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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16101

FusionGeneSummary for HERC2P2_CACNA2D1

check button Fusion gene summary
Fusion gene informationFusion gene name: HERC2P2_CACNA2D1
Fusion gene ID: 16101
HgeneTgene
Gene symbol

HERC2P2

CACNA2D1

Gene ID

400322

781

Gene namehect domain and RLD 2 pseudogene 2calcium voltage-gated channel auxiliary subunit alpha2delta 1
SynonymsD15F37S3|MN7CACNA2|CACNL2A|CCHL2A|LINC01112|lncRNA-N3
Cytomap

15q11.2

7q21.11

Type of genepseudoprotein-coding
Description-voltage-dependent calcium channel subunit alpha-2/delta-1calcium channel, L type, alpha 2 polypeptidecalcium channel, voltage-dependent, alpha 2/delta subunit 1dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunitvoltage-gated calciu
Modification date2018051920180522
UniProtAcc

P54289

Ensembl transtripts involved in fusion geneENST00000560464, ENST00000356860, 
ENST00000356253, ENST00000423588, 
ENST00000464354, ENST00000535308, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 7 X 2=56
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/56*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HERC2P2 [Title/Abstract] AND CACNA2D1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCACNA2D1

GO:0006816

calcium ion transport

1309651|11160515

TgeneCACNA2D1

GO:0051924

regulation of calcium ion transport

1309651


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A7EF-01AHERC2P2chr15

23293373

+CACNA2D1chr7

81964567

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000560464ENST00000356860HERC2P2chr15

23293373

+CACNA2D1chr7

81964567

-
5UTR-3CDSENST00000560464ENST00000356253HERC2P2chr15

23293373

+CACNA2D1chr7

81964567

-
5UTR-3CDSENST00000560464ENST00000423588HERC2P2chr15

23293373

+CACNA2D1chr7

81964567

-
5UTR-intronENST00000560464ENST00000464354HERC2P2chr15

23293373

+CACNA2D1chr7

81964567

-
5UTR-intronENST00000560464ENST00000535308HERC2P2chr15

23293373

+CACNA2D1chr7

81964567

-

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FusionProtFeatures for HERC2P2_CACNA2D1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HERC2P2

CACNA2D1

P54289

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. The alpha-2/delta subunit of voltage-dependent calciumchannels regulates calcium current density andactivation/inactivation kinetics of the calcium channel. Plays animportant role in excitation-contraction coupling (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HERC2P2_CACNA2D1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HERC2P2_CACNA2D1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HERC2P2USP20, DISC1, FBXW7CACNA2D1RAB11A, NDUFS4, STT3B, CCDC8, ABCE1, TAZ, ITM2B, DNAAF2, SUSD4, GLT8D2, LMAN2, TMEM185A, BTNL8, PTCH1, PTPRK, ISLR, ERLIN2, PON2, USP7, HNRNPU, CNOT2, MYH7B, SCGB1D4, PRSS33, DEFA1, LMAN2L, SCGB1D1, C7orf69, LYZL1, FUT3, SLC34A2, CYP19A1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HERC2P2_CACNA2D1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCACNA2D1P54289DB00308IbutilideVoltage-dependent calcium channel subunit alpha-2/delta-1small moleculeapproved
TgeneCACNA2D1P54289DB00381AmlodipineVoltage-dependent calcium channel subunit alpha-2/delta-1small moleculeapproved
TgeneCACNA2D1P54289DB00401NisoldipineVoltage-dependent calcium channel subunit alpha-2/delta-1small moleculeapproved
TgeneCACNA2D1P54289DB01115NifedipineVoltage-dependent calcium channel subunit alpha-2/delta-1small moleculeapproved
TgeneCACNA2D1P54289DB04838CyclandelateVoltage-dependent calcium channel subunit alpha-2/delta-1small moleculeapproved
TgeneCACNA2D1P54289DB00270IsradipineVoltage-dependent calcium channel subunit alpha-2/delta-1small moleculeapproved|investigational
TgeneCACNA2D1P54289DB00622NicardipineVoltage-dependent calcium channel subunit alpha-2/delta-1small moleculeapproved|investigational
TgeneCACNA2D1P54289DB00996GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-1small moleculeapproved|investigational
TgeneCACNA2D1P54289DB01023FelodipineVoltage-dependent calcium channel subunit alpha-2/delta-1small moleculeapproved|investigational
TgeneCACNA2D1P54289DB01054NitrendipineVoltage-dependent calcium channel subunit alpha-2/delta-1small moleculeapproved|investigational
TgeneCACNA2D1P54289DB06712NilvadipineVoltage-dependent calcium channel subunit alpha-2/delta-1small moleculeapproved|investigational
TgeneCACNA2D1P54289DB00653Magnesium sulfateVoltage-dependent calcium channel subunit alpha-2/delta-1small moleculeapproved|investigational|vet_approved

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RelatedDiseases for HERC2P2_CACNA2D1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCACNA2D1C0027796Neuralgia4CTD_human
TgeneCACNA2D1C0020429Hyperalgesia3CTD_human
TgeneCACNA2D1C0009375Colonic Neoplasms1CTD_human
TgeneCACNA2D1C0020538Hypertensive disease1CTD_human
TgeneCACNA2D1C0030193Pain1CTD_human