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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16265

FusionGeneSummary for HIST2H2BE_PFDN6

check button Fusion gene summary
Fusion gene informationFusion gene name: HIST2H2BE_PFDN6
Fusion gene ID: 16265
HgeneTgene
Gene symbol

HIST2H2BE

PFDN6

Gene ID

8349

10471

Gene namehistone cluster 2 H2B family member eprefoldin subunit 6
SynonymsGL105|H2B|H2B.1|H2BFQ|H2BGL105|H2BQH2-KE2|HKE2|KE-2|PFD6
Cytomap

1q21.2

6p21.32

Type of geneprotein-codingprotein-coding
Descriptionhistone H2B type 2-EH2B histone family, member Qhistone 2, H2behistone H2B-GL105histone H2B.qhistone cluster 2, H2beprefoldin subunit 6HLA class II region expressed gene KE2KE2 protein
Modification date2018052320180523
UniProtAcc

Q16778

O15212

Ensembl transtripts involved in fusion geneENST00000369155, ENST00000395131, 
ENST00000374606, ENST00000374610, 
ENST00000374607, ENST00000463584, 
ENST00000445559, ENST00000452658, 
ENST00000448594, ENST00000547952, 
ENST00000491095, ENST00000412289, 
ENST00000425878, ENST00000442285, 
ENST00000552711, ENST00000474406, 
ENST00000431830, ENST00000432391, 
ENST00000451970, ENST00000547641, 
ENST00000468094, ENST00000399385, 
ENST00000399383, ENST00000383207, 
ENST00000548040, ENST00000482292, 
Fusion gene scores* DoF score4 X 4 X 2=321 X 1 X 1=1
# samples 41
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: HIST2H2BE [Title/Abstract] AND PFDN6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHIST2H2BE

GO:0002227

innate immune response in mucosa

12860195

HgeneHIST2H2BE

GO:0019731

antibacterial humoral response

12860195

HgeneHIST2H2BE

GO:0050830

defense response to Gram-positive bacterium

12860195

HgeneHIST2H2BE

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

12860195

TgenePFDN6

GO:0051131

chaperone-mediated protein complex assembly

9630229


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP246346HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000369155ENST00000395131HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000374606HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000374610HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000374607HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000463584HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000445559HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000452658HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000448594HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000547952HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000491095HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000412289HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000425878HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000442285HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000552711HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000474406HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000431830HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000432391HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000451970HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000547641HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000468094HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-5UTRENST00000369155ENST00000399385HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-5UTRENST00000369155ENST00000399383HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-5UTRENST00000369155ENST00000383207HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-5UTRENST00000369155ENST00000548040HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+
intron-intronENST00000369155ENST00000482292HIST2H2BEchr1

149857736

-PFDN6chr6

4489620

+

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FusionProtFeatures for HIST2H2BE_PFDN6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HIST2H2BE

Q16778

PFDN6

O15212

Core component of nucleosome. Nucleosomes wrap andcompact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as a template. Histonesthereby play a central role in transcription regulation, DNArepair, DNA replication and chromosomal stability. DNAaccessibility is regulated via a complex set of post-translationalmodifications of histones, also called histone code, andnucleosome remodeling. Has broad antibacterial activity. May contribute to theformation of the functional antimicrobial barrier of the colonicepithelium, and to the bactericidal activity of amniotic fluid. Binds specifically to cytosolic chaperonin (c-CPN) andtransfers target proteins to it. Binds to nascent polypeptidechain and promotes folding in an environment in which there aremany competing pathways for nonnative proteins.{ECO:0000269|PubMed:9630229}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HIST2H2BE_PFDN6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HIST2H2BE_PFDN6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HIST2H2BE_PFDN6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HIST2H2BE_PFDN6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource