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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16056

FusionGeneSummary for HECW1_HECW1

check button Fusion gene summary
Fusion gene informationFusion gene name: HECW1_HECW1
Fusion gene ID: 16056
HgeneTgene
Gene symbol

HECW1

HECW1

Gene ID

23072

23072

Gene nameHECT, C2 and WW domain containing E3 ubiquitin protein ligase 1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
SynonymsNEDL1NEDL1
Cytomap

7p14.1-p13

7p14.1-p13

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase HECW1HECT type E3 ubiquitin ligaseHECT-type E3 ubiquitin transferase HECW1NEDD4-like ubiquitin-protein ligase 1E3 ubiquitin-protein ligase HECW1HECT type E3 ubiquitin ligaseHECT-type E3 ubiquitin transferase HECW1NEDD4-like ubiquitin-protein ligase 1
Modification date2018052320180523
UniProtAcc

Q76N89

Q76N89

Ensembl transtripts involved in fusion geneENST00000395891, ENST00000453890, 
ENST00000471043, 
ENST00000395891, 
ENST00000453890, ENST00000471043, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 5 X 4=100
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HECW1 [Title/Abstract] AND HECW1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW895684HECW1chr7

43581597

+HECW1chr7

43495894

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000395891ENST00000395891HECW1chr7

43581597

+HECW1chr7

43495894

+
Frame-shiftENST00000395891ENST00000453890HECW1chr7

43581597

+HECW1chr7

43495894

+
5CDS-intronENST00000395891ENST00000471043HECW1chr7

43581597

+HECW1chr7

43495894

+
Frame-shiftENST00000453890ENST00000395891HECW1chr7

43581597

+HECW1chr7

43495894

+
Frame-shiftENST00000453890ENST00000453890HECW1chr7

43581597

+HECW1chr7

43495894

+
5CDS-intronENST00000453890ENST00000471043HECW1chr7

43581597

+HECW1chr7

43495894

+
intron-3CDSENST00000471043ENST00000395891HECW1chr7

43581597

+HECW1chr7

43495894

+
intron-3CDSENST00000471043ENST00000453890HECW1chr7

43581597

+HECW1chr7

43495894

+
intron-intronENST00000471043ENST00000471043HECW1chr7

43581597

+HECW1chr7

43495894

+

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FusionProtFeatures for HECW1_HECW1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HECW1

Q76N89

HECW1

Q76N89

E3 ubiquitin-protein ligase that mediates ubiquitinationand subsequent degradation of DVL1. Also targets the mutant SOD1protein involved in familial amyotrophic lateral sclerosis (FALS).Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 thatlead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}. E3 ubiquitin-protein ligase that mediates ubiquitinationand subsequent degradation of DVL1. Also targets the mutant SOD1protein involved in familial amyotrophic lateral sclerosis (FALS).Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 thatlead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HECW1_HECW1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HECW1_HECW1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HECW1DVL1, SSR4, SOD1, SCNN1A, SCNN1B, TNK2, CACNA1A, TP53, RNF43, GFI1B, USP7, FBXL15, HECW2, LDLRAD4, MPHOSPH8, UBC, UBE2D1, UBE2D2, UBE2D3, UBE2L3, HECW1, UBE2J2, FAM189BHECW1DVL1, SSR4, SOD1, SCNN1A, SCNN1B, TNK2, CACNA1A, TP53, RNF43, GFI1B, USP7, FBXL15, HECW2, LDLRAD4, MPHOSPH8, UBC, UBE2D1, UBE2D2, UBE2D3, UBE2L3, HECW1, UBE2J2, FAM189B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HECW1_HECW1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HECW1_HECW1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource