|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 16316 |
FusionGeneSummary for HKR1_CHMP2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HKR1_CHMP2A | Fusion gene ID: 16316 | Hgene | Tgene | Gene symbol | HKR1 | CHMP2A | Gene ID | 284459 | 27243 |
| Gene name | HKR1, GLI-Kruppel zinc finger family member | charged multivesicular body protein 2A | |
| Synonyms | ZNF875 | BC-2|BC2|CHMP2|VPS2|VPS2A | |
| Cytomap | 19q13.12 | 19q13.43 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Krueppel-related zinc finger protein 1oncogene HKR1zinc finger protein 875 | charged multivesicular body protein 2aVPS2 homolog Achromatin modifying protein 2Aputative breast adenocarcinoma marker (32kD)putative breast adenocarcinoma marker BC-2vacuolar protein sorting-associated protein 2-1vps2-1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P10072 | O43633 | |
| Ensembl transtripts involved in fusion gene | ENST00000591471, ENST00000589218, ENST00000544914, ENST00000591417, ENST00000592168, ENST00000392153, ENST00000589392, ENST00000324411, ENST00000591259, ENST00000541583, ENST00000591134, ENST00000586897, | ENST00000600118, ENST00000601220, ENST00000312547, | |
| Fusion gene scores | * DoF score | 7 X 4 X 6=168 | 3 X 3 X 3=27 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HKR1 [Title/Abstract] AND CHMP2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CHMP2A | GO:0039702 | viral budding via host ESCRT complex | 24878737 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-KK-A8IA-01A | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000591471 | ENST00000600118 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000591471 | ENST00000601220 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000591471 | ENST00000312547 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000589218 | ENST00000600118 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000589218 | ENST00000601220 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000589218 | ENST00000312547 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000544914 | ENST00000600118 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000544914 | ENST00000601220 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000544914 | ENST00000312547 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000591417 | ENST00000600118 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000591417 | ENST00000601220 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000591417 | ENST00000312547 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000592168 | ENST00000600118 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000592168 | ENST00000601220 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000592168 | ENST00000312547 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| In-frame | ENST00000392153 | ENST00000600118 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| In-frame | ENST00000392153 | ENST00000601220 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| In-frame | ENST00000392153 | ENST00000312547 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| In-frame | ENST00000589392 | ENST00000600118 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| In-frame | ENST00000589392 | ENST00000601220 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| In-frame | ENST00000589392 | ENST00000312547 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| 5UTR-3CDS | ENST00000324411 | ENST00000600118 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| 5UTR-3CDS | ENST00000324411 | ENST00000601220 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| 5UTR-3CDS | ENST00000324411 | ENST00000312547 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| In-frame | ENST00000591259 | ENST00000600118 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| In-frame | ENST00000591259 | ENST00000601220 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| In-frame | ENST00000591259 | ENST00000312547 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000541583 | ENST00000600118 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000541583 | ENST00000601220 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000541583 | ENST00000312547 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000591134 | ENST00000600118 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000591134 | ENST00000601220 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000591134 | ENST00000312547 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000586897 | ENST00000600118 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000586897 | ENST00000601220 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
| intron-3CDS | ENST00000586897 | ENST00000312547 | HKR1 | chr19 | 37826159 | + | CHMP2A | chr19 | 59063552 | - |
Top |
FusionProtFeatures for HKR1_CHMP2A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HKR1 | CHMP2A |
| May be involved in transcriptional regulation. | Probable core component of the endosomal sortingrequired for transport complex III (ESCRT-III) which is involvedin multivesicular bodies (MVBs) formation and sorting of endosomalcargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from thelimiting membrane of the endosome and mostly are delivered tolysosomes enabling degradation of membrane proteins, such asstimulated growth factor receptors, lysosomal enzymes and lipids.The MVB pathway appears to require the sequential function ofESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostlydissociate from the invaginating membrane before the ILV isreleased. The ESCRT machinery also functions in topologicallyequivalent membrane fission events, such as the terminal stages ofcytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-IIIcomplex promotes nuclear envelope sealing and mitotic spindledisassembly during late anaphase (PubMed:26040712). ESCRT-IIIproteins are believed to mediate the necessary vesicle extrusionand/or membrane fission activities, possibly in conjunction withthe AAA ATPase VPS4. {ECO:0000269|PubMed:21310966,ECO:0000269|PubMed:26040712, ECO:0000305}. (Microbial infection) The ESCRT machinery functions intopologically equivalent membrane fission events, such as thebudding of enveloped viruses (HIV-1 and other lentiviruses).Involved in HIV-1 p6- and p9-dependent virus release.{ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for HKR1_CHMP2A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_HKR1_ENST00000392153_chr19_37826159_+_CHMP2A_ENST00000600118_chr19_59063552_-_118aa MATGLLRAKKELKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGG >In-frame_HKR1_ENST00000392153_chr19_37826159_+_CHMP2A_ENST00000601220_chr19_59063552_-_118aa MATGLLRAKKELKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGG >In-frame_HKR1_ENST00000392153_chr19_37826159_+_CHMP2A_ENST00000312547_chr19_59063552_-_118aa MATGLLRAKKELKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGG >In-frame_HKR1_ENST00000589392_chr19_37826159_+_CHMP2A_ENST00000600118_chr19_59063552_-_118aa MATGLLRAKKELKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGG >In-frame_HKR1_ENST00000589392_chr19_37826159_+_CHMP2A_ENST00000601220_chr19_59063552_-_118aa MATGLLRAKKELKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGG >In-frame_HKR1_ENST00000589392_chr19_37826159_+_CHMP2A_ENST00000312547_chr19_59063552_-_118aa MATGLLRAKKELKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGG >In-frame_HKR1_ENST00000591259_chr19_37826159_+_CHMP2A_ENST00000600118_chr19_59063552_-_118aa MATGLLRAKKELKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGG >In-frame_HKR1_ENST00000591259_chr19_37826159_+_CHMP2A_ENST00000601220_chr19_59063552_-_118aa MATGLLRAKKELKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGG >In-frame_HKR1_ENST00000591259_chr19_37826159_+_CHMP2A_ENST00000312547_chr19_59063552_-_118aa MATGLLRAKKELKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_HKR1_ENST00000392153_chr19_37826159_+_CHMP2A_ENST00000600118_chr19_59063552_-_354nt ATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATC ATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCC CAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGG >In-frame_HKR1_ENST00000392153_chr19_37826159_+_CHMP2A_ENST00000601220_chr19_59063552_-_354nt ATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATC ATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCC CAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGG >In-frame_HKR1_ENST00000392153_chr19_37826159_+_CHMP2A_ENST00000312547_chr19_59063552_-_354nt ATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATC ATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCC CAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGG >In-frame_HKR1_ENST00000589392_chr19_37826159_+_CHMP2A_ENST00000600118_chr19_59063552_-_354nt ATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATC ATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCC CAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGG >In-frame_HKR1_ENST00000589392_chr19_37826159_+_CHMP2A_ENST00000601220_chr19_59063552_-_354nt ATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATC ATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCC CAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGG >In-frame_HKR1_ENST00000589392_chr19_37826159_+_CHMP2A_ENST00000312547_chr19_59063552_-_354nt ATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATC ATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCC CAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGG >In-frame_HKR1_ENST00000591259_chr19_37826159_+_CHMP2A_ENST00000600118_chr19_59063552_-_354nt ATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATC ATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCC CAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGG >In-frame_HKR1_ENST00000591259_chr19_37826159_+_CHMP2A_ENST00000601220_chr19_59063552_-_354nt ATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATC ATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCC CAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGG >In-frame_HKR1_ENST00000591259_chr19_37826159_+_CHMP2A_ENST00000312547_chr19_59063552_-_354nt ATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATC ATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCC CAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_HKR1_ENST00000392153_chr19_37826159_+_CHMP2A_ENST00000600118_chr19_59063552_-_610nt CAGGCGCGTTAAGCTGGTTGGGACCCGGGAAGGCCTCCCTCTTAAGGTCTTTCCCACACCTCTGCACCTTGTTACCTGACTTTCGGCTTC AGGATCCGCAGCGTGCACCCGCGTTCCATCTGTCTTCTGAGACTTTGCCCTTCTCCAGGAAGAGCACTCAGGAGACCAGGAAAATGGCCA CAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATCATGGATA TGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCCCAGGTTC TGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGGAAAAAAG CAGAGGCCGCAGCCTCAGCCCTAGCTGATGCTGATGCAGACCTGGAGGAACGGCTTAAGAACCTGCGGAGGGACTGAGTGCCCCTGCCAC >In-frame_HKR1_ENST00000392153_chr19_37826159_+_CHMP2A_ENST00000601220_chr19_59063552_-_610nt CAGGCGCGTTAAGCTGGTTGGGACCCGGGAAGGCCTCCCTCTTAAGGTCTTTCCCACACCTCTGCACCTTGTTACCTGACTTTCGGCTTC AGGATCCGCAGCGTGCACCCGCGTTCCATCTGTCTTCTGAGACTTTGCCCTTCTCCAGGAAGAGCACTCAGGAGACCAGGAAAATGGCCA CAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATCATGGATA TGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCCCAGGTTC TGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGGAAAAAAG CAGAGGCCGCAGCCTCAGCCCTAGCTGATGCTGATGCAGACCTGGAGGAACGGCTTAAGAACCTGCGGAGGGACTGAGTGCCCCTGCCAC >In-frame_HKR1_ENST00000392153_chr19_37826159_+_CHMP2A_ENST00000312547_chr19_59063552_-_610nt CAGGCGCGTTAAGCTGGTTGGGACCCGGGAAGGCCTCCCTCTTAAGGTCTTTCCCACACCTCTGCACCTTGTTACCTGACTTTCGGCTTC AGGATCCGCAGCGTGCACCCGCGTTCCATCTGTCTTCTGAGACTTTGCCCTTCTCCAGGAAGAGCACTCAGGAGACCAGGAAAATGGCCA CAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATCATGGATA TGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCCCAGGTTC TGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGGAAAAAAG CAGAGGCCGCAGCCTCAGCCCTAGCTGATGCTGATGCAGACCTGGAGGAACGGCTTAAGAACCTGCGGAGGGACTGAGTGCCCCTGCCAC >In-frame_HKR1_ENST00000589392_chr19_37826159_+_CHMP2A_ENST00000600118_chr19_59063552_-_574nt GCGTTAAGCTGGTTGGGACCCGGGAAGGCCTCCCTCTTAAGGTCTTTCCCACACCTCTGCACCTTGTTACCTGACTTTCGGCTTCAGGAT CCGCAGCGTGCACCCGCGTTCCGAAGAGCACTCAGGAGACCAGGAAAATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGC CCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATCATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATG CCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCCCAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGT CGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGGAAAAAAGCAGAGGCCGCAGCCTCAGCCCTAGCTGATGCTGATG CAGACCTGGAGGAACGGCTTAAGAACCTGCGGAGGGACTGAGTGCCCCTGCCACTCCGAGATAACCAGTGGATGCCCAGGATCTTTTACC >In-frame_HKR1_ENST00000589392_chr19_37826159_+_CHMP2A_ENST00000601220_chr19_59063552_-_574nt GCGTTAAGCTGGTTGGGACCCGGGAAGGCCTCCCTCTTAAGGTCTTTCCCACACCTCTGCACCTTGTTACCTGACTTTCGGCTTCAGGAT CCGCAGCGTGCACCCGCGTTCCGAAGAGCACTCAGGAGACCAGGAAAATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGC CCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATCATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATG CCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCCCAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGT CGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGGAAAAAAGCAGAGGCCGCAGCCTCAGCCCTAGCTGATGCTGATG CAGACCTGGAGGAACGGCTTAAGAACCTGCGGAGGGACTGAGTGCCCCTGCCACTCCGAGATAACCAGTGGATGCCCAGGATCTTTTACC >In-frame_HKR1_ENST00000589392_chr19_37826159_+_CHMP2A_ENST00000312547_chr19_59063552_-_574nt GCGTTAAGCTGGTTGGGACCCGGGAAGGCCTCCCTCTTAAGGTCTTTCCCACACCTCTGCACCTTGTTACCTGACTTTCGGCTTCAGGAT CCGCAGCGTGCACCCGCGTTCCGAAGAGCACTCAGGAGACCAGGAAAATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGC CCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATCATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATG CCATGGGTGATGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCCCAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGT CGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGGAAAAAAGCAGAGGCCGCAGCCTCAGCCCTAGCTGATGCTGATG CAGACCTGGAGGAACGGCTTAAGAACCTGCGGAGGGACTGAGTGCCCCTGCCACTCCGAGATAACCAGTGGATGCCCAGGATCTTTTACC >In-frame_HKR1_ENST00000591259_chr19_37826159_+_CHMP2A_ENST00000600118_chr19_59063552_-_564nt GTCTTTCCCACACCTCTGCACCTTGTTACCTGACTTTCGGCTTCAGGATCCGCAGCGTGCACCCGCGTTCCATCTGTCTTCTGAGACTTT GCCCTTCTCCAGGAAGAGCACTCAGGAGACCAGGAAAATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCA GAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATCATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGA TGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCCCAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCC CTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGGAAAAAAGCAGAGGCCGCAGCCTCAGCCCTAGCTGATGCTGATGCAGACCTGGA GGAACGGCTTAAGAACCTGCGGAGGGACTGAGTGCCCCTGCCACTCCGAGATAACCAGTGGATGCCCAGGATCTTTTACCACAACCCCTC >In-frame_HKR1_ENST00000591259_chr19_37826159_+_CHMP2A_ENST00000601220_chr19_59063552_-_564nt GTCTTTCCCACACCTCTGCACCTTGTTACCTGACTTTCGGCTTCAGGATCCGCAGCGTGCACCCGCGTTCCATCTGTCTTCTGAGACTTT GCCCTTCTCCAGGAAGAGCACTCAGGAGACCAGGAAAATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCA GAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATCATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGA TGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCCCAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCC CTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGGAAAAAAGCAGAGGCCGCAGCCTCAGCCCTAGCTGATGCTGATGCAGACCTGGA GGAACGGCTTAAGAACCTGCGGAGGGACTGAGTGCCCCTGCCACTCCGAGATAACCAGTGGATGCCCAGGATCTTTTACCACAACCCCTC >In-frame_HKR1_ENST00000591259_chr19_37826159_+_CHMP2A_ENST00000312547_chr19_59063552_-_564nt GTCTTTCCCACACCTCTGCACCTTGTTACCTGACTTTCGGCTTCAGGATCCGCAGCGTGCACCCGCGTTCCATCTGTCTTCTGAGACTTT GCCCTTCTCCAGGAAGAGCACTCAGGAGACCAGGAAAATGGCCACAGGGCTCCTGAGAGCCAAAAAAGAGCTGAAGTTGCCCCAGATCCA GAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATCATGGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGA TGAGGAAGATGAAGAGGAGAGTGATGCTGTGGTGTCCCAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCTGTCGAACCTCCC CTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGGAAAAAAGCAGAGGCCGCAGCCTCAGCCCTAGCTGATGCTGATGCAGACCTGGA GGAACGGCTTAAGAACCTGCGGAGGGACTGAGTGCCCCTGCCACTCCGAGATAACCAGTGGATGCCCAGGATCTTTTACCACAACCCCTC |
Top |
FusionGenePPI for HKR1_CHMP2A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HKR1 | CDK11A | CHMP2A | STAMBP, CHMP3, VTA1, VPS4B, VPS4A, USP8, USP54, CHMP2A, NOL4, EIF2B5, MITD1, RANBP2, ERLIN1, PPP1CA, RRBP1, ITGA4, E2F4, TGFB3, DOCK8, UFD1L, CHMP4B, CDV3, CHMP2B, CSTF2, HNRNPA3, EIF4EBP1, PARVA, XPO1, RAB2A, RAB5C, RAB7A, ATP6AP2, TFG, TRIM35, DECR1, CHMP5, SIX2, SPAST, SNAP23, CCDC83, OSTF1, DLST |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HKR1_CHMP2A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HKR1_CHMP2A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|