FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 16008

FusionGeneSummary for HEATR3_CHRNB3

check button Fusion gene summary
Fusion gene informationFusion gene name: HEATR3_CHRNB3
Fusion gene ID: 16008
HgeneTgene
Gene symbol

HEATR3

CHRNB3

Gene ID

55027

1142

Gene nameHEAT repeat containing 3cholinergic receptor nicotinic beta 3 subunit
SynonymsSYO1-
Cytomap

16q12.1

8p11.21

Type of geneprotein-codingprotein-coding
DescriptionHEAT repeat-containing protein 3symportin 1neuronal acetylcholine receptor subunit beta-3acetylcholine receptor, neuronal nicotinic, beta-3 subunitacetylcholine receptor, nicotinic, beta 3 (neuronal)cholinergic receptor, nicotinic beta 3cholinergic receptor, nicotinic, beta 3 (neuronal)cholin
Modification date2018052320180523
UniProtAcc

Q7Z4Q2

Q05901

Ensembl transtripts involved in fusion geneENST00000299192, ENST00000285767, 
ENST00000564942, 
ENST00000531610, 
ENST00000289957, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 1=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: HEATR3 [Title/Abstract] AND CHRNB3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-B6-A0RM-01AHEATR3chr16

50100450

+CHRNB3chr8

42585737

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000299192ENST00000531610HEATR3chr16

50100450

+CHRNB3chr8

42585737

+
5CDS-intronENST00000299192ENST00000289957HEATR3chr16

50100450

+CHRNB3chr8

42585737

+
intron-intronENST00000285767ENST00000531610HEATR3chr16

50100450

+CHRNB3chr8

42585737

+
intron-intronENST00000285767ENST00000289957HEATR3chr16

50100450

+CHRNB3chr8

42585737

+
intron-intronENST00000564942ENST00000531610HEATR3chr16

50100450

+CHRNB3chr8

42585737

+
intron-intronENST00000564942ENST00000289957HEATR3chr16

50100450

+CHRNB3chr8

42585737

+

Top

FusionProtFeatures for HEATR3_CHRNB3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HEATR3

Q7Z4Q2

CHRNB3

Q05901

After binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for HEATR3_CHRNB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for HEATR3_CHRNB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HEATR3ELAVL1, CA9, EGFR, SURF2, COMTD1, TMEM171, B3GAT3, PNKD, LMAN2, LYPD3, PTGER3, SCN2B, SCARA3, ST13, DSP, HNRNPD, LNPEP, NCK1, SMS, NCAPH, SGTB, KDM1B, SIGLECL1, TMEM206, UXS1, CD70, EPHA1, CHRM3, FZD10, CHRM4, HTR2C, GYPB, TMEM186, VIPR2, CD83, LRFN4, ST6GAL1, PTPN1, PTPRN, TPTECHRNB3TYRO3, LEMD2, ZG16B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for HEATR3_CHRNB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCHRNB3Q05901DB00184NicotineNeuronal acetylcholine receptor subunit beta-3small moleculeapproved
TgeneCHRNB3Q05901DB00674GalantamineNeuronal acetylcholine receptor subunit beta-3small moleculeapproved
TgeneCHRNB3Q05901DB00898EthanolNeuronal acetylcholine receptor subunit beta-3small moleculeapproved

Top

RelatedDiseases for HEATR3_CHRNB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCHRNB3C0005586Bipolar Disorder3PSYGENET
TgeneCHRNB3C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneCHRNB3C0011570Mental Depression1PSYGENET
TgeneCHRNB3C0011581Depressive disorder1PSYGENET
TgeneCHRNB3C0600427Cocaine Dependence1PSYGENET
TgeneCHRNB3C1861063TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)1CTD_human
TgeneCHRNB3C3496069cocaine use1PSYGENET