCA
GAGGAGTGAATCCTAGGCCTGGCCACAGTAGAATCGCCTGGAGAATTTAAGAAAAAAATTGTTGGGCACTCACTCTTTCCAGTGATCTTT
ATTTAGTTGGCTTACAATGGAATACAGGTATGGTTCATGTTTTTAAATTTGTCCAGGTGTTTCTATTGTGCAGTCACAGTTGAAAACCAT
TGTCTTCGAGAATAGCTATTCTATCTTGCCAGTTACAATAAGTGGATAGCTATATTTTCACATAAATTATAGTTTACAGATGTTTGGAGG
GGGAAGACAGGATCTGAGGTGTTTTGATATGACTGTTAGCACCAAAATCTGAATGCCTTAATTGTTGAATGTGTTAAATTGGATAATTAA

>In-frame_HMGXB3_ENST00000502717_chr5_149386210_+_PAM_ENST00000346918_chr5_102237060_+_3409nt
GCCGGGACGGGTCTCCCTGGCGATCCGTGGTGTGCCGCTACTGCCGGTGCAGCCGCCAAACCGGTGCCTCGGTGACGACCGTGTCCCTGC
CGTCTTCCTCGAGCTCCCCGGGGCTTGACCCCCGGGGCCCTCGGCAGGCATCGGTGAGGAGCCTGCGGAGCGAACCTGTGCTCCTATTCT
TGCCCTTCAGGACCCCATATCGCGACTCCGAGGAGGGGAAGCGAGAGGGGCTGTCGCGACTCCGCGCCGTGTGTCGCCGGGCGGGGCCGC
GGGGCCGGGGCTCCTTCAGCCCCCGGGATGCGCGCGCGAGCCCTCGCCTCCACTTCCTTGTTGCTGCTGTCACGACTGGAGCCGCCTCTC
GCCGACAGCGGGGAGCGCGAGTGCGCCAGCCATCCCCCTCGTCCAGCCGCCGGGCCAAGCGCCTCCGGGAATGTGAGCGGCGCAGCTTGC
ACGCTCCTCCGGCCATGGACGCATCATATGATGGTACTGAGGTAACTGTCGTGATGGAGGAAATTGAGGAAGCCTATTGTTACACCTCTC
CTGGGCCACCCAAGAAGAAGAAAAAGTATAAAATACATGGAGAAAAGACAAAGAAACCCAGGTCTGCTTACCTTCTGTACTATTACGACA
TCTACCTGAAAGTGCAGCAGGAGCTCCCCCACCTCCCTCAGTCTGAGATCAATAAGAAGATTAGTGAGAGTTGGAGGCTTCTCAGCGTGG
CCGAGAGGAGTTACTACTTGGAGAAAGCCAAACTAGAGAAGGAAGGTTTGGATCCTTCCGATACATACTTCTGCATGTCTATGCGAATAC
CAGTGGATGAGGAAGCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGATACTGTCCATCACATGTTACTTTTTGGATGCAATATGC
CTTCATCCACTGGAAGTTACTGGTTTTGTGATGAAGGAACCTGTACAGATAAAGCCAATATTCTGTATGCCTGGGCGAGAAATGCTCCCC
CTACCCGGCTCCCCAAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGTAAATACTTTGTACTACAGGTACACTATGGGGATATTA
GTGCTTTTAGAGATAATAACAAGGACTGTTCTGGTGTGTCCTTACACCTCACACGTCTGCCACAGCCTTTAATTGCTGGCATGTACCTTA
TGATGTCTGTTGACACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGACATTTCATGCCATTATAAAAATTATCCAATGCATGTCT
TTGCCTATAGAGTTCACACTCACCATTTAGGTAAGGTAGTAAGTGGATACAGAGTAAGAAATGGACAGTGGACACTGATTGGACGGCAGA
GCCCTCAGCTGCCACAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGTTTTGGTGACCTACTGGCTGCAAGATGTGTATTCACTG
GTGAAGGAAGGACAGAAGCCACACACATTGGTGGCACGTCTAGTGATGAAATGTGCAACTTATACATTATGTATTACATGGAAGCCAAGC
ATGCAGTTTCTTTCATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGAACCATACCACCAGAGGCCAACATTCCAATTCCCGTGA
AGTCTGATATGGTTATGATGCATGAACATCATAAAGAAACAGAATATAAAGATAAGATTCCTTTACTACAGCAGCCAAAACGAGAAGAAG
AAGAAGTGTTAGACCAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGAGAAAGGGAAGATGTTGTTCATGTGCACAAATATAATC
CTACAGAAAAGGCAGAATCAGAGTCAGACCTGGTAGCTGAGATTGCAAATGTAGTCCAAAAAAAGGATCTTGGTCGATCTGATGCCAGAG
AGGGTGCAGAACATGAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCACAAATTCCACAGACTAGTATCTACCTTGAGGCCACCAG
AGAGCAGAGTTTTCTCATTACAGCAGCCCCCACCTGGTGAAGGCACCTGGGAACCAGAACACACAGGAGATTTCCACATGGAAGAGGCAC
TGGATTGGCCTGGAGTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTAGACCCTAAGAATAACCTGGTGATTTTCCACAGAGGTG
ACCATGTCTGGGATGGAAACTCGTTTGACAGCAAGTTTGTTTACCAGCAAATAGGACTCGGACCAATTGAAGAAGACACTATTCTTGTCA
TAGATCCAAATAATGCTGCAGTACTCCAGTCCAGTGGAAAAAATCTGTTTTACTTGCCACATGGCTTGAGTATAGATAAAGATGGGAATT
ATTGGGTCACAGACGTGGCTCTCCATCAGGTGTTCAAACTGGATCCAAACAATAAAGAAGGCCCTGTATTAATCCTGGGAAGGAGCATGC
AACCAGGCAGTGACCAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGATCCAGGCACTGGAGCCATTTATGTATCAGATGGTTACT
GCAACAGCAGGATTGTGCAGTTTTCACCAAGTGGAAAGTTCATCACACAGTGGGGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCAGGCC
AGTTCACTGTTCCTCACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGTGTGGCAGACCGGGAAAATGGTCGGATCCAGTGTTTTA
AAACTGACACCAAAGAATTTGTGAGAGAGATTAAGCATTCATCATTTGGAAGAAATGTATTTGCAATTTCATATATACCAGGCTTGCTCT
TTGCAGTGAATGGGAAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTTGTGATGAACTTTTCCAATGGGGAAATTATAGACATCT
TCAAGCCAGTGCGCAAGCACTTTGATATGCCTCATGATATTGTTGCATCTGAAGATGGGACTGTGTACATTGGAGATGCTCATACCAACA
CCGTGTGGAAGTTCACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAGGCTGGCATTGAGGTCCAGGAAATCAAAGGAAAGGGAA
GTGGAGGCTTAAACCTTGGTAATTTCTTTGCAAGCCGTAAGGGCTACAGTCGAAAAGGGTTTGACCGGCTTAGCACTGAGGGCAGTGACC
AAGAGAAAGAGGATGATGGAAGTGAATCAGAAGAGGAGTATTCAGCACCTCTGCCTGCGCTCGCACCTTCCTCCTCCTGAAAACCAAGCT
TTGATTTAGATTGAGTAAGATTTACCCAGAATGTCAGATTCCTTTCCCTTTAGCACGTTTAAAGTTCTGTGTATTTAATTGTAAACTGTA


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FusionGenePPI for HMGXB3_PAM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HMGXB3TK1, CDKN1A, CDK4, SMN1, ANXA7, PFDN1PAMKALRN, TSC2, TSC1, RASSF9, CALM1, TAZ, SUSD4, IDS, SERPINA6, TMEM25, ART3, B3GNT2, PTCH1, DPEP2, UBR2, GLP1R, RALB, DKKL1, GAA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePAMchr5:149386210chr5:102237060ENST00000304400+125925_94270975RASSF9
TgenePAMchr5:149386210chr5:102237060ENST00000346918+123925_94270888RASSF9
TgenePAMchr5:149386210chr5:102237060ENST00000348126+124925_94270867RASSF9
TgenePAMchr5:149386210chr5:102237060ENST00000438793+125925_94270974RASSF9
TgenePAMchr5:149386210chr5:102237060ENST00000455264+124925_94270906RASSF9


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HMGXB3_PAM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePAMP19021DB00126Vitamin CPeptidyl-glycine alpha-amidating monooxygenasesmall moleculeapproved|nutraceutical

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RelatedDiseases for HMGXB3_PAM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePAMC0003469Anxiety Disorders1CTD_human
TgenePAMC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgenePAMC0036572Seizures1CTD_human