	FusionGeneSummary
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	FusionGeneSequence
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Fusion gene ID: 16374

FusionGeneSummary for HLA-DRA_PEX5L

Fusion gene summary

Fusion gene information	Fusion gene name: HLA-DRA_PEX5L
	Fusion gene ID: 16374
		Hgene	Tgene
	Gene symbol	HLA-DRA	PEX5L
	Gene ID	3122	51555
	Gene name	major histocompatibility complex, class II, DR alpha	peroxisomal biogenesis factor 5 like
	Synonyms	HLA-DRA1	PEX5R\|PEX5RP\|PXR2\|PXR2B\|TRIP8b
	Cytomap	6p21.32	3q26.33
	Type of gene	protein-coding	protein-coding
	Description	HLA class II histocompatibility antigen, DR alpha chainMHC class II antigen DRAhistocompatibility antigen HLA-DR alpha	PEX5-related proteinHCN channel auxiliary subunitPEX2-related proteinPEX5-like proteinPex5p-related proteinperoxin-5-related proteinperoxisome biogenesis factor 5-liketetratricopeptide repeat-containing Rab8b-interacting protein
	Modification date	20180522	20180523
	UniProtAcc	P01903	Q8IYB4
	Ensembl transtripts involved in fusion gene	ENST00000395388, ENST00000374982, ENST00000383127, ENST00000459705, ENST00000434866, ENST00000416883, ENST00000481943, ENST00000411505, ENST00000414698, ENST00000546379, ENST00000493431, ENST00000418111, ENST00000383259, ENST00000551750, ENST00000461633, ENST00000383258, ENST00000442960, ENST00000549531, ENST00000482781, ENST00000415767, ENST00000411524, ENST00000553193, ENST00000498597, ENST00000427753,	ENST00000467460, ENST00000263962, ENST00000392649, ENST00000485199, ENST00000468741, ENST00000476138, ENST00000467440, ENST00000472994, ENST00000464614, ENST00000465751,
Fusion gene scores	* DoF score	6 X 6 X 2=72	6 X 6 X 4=144
	# samples	7	6
	** MAII score	log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HLA-DRA [Title/Abstract] AND PEX5L [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HLA-DRA	GO:0002503	peptide antigen assembly with MHC class II protein complex	1448172\|7606781\|22733780
Hgene	HLA-DRA	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	21502329
Hgene	HLA-DRA	GO:0002506	polysaccharide assembly with MHC class II protein complex	21502329

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AB209166	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000395388	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000395388	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000395388	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000395388	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000395388	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000395388	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000395388	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000395388	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000395388	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000395388	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000374982	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000374982	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000374982	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000374982	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000374982	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000374982	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000374982	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000374982	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000374982	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000374982	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383127	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383127	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383127	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383127	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383127	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383127	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383127	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383127	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383127	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383127	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000459705	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000459705	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000459705	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000459705	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000459705	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000459705	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000459705	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000459705	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000459705	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000459705	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000434866	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000434866	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000434866	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000434866	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000434866	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000434866	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000434866	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000434866	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000434866	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000434866	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000416883	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000416883	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000416883	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000416883	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000416883	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000416883	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000416883	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000416883	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000416883	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000416883	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000481943	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000481943	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000481943	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000481943	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000481943	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000481943	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000481943	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000481943	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000481943	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000481943	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000411505	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000411505	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000411505	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000411505	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000411505	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000411505	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000411505	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000411505	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000411505	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
5CDS-intron	ENST00000411505	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000414698	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000414698	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000414698	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000414698	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000414698	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000414698	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000414698	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000414698	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000414698	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000414698	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000546379	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000546379	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000546379	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000546379	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000546379	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000546379	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000546379	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000546379	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000546379	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000546379	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000493431	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000493431	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000493431	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000493431	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000493431	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000493431	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000493431	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000493431	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000493431	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000493431	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000418111	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000418111	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000418111	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000418111	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000418111	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000418111	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000418111	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000418111	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000418111	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000418111	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383259	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383259	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383259	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383259	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383259	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383259	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383259	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383259	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383259	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383259	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000551750	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000551750	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000551750	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000551750	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000551750	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000551750	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000551750	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000551750	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000551750	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000551750	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000461633	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000461633	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000461633	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000461633	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000461633	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000461633	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000461633	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000461633	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000461633	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000461633	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383258	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383258	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383258	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383258	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383258	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383258	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383258	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383258	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383258	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000383258	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000442960	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000442960	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000442960	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000442960	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000442960	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000442960	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000442960	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000442960	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000442960	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000442960	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000549531	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000549531	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000549531	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000549531	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000549531	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000549531	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000549531	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000549531	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000549531	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000549531	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000482781	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000482781	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000482781	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000482781	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000482781	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000482781	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000482781	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000482781	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000482781	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000482781	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000415767	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000415767	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000415767	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000415767	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000415767	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000415767	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000415767	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000415767	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000415767	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000415767	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000411524	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000411524	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000411524	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000411524	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000411524	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000411524	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000411524	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000411524	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000411524	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000411524	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000553193	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000553193	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000553193	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000553193	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000553193	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000553193	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000553193	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000553193	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000553193	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000553193	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000498597	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000498597	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000498597	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000498597	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000498597	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000498597	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000498597	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000498597	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000498597	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000498597	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000427753	ENST00000467460	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000427753	ENST00000263962	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000427753	ENST00000392649	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000427753	ENST00000485199	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000427753	ENST00000468741	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000427753	ENST00000476138	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000427753	ENST00000467440	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000427753	ENST00000472994	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000427753	ENST00000464614	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-
intron-intron	ENST00000427753	ENST00000465751	HLA-DRA	chr6	3689255	+	PEX5L	chr3	179749172	-

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FusionProtFeatures for HLA-DRA_PEX5L

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HLA-DRA P01903	PEX5L Q8IYB4
Binds peptides derived from antigens that access theendocytic route of antigen presenting cells (APC) and presentsthem on the cell surface for recognition by the CD4 T-cells. Thepeptide binding cleft accommodates peptides of 10-30 residues. Thepeptides presented by MHC class II molecules are generated mostlyby degradation of proteins that access the endocytic route, wherethey are processed by lysosomal proteases and other hydrolases.Exogenous antigens that have been endocytosed by the APC are thusreadily available for presentation via MHC II molecules, and forthis reason this antigen presentation pathway is usually referredto as exogenous. As membrane proteins on their way to degradationin lysosomes as part of their normal turn-over are also containedin the endosomal/lysosomal compartments, exogenous antigens mustcompete with those derived from endogenous components. Autophagyis also a source of endogenous peptides, autophagosomesconstitutively fuse with MHC class II loading compartments. Inaddition to APCs, other cells of the gastrointestinal tract, suchas epithelial cells, express MHC class II molecules and CD74 andact as APCs, which is an unusual trait of the GI tract. To producea MHC class II molecule that presents an antigen, three MHC classII molecules (heterodimers of an alpha and a beta chain) associatewith a CD74 trimer in the ER to form a heterononamer. Soon afterthe entry of this complex into the endosomal/lysosomal systemwhere antigen processing occurs, CD74 undergoes a sequentialdegradation by various proteases, including CTSS and CTSL, leavinga small fragment termed CLIP (class-II-associated invariant chainpeptide). The removal of CLIP is facilitated by HLA-DM via directbinding to the alpha-beta-CLIP complex so that CLIP is released.HLA-DM stabilizes MHC class II molecules until primary highaffinity antigenic peptides are bound. The MHC II molecule boundto a peptide is then transported to the cell membrane surface. InB-cells, the interaction between HLA-DM and MHC class II moleculesis regulated by HLA-DO. Primary dendritic cells (DCs) also toexpress HLA-DO. Lysosomal microenvironment has been implicated inthe regulation of antigen loading into MHC II molecules, increasedacidification produces increased proteolysis and efficient peptideloading.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for HLA-DRA_PEX5L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HLA-DRA_PEX5L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for HLA-DRA_PEX5L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for HLA-DRA_PEX5L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HLA-DRA	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Hgene	HLA-DRA	C0026769	Multiple Sclerosis	1	CTD_human
Hgene	HLA-DRA	C0030567	Parkinson Disease	1	CTD_human
Tgene	PEX5L	C0011570	Mental Depression	1	PSYGENET
Tgene	PEX5L	C0011581	Depressive disorder	1	PSYGENET

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Fusion gene ID: 16374

FusionGeneSummary for HLA-DRA_PEX5L

FusionProtFeatures for HLA-DRA_PEX5L

FusionGeneSequence for HLA-DRA_PEX5L

FusionGenePPI for HLA-DRA_PEX5L

RelatedDrugs for HLA-DRA_PEX5L

RelatedDiseases for HLA-DRA_PEX5L