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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16254

FusionGeneSummary for HIST1H2BK_FAM134C

check button Fusion gene summary
Fusion gene informationFusion gene name: HIST1H2BK_FAM134C
Fusion gene ID: 16254
HgeneTgene
Gene symbol

HIST1H2BK

FAM134C

Gene ID

85236

Gene namehistone cluster 1 H2B family member k
SynonymsH2B/S|H2BFAiii|H2BFT|H2BK
Cytomap

6p22.1

Type of geneprotein-coding
Descriptionhistone H2B type 1-KH2B KH2B histone family, member THIRA-interacting protein 1histone 1, H2bkhistone cluster 1, H2bkhistone family member
Modification date20180523
UniProtAcc

O60814

Ensembl transtripts involved in fusion geneENST00000396891, ENST00000356950, 
ENST00000309428, ENST00000585894, 
ENST00000543197, 
Fusion gene scores* DoF score2 X 2 X 1=410 X 8 X 5=400
# samples 210
** MAII scorelog2(2/4*10)=2.32192809488736log2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HIST1H2BK [Title/Abstract] AND FAM134C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHIST1H2BK

GO:0002227

innate immune response in mucosa

12860195

HgeneHIST1H2BK

GO:0019731

antibacterial humoral response

12860195

HgeneHIST1H2BK

GO:0031640

killing of cells of other organism

15019208

HgeneHIST1H2BK

GO:0050829

defense response to Gram-negative bacterium

15019208

HgeneHIST1H2BK

GO:0050830

defense response to Gram-positive bacterium

12860195

HgeneHIST1H2BK

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

12860195|15019208


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA664421HIST1H2BKchr6

27114142

-FAM134Cchr17

40761668

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000396891ENST00000309428HIST1H2BKchr6

27114142

-FAM134Cchr17

40761668

+
intron-intronENST00000396891ENST00000585894HIST1H2BKchr6

27114142

-FAM134Cchr17

40761668

+
intron-intronENST00000396891ENST00000543197HIST1H2BKchr6

27114142

-FAM134Cchr17

40761668

+
intron-intronENST00000356950ENST00000309428HIST1H2BKchr6

27114142

-FAM134Cchr17

40761668

+
intron-intronENST00000356950ENST00000585894HIST1H2BKchr6

27114142

-FAM134Cchr17

40761668

+
intron-intronENST00000356950ENST00000543197HIST1H2BKchr6

27114142

-FAM134Cchr17

40761668

+

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FusionProtFeatures for HIST1H2BK_FAM134C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HIST1H2BK

O60814

FAM134C

Core component of nucleosome. Nucleosomes wrap andcompact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as a template. Histonesthereby play a central role in transcription regulation, DNArepair, DNA replication and chromosomal stability. DNAaccessibility is regulated via a complex set of post-translationalmodifications of histones, also called histone code, andnucleosome remodeling. Has broad antibacterial activity. May contribute to theformation of the functional antimicrobial barrier of the colonicepithelium, and to the bactericidal activity of amniotic fluid. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HIST1H2BK_FAM134C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HIST1H2BK_FAM134C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HIST1H2BK_FAM134C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HIST1H2BK_FAM134C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHIST1H2BKC1458155Mammary Neoplasms1CTD_human