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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16306

FusionGeneSummary for HK1_HK1

check button Fusion gene summary
Fusion gene informationFusion gene name: HK1_HK1
Fusion gene ID: 16306
HgeneTgene
Gene symbol

HK1

HK1

Gene ID

255061

255061

Gene nametachykinin 4tachykinin 4
SynonymsEK|HK-1|HK1|PPT-CEK|HK-1|HK1|PPT-C
Cytomap

17q21.33

17q21.33

Type of geneprotein-codingprotein-coding
Descriptiontachykinin-4endokininpreprotachykinin-Ctachykinin 4 (hemokinin)tachykinin-4endokininpreprotachykinin-Ctachykinin 4 (hemokinin)
Modification date2018052320180523
UniProtAcc

P19367

P19367

Ensembl transtripts involved in fusion geneENST00000360289, ENST00000448642, 
ENST00000404387, ENST00000298649, 
ENST00000359426, ENST00000494253, 
ENST00000360289, ENST00000448642, 
ENST00000404387, ENST00000298649, 
ENST00000359426, ENST00000494253, 
Fusion gene scores* DoF score7 X 10 X 3=2107 X 8 X 6=336
# samples 1010
** MAII scorelog2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HK1 [Title/Abstract] AND HK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHK1

GO:1902093

positive regulation of flagellated sperm motility

17437961

TgeneHK1

GO:1902093

positive regulation of flagellated sperm motility

17437961


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW841510HK1chr10

71161498

-HK1chr10

71161318

+
ChiTaRS3.1AW903811HK1chr10

71151936

-HK1chr10

71161134

+
ChiTaRS3.1BE162082HK1chr10

71050599

-HK1chr10

71050898

+
ChiTaRS3.1W28999HK1chr10

71142439

-HK1chr10

71144584

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000360289ENST00000360289HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000360289ENST00000448642HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-intronENST00000360289ENST00000404387HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000360289ENST00000298649HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000360289ENST00000359426HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-intronENST00000360289ENST00000494253HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000448642ENST00000360289HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000448642ENST00000448642HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-intronENST00000448642ENST00000404387HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000448642ENST00000298649HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000448642ENST00000359426HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-intronENST00000448642ENST00000494253HK1chr10

71161498

-HK1chr10

71161318

+
intron-3UTRENST00000404387ENST00000360289HK1chr10

71161498

-HK1chr10

71161318

+
intron-3UTRENST00000404387ENST00000448642HK1chr10

71161498

-HK1chr10

71161318

+
intron-intronENST00000404387ENST00000404387HK1chr10

71161498

-HK1chr10

71161318

+
intron-3UTRENST00000404387ENST00000298649HK1chr10

71161498

-HK1chr10

71161318

+
intron-3UTRENST00000404387ENST00000359426HK1chr10

71161498

-HK1chr10

71161318

+
intron-intronENST00000404387ENST00000494253HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000298649ENST00000360289HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000298649ENST00000448642HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-intronENST00000298649ENST00000404387HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000298649ENST00000298649HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000298649ENST00000359426HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-intronENST00000298649ENST00000494253HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000359426ENST00000360289HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000359426ENST00000448642HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-intronENST00000359426ENST00000404387HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000359426ENST00000298649HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-3UTRENST00000359426ENST00000359426HK1chr10

71161498

-HK1chr10

71161318

+
3UTR-intronENST00000359426ENST00000494253HK1chr10

71161498

-HK1chr10

71161318

+
intron-3UTRENST00000494253ENST00000360289HK1chr10

71161498

-HK1chr10

71161318

+
intron-3UTRENST00000494253ENST00000448642HK1chr10

71161498

-HK1chr10

71161318

+
intron-intronENST00000494253ENST00000404387HK1chr10

71161498

-HK1chr10

71161318

+
intron-3UTRENST00000494253ENST00000298649HK1chr10

71161498

-HK1chr10

71161318

+
intron-3UTRENST00000494253ENST00000359426HK1chr10

71161498

-HK1chr10

71161318

+
intron-intronENST00000494253ENST00000494253HK1chr10

71161498

-HK1chr10

71161318

+
5CDS-3UTRENST00000360289ENST00000360289HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000360289ENST00000448642HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-intronENST00000360289ENST00000404387HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000360289ENST00000298649HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000360289ENST00000359426HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-intronENST00000360289ENST00000494253HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000448642ENST00000360289HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000448642ENST00000448642HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-intronENST00000448642ENST00000404387HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000448642ENST00000298649HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000448642ENST00000359426HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-intronENST00000448642ENST00000494253HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000404387ENST00000360289HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000404387ENST00000448642HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-intronENST00000404387ENST00000404387HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000404387ENST00000298649HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000404387ENST00000359426HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-intronENST00000404387ENST00000494253HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000298649ENST00000360289HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000298649ENST00000448642HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-intronENST00000298649ENST00000404387HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000298649ENST00000298649HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000298649ENST00000359426HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-intronENST00000298649ENST00000494253HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000359426ENST00000360289HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000359426ENST00000448642HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-intronENST00000359426ENST00000404387HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000359426ENST00000298649HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-3UTRENST00000359426ENST00000359426HK1chr10

71151936

-HK1chr10

71161134

+
5CDS-intronENST00000359426ENST00000494253HK1chr10

71151936

-HK1chr10

71161134

+
intron-3UTRENST00000494253ENST00000360289HK1chr10

71151936

-HK1chr10

71161134

+
intron-3UTRENST00000494253ENST00000448642HK1chr10

71151936

-HK1chr10

71161134

+
intron-intronENST00000494253ENST00000404387HK1chr10

71151936

-HK1chr10

71161134

+
intron-3UTRENST00000494253ENST00000298649HK1chr10

71151936

-HK1chr10

71161134

+
intron-3UTRENST00000494253ENST00000359426HK1chr10

71151936

-HK1chr10

71161134

+
intron-intronENST00000494253ENST00000494253HK1chr10

71151936

-HK1chr10

71161134

+
intron-intronENST00000360289ENST00000360289HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000360289ENST00000448642HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000360289ENST00000404387HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000360289ENST00000298649HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000360289ENST00000359426HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000360289ENST00000494253HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000448642ENST00000360289HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000448642ENST00000448642HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000448642ENST00000404387HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000448642ENST00000298649HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000448642ENST00000359426HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000448642ENST00000494253HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000404387ENST00000360289HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000404387ENST00000448642HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000404387ENST00000404387HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000404387ENST00000298649HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000404387ENST00000359426HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000404387ENST00000494253HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000298649ENST00000360289HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000298649ENST00000448642HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000298649ENST00000404387HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000298649ENST00000298649HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000298649ENST00000359426HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000298649ENST00000494253HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000359426ENST00000360289HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000359426ENST00000448642HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000359426ENST00000404387HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000359426ENST00000298649HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000359426ENST00000359426HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000359426ENST00000494253HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000494253ENST00000360289HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000494253ENST00000448642HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000494253ENST00000404387HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000494253ENST00000298649HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000494253ENST00000359426HK1chr10

71050599

-HK1chr10

71050898

+
intron-intronENST00000494253ENST00000494253HK1chr10

71050599

-HK1chr10

71050898

+
Frame-shiftENST00000360289ENST00000360289HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000360289ENST00000448642HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000360289ENST00000404387HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000360289ENST00000298649HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000360289ENST00000359426HK1chr10

71142439

-HK1chr10

71144584

+
5CDS-3UTRENST00000360289ENST00000494253HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000448642ENST00000360289HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000448642ENST00000448642HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000448642ENST00000404387HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000448642ENST00000298649HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000448642ENST00000359426HK1chr10

71142439

-HK1chr10

71144584

+
5CDS-3UTRENST00000448642ENST00000494253HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000404387ENST00000360289HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000404387ENST00000448642HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000404387ENST00000404387HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000404387ENST00000298649HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000404387ENST00000359426HK1chr10

71142439

-HK1chr10

71144584

+
5CDS-3UTRENST00000404387ENST00000494253HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000298649ENST00000360289HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000298649ENST00000448642HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000298649ENST00000404387HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000298649ENST00000298649HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000298649ENST00000359426HK1chr10

71142439

-HK1chr10

71144584

+
5CDS-3UTRENST00000298649ENST00000494253HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000359426ENST00000360289HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000359426ENST00000448642HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000359426ENST00000404387HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000359426ENST00000298649HK1chr10

71142439

-HK1chr10

71144584

+
Frame-shiftENST00000359426ENST00000359426HK1chr10

71142439

-HK1chr10

71144584

+
5CDS-3UTRENST00000359426ENST00000494253HK1chr10

71142439

-HK1chr10

71144584

+
3UTR-3CDSENST00000494253ENST00000360289HK1chr10

71142439

-HK1chr10

71144584

+
3UTR-3CDSENST00000494253ENST00000448642HK1chr10

71142439

-HK1chr10

71144584

+
3UTR-3CDSENST00000494253ENST00000404387HK1chr10

71142439

-HK1chr10

71144584

+
3UTR-3CDSENST00000494253ENST00000298649HK1chr10

71142439

-HK1chr10

71144584

+
3UTR-3CDSENST00000494253ENST00000359426HK1chr10

71142439

-HK1chr10

71144584

+
3UTR-3UTRENST00000494253ENST00000494253HK1chr10

71142439

-HK1chr10

71144584

+

Top

FusionProtFeatures for HK1_HK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HK1

P19367

HK1

P19367


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for HK1_HK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for HK1_HK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for HK1_HK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for HK1_HK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHK1C3150343HEMOLYTIC ANEMIA, NONSPHEROCYTIC, DUE TO HEXOKINASE DEFICIENCY2CTD_human;ORPHANET;UNIPROT
HgeneHK1C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneHK1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneHK1C0036341Schizophrenia1PSYGENET
HgeneHK1C0151744Myocardial Ischemia1CTD_human
TgeneHK1C3150343HEMOLYTIC ANEMIA, NONSPHEROCYTIC, DUE TO HEXOKINASE DEFICIENCY2CTD_human;ORPHANET;UNIPROT
TgeneHK1C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneHK1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneHK1C0036341Schizophrenia1PSYGENET
TgeneHK1C0151744Myocardial Ischemia1CTD_human