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Fusion gene ID: 16484 |
FusionGeneSummary for HMGN3_NCOA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HMGN3_NCOA2 | Fusion gene ID: 16484 | Hgene | Tgene | Gene symbol | HMGN3 | NCOA2 | Gene ID | 9324 | 10499 |
| Gene name | high mobility group nucleosomal binding domain 3 | nuclear receptor coactivator 2 | |
| Synonyms | PNAS-24|PNAS-25|TRIP7 | GRIP1|KAT13C|NCoA-2|SRC2|TIF2|bHLHe75 | |
| Cytomap | 6q14.1 | 8q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | high mobility group nucleosome-binding domain-containing protein 3TR-interacting protein 7thyroid hormone receptor interacting protein 7 | nuclear receptor coactivator 2class E basic helix-loop-helix protein 75glucocorticoid receptor-interacting protein-1p160 steroid receptor coactivator 2transcriptional intermediary factor 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q15651 | Q15596 | |
| Ensembl transtripts involved in fusion gene | ENST00000275036, ENST00000344726, | ENST00000452400, ENST00000267974, ENST00000524223, | |
| Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 6 X 7 X 2=84 |
| # samples | 7 | 8 | |
| ** MAII score | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/84*10)=-0.070389327891398 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HMGN3 [Title/Abstract] AND NCOA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG222207 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000275036 | ENST00000452400 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
| intron-intron | ENST00000275036 | ENST00000267974 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
| intron-intron | ENST00000275036 | ENST00000524223 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
| intron-intron | ENST00000344726 | ENST00000452400 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
| intron-intron | ENST00000344726 | ENST00000267974 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
| intron-intron | ENST00000344726 | ENST00000524223 | HMGN3 | chr6 | 79923102 | - | NCOA2 | chr8 | 71294977 | - |
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FusionProtFeatures for HMGN3_NCOA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HMGN3 | NCOA2 |
| Binds to nucleosomes, regulating chromatin structure andconsequently, chromatin-dependent processes such as transcription,DNA replication and DNA repair. Affects both insulin and glucagonlevels and modulates the expression of pancreatic genes involvedin insulin secretion. Regulates the expression of the glucosetransporter SLC2A2 by binding specifically to its promoter regionand recruiting PDX1 and additional transcription factors.Regulates the expression of SLC6A9, a glycine transporter whichregulates the glycine concentration in synaptic junctions in thecentral nervous system, by binding to its transcription startsite. May play a role in ocular development and astrocyte function(By similarity). {ECO:0000250}. | Transcriptional coactivator for steroid receptors andnuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Requiredwith NCOA1 to control energy balance between white and brownadipose tissues. Critical regulator of glucose metabolismregulation, acts as RORA coactivator to specifically modulate G6PCexpression. Involved in the positive regulation of thetranscriptional activity of the glucocorticoid receptor NR3C1 bysumoylation enhancer RWDD3. Positively regulates the circadianclock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).{ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:23508108,ECO:0000269|PubMed:9430642}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HMGN3_NCOA2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HMGN3_NCOA2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HMGN3_NCOA2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | NCOA2 | Q15596 | DB00255 | Diethylstilbestrol | Nuclear receptor coactivator 2 | small molecule | approved|investigational |
| Tgene | NCOA2 | Q15596 | DB00783 | Estradiol | Nuclear receptor coactivator 2 | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for HMGN3_NCOA2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NCOA2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | NCOA2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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