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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1617

FusionGeneSummary for AMN1_FAR2

check button Fusion gene summary
Fusion gene informationFusion gene name: AMN1_FAR2
Fusion gene ID: 1617
HgeneTgene
Gene symbol

AMN1

FAR2

Gene ID

196394

55711

Gene nameantagonist of mitotic exit network 1 homologfatty acyl-CoA reductase 2
Synonyms-HEL-S-81|MLSTD1|SDR10E2
Cytomap

12p11.21

12p11.22

Type of geneprotein-codingprotein-coding
Descriptionprotein AMN1 homologfatty acyl-CoA reductase 2epididymis secretory protein Li 81male sterility domain-containing protein 1short chain dehydrogenase/reductase family 10E, member 2
Modification date2018052320180523
UniProtAcc

Q8IY45

Q96K12

Ensembl transtripts involved in fusion geneENST00000281471, ENST00000537562, 
ENST00000541931, ENST00000536761, 
ENST00000542781, ENST00000541541, 
ENST00000536681, ENST00000549080, 
ENST00000182377, ENST00000547116, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 2 X 3=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AMN1 [Title/Abstract] AND FAR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFAR2

GO:0035336

long-chain fatty-acyl-CoA metabolic process

15220348


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-80-5611-01AAMN1chr12

31841941

-FAR2chr12

29460591

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000281471ENST00000536681AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000281471ENST00000549080AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000281471ENST00000182377AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000281471ENST00000547116AMN1chr12

31841941

-FAR2chr12

29460591

+
In-frameENST00000537562ENST00000536681AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000537562ENST00000549080AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000537562ENST00000182377AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000537562ENST00000547116AMN1chr12

31841941

-FAR2chr12

29460591

+
Frame-shiftENST00000541931ENST00000536681AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000541931ENST00000549080AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000541931ENST00000182377AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000541931ENST00000547116AMN1chr12

31841941

-FAR2chr12

29460591

+
Frame-shiftENST00000536761ENST00000536681AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000536761ENST00000549080AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000536761ENST00000182377AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000536761ENST00000547116AMN1chr12

31841941

-FAR2chr12

29460591

+
Frame-shiftENST00000542781ENST00000536681AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000542781ENST00000549080AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000542781ENST00000182377AMN1chr12

31841941

-FAR2chr12

29460591

+
5CDS-intronENST00000542781ENST00000547116AMN1chr12

31841941

-FAR2chr12

29460591

+
intron-3CDSENST00000541541ENST00000536681AMN1chr12

31841941

-FAR2chr12

29460591

+
intron-intronENST00000541541ENST00000549080AMN1chr12

31841941

-FAR2chr12

29460591

+
intron-intronENST00000541541ENST00000182377AMN1chr12

31841941

-FAR2chr12

29460591

+
intron-intronENST00000541541ENST00000547116AMN1chr12

31841941

-FAR2chr12

29460591

+

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FusionProtFeatures for AMN1_FAR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AMN1

Q8IY45

FAR2

Q96K12

Catalyzes the reduction of saturated but not unsaturatedC16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity canbe observed with shorter fatty acyl-CoA substrates(PubMed:15220348). It may play a role in the production of etherlipids/plasmalogens and wax monoesters which synthesis requiresfatty alcohols as substrates (By similarity).{ECO:0000250|UniProtKB:Q8WVX9, ECO:0000269|PubMed:15220348}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AMN1_FAR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AMN1_ENST00000537562_chr12_31841941_-_FAR2_ENST00000536681_chr12_29460591_+_334aa
VVRRCYYXRDYTQADQRLAQYLYLHQGLGRNGGAAREQEPEHCHHKALHCGSNLAGAFPRLGXXYKWTXWNHYCDWERVSSGHKSYSNGC
GRRNSSXYSRQSHASCRMVYCSSQTXVNISLPHYIWXHESLQLAQNGSPSLGNLXKNPIXETFQEAKCXFYQQQLHITVLECGQPPGPCH
YLXLLSAAHWKEAQDDKAHESAFKNCFHVGVFHQPELGMEHVQYRNADVXAESXRPESIQLXRAPVELVGIHXKLCFGSXKILIERGYGW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AMN1_ENST00000537562_chr12_31841941_-_FAR2_ENST00000536681_chr12_29460591_+_1003nt
GTGGTTAGACGATGCTATTATTGACGAGATTACACCCAAGCTGATCAGAGATTGGCCCAATATTTATACCTACACCAAGGCCTTGGGAGA
AATGGTGGTGCAGCAAGAGAGCAGGAACCTGAACATTGCCATCATAAGGCCCTCCATTGTGGGAGCAACTTGGCAGGAGCCTTTCCCAGG
TTGGGTTGATAATATAAATGGACCTAATGGAATCATTATTGCGACTGGGAAAGGGTTTCTTCGGGCCATAAAAGCTACTCCAATGGCTGT
GGCAGACGTAATTCCAGTTGATACAGTCGTCAATCTCATGCTAGCTGTAGGATGGTATACTGCAGTTCACAGACCTAAGTCAACATTAGT
CTACCACATTACATCTGGTAACATGAATCCCTGCAATTGGCACAAAATGGGAGTCCAAGTCTTGGCAACCTTTGAAAAAATCCCATTTGA
GAGACCTTTCAGGAGGCCAAATGCTAATTTTACCAGCAACAGCTTCACATCACAGTACTGGAATGCGGTCAGCCACCGGGCCCCTGCCAT
TATCTATGACTGCTATCTGCGGCTCACTGGAAGGAAGCCCAGGATGACAAAGCTCATGAATCGGCTTTTAAGAACTGTTTCCATGTTGGA
GTATTTCATCAACCGGAGTTGGGAATGGAGCACGTACAATACAGAAATGCTGATGTCTGAGCTGAGTCCTGAAGACCAGAGAGTATTCAA
CTTTGACGTGCGCCAGTTGAACTGGTTGGAATACATTGAAAATTATGTTTTGGGAGTTAAAAAATACTTATTGAAAGAGGATATGGCTGG
GATCCCAAAAGCAAAGCAACGCTTAAAAAGGCTCCGAAATATTCACTACCTCTTTAATACTGCCCTCTTCCTTATCGCCTGGCGCCTTCT
CATTGCAAGATCTCAGATGGCTCGGAATGTCTGGTTCTTCATTGTAAGCTTCTGTTATAAATTCCTCTCCTACTTTAGAGCATCCAGCAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_AMN1_ENST00000537562_chr12_31841941_-_FAR2_ENST00000536681_chr12_29460591_+_3930nt
CGATGCCTCGCCCACGGCGGGTCAGTCAGCTCCTGGATCTTGATGCTTAGGAAAGATTTTATATCATTAAAAAGAAATTGGGAGGTCACT
TCCAAGATGGCTAAATGGGAACAGCTCCAGTCTGCAGCTCCCAGCAAGATTGACGCAGAAGATGGGCGATTTCTGCATTTCCAACTGAGA
TGCTACTGGACTTGAATGGTTAATAAAATTGCACAATGTTGTTGGTGGCAGTGACTTCTTTCTGTTCAGATTAAGGCCGAGCACAAGGCT
CATGCCTGTAATCCCAGCAGTTTGGGAGGCCAAGGTGGGAGGCTCACTTCAGCCCAGGAGTTCAAGACCGGCCTGGGCAACATATAGAGA
CCCCATCTCTACAAGAAATACAGAAAATTAGCTGATTGTGGTGGTGCATGTCTGTAGTCCCAACTACTTGGGAGGCTGAGATGCCTTTGG
TGCTTCATGAAGAATATTTCCAGATATCTCACAGACATTAAGCCTTTGCCTCCCAACATAAAAGACAGACTGATTAAAATAATGAGTATG
CAGGGACAGATAACAGATTCAAATATAAGTGAGATTTTACATCCTGAAGTCCAAACTCTAGATCTACGGAGCTGCGATATATCAGATGCT
GCTCTCCTGCACCTGTCTAACTGTAGAAAACTGAAGAAATTAAATTTAAATGCTTCAAAAGGGAACCGAGTTTCTGTAACTTCAGAAGGA
ATAAAAGCTGTGGCTTCATCTTGTTCATACCTACACGAAGCTTCTTTGAAAAGATGCTGCAATCTCACTGACGAAGGAGTCGTTGCTCTT
GCACTCAATTGCCAGCTGCTAAAGATCATCGATTTAGGTGGCTGCTTAAGTATTACTGATGTGTCCTTACATGCATTAGGAAAAAACTGC
CCATTTTTGCAGTGTGTCGACTTTTCAGCTACTCAGGTATCTGACAGTGGTGTGATTGCACTTGTTAGTGGACCTTGTGCGAAGAAATTA
GAGGAGATTCATATGGGACATTGTGTAAATCTGACTGATGGGGCTGTCGAAGCTGTCCTTACTTACTGTCCTCAAATACGTATATTACTC
TTCCATGGATGCCCCTTGATAACAGGTGGTTAGACGATGCTATTATTGACGAGATTACACCCAAGCTGATCAGAGATTGGCCCAATATTT
ATACCTACACCAAGGCCTTGGGAGAAATGGTGGTGCAGCAAGAGAGCAGGAACCTGAACATTGCCATCATAAGGCCCTCCATTGTGGGAG
CAACTTGGCAGGAGCCTTTCCCAGGTTGGGTTGATAATATAAATGGACCTAATGGAATCATTATTGCGACTGGGAAAGGGTTTCTTCGGG
CCATAAAAGCTACTCCAATGGCTGTGGCAGACGTAATTCCAGTTGATACAGTCGTCAATCTCATGCTAGCTGTAGGATGGTATACTGCAG
TTCACAGACCTAAGTCAACATTAGTCTACCACATTACATCTGGTAACATGAATCCCTGCAATTGGCACAAAATGGGAGTCCAAGTCTTGG
CAACCTTTGAAAAAATCCCATTTGAGAGACCTTTCAGGAGGCCAAATGCTAATTTTACCAGCAACAGCTTCACATCACAGTACTGGAATG
CGGTCAGCCACCGGGCCCCTGCCATTATCTATGACTGCTATCTGCGGCTCACTGGAAGGAAGCCCAGGATGACAAAGCTCATGAATCGGC
TTTTAAGAACTGTTTCCATGTTGGAGTATTTCATCAACCGGAGTTGGGAATGGAGCACGTACAATACAGAAATGCTGATGTCTGAGCTGA
GTCCTGAAGACCAGAGAGTATTCAACTTTGACGTGCGCCAGTTGAACTGGTTGGAATACATTGAAAATTATGTTTTGGGAGTTAAAAAAT
ACTTATTGAAAGAGGATATGGCTGGGATCCCAAAAGCAAAGCAACGCTTAAAAAGGCTCCGAAATATTCACTACCTCTTTAATACTGCCC
TCTTCCTTATCGCCTGGCGCCTTCTCATTGCAAGATCTCAGATGGCTCGGAATGTCTGGTTCTTCATTGTAAGCTTCTGTTATAAATTCC
TCTCCTACTTTAGAGCATCCAGCACGCTCAAAGTTTAAGAGCATTTAGCCATCGCTTTTTATCTGGAACCTCTCAGATACCTCTAAAACA
GCAAACTGTGATTCTCAAGATTAGAAAGTAACAAGGAATATGCCCAAACTGTCAAATGTCACCTGTTATGTATTCGTCCCTATTCCTTAA
CTATGTATTTTTATTTCAGTGAGAGAAGGAAAGTTGTAAACTAGCCCATAGTCACCTATATTTTAGGGAAAAAAATCCAAATTGTTTCCT
AACATTCTATTTTATGCCCTTGCGTATTAAACGTGAAAGTACTCCCACTTTTCTATATTTAGTTTTTCTTTTCTCTCTGAGATGATTCAT
TTAAACTCAGTAAATATGGAAAGATGCATGGCAGAAGCTGAAATGAGCTCAAGCAGTACTAACCTTGGAACCATTCTGGGTACCCAAAAG
AAAAATTTAAAATCAAGATGAGTAAAAGGAGAATGGTCTCAATATCCTCAAAAATGCAGTAAGAGAAGTAATTCCCCACTGAAAATGTCT
CTCTTTCTTTCTATGTTATACCCTGGAGTCCTGGTTGAGGGGTGGGGGAATCAGAAAAGTAGGTTTACATTTAACATTTTTCTTAACTAC
ATTCACTTCTTAAAAAGGAACAAGAAGTGTAAATAAGTATGTATAGAGTGAGGGATTAAGCATATTTGCATTGGGGACTCGTGTATTATG
CTTTTAAGTCAAAATTAATATTCTCAAATTCGAATTTGATAGCTATTATTTCTAAATCTTTTTAATCCTCAATTTTCCTGGTAACCTTCT
TTCAAGAGTCTCCTTCTTCTAAAAGTTGCCAAACCCTTTATATTTAAGCTTTTTCCACTCAGGACTCAATTAGAGTGGTCAACAGGGAGA
GGGATGGTCCCATTTGATCTTTGCCACTGAGCAAAACAAAACTTCAAATGAACTTTTAAACTGTAGCTTTAGTCTTCTGGTATAAAGTGG
GGAAGATTACACTTATGTGATCACCAAAGGATTTACTAGTATCTTGGTCATTCCAATTGCACAATGTTAACTGTACAACACACAGCAGAA
AAGTGAATAGACTTCACTAAGGGATTCTAAGTTTAGAAAATAGGTTTTGTTTTCTTAAAAAATTTTGTGTATAATACAAACTAATGAAAA
CTATACATATTCTCCAATTCCTATAGTAATAATAATGTAACTGTTACACCAACTTTCCTCATATTTGAGAGATGAGTACATGTTGGATTG
CAGCATTTCTTCATGTTAAAAACATGGAATATTATTCAAATATAGTACTTGGGGCCTAAACAACTAAAATTAGTCACCGCATAACTAGTT
GAAAATGGCATAGGCATAAAATGTTAATAAAGAATGGCAGTTATATTTATGCTCACTTCCTGGAGTAATTGGGTAATATTCAGAAAGGCA
CATCGTGGTAGTTTAAGTGTACAAGGCCTTAGGGCAGTATCTAGCCCAGTATTATTCCAGATTCTCCTGAGCTCTATATAAAGGGCATTT
TGGAGGAACTCTTCTGGGCAATATCTTTCCCAATCTCATCTAAATTCTGGGAAATATTTTCCATAGCAGACAACCCAGCTCTGAAACTAA
GCACCTGGTGATCTTTAGTTTGAGATGTCTATATGGTACTTTTGAGTTATATCAATTAAGATACAAGCTATAGACATGATAAAAATATGA
AATCAAGATATAGCTCAGTGGGATTGGATTAAGACATAATAATAGTTCTAAGAATTCACTTTTGATTGTATGTTTTACCAATTCAATAAT


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FusionGenePPI for AMN1_FAR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AMN1FAR2PEX19, SLC39A4, VSIG4, ERGIC3, IQCF1, ATP2B2, B4GAT1, SCN3B, PCDHGB1, SLC39A12, CHRNA3, VNN2, GRPR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AMN1_FAR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AMN1_FAR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource