|
Fusion gene ID: 16060 |
FusionGeneSummary for HEG1_GNAS |
Fusion gene summary |
Fusion gene information | Fusion gene name: HEG1_GNAS | Fusion gene ID: 16060 | Hgene | Tgene | Gene symbol | HEG1 | GNAS | Gene ID | 57493 | 2778 |
Gene name | heart development protein with EGF like domains 1 | GNAS complex locus | |
Synonyms | HEG|MST112|MSTP112 | AHO|C20orf45|GNAS1|GPSA|GSA|GSP|NESP|PITA3|POH|SCG6|SgVI | |
Cytomap | 3q21.2 | 20q13.32 | |
Type of gene | protein-coding | protein-coding | |
Description | protein HEG homolog 1HEG homolog 1heart of glass | protein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9ULI3 | Q5JWF2 | |
Ensembl transtripts involved in fusion gene | ENST00000311127, ENST00000477536, | ENST00000313949, ENST00000371098, ENST00000371075, ENST00000371100, ENST00000371099, ENST00000371102, ENST00000464624, ENST00000306120, ENST00000371095, ENST00000371085, ENST00000354359, ENST00000265620, ENST00000306090, ENST00000371081, | |
Fusion gene scores | * DoF score | 4 X 5 X 6=120 | 33 X 25 X 8=6600 |
# samples | 7 | 35 | |
** MAII score | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(35/6600*10)=-4.23703919730085 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HEG1 [Title/Abstract] AND GNAS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF087649 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000311127 | ENST00000313949 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000311127 | ENST00000371098 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-3UTR | ENST00000311127 | ENST00000371075 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-3UTR | ENST00000311127 | ENST00000371100 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000311127 | ENST00000371099 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000311127 | ENST00000371102 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-3UTR | ENST00000311127 | ENST00000464624 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000311127 | ENST00000306120 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000311127 | ENST00000371095 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000311127 | ENST00000371085 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000311127 | ENST00000354359 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000311127 | ENST00000265620 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000311127 | ENST00000306090 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000311127 | ENST00000371081 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-3UTR | ENST00000477536 | ENST00000313949 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000477536 | ENST00000371098 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-3UTR | ENST00000477536 | ENST00000371075 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-3UTR | ENST00000477536 | ENST00000371100 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000477536 | ENST00000371099 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000477536 | ENST00000371102 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-3UTR | ENST00000477536 | ENST00000464624 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000477536 | ENST00000306120 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000477536 | ENST00000371095 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000477536 | ENST00000371085 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000477536 | ENST00000354359 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000477536 | ENST00000265620 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000477536 | ENST00000306090 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
intron-intron | ENST00000477536 | ENST00000371081 | HEG1 | chr3 | 124756747 | - | GNAS | chr20 | 57485060 | - |
Top |
FusionProtFeatures for HEG1_GNAS |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
HEG1 | GNAS |
Receptor component of the CCM signaling pathway which isa crucial regulator of heart and vessel formation and integrityMay act through the stabilization of endothelial cell junctions.{ECO:0000250}. | Guanine nucleotide-binding proteins (G proteins)function as transducers in numerous signaling pathways controlledby G protein-coupled receptors (GPCRs). Signaling involves theactivation of adenylyl cyclases, resulting in increased levels ofthe signaling molecule cAMP. GNAS functions downstream of severalGPCRs, including beta-adrenergic receptors. XLas isoforms interactwith the same set of receptors as GNAS isoforms (By similarity).{ECO:0000250|UniProtKB:Q6R0H7}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for HEG1_GNAS |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for HEG1_GNAS |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for HEG1_GNAS |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HEG1_GNAS |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GNAS | C3494506 | Pseudohypoparathyroidism, Type Ia | 13 | CTD_human;ORPHANET;UNIPROT |
Tgene | GNAS | C0242292 | McCune-Albright Syndrome | 5 | ORPHANET;UNIPROT |
Tgene | GNAS | C2931404 | Albright's hereditary osteodystrophy | 4 | CTD_human |
Tgene | GNAS | C0016065 | Polyostotic fibrous dysplasia | 3 | CTD_human;HPO;ORPHANET |
Tgene | GNAS | C0033806 | Pseudohypoparathyroidism | 3 | CTD_human;HPO |
Tgene | GNAS | C1857451 | Acth-Independent Macronodular Adrenal Hyperplasia | 3 | ORPHANET;UNIPROT |
Tgene | GNAS | C0014130 | Endocrine System Diseases | 2 | CTD_human |
Tgene | GNAS | C0034013 | Precocious Puberty | 2 | CTD_human;HPO |
Tgene | GNAS | C0221263 | Cafe-au-Lait Spots | 2 | CTD_human |
Tgene | GNAS | C0001206 | Acromegaly | 1 | CTD_human;HPO |
Tgene | GNAS | C0001624 | Adrenal Gland Neoplasms | 1 | CTD_human |
Tgene | GNAS | C0011573 | Endogenous depression | 1 | PSYGENET |
Tgene | GNAS | C0019087 | Hemorrhagic Disorders | 1 | CTD_human |
Tgene | GNAS | C0020538 | Hypertensive disease | 1 | CTD_human;HPO |
Tgene | GNAS | C0021655 | Insulin Resistance | 1 | CTD_human |
Tgene | GNAS | C0023897 | Liver Diseases, Parasitic | 1 | CTD_human |
Tgene | GNAS | C0027819 | Neuroblastoma | 1 | CTD_human |
Tgene | GNAS | C0028754 | Obesity | 1 | CTD_human;HPO |
Tgene | GNAS | C0029396 | Heterotopic Ossification | 1 | CTD_human;HPO |
Tgene | GNAS | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Tgene | GNAS | C0033835 | Pseudopseudohypoparathyroidism | 1 | CTD_human;ORPHANET |
Tgene | GNAS | C0035204 | Respiration Disorders | 1 | CTD_human |
Tgene | GNAS | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | GNAS | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
Tgene | GNAS | C0039231 | Tachycardia | 1 | CTD_human |
Tgene | GNAS | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
Tgene | GNAS | C0221357 | Brachydactyly | 1 | CTD_human;HPO |
Tgene | GNAS | C0242184 | Hypoxia | 1 | CTD_human |
Tgene | GNAS | C0242216 | Biliary calculi | 1 | CTD_human |
Tgene | GNAS | C0334041 | Osteoma cutis | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | GNAS | C0346302 | Growth Hormone-Secreting Pituitary Adenoma | 1 | CTD_human |
Tgene | GNAS | C2932715 | Pseudohypoparathyroidism Type 1B | 1 | CTD_human;ORPHANET |
Tgene | GNAS | C2932716 | Pseudohypoparathyroidism Type 1C | 1 | ORPHANET;UNIPROT |
Tgene | GNAS | C3714756 | Intellectual Disability | 1 | CTD_human;HPO |