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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16318

FusionGeneSummary for HKR1_HKR1

check button Fusion gene summary
Fusion gene informationFusion gene name: HKR1_HKR1
Fusion gene ID: 16318
HgeneTgene
Gene symbol

HKR1

HKR1

Gene ID

284459

284459

Gene nameHKR1, GLI-Kruppel zinc finger family memberHKR1, GLI-Kruppel zinc finger family member
SynonymsZNF875ZNF875
Cytomap

19q13.12

19q13.12

Type of geneprotein-codingprotein-coding
DescriptionKrueppel-related zinc finger protein 1oncogene HKR1zinc finger protein 875Krueppel-related zinc finger protein 1oncogene HKR1zinc finger protein 875
Modification date2018052320180523
UniProtAcc

P10072

P10072

Ensembl transtripts involved in fusion geneENST00000591471, ENST00000589218, 
ENST00000544914, ENST00000591417, 
ENST00000592168, ENST00000392153, 
ENST00000589392, ENST00000324411, 
ENST00000591259, ENST00000541583, 
ENST00000591134, ENST00000586897, 
ENST00000591471, ENST00000589218, 
ENST00000544914, ENST00000591417, 
ENST00000592168, ENST00000392153, 
ENST00000589392, ENST00000324411, 
ENST00000591259, ENST00000541583, 
ENST00000591134, ENST00000586897, 
Fusion gene scores* DoF score7 X 4 X 6=1685 X 5 X 2=50
# samples 75
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: HKR1 [Title/Abstract] AND HKR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF352587HKR1chr19

37853755

-HKR1chr19

37853956

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000591471ENST00000591471HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000591471ENST00000589218HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000591471ENST00000544914HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000591471ENST00000591417HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000591471ENST00000592168HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000591471ENST00000392153HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000591471ENST00000589392HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000591471ENST00000324411HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000591471ENST00000591259HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000591471ENST00000541583HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000591471ENST00000591134HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000591471ENST00000586897HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-3CDSENST00000589218ENST00000591471HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000589218ENST00000589218HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000589218ENST00000544914HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000589218ENST00000591417HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000589218ENST00000592168HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000589218ENST00000392153HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000589218ENST00000589392HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000589218ENST00000324411HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000589218ENST00000591259HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000589218ENST00000541583HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000589218ENST00000591134HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000589218ENST00000586897HKR1chr19

37853755

-HKR1chr19

37853956

+
In-frameENST00000544914ENST00000591471HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000544914ENST00000589218HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000544914ENST00000544914HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000544914ENST00000591417HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000544914ENST00000592168HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000544914ENST00000392153HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000544914ENST00000589392HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000544914ENST00000324411HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000544914ENST00000591259HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000544914ENST00000541583HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000544914ENST00000591134HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000544914ENST00000586897HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-3CDSENST00000591417ENST00000591471HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591417ENST00000589218HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591417ENST00000544914HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591417ENST00000591417HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591417ENST00000592168HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591417ENST00000392153HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591417ENST00000589392HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591417ENST00000324411HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591417ENST00000591259HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591417ENST00000541583HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591417ENST00000591134HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591417ENST00000586897HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-3CDSENST00000592168ENST00000591471HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000592168ENST00000589218HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000592168ENST00000544914HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000592168ENST00000591417HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000592168ENST00000592168HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000592168ENST00000392153HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000592168ENST00000589392HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000592168ENST00000324411HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000592168ENST00000591259HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000592168ENST00000541583HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000592168ENST00000591134HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000592168ENST00000586897HKR1chr19

37853755

-HKR1chr19

37853956

+
Frame-shiftENST00000392153ENST00000591471HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000392153ENST00000589218HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000392153ENST00000544914HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000392153ENST00000591417HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000392153ENST00000592168HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000392153ENST00000392153HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000392153ENST00000589392HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000392153ENST00000324411HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000392153ENST00000591259HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000392153ENST00000541583HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000392153ENST00000591134HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000392153ENST00000586897HKR1chr19

37853755

-HKR1chr19

37853956

+
In-frameENST00000589392ENST00000591471HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000589392ENST00000589218HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000589392ENST00000544914HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000589392ENST00000591417HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000589392ENST00000592168HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000589392ENST00000392153HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000589392ENST00000589392HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000589392ENST00000324411HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000589392ENST00000591259HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000589392ENST00000541583HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000589392ENST00000591134HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000589392ENST00000586897HKR1chr19

37853755

-HKR1chr19

37853956

+
In-frameENST00000324411ENST00000591471HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000324411ENST00000589218HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000324411ENST00000544914HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000324411ENST00000591417HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000324411ENST00000592168HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000324411ENST00000392153HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000324411ENST00000589392HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000324411ENST00000324411HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000324411ENST00000591259HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000324411ENST00000541583HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000324411ENST00000591134HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000324411ENST00000586897HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-3CDSENST00000591259ENST00000591471HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591259ENST00000589218HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591259ENST00000544914HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591259ENST00000591417HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591259ENST00000592168HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591259ENST00000392153HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591259ENST00000589392HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591259ENST00000324411HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591259ENST00000591259HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591259ENST00000541583HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591259ENST00000591134HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591259ENST00000586897HKR1chr19

37853755

-HKR1chr19

37853956

+
Frame-shiftENST00000541583ENST00000591471HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000541583ENST00000589218HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000541583ENST00000544914HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000541583ENST00000591417HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000541583ENST00000592168HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000541583ENST00000392153HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000541583ENST00000589392HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000541583ENST00000324411HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000541583ENST00000591259HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000541583ENST00000541583HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000541583ENST00000591134HKR1chr19

37853755

-HKR1chr19

37853956

+
5CDS-intronENST00000541583ENST00000586897HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-3CDSENST00000591134ENST00000591471HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591134ENST00000589218HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591134ENST00000544914HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591134ENST00000591417HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591134ENST00000592168HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591134ENST00000392153HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591134ENST00000589392HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591134ENST00000324411HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591134ENST00000591259HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591134ENST00000541583HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591134ENST00000591134HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000591134ENST00000586897HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-3CDSENST00000586897ENST00000591471HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000586897ENST00000589218HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000586897ENST00000544914HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000586897ENST00000591417HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000586897ENST00000592168HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000586897ENST00000392153HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000586897ENST00000589392HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000586897ENST00000324411HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000586897ENST00000591259HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000586897ENST00000541583HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000586897ENST00000591134HKR1chr19

37853755

-HKR1chr19

37853956

+
intron-intronENST00000586897ENST00000586897HKR1chr19

37853755

-HKR1chr19

37853956

+

Top

FusionProtFeatures for HKR1_HKR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HKR1

P10072

HKR1

P10072

May be involved in transcriptional regulation. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for HKR1_HKR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for HKR1_HKR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HKR1_HKR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HKR1_HKR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource