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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16331

FusionGeneSummary for HLA-B_FKBP8

check button Fusion gene summary
Fusion gene informationFusion gene name: HLA-B_FKBP8
Fusion gene ID: 16331
HgeneTgene
Gene symbol

HLA-B

FKBP8

Gene ID

3106

23770

Gene namemajor histocompatibility complex, class I, BFK506 binding protein 8
SynonymsAS|B-4901|HLABFKBP38|FKBPr38
Cytomap

6p21.33

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionmajor histocompatibility complex, class I, BHLA class I antigen HLA-BHLA class I histocompatibility antigen, B alpha chainMHC HLA-B cell surface glycoproteinMHC HLA-B transmembrane glycoproteinMHC class 1 antigenMHC class I antigen HLA-B alpha chainpeptidyl-prolyl cis-trans isomerase FKBP838 kDa FK506-binding protein38 kDa FKBPFK506 binding protein 8, 38kDaFKBP-38FKBP-8PPIase FKBP8hFKBP38rotamase
Modification date2018052720180522
UniProtAcc

Q95365

Q14318

Ensembl transtripts involved in fusion geneENST00000412585, ENST00000425848, 
ENST00000450871, ENST00000359635, 
ENST00000435618, ENST00000421349, 
ENST00000597960, ENST00000610101, 
ENST00000596558, ENST00000222308, 
ENST00000608443, ENST00000453489, 
Fusion gene scores* DoF score17 X 11 X 8=149611 X 11 X 5=605
# samples 1913
** MAII scorelog2(19/1496*10)=-2.97703885155669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/605*10)=-2.2184235191335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HLA-B [Title/Abstract] AND FKBP8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ063441HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000412585ENST00000597960HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000412585ENST00000610101HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000412585ENST00000596558HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000412585ENST00000222308HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000412585ENST00000608443HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000412585ENST00000453489HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-3CDSENST00000425848ENST00000597960HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000425848ENST00000610101HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000425848ENST00000596558HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000425848ENST00000222308HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000425848ENST00000608443HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000425848ENST00000453489HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-3CDSENST00000450871ENST00000597960HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000450871ENST00000610101HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000450871ENST00000596558HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000450871ENST00000222308HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000450871ENST00000608443HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000450871ENST00000453489HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-3CDSENST00000359635ENST00000597960HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000359635ENST00000610101HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000359635ENST00000596558HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000359635ENST00000222308HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000359635ENST00000608443HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000359635ENST00000453489HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-3CDSENST00000435618ENST00000597960HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000435618ENST00000610101HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000435618ENST00000596558HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000435618ENST00000222308HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000435618ENST00000608443HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000435618ENST00000453489HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-3CDSENST00000421349ENST00000597960HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000421349ENST00000610101HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000421349ENST00000596558HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000421349ENST00000222308HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000421349ENST00000608443HLA-Bchr6

2628787

+FKBP8chr19

18650473

-
intron-intronENST00000421349ENST00000453489HLA-Bchr6

2628787

+FKBP8chr19

18650473

-

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FusionProtFeatures for HLA-B_FKBP8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HLA-B

Q95365

FKBP8

Q14318

Constitutively inactive PPiase, which becomes activewhen bound to calmodulin and calcium. Seems to act as a chaperonefor BCL2, targets it to the mitochondria and modulates itsphosphorylation state. The BCL2/FKBP8/calmodulin/calcium complexprobably interferes with the binding of BCL2 to its targets. Theactive form of FKBP8 may therefore play a role in the regulationof apoptosis. {ECO:0000269|PubMed:12510191,ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HLA-B_FKBP8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HLA-B_FKBP8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HLA-B_FKBP8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for HLA-B_FKBP8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHLA-BC0038325Stevens-Johnson Syndrome9CTD_human;ORPHANET
HgeneHLA-BC0041755Adverse reaction to drug5CTD_human
HgeneHLA-BC0013182Drug Allergy4CTD_human
HgeneHLA-BC0033687Proteinuria4CTD_human
HgeneHLA-BC0038013Ankylosing spondylitis3CTD_human
HgeneHLA-BC0004943Behcet Syndrome2CTD_human;ORPHANET
HgeneHLA-BC0011603Dermatitis2CTD_human
HgeneHLA-BC0026896Myasthenia Gravis2CTD_human
HgeneHLA-BC0036341Schizophrenia2PSYGENET
HgeneHLA-BC0011609Drug Eruptions1CTD_human
HgeneHLA-BC0011633Dermatomyositis1CTD_human
HgeneHLA-BC0015230Exanthema1CTD_human
HgeneHLA-BC0017638Glioma1CTD_human
HgeneHLA-BC0019693HIV Infections1CTD_human
HgeneHLA-BC0020517Hypersensitivity1CTD_human
HgeneHLA-BC0027697Nephritis1CTD_human
HgeneHLA-BC0033975Psychotic Disorders1PSYGENET
HgeneHLA-BC0039103Synovitis1CTD_human
HgeneHLA-BC4277682Chemical and Drug Induced Liver Injury1CTD_human