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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 16028

FusionGeneSummary for HEBP2_JMJD1C

check button Fusion gene summary
Fusion gene informationFusion gene name: HEBP2_JMJD1C
Fusion gene ID: 16028
HgeneTgene
Gene symbol

HEBP2

JMJD1C

Gene ID

23593

221037

Gene nameheme binding protein 2jumonji domain containing 1C
SynonymsC6ORF34B|C6orf34|PP23|SOULKDM3C|TRIP-8|TRIP8
Cytomap

6q24.1

10q21.3

Type of geneprotein-codingprotein-coding
Descriptionheme-binding protein 2placental protein 23probable JmjC domain-containing histone demethylation protein 2CTR-interacting protein 8thyroid hormone receptor interactor 8thyroid receptor-interacting protein 8
Modification date2018052320180523
UniProtAcc

Q9Y5Z4

Q15652

Ensembl transtripts involved in fusion geneENST00000448741, ENST00000607197, 
ENST00000367697, 
ENST00000399262, 
ENST00000402544, ENST00000399251, 
ENST00000542921, ENST00000489372, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 3=108
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HEBP2 [Title/Abstract] AND JMJD1C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM968067HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000448741ENST00000399262HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000448741ENST00000402544HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000448741ENST00000399251HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000448741ENST00000542921HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000448741ENST00000489372HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000607197ENST00000399262HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000607197ENST00000402544HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000607197ENST00000399251HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000607197ENST00000542921HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000607197ENST00000489372HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000367697ENST00000399262HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000367697ENST00000402544HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000367697ENST00000399251HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000367697ENST00000542921HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+
intron-intronENST00000367697ENST00000489372HEBP2chr6

138733861

-JMJD1Cchr10

65043429

+

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FusionProtFeatures for HEBP2_JMJD1C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HEBP2

Q9Y5Z4

JMJD1C

Q15652

Can promote mitochondrial permeability transition andfacilitate necrotic cell death under different types of stressconditions. {ECO:0000269|PubMed:17098234}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HEBP2_JMJD1C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HEBP2_JMJD1C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HEBP2_JMJD1C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HEBP2_JMJD1C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHEBP2C0023903Liver neoplasms1CTD_human
TgeneJMJD1CC0004352Autistic Disorder1CTD_human
TgeneJMJD1CC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneJMJD1CC3495559Juvenile arthritis1CTD_human