|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 16275 |
FusionGeneSummary for HIST4H4_RERG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HIST4H4_RERG | Fusion gene ID: 16275 | Hgene | Tgene | Gene symbol | HIST4H4 | RERG | Gene ID | 121504 | 85004 |
| Gene name | histone cluster 4 H4 | RAS like estrogen regulated growth inhibitor | |
| Synonyms | H4/p | - | |
| Cytomap | 12p12.3 | 12p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone H4histone 4, H4 | ras-related and estrogen-regulated growth inhibitor | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P62805 | Q96A58 | |
| Ensembl transtripts involved in fusion gene | ENST00000541592, ENST00000539745, | ENST00000256953, ENST00000538313, ENST00000536465, ENST00000546331, ENST00000537647, ENST00000437578, | |
| Fusion gene scores | * DoF score | 6 X 2 X 4=48 | 3 X 3 X 4=36 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/48*10)=0.54432051622381 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HIST4H4 [Title/Abstract] AND RERG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HIST4H4 | GO:0006334 | nucleosome assembly | 20498094|21636898|24699735|25615412 |
| Hgene | HIST4H4 | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
| Hgene | HIST4H4 | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Hgene | HIST4H4 | GO:0045653 | negative regulation of megakaryocyte differentiation | 18474616 |
| Hgene | HIST4H4 | GO:0051290 | protein heterotetramerization | 20498094 |
| Tgene | RERG | GO:0008285 | negative regulation of cell proliferation | 11533059 |
| Tgene | RERG | GO:0009725 | response to hormone | 11533059 |
| Tgene | RERG | GO:0030308 | negative regulation of cell growth | 11533059 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E9-A1NA-01A | HIST4H4 | chr12 | 14923613 | - | RERG | chr12 | 15274053 | - |
| TCGA | LD | PAAD | TCGA-F2-6879-01A | HIST4H4 | chr12 | 14921873 | - | RERG | chr12 | 15274053 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000541592 | ENST00000256953 | HIST4H4 | chr12 | 14923613 | - | RERG | chr12 | 15274053 | - |
| intron-3CDS | ENST00000541592 | ENST00000538313 | HIST4H4 | chr12 | 14923613 | - | RERG | chr12 | 15274053 | - |
| intron-3CDS | ENST00000541592 | ENST00000536465 | HIST4H4 | chr12 | 14923613 | - | RERG | chr12 | 15274053 | - |
| intron-intron | ENST00000541592 | ENST00000546331 | HIST4H4 | chr12 | 14923613 | - | RERG | chr12 | 15274053 | - |
| intron-intron | ENST00000541592 | ENST00000537647 | HIST4H4 | chr12 | 14923613 | - | RERG | chr12 | 15274053 | - |
| intron-intron | ENST00000541592 | ENST00000437578 | HIST4H4 | chr12 | 14923613 | - | RERG | chr12 | 15274053 | - |
| intron-3CDS | ENST00000539745 | ENST00000256953 | HIST4H4 | chr12 | 14923613 | - | RERG | chr12 | 15274053 | - |
| intron-3CDS | ENST00000539745 | ENST00000538313 | HIST4H4 | chr12 | 14923613 | - | RERG | chr12 | 15274053 | - |
| intron-3CDS | ENST00000539745 | ENST00000536465 | HIST4H4 | chr12 | 14923613 | - | RERG | chr12 | 15274053 | - |
| intron-intron | ENST00000539745 | ENST00000546331 | HIST4H4 | chr12 | 14923613 | - | RERG | chr12 | 15274053 | - |
| intron-intron | ENST00000539745 | ENST00000537647 | HIST4H4 | chr12 | 14923613 | - | RERG | chr12 | 15274053 | - |
| intron-intron | ENST00000539745 | ENST00000437578 | HIST4H4 | chr12 | 14923613 | - | RERG | chr12 | 15274053 | - |
| intron-3CDS | ENST00000541592 | ENST00000256953 | HIST4H4 | chr12 | 14921873 | - | RERG | chr12 | 15274053 | - |
| intron-3CDS | ENST00000541592 | ENST00000538313 | HIST4H4 | chr12 | 14921873 | - | RERG | chr12 | 15274053 | - |
| intron-3CDS | ENST00000541592 | ENST00000536465 | HIST4H4 | chr12 | 14921873 | - | RERG | chr12 | 15274053 | - |
| intron-intron | ENST00000541592 | ENST00000546331 | HIST4H4 | chr12 | 14921873 | - | RERG | chr12 | 15274053 | - |
| intron-intron | ENST00000541592 | ENST00000537647 | HIST4H4 | chr12 | 14921873 | - | RERG | chr12 | 15274053 | - |
| intron-intron | ENST00000541592 | ENST00000437578 | HIST4H4 | chr12 | 14921873 | - | RERG | chr12 | 15274053 | - |
| intron-3CDS | ENST00000539745 | ENST00000256953 | HIST4H4 | chr12 | 14921873 | - | RERG | chr12 | 15274053 | - |
| intron-3CDS | ENST00000539745 | ENST00000538313 | HIST4H4 | chr12 | 14921873 | - | RERG | chr12 | 15274053 | - |
| intron-3CDS | ENST00000539745 | ENST00000536465 | HIST4H4 | chr12 | 14921873 | - | RERG | chr12 | 15274053 | - |
| intron-intron | ENST00000539745 | ENST00000546331 | HIST4H4 | chr12 | 14921873 | - | RERG | chr12 | 15274053 | - |
| intron-intron | ENST00000539745 | ENST00000537647 | HIST4H4 | chr12 | 14921873 | - | RERG | chr12 | 15274053 | - |
| intron-intron | ENST00000539745 | ENST00000437578 | HIST4H4 | chr12 | 14921873 | - | RERG | chr12 | 15274053 | - |
Top |
FusionProtFeatures for HIST4H4_RERG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HIST4H4 | RERG |
| Core component of nucleosome. Nucleosomes wrap andcompact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as a template. Histonesthereby play a central role in transcription regulation, DNArepair, DNA replication and chromosomal stability. DNAaccessibility is regulated via a complex set of post-translationalmodifications of histones, also called histone code, andnucleosome remodeling. | Binds GDP/GTP and possesses intrinsic GTPase activity.Has higher affinity for GDP than for GTP. In cell linesoverexpression leads to a reduction in the rate of proliferation,colony formation and in tumorigenic potential.{ECO:0000269|PubMed:11533059}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for HIST4H4_RERG |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for HIST4H4_RERG |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HIST4H4 | DNTTIP2, HDAC9, SETDB1, CBX5, EP300, TAF1A, SET, ANP32A, KAT2B, NCOA3, CREBBP, BRD4, HIST3H3, RBBP7, ASF1B, COPRS, H2AFX, PRMT6, CTNNBL1, PRMT1, UCHL5, RAG1, HDAC5, L3MBTL2, RNF2, ARID4A, HAT1, CHAF1A, HDAC8, RAD21, HJURP, HDGF, HDAC6, USP16, MSL3, CUL3, CUL5, CUL2, COPS5, CAND1, SETD8, TRIM24, NSD1, MEN1, NOC2L, GRB2, EPS15, HIST1H3B, CENPA, RB1, PRAME, H3F3A, DAXX, ASF1A, ITGA4, CBX2, CBX4, CBX8, VHL, FBXO6, KAT2A, GNB2, FUS, SIAH1, NCOA2, LRWD1, ORC2, ORC3, ORC4, ORC5, KAT6A, WDR5, CUL7, OBSL1, EZH2, SUZ12, EED, BMI1, RBBP4, PRMT5, MLLT1, HIST1H3E, MCM2, KAT5, C4orf27 | RERG | FBXW7, ARHGEF17 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HIST4H4_RERG |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HIST4H4_RERG |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|