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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16084

FusionGeneSummary for HELZ_TAF15

check button Fusion gene summary
Fusion gene informationFusion gene name: HELZ_TAF15
Fusion gene ID: 16084
HgeneTgene
Gene symbol

HELZ

TAF15

Gene ID

9931

8148

Gene namehelicase with zinc fingerTATA-box binding protein associated factor 15
SynonymsDHRC|DRHC|HUMORF5Npl3|RBP56|TAF2N|TAFII68
Cytomap

17q24.2

17q12

Type of geneprotein-codingprotein-coding
Descriptionprobable helicase with zinc finger domaindown-regulated in human cancers proteinhelicase with zinc finger domainTATA-binding protein-associated factor 2NRBP56/CSMF fusionTAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)TATA box-bin
Modification date2018052620180523
UniProtAcc

P42694

Q92804

Ensembl transtripts involved in fusion geneENST00000358691, ENST00000580168, 
ENST00000580662, 
ENST00000588240, 
ENST00000592237, ENST00000311979, 
Fusion gene scores* DoF score17 X 16 X 7=19047 X 5 X 6=210
# samples 177
** MAII scorelog2(17/1904*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HELZ [Title/Abstract] AND TAF15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-3C-AALI-01AHELZchr17

65124767

-TAF15chr17

34144720

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000358691ENST00000588240HELZchr17

65124767

-TAF15chr17

34144720

+
5CDS-5UTRENST00000358691ENST00000592237HELZchr17

65124767

-TAF15chr17

34144720

+
5CDS-5UTRENST00000358691ENST00000311979HELZchr17

65124767

-TAF15chr17

34144720

+
Frame-shitENST00000580168ENST00000588240HELZchr17

65124767

-TAF15chr17

34144720

+
5CDS-5UTRENST00000580168ENST00000592237HELZchr17

65124767

-TAF15chr17

34144720

+
5CDS-5UTRENST00000580168ENST00000311979HELZchr17

65124767

-TAF15chr17

34144720

+
intron-3CDSENST00000580662ENST00000588240HELZchr17

65124767

-TAF15chr17

34144720

+
intron-5UTRENST00000580662ENST00000592237HELZchr17

65124767

-TAF15chr17

34144720

+
intron-5UTRENST00000580662ENST00000311979HELZchr17

65124767

-TAF15chr17

34144720

+

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FusionProtFeatures for HELZ_TAF15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HELZ

P42694

TAF15

Q92804

May act as a helicase that plays a role in RNAmetabolism in multiple tissues and organs within the developingembryo. RNA and ssDNA-binding protein that may play specificroles during transcription initiation at distinct promoters. Canenter the preinitiation complex together with the RNA polymeraseII (Pol II). {ECO:0000269|PubMed:19124016}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HELZ_TAF15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HELZ_TAF15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HELZSMYD3, SH3YL1, GRB2, ELAVL1, SIRT7, MYC, STAT5A, TARDBP, SAV1, TUBG1, NXF1, BMI1, KLHL20, BCAT1, GNB2L1, RCBTB1, RBFOX2, CHIA, CCNJL, FBXW11, CLTC, SEC16A, GAN, DUSP18, EYA2, EYA4, PIGT, CELA3A, ESRP1, CELA1, CLASRP, NXF2, THSD4, HCFC2, KIAA0430, NISCH, SOWAHA, EIF4ENIF1, PAN2, PCGF5, PCGF3, CTBP1, CREBBP, ARID3A, KIAA1671, POM121C, ERF, C15orf39, FBRS, NUP50, ECSIT, RBL1, RB1, POM121, PAN3, CTBP2, RNF2, EBF3, ARID3B, FBXL19, G3BP1TAF15SAFB, PRMT1, TAF7, TAF5, TAF13, TAF11, POLR2C, POLR2G, POLR2E, SF1, KAT2B, POLR2A, HIST2H2AC, HIST1H3A, HIST2H4A, CACNA1A, SIRT7, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, DDB1, TPR, SAP30BP, RNF168, SCARB2, TPM2, TMED9, MED26, PRMT8, FUS, RPA3, RPA2, RPA1, HIST3H3, CUL7, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, RPS6KB2, ACAA2, SFN, HNRNPA1, PPP1CB, MATR3, MED12, MCM2, NF2, DNPEP, KLHL8, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HELZ_TAF15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HELZ_TAF15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTAF15C0029463Osteosarcoma1CTD_human
TgeneTAF15C0038356Stomach Neoplasms1CTD_human