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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16030

FusionGeneSummary for HECTD1_DHRS4L2

check button Fusion gene summary
Fusion gene informationFusion gene name: HECTD1_DHRS4L2
Fusion gene ID: 16030
HgeneTgene
Gene symbol

HECTD1

DHRS4L2

Gene ID

25831

317749

Gene nameHECT domain E3 ubiquitin protein ligase 1dehydrogenase/reductase 4 like 2
SynonymsEULIRSDR25C3
Cytomap

14q12

14q11.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase HECTD1E3 ligase for inhibin receptorHECT domain containing E3 ubiquitin protein ligase 1HECT domain-containing protein 1HECT-type E3 ubiquitin transferase HECTD1dehydrogenase/reductase SDR family member 4-like 2NADP(H)-dependent retinol dehydrogenase/reductase short isoform-like proteinNADPH-dependent retinol dehydrogenase/reductase-like protein 2dehydrogenase/reductase (SDR family) member 4 like 2dehydrogena
Modification date2018052320180519
UniProtAcc

Q9ULT8

Q6PKH6

Ensembl transtripts involved in fusion geneENST00000399332, ENST00000553700, 
ENST00000556474, 
ENST00000534993, 
ENST00000543805, ENST00000397071, 
ENST00000335125, ENST00000558753, 
ENST00000537912, ENST00000545240, 
ENST00000382755, 
Fusion gene scores* DoF score8 X 8 X 5=3203 X 3 X 3=27
# samples 123
** MAII scorelog2(12/320*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HECTD1 [Title/Abstract] AND DHRS4L2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKICHTCGA-KL-8339-01AHECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000399332ENST00000534993HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000399332ENST00000543805HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000399332ENST00000397071HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000399332ENST00000335125HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000399332ENST00000558753HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000399332ENST00000537912HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000399332ENST00000545240HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000399332ENST00000382755HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000553700ENST00000534993HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000553700ENST00000543805HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000553700ENST00000397071HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000553700ENST00000335125HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000553700ENST00000558753HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000553700ENST00000537912HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000553700ENST00000545240HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
5CDS-5UTRENST00000553700ENST00000382755HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
intron-5UTRENST00000556474ENST00000534993HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
intron-5UTRENST00000556474ENST00000543805HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
intron-5UTRENST00000556474ENST00000397071HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
intron-5UTRENST00000556474ENST00000335125HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
intron-5UTRENST00000556474ENST00000558753HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
intron-5UTRENST00000556474ENST00000537912HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
intron-5UTRENST00000556474ENST00000545240HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+
intron-5UTRENST00000556474ENST00000382755HECTD1chr14

31614013

-DHRS4L2chr14

24459391

+

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FusionProtFeatures for HECTD1_DHRS4L2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HECTD1

Q9ULT8

DHRS4L2

Q6PKH6

E3 ubiquitin-protein ligase which accepts ubiquitin froman E2 ubiquitin-conjugating enzyme in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates.Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 whichleads to its intracellular localization and reduced secretion.Negatively regulating HSP90AA1 secretion in cranial mesenchymecells may impair their emigration and may be essential for thecorrect development of the cranial neural folds and neural tubeclosure. {ECO:0000250|UniProtKB:Q69ZR2}. Probable oxidoreductase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HECTD1_DHRS4L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HECTD1_DHRS4L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HECTD1ZRANB1, IGSF1, SIRT7, APC, YWHAQ, ANKRD28, BTF3L4, KIAA0101, TCEAL4, TPM2, PPP2R5D, PRDX1, RIOK2, ZNF622, SHFM1, UBC, AARSD1, TP53, TUBGCP3, DIRAS3, C9orf24, GEM, RASSF6, DNM3, ATP6V1C2, BMP15, SETDB1, AP1M2, TTLL1, CAMKMT, ZNHIT3, HSPB1, FBXW11, NIN, RPGRIP1L, DYNLT1, FBXW7, ESR1, NCAPG, SMC2, SMC4, NCAPH, NCAPD2, NCAPH2, HECTD1, UBE2D3, IQGAP1, EPB41L5, ZNF695, CINP, CAPN6, ZNF223, GMNN, HIF1AN, MTNR1B, TRIM25DHRS4L2MTIF2, AARS2, DHRS4, ZZEF1, ACOT7, D2HGDH


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HECTD1_DHRS4L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HECTD1_DHRS4L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource