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Fusion gene ID: 16262 |
FusionGeneSummary for HIST1H4I_BCL6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HIST1H4I_BCL6 | Fusion gene ID: 16262 | Hgene | Tgene | Gene symbol | HIST1H4I | BCL6 | Gene ID | 8294 | 604 |
| Gene name | histone cluster 1 H4 family member i | B cell CLL/lymphoma 6 | |
| Synonyms | H4/m|H4FM|H4M | BCL5|BCL6A|LAZ3|ZBTB27|ZNF51 | |
| Cytomap | 6p22.1 | 3q27.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone H4H4 histone family, member MHistone 4 family, member Mhistone 1, H4ihistone cluster 1, H4ihistone family member | B-cell lymphoma 6 proteinB-cell lymphoma 5 proteinB-cell lymphoma 6 protein transcriptBCL-5BCL-6cys-his2 zinc finger transcription factorlymphoma-associated zinc finger gene on chromosome 3protein LAZ-3zinc finger and BTB domain-containing protein | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | P62805 | P41182 | |
| Ensembl transtripts involved in fusion gene | ENST00000354348, | ENST00000406870, ENST00000232014, ENST00000450123, ENST00000496823, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 5 X 2=40 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/40*10)=0.584962500721156 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: HIST1H4I [Title/Abstract] AND BCL6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HIST1H4I | GO:0006334 | nucleosome assembly | 20498094|21636898|24699735|25615412 |
| Hgene | HIST1H4I | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
| Hgene | HIST1H4I | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Hgene | HIST1H4I | GO:0045653 | negative regulation of megakaryocyte differentiation | 18474616 |
| Hgene | HIST1H4I | GO:0051290 | protein heterotetramerization | 20498094 |
| Tgene | BCL6 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11929873|15577913 |
| Tgene | BCL6 | GO:0006974 | cellular response to DNA damage stimulus | 15577913 |
| Tgene | BCL6 | GO:0030308 | negative regulation of cell growth | 10490843 |
| Tgene | BCL6 | GO:0043065 | positive regulation of apoptotic process | 10490843 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-CD-8531-01A | HIST1H4I | chr6 | 27107109 | + | BCL6 | chr3 | 187452695 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000354348 | ENST00000406870 | HIST1H4I | chr6 | 27107109 | + | BCL6 | chr3 | 187452695 | - |
| 5CDS-5UTR | ENST00000354348 | ENST00000232014 | HIST1H4I | chr6 | 27107109 | + | BCL6 | chr3 | 187452695 | - |
| 5CDS-intron | ENST00000354348 | ENST00000450123 | HIST1H4I | chr6 | 27107109 | + | BCL6 | chr3 | 187452695 | - |
| 5CDS-intron | ENST00000354348 | ENST00000496823 | HIST1H4I | chr6 | 27107109 | + | BCL6 | chr3 | 187452695 | - |
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FusionProtFeatures for HIST1H4I_BCL6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HIST1H4I | BCL6 |
| Core component of nucleosome. Nucleosomes wrap andcompact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as a template. Histonesthereby play a central role in transcription regulation, DNArepair, DNA replication and chromosomal stability. DNAaccessibility is regulated via a complex set of post-translationalmodifications of histones, also called histone code, andnucleosome remodeling. | Transcriptional repressor mainly required for germinalcenter (GC) formation and antibody affinity maturation which hasdifferent mechanisms of action specific to the lineage andbiological functions. Forms complexes with different corepressorsand histone deacetylases to repress the transcriptional expressionof different subsets of target genes. Represses its target genesby binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptionalactivity of transcription factors. In GC B-cells, represses genesthat function in differentiation, inflammation, apoptosis and cellcycle control, also autoregulates its transcriptional expressionand up-regulates, indirectly, the expression of some genesimportant for GC reactions, such as AICDA, through the repressionof microRNAs expression, like miR155. An important function is toallow GC B-cells to proliferate very rapidly in response to T-celldependent antigens and tolerate the physiological DNA breaksrequired for immunglobulin class switch recombination and somatichypermutation without inducing a p53/TP53-dependent apoptoticresponse. In follicular helper CD4(+) T-cells (T(FH) cells),promotes the expression of T(FH)-related genes but inhibits thedifferentiation of T(H)1, T(H)2 and T(H)17 cells. Also requiredfor the establishment and maintenance of immunological memory forboth T- and B-cells. Suppresses macrophage proliferation throughcompetition with STAT5 for STAT-binding motifs binding on certaintarget genes, such as CCL2 and CCND2. In response to genotoxicstress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controlsneurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets,such as HES5, including the recruitment of the deacetylase SIRT1and resulting in an epigenetic silencing leading to neuronaldifferentiation. {ECO:0000269|PubMed:10981963,ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651,ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082,ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238,ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614,ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289,ECO:0000269|PubMed:9649500}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HIST1H4I_BCL6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HIST1H4I_BCL6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HIST1H4I | UCHL5, RAD21, HDGF, H2AFZ, BPTF, CUL3, CUL5, CUL2, COPS5, CAND1, TRIM24, KAT6A, APP, VCAM1, FN1, ITGA4, FBXO6, ENO1, SHMT2, CUL7, OBSL1, MCM2, NAA40 | BCL6 | HDAC5, HDAC4, HDAC7, BCOR, NCOR2, NCOR1, HDAC1, IRF4, SIN3A, JUN, JUND, JUNB, ZBTB7A, PML, ZBTB16, BACH2, SPI1, BCL6B, EP300, HDAC2, MTA3, MBD3, CHD3, CREBBP, EBF1, HDAC9, PPARGC1A, HNF1A, YY1, E2F3, BCL11A, ATF7, POU2F3, SMARCA4, HELZ2, KDM2A, KMT2B, TRAF3IP3, ZNF443, ZMYND8, SAE1, DDX6, ERCC5, PARP12, LSM1, OSBPL1A, MAPK8IP3, MED23, WNT16, TNFRSF8, ARNT2, LPAR2, EPHB6, NKRF, SMO, LPAR4, PRKD3, PIKFYVE, EIF2AK3, DROSHA, EHMT1, IDI2, TRIB3, SPTLC2, PCDH9, PANX3, CSMD1, ARHGAP35, PPAP2B, SENP7, EIF4ENIF1, CACNA1A, WNK4, DNAH9, KIF13B, HSF4, WDR35, UTP6, OLA1, FBXO11, CDK19, CDK8, MED6, MED17, FOXM1, PIN1, HBEGF, HSP90AA1, NACC1, BCL6, PATZ1, RUNX1T1, CTBP1, RAF1, CUL3, PELI1, AES, KIFC3, SIAH1, TRAF1, BLZF1, ZBTB7B, CUTC, LIMS3, TP53, TWIST1, CTNNB1, IL32, PRKCE, ZBTB17, USP7, HDAC3, CARKD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HIST1H4I_BCL6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HIST1H4I_BCL6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | BCL6 | C0024305 | Lymphoma, Non-Hodgkin | 1 | CTD_human |
| Tgene | BCL6 | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
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