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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 16198

FusionGeneSummary for HIPK2_ADCK2

check button Fusion gene summary
Fusion gene informationFusion gene name: HIPK2_ADCK2
Fusion gene ID: 16198
HgeneTgene
Gene symbol

HIPK2

ADCK2

Gene ID

28996

90956

Gene namehomeodomain interacting protein kinase 2aarF domain containing kinase 2
SynonymsPRO0593AARF
Cytomap

7q34

7q34

Type of geneprotein-codingprotein-coding
Descriptionhomeodomain-interacting protein kinase 2hHIPk2uncharacterized aarF domain-containing protein kinase 2putative ubiquinone biosynthesis protein AarF
Modification date2018052220180519
UniProtAcc

Q9H2X6

Q7Z695

Ensembl transtripts involved in fusion geneENST00000406875, ENST00000428878, 
ENST00000342645, 
ENST00000072869, 
ENST00000476491, 
Fusion gene scores* DoF score11 X 7 X 9=6932 X 1 X 1=2
# samples 122
** MAII scorelog2(12/693*10)=-2.5298209465287
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/2*10)=3.32192809488736
Context

PubMed: HIPK2 [Title/Abstract] AND ADCK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHIPK2

GO:0006468

protein phosphorylation

19448668

HgeneHIPK2

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

14647468

HgeneHIPK2

GO:0045766

positive regulation of angiogenesis

19046997

HgeneHIPK2

GO:0060395

SMAD protein signal transduction

12874272


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-78-7154-01AHIPK2chr7

139477404

-ADCK2chr7

140374411

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000406875ENST00000072869HIPK2chr7

139477404

-ADCK2chr7

140374411

+
In-frameENST00000406875ENST00000476491HIPK2chr7

139477404

-ADCK2chr7

140374411

+
In-frameENST00000428878ENST00000072869HIPK2chr7

139477404

-ADCK2chr7

140374411

+
In-frameENST00000428878ENST00000476491HIPK2chr7

139477404

-ADCK2chr7

140374411

+
intron-3CDSENST00000342645ENST00000072869HIPK2chr7

139477404

-ADCK2chr7

140374411

+
intron-3CDSENST00000342645ENST00000476491HIPK2chr7

139477404

-ADCK2chr7

140374411

+

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FusionProtFeatures for HIPK2_ADCK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HIPK2

Q9H2X6

ADCK2

Q7Z695

Serine/threonine-protein kinase involved intranscription regulation, p53/TP53-mediated cellular apoptosis andregulation of the cell cycle. Acts as a corepressor of severaltranscription factors, including SMAD1 and POU4F1/Brn3a andprobably NK homeodomain transcription factors. PhosphorylatesPDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300,CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotesapoptosis through the activation of p53/TP53 both at thetranscription level and at the protein level (by phosphorylationand indirect acetylation). The phosphorylation of p53/TP53 may bemediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in theresponse to hypoxia by acting as a transcriptional co-suppressorof HIF1A. Mediates transcriptional activation of TP73. In responseto TGFB, cooperates with DAXX to activate JNK. Negative regulatorthrough phosphorylation and subsequent proteasomal degradation ofCTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-cateninsignaling pathway acts as an intermediate kinase betweenMAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB.Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcriptionfactors by phosphorylation in response to genotoxic stress. Inresponse to DNA damage, stabilizes PML by phosphorylation. PML,HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involvedin erythroid differentiation, especially during fetal livererythropoiesis. Phosphorylation of RUNX1 and EP300 stimulatesEP300 transcription regulation activity. Triggers ZBTB4 proteindegradation in response to DNA damage. Modulates HMGA1 DNA-bindingaffinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in theregulation of eye size, lens formation and retinal laminationduring late embryogenesis. {ECO:0000269|PubMed:11740489,ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404,ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985,ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875,ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579,ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997,ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497,ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728,ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925,ECO:0000269|PubMed:22825850}. The function of this protein is not yet clear. It is notknown if it has protein kinase activity and what type of substrateit would phosphorylate (Ser, Thr or Tyr).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-1151088_109461199Compositional biasNote=Poly-Ala
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-1151088_109461172Compositional biasNote=Poly-Ala
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115199_52761199DomainProtein kinase
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115199_52761172DomainProtein kinase
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115802_80561199MotifNote=Nuclear localization signal 1 (NLS1)
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115832_83561199MotifNote=Nuclear localization signal 2 (NLS2)
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115802_80561172MotifNote=Nuclear localization signal 1 (NLS1)
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115832_83561172MotifNote=Nuclear localization signal 2 (NLS2)
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115205_21361199Nucleotide bindingATP
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115205_21361172Nucleotide bindingATP
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115873_98061199RegionRequired for localization to nuclear speckles
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-11597_23061199RegionTranscriptional corepression
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115984_119861199RegionNote=Autoinhibitory domain (AID)
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115873_98061172RegionRequired for localization to nuclear speckles
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-11597_23061172RegionTranscriptional corepression
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115984_119861172RegionNote=Autoinhibitory domain (AID)
TgeneADCK2chr7:139477404chr7:140374411ENST00000072869+08200_618311627DomainNote=Protein kinase
TgeneADCK2chr7:139477404chr7:140374411ENST00000072869+08206_214311627Nucleotide bindingATP
TgeneADCK2chr7:139477404chr7:140374411ENST00000072869+08103_123311627TransmembraneHelical


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FusionGeneSequence for HIPK2_ADCK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HIPK2_ENST00000406875_chr7_139477404_-_ADCK2_ENST00000072869_chr7_140374411_+_322aa
MAPVYEGVAPWPARSGAYGPAADEDWQPSPGSFARHQVAXLAXDCGGIXEADGPTDXPALRSSESRTLPGQLPECESRQVPHPSAPLCHQ
RSLGGNVXRECACVQLPAGRNSRGLEKEDCTAGDQHAPEDDICGXLCPCRPSPWKHPGSGCQRPVLESGGAAAAGGHLXHSGGGRAIFPL
PAATGAAGCWHCGGAAGPXPEEFPGSFHGCGDGAGPESGXADPASCPGQRVQGRGGVQNRDGHAGDPGQEEHHHPGEASCVQPSLXCLXV

>In-frame_HIPK2_ENST00000406875_chr7_139477404_-_ADCK2_ENST00000476491_chr7_140374411_+_286aa
MAPVYEGVAPWPARSGAYGPAADEDWQPSPGSFARHQVAXLAXDCGGIXEADGPTDXPALRSSESRTLPGQLPECESRQVPHPSAPLCHQ
RSLGGNVXRECACVQLPAGRNSRGLEKEDCTAGDQHAPEDDICGXLCPCRPSPWKHPGSGCQRPVLESGGAAAAGGHLXHSGGGRAIFPL
PAATGAAGCWHCGGAAGPXPEEFPGSFHGCGDGAGPESGXADPASCPGQRVQGRGGVQNRDGHAGDPGQEEHHHPGEASCVQPSLXCLXV

>In-frame_HIPK2_ENST00000428878_chr7_139477404_-_ADCK2_ENST00000072869_chr7_140374411_+_322aa
MAPVYEGVAPWPARSGAYGPAADEDWQPSPGSFARHQVAXLAXDCGGIXEADGPTDXPALRSSESRTLPGQLPECESRQVPHPSAPLCHQ
RSLGGNVXRECACVQLPAGRNSRGLEKEDCTAGDQHAPEDDICGXLCPCRPSPWKHPGSGCQRPVLESGGAAAAGGHLXHSGGGRAIFPL
PAATGAAGCWHCGGAAGPXPEEFPGSFHGCGDGAGPESGXADPASCPGQRVQGRGGVQNRDGHAGDPGQEEHHHPGEASCVQPSLXCLXV

>In-frame_HIPK2_ENST00000428878_chr7_139477404_-_ADCK2_ENST00000476491_chr7_140374411_+_286aa
MAPVYEGVAPWPARSGAYGPAADEDWQPSPGSFARHQVAXLAXDCGGIXEADGPTDXPALRSSESRTLPGQLPECESRQVPHPSAPLCHQ
RSLGGNVXRECACVQLPAGRNSRGLEKEDCTAGDQHAPEDDICGXLCPCRPSPWKHPGSGCQRPVLESGGAAAAGGHLXHSGGGRAIFPL
PAATGAAGCWHCGGAAGPXPEEFPGSFHGCGDGAGPESGXADPASCPGQRVQGRGGVQNRDGHAGDPGQEEHHHPGEASCVQPSLXCLXV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HIPK2_ENST00000406875_chr7_139477404_-_ADCK2_ENST00000072869_chr7_140374411_+_967nt
ATGGCCCCCGTGTACGAAGGTGTTGCACCCTGGCCTGCTCGCTCAGGTGCATATGGACCTGCTGCTGATGAAGATTGGCAGCCGAGTCCT
GGGAGTTTTGCCAGGCATCAAGTGGCTTAGCTTGCCTGAGATTGTGGAGGAATTTGAGAAGCTGATGGTCCAACAGATTGACCTGCGTTA
CGAAGCTCAGAATCTAGAACACTTCCAGGTCAACTTCCGGAATGTGAAAGCCGTCAAGTTCCCCACCCCTCTGCGCCCCTTTGTCACCAG
AGAAGTCTTGGTGGAAACGTATGAAGAGAGTGTGCCTGTGTCCAGTTACCAGCAGGCAGGAATTCCCGTGGACTTGAAAAGGAAGATTGC
ACGGCTGGGGATCAACATGCTCCTGAAGATGATATTTGTGGATAACTTTGTCCATGCAGACCTTCACCCTGGAAACATCCTGGTTCAGGG
TGCCAACGGCCTGTCCTCGAGTCAGGAGGCGCAGCTGCAGCAGGCGGACATCTGTGACACTCTGGTGGTGGCCGTGCCATCTTCCCTCTG
CCCGCTGCGACTGGTGCTGCTGGATGCTGGCATTGTGGCGGAGCTGCAGGCCCCTGACCTGAGGAATTTCCGGGCAGTTTTCATGGCTGT
GGTGATGGGGCAGGGCCAGAGAGTGGCTGAGCTGATCCTGCATCATGCCCGGGCCAGCGAGTGCAGGGACGTGGAGGGGTTCAAAACCGA
GATGGCCATGCTGGTGACCCAGGCCAGGAAGAACACCATCACCCTGGAGAAGCTTCATGTGTCCAGCCTTCTCTCTAGTGTCTTTAAGTT
GCTGATGACTCACAAGGTAAAGCTTGAGAGCAACTTTGCCTCCATTGTGTTTGCCATCATGGTGTTGGAGGGGCTTGGCCGCTCACTGGA

>In-frame_HIPK2_ENST00000406875_chr7_139477404_-_ADCK2_ENST00000476491_chr7_140374411_+_859nt
ATGGCCCCCGTGTACGAAGGTGTTGCACCCTGGCCTGCTCGCTCAGGTGCATATGGACCTGCTGCTGATGAAGATTGGCAGCCGAGTCCT
GGGAGTTTTGCCAGGCATCAAGTGGCTTAGCTTGCCTGAGATTGTGGAGGAATTTGAGAAGCTGATGGTCCAACAGATTGACCTGCGTTA
CGAAGCTCAGAATCTAGAACACTTCCAGGTCAACTTCCGGAATGTGAAAGCCGTCAAGTTCCCCACCCCTCTGCGCCCCTTTGTCACCAG
AGAAGTCTTGGTGGAAACGTATGAAGAGAGTGTGCCTGTGTCCAGTTACCAGCAGGCAGGAATTCCCGTGGACTTGAAAAGGAAGATTGC
ACGGCTGGGGATCAACATGCTCCTGAAGATGATATTTGTGGATAACTTTGTCCATGCAGACCTTCACCCTGGAAACATCCTGGTTCAGGG
TGCCAACGGCCTGTCCTCGAGTCAGGAGGCGCAGCTGCAGCAGGCGGACATCTGTGACACTCTGGTGGTGGCCGTGCCATCTTCCCTCTG
CCCGCTGCGACTGGTGCTGCTGGATGCTGGCATTGTGGCGGAGCTGCAGGCCCCTGACCTGAGGAATTTCCGGGCAGTTTTCATGGCTGT
GGTGATGGGGCAGGGCCAGAGAGTGGCTGAGCTGATCCTGCATCATGCCCGGGCCAGCGAGTGCAGGGACGTGGAGGGGTTCAAAACCGA
GATGGCCATGCTGGTGACCCAGGCCAGGAAGAACACCATCACCCTGGAGAAGCTTCATGTGTCCAGCCTTCTCTCTAGTGTCTTTAAGTT

>In-frame_HIPK2_ENST00000428878_chr7_139477404_-_ADCK2_ENST00000072869_chr7_140374411_+_967nt
ATGGCCCCCGTGTACGAAGGTGTTGCACCCTGGCCTGCTCGCTCAGGTGCATATGGACCTGCTGCTGATGAAGATTGGCAGCCGAGTCCT
GGGAGTTTTGCCAGGCATCAAGTGGCTTAGCTTGCCTGAGATTGTGGAGGAATTTGAGAAGCTGATGGTCCAACAGATTGACCTGCGTTA
CGAAGCTCAGAATCTAGAACACTTCCAGGTCAACTTCCGGAATGTGAAAGCCGTCAAGTTCCCCACCCCTCTGCGCCCCTTTGTCACCAG
AGAAGTCTTGGTGGAAACGTATGAAGAGAGTGTGCCTGTGTCCAGTTACCAGCAGGCAGGAATTCCCGTGGACTTGAAAAGGAAGATTGC
ACGGCTGGGGATCAACATGCTCCTGAAGATGATATTTGTGGATAACTTTGTCCATGCAGACCTTCACCCTGGAAACATCCTGGTTCAGGG
TGCCAACGGCCTGTCCTCGAGTCAGGAGGCGCAGCTGCAGCAGGCGGACATCTGTGACACTCTGGTGGTGGCCGTGCCATCTTCCCTCTG
CCCGCTGCGACTGGTGCTGCTGGATGCTGGCATTGTGGCGGAGCTGCAGGCCCCTGACCTGAGGAATTTCCGGGCAGTTTTCATGGCTGT
GGTGATGGGGCAGGGCCAGAGAGTGGCTGAGCTGATCCTGCATCATGCCCGGGCCAGCGAGTGCAGGGACGTGGAGGGGTTCAAAACCGA
GATGGCCATGCTGGTGACCCAGGCCAGGAAGAACACCATCACCCTGGAGAAGCTTCATGTGTCCAGCCTTCTCTCTAGTGTCTTTAAGTT
GCTGATGACTCACAAGGTAAAGCTTGAGAGCAACTTTGCCTCCATTGTGTTTGCCATCATGGTGTTGGAGGGGCTTGGCCGCTCACTGGA

>In-frame_HIPK2_ENST00000428878_chr7_139477404_-_ADCK2_ENST00000476491_chr7_140374411_+_859nt
ATGGCCCCCGTGTACGAAGGTGTTGCACCCTGGCCTGCTCGCTCAGGTGCATATGGACCTGCTGCTGATGAAGATTGGCAGCCGAGTCCT
GGGAGTTTTGCCAGGCATCAAGTGGCTTAGCTTGCCTGAGATTGTGGAGGAATTTGAGAAGCTGATGGTCCAACAGATTGACCTGCGTTA
CGAAGCTCAGAATCTAGAACACTTCCAGGTCAACTTCCGGAATGTGAAAGCCGTCAAGTTCCCCACCCCTCTGCGCCCCTTTGTCACCAG
AGAAGTCTTGGTGGAAACGTATGAAGAGAGTGTGCCTGTGTCCAGTTACCAGCAGGCAGGAATTCCCGTGGACTTGAAAAGGAAGATTGC
ACGGCTGGGGATCAACATGCTCCTGAAGATGATATTTGTGGATAACTTTGTCCATGCAGACCTTCACCCTGGAAACATCCTGGTTCAGGG
TGCCAACGGCCTGTCCTCGAGTCAGGAGGCGCAGCTGCAGCAGGCGGACATCTGTGACACTCTGGTGGTGGCCGTGCCATCTTCCCTCTG
CCCGCTGCGACTGGTGCTGCTGGATGCTGGCATTGTGGCGGAGCTGCAGGCCCCTGACCTGAGGAATTTCCGGGCAGTTTTCATGGCTGT
GGTGATGGGGCAGGGCCAGAGAGTGGCTGAGCTGATCCTGCATCATGCCCGGGCCAGCGAGTGCAGGGACGTGGAGGGGTTCAAAACCGA
GATGGCCATGCTGGTGACCCAGGCCAGGAAGAACACCATCACCCTGGAGAAGCTTCATGTGTCCAGCCTTCTCTCTAGTGTCTTTAAGTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_HIPK2_ENST00000406875_chr7_139477404_-_ADCK2_ENST00000072869_chr7_140374411_+_1380nt
CTCAAGATGGCAGATTCCGACTGAGGCTGGGGGGGCCGAGCTCGCGCGCCGCTTTCCCGTCCCCGTTGCCATGAACCGCGGACACCCCGG
CCCCGATGGCCCCCGTGTACGAAGGTGTTGCACCCTGGCCTGCTCGCTCAGGTGCATATGGACCTGCTGCTGATGAAGATTGGCAGCCGA
GTCCTGGGAGTTTTGCCAGGCATCAAGTGGCTTAGCTTGCCTGAGATTGTGGAGGAATTTGAGAAGCTGATGGTCCAACAGATTGACCTG
CGTTACGAAGCTCAGAATCTAGAACACTTCCAGGTCAACTTCCGGAATGTGAAAGCCGTCAAGTTCCCCACCCCTCTGCGCCCCTTTGTC
ACCAGAGAAGTCTTGGTGGAAACGTATGAAGAGAGTGTGCCTGTGTCCAGTTACCAGCAGGCAGGAATTCCCGTGGACTTGAAAAGGAAG
ATTGCACGGCTGGGGATCAACATGCTCCTGAAGATGATATTTGTGGATAACTTTGTCCATGCAGACCTTCACCCTGGAAACATCCTGGTT
CAGGGTGCCAACGGCCTGTCCTCGAGTCAGGAGGCGCAGCTGCAGCAGGCGGACATCTGTGACACTCTGGTGGTGGCCGTGCCATCTTCC
CTCTGCCCGCTGCGACTGGTGCTGCTGGATGCTGGCATTGTGGCGGAGCTGCAGGCCCCTGACCTGAGGAATTTCCGGGCAGTTTTCATG
GCTGTGGTGATGGGGCAGGGCCAGAGAGTGGCTGAGCTGATCCTGCATCATGCCCGGGCCAGCGAGTGCAGGGACGTGGAGGGGTTCAAA
ACCGAGATGGCCATGCTGGTGACCCAGGCCAGGAAGAACACCATCACCCTGGAGAAGCTTCATGTGTCCAGCCTTCTCTCTAGTGTCTTT
AAGTTGCTGATGACTCACAAGGTAAAGCTTGAGAGCAACTTTGCCTCCATTGTGTTTGCCATCATGGTGTTGGAGGGGCTTGGCCGCTCA
CTGGACCCCAAACTGGACATCCTGGAGGCAGCGAGGCCCTTCCTCCTCACGGGCCCAGTGTGCCCCCCGTGATGGGGCAGTGGCCTCTGT
GGGCCCTTGTCAAGAGCTGGAGGCCACTCCCAAGAGCCTCTCCTATGGCAGCTGGGACGTTTTAAAATTGGGACACCAATTTCAAATGTA
ACCCTCCAGTGGTGGAAGGCACACCATGGCTTCCTCTGCTTGGTTTGAGGGTCTGTTCAAAAGCTTTGGGCCAATTAGGGAGTAAAAGGA
GGGAAGGGGCCTATCCATTCCATTGTGGAAGCTGGGCCAGGTGCCAGGGACACTCTCCTTCAGGGAAAATGTTATGTGGAGGAGGACGAA

>In-frame_HIPK2_ENST00000406875_chr7_139477404_-_ADCK2_ENST00000476491_chr7_140374411_+_1095nt
CTCAAGATGGCAGATTCCGACTGAGGCTGGGGGGGCCGAGCTCGCGCGCCGCTTTCCCGTCCCCGTTGCCATGAACCGCGGACACCCCGG
CCCCGATGGCCCCCGTGTACGAAGGTGTTGCACCCTGGCCTGCTCGCTCAGGTGCATATGGACCTGCTGCTGATGAAGATTGGCAGCCGA
GTCCTGGGAGTTTTGCCAGGCATCAAGTGGCTTAGCTTGCCTGAGATTGTGGAGGAATTTGAGAAGCTGATGGTCCAACAGATTGACCTG
CGTTACGAAGCTCAGAATCTAGAACACTTCCAGGTCAACTTCCGGAATGTGAAAGCCGTCAAGTTCCCCACCCCTCTGCGCCCCTTTGTC
ACCAGAGAAGTCTTGGTGGAAACGTATGAAGAGAGTGTGCCTGTGTCCAGTTACCAGCAGGCAGGAATTCCCGTGGACTTGAAAAGGAAG
ATTGCACGGCTGGGGATCAACATGCTCCTGAAGATGATATTTGTGGATAACTTTGTCCATGCAGACCTTCACCCTGGAAACATCCTGGTT
CAGGGTGCCAACGGCCTGTCCTCGAGTCAGGAGGCGCAGCTGCAGCAGGCGGACATCTGTGACACTCTGGTGGTGGCCGTGCCATCTTCC
CTCTGCCCGCTGCGACTGGTGCTGCTGGATGCTGGCATTGTGGCGGAGCTGCAGGCCCCTGACCTGAGGAATTTCCGGGCAGTTTTCATG
GCTGTGGTGATGGGGCAGGGCCAGAGAGTGGCTGAGCTGATCCTGCATCATGCCCGGGCCAGCGAGTGCAGGGACGTGGAGGGGTTCAAA
ACCGAGATGGCCATGCTGGTGACCCAGGCCAGGAAGAACACCATCACCCTGGAGAAGCTTCATGTGTCCAGCCTTCTCTCTAGTGTCTTT
AAGTTGCTGATGACTCACAAGGTAAAATCACAGTTTATCCCTGCACCTTCATAGATTATGTTGCTCGTCTTAGAGACCACCAGGCAGCGA
ATGGAGTCAAGCCCTTGCGCTCTCCGAGAGTCCTGCCCTGACTACAGGACTAGTTTCTCCCATTCTTTCCTTCTCCAGGATAAAGTTCCT

>In-frame_HIPK2_ENST00000428878_chr7_139477404_-_ADCK2_ENST00000072869_chr7_140374411_+_1440nt
CACGGGAGGCGGTGATGCGGGCGCGGGCGGCCTCGGCTGCGCCGAGAGCGGAGACACAGGCTCAAGATGGCAGATTCCGACTGAGGCTGG
GGGGGCCGAGCTCGCGCGCCGCTTTCCCGTCCCCGTTGCCATGAACCGCGGACACCCCGGCCCCGATGGCCCCCGTGTACGAAGGTGTTG
CACCCTGGCCTGCTCGCTCAGGTGCATATGGACCTGCTGCTGATGAAGATTGGCAGCCGAGTCCTGGGAGTTTTGCCAGGCATCAAGTGG
CTTAGCTTGCCTGAGATTGTGGAGGAATTTGAGAAGCTGATGGTCCAACAGATTGACCTGCGTTACGAAGCTCAGAATCTAGAACACTTC
CAGGTCAACTTCCGGAATGTGAAAGCCGTCAAGTTCCCCACCCCTCTGCGCCCCTTTGTCACCAGAGAAGTCTTGGTGGAAACGTATGAA
GAGAGTGTGCCTGTGTCCAGTTACCAGCAGGCAGGAATTCCCGTGGACTTGAAAAGGAAGATTGCACGGCTGGGGATCAACATGCTCCTG
AAGATGATATTTGTGGATAACTTTGTCCATGCAGACCTTCACCCTGGAAACATCCTGGTTCAGGGTGCCAACGGCCTGTCCTCGAGTCAG
GAGGCGCAGCTGCAGCAGGCGGACATCTGTGACACTCTGGTGGTGGCCGTGCCATCTTCCCTCTGCCCGCTGCGACTGGTGCTGCTGGAT
GCTGGCATTGTGGCGGAGCTGCAGGCCCCTGACCTGAGGAATTTCCGGGCAGTTTTCATGGCTGTGGTGATGGGGCAGGGCCAGAGAGTG
GCTGAGCTGATCCTGCATCATGCCCGGGCCAGCGAGTGCAGGGACGTGGAGGGGTTCAAAACCGAGATGGCCATGCTGGTGACCCAGGCC
AGGAAGAACACCATCACCCTGGAGAAGCTTCATGTGTCCAGCCTTCTCTCTAGTGTCTTTAAGTTGCTGATGACTCACAAGGTAAAGCTT
GAGAGCAACTTTGCCTCCATTGTGTTTGCCATCATGGTGTTGGAGGGGCTTGGCCGCTCACTGGACCCCAAACTGGACATCCTGGAGGCA
GCGAGGCCCTTCCTCCTCACGGGCCCAGTGTGCCCCCCGTGATGGGGCAGTGGCCTCTGTGGGCCCTTGTCAAGAGCTGGAGGCCACTCC
CAAGAGCCTCTCCTATGGCAGCTGGGACGTTTTAAAATTGGGACACCAATTTCAAATGTAACCCTCCAGTGGTGGAAGGCACACCATGGC
TTCCTCTGCTTGGTTTGAGGGTCTGTTCAAAAGCTTTGGGCCAATTAGGGAGTAAAAGGAGGGAAGGGGCCTATCCATTCCATTGTGGAA
GCTGGGCCAGGTGCCAGGGACACTCTCCTTCAGGGAAAATGTTATGTGGAGGAGGACGAATAAATTTATTTTGTTTTCCTGTTTTTCTCA

>In-frame_HIPK2_ENST00000428878_chr7_139477404_-_ADCK2_ENST00000476491_chr7_140374411_+_1155nt
CACGGGAGGCGGTGATGCGGGCGCGGGCGGCCTCGGCTGCGCCGAGAGCGGAGACACAGGCTCAAGATGGCAGATTCCGACTGAGGCTGG
GGGGGCCGAGCTCGCGCGCCGCTTTCCCGTCCCCGTTGCCATGAACCGCGGACACCCCGGCCCCGATGGCCCCCGTGTACGAAGGTGTTG
CACCCTGGCCTGCTCGCTCAGGTGCATATGGACCTGCTGCTGATGAAGATTGGCAGCCGAGTCCTGGGAGTTTTGCCAGGCATCAAGTGG
CTTAGCTTGCCTGAGATTGTGGAGGAATTTGAGAAGCTGATGGTCCAACAGATTGACCTGCGTTACGAAGCTCAGAATCTAGAACACTTC
CAGGTCAACTTCCGGAATGTGAAAGCCGTCAAGTTCCCCACCCCTCTGCGCCCCTTTGTCACCAGAGAAGTCTTGGTGGAAACGTATGAA
GAGAGTGTGCCTGTGTCCAGTTACCAGCAGGCAGGAATTCCCGTGGACTTGAAAAGGAAGATTGCACGGCTGGGGATCAACATGCTCCTG
AAGATGATATTTGTGGATAACTTTGTCCATGCAGACCTTCACCCTGGAAACATCCTGGTTCAGGGTGCCAACGGCCTGTCCTCGAGTCAG
GAGGCGCAGCTGCAGCAGGCGGACATCTGTGACACTCTGGTGGTGGCCGTGCCATCTTCCCTCTGCCCGCTGCGACTGGTGCTGCTGGAT
GCTGGCATTGTGGCGGAGCTGCAGGCCCCTGACCTGAGGAATTTCCGGGCAGTTTTCATGGCTGTGGTGATGGGGCAGGGCCAGAGAGTG
GCTGAGCTGATCCTGCATCATGCCCGGGCCAGCGAGTGCAGGGACGTGGAGGGGTTCAAAACCGAGATGGCCATGCTGGTGACCCAGGCC
AGGAAGAACACCATCACCCTGGAGAAGCTTCATGTGTCCAGCCTTCTCTCTAGTGTCTTTAAGTTGCTGATGACTCACAAGGTAAAATCA
CAGTTTATCCCTGCACCTTCATAGATTATGTTGCTCGTCTTAGAGACCACCAGGCAGCGAATGGAGTCAAGCCCTTGCGCTCTCCGAGAG


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FusionGenePPI for HIPK2_ADCK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HIPK2DAXX, SP100, UBE2I, SUMO1, SKI, SMAD1, SMAD2, SMAD3, TP53INP1, TP53, CREBBP, RANBP9, NKX2-1, TRADD, TP73, TP63, FBXW7, BTRC, CUL1, MYB, RUNX1, EP300, HIPK2, NLK, MAP3K7, MYBL1, MYBL2, WSB1, SIAH1P1, SIAH1, SIAH2, CXCL1, AXIN1, HIST2H2BE, SENP2, SENP1, FBXO3, PML, CBX4, PAX6, CHMP4B, DCAF7, DYRK1A, DYRK1B, MAP3K1, MDM2, ZBTB4, MECP2, MBP, MKNK1, AATF, XAF1, SUMO2, SUMO3, RGMA, ABL1, PARP1, HSPA1A, STUB1, LZTS2, ACTBL2, TRIM25ADCK2YWHAQ, ADCK2, PDK2, STOML2, GPI, PMPCB, NRD1, CLPB, MRPL22, SLC4A8, ZNRF4, KCNA5, IL17RC, LRRC8B, NMUR2, TMCO3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115935_104961199AXIN1
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115935_104961172AXIN1
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115774_87661199CTBP1
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115774_87661172CTBP1
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115189_52061199DAXX
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115189_52061172DAXX
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115787_89761199HMGA1
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115787_89761172HMGA1
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115752_89761199POU4F1
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115752_89761172POU4F1
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115539_84461199SKI and SMAD1
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115539_84461172SKI and SMAD1
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115846_94161199TP53 and TP73
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115846_94161172TP53 and TP73
HgeneHIPK2chr7:139477404chr7:140374411ENST00000406875-115873_90761199UBE2I
HgeneHIPK2chr7:139477404chr7:140374411ENST00000428878-115873_90761172UBE2I


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HIPK2_ADCK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HIPK2_ADCK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource