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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 16002

FusionGeneSummary for HDLBP_TMC1

check button Fusion gene summary
Fusion gene informationFusion gene name: HDLBP_TMC1
Fusion gene ID: 16002
HgeneTgene
Gene symbol

HDLBP

TMC1

Gene ID

3069

117531

Gene namehigh density lipoprotein binding proteintransmembrane channel like 1
SynonymsHBP|PRO2900|VGLDFNA36|DFNB11|DFNB7
Cytomap

2q37.3

9q21.13

Type of geneprotein-codingprotein-coding
DescriptionvigilinHDL-binding proteintransmembrane channel-like protein 1transmembrane cochlear-expressed protein 1transmembrane, cochlear expressed, 1
Modification date2018052220180523
UniProtAcc

Q00341

Q8TDI8

Ensembl transtripts involved in fusion geneENST00000391976, ENST00000310931, 
ENST00000391975, ENST00000427183, 
ENST00000476807, 		ENST00000297784, 
ENST00000340019, ENST00000396237, 
ENST00000486417, 
Fusion gene scores* DoF score21 X 18 X 6=22683 X 3 X 3=27
# samples 233
** MAII scorelog2(23/2268*10)=-3.30171487399785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HDLBP [Title/Abstract] AND TMC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-A631-01AHDLBPchr2

242186471

-TMC1chr9

75445367

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000391976ENST00000297784HDLBPchr2

242186471

-TMC1chr9

75445367

+
In-frameENST00000391976ENST00000340019HDLBPchr2

242186471

-TMC1chr9

75445367

+
In-frameENST00000391976ENST00000396237HDLBPchr2

242186471

-TMC1chr9

75445367

+
5CDS-3UTRENST00000391976ENST00000486417HDLBPchr2

242186471

-TMC1chr9

75445367

+
In-frameENST00000310931ENST00000297784HDLBPchr2

242186471

-TMC1chr9

75445367

+
In-frameENST00000310931ENST00000340019HDLBPchr2

242186471

-TMC1chr9

75445367

+
In-frameENST00000310931ENST00000396237HDLBPchr2

242186471

-TMC1chr9

75445367

+
5CDS-3UTRENST00000310931ENST00000486417HDLBPchr2

242186471

-TMC1chr9

75445367

+
Frame-shiftENST00000391975ENST00000297784HDLBPchr2

242186471

-TMC1chr9

75445367

+
Frame-shiftENST00000391975ENST00000340019HDLBPchr2

242186471

-TMC1chr9

75445367

+
Frame-shiftENST00000391975ENST00000396237HDLBPchr2

242186471

-TMC1chr9

75445367

+
5CDS-3UTRENST00000391975ENST00000486417HDLBPchr2

242186471

-TMC1chr9

75445367

+
In-frameENST00000427183ENST00000297784HDLBPchr2

242186471

-TMC1chr9

75445367

+
In-frameENST00000427183ENST00000340019HDLBPchr2

242186471

-TMC1chr9

75445367

+
In-frameENST00000427183ENST00000396237HDLBPchr2

242186471

-TMC1chr9

75445367

+
5CDS-3UTRENST00000427183ENST00000486417HDLBPchr2

242186471

-TMC1chr9

75445367

+
intron-3CDSENST00000476807ENST00000297784HDLBPchr2

242186471

-TMC1chr9

75445367

+
intron-3CDSENST00000476807ENST00000340019HDLBPchr2

242186471

-TMC1chr9

75445367

+
intron-3CDSENST00000476807ENST00000396237HDLBPchr2

242186471

-TMC1chr9

75445367

+
intron-3UTRENST00000476807ENST00000486417HDLBPchr2

242186471

-TMC1chr9

75445367

+

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FusionProtFeatures for HDLBP_TMC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HDLBP

Q00341

TMC1

Q8TDI8

Appears to play a role in cell sterol metabolism. It mayfunction to protect cells from over-accumulation of cholesterol. Probable ion channel required for the normal function ofcochlear hair cells. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528158_2296061269DomainKH 1
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528230_3026061269DomainKH 2
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528303_3716061269DomainKH 3
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528372_4426061269DomainKH 4
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528443_5146061269DomainKH 5
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528515_5886061269DomainKH 6
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528158_2296061269DomainKH 1
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528230_3026061269DomainKH 2
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528303_3716061269DomainKH 3
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528372_4426061269DomainKH 4
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528443_5146061269DomainKH 5
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528515_5886061269DomainKH 6
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528158_2296061269DomainKH 1
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528230_3026061269DomainKH 2
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528303_3716061269DomainKH 3
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528372_4426061269DomainKH 4
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528443_5146061269DomainKH 5
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528515_5886061269DomainKH 6
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528158_2295731236DomainKH 1
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528230_3025731236DomainKH 2
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528303_3715731236DomainKH 3
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528372_4425731236DomainKH 4
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528443_5145731236DomainKH 5
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+2024749_757709761Compositional biasNote=Poly-Ala
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+1923749_757709761Compositional biasNote=Poly-Ala
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+1620749_757709761Compositional biasNote=Poly-Ala
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+2024721_760709761Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+1923721_760709761Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+1620721_760709761Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-15281060_11346061269DomainKH 13
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-15281135_12096061269DomainKH 14
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528589_6606061269DomainKH 7
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528661_7346061269DomainKH 8
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528735_8076061269DomainKH 9
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528808_8806061269DomainKH 10
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528881_9796061269DomainKH 11
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528980_10596061269DomainKH 12
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-15281060_11346061269DomainKH 13
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-15281135_12096061269DomainKH 14
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528589_6606061269DomainKH 7
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528661_7346061269DomainKH 8
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528735_8076061269DomainKH 9
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528808_8806061269DomainKH 10
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528881_9796061269DomainKH 11
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528980_10596061269DomainKH 12
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-15281060_11346061269DomainKH 13
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-15281135_12096061269DomainKH 14
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528589_6606061269DomainKH 7
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528661_7346061269DomainKH 8
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528735_8076061269DomainKH 9
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528808_8806061269DomainKH 10
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528881_9796061269DomainKH 11
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528980_10596061269DomainKH 12
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-15281060_11345731236DomainKH 13
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-15281135_12095731236DomainKH 14
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528515_5885731236DomainKH 6
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528589_6605731236DomainKH 7
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528661_7345731236DomainKH 8
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528735_8075731236DomainKH 9
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528808_8805731236DomainKH 10
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528881_9795731236DomainKH 11
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528980_10595731236DomainKH 12
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+20244_178709761Compositional biasNote=Arg/Asp/Glu/Lys-rich (highly charged)
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+19234_178709761Compositional biasNote=Arg/Asp/Glu/Lys-rich (highly charged)
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+16204_178709761Compositional biasNote=Arg/Asp/Glu/Lys-rich (highly charged)
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+20241_199709761Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+2024221_272709761Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+2024294_365709761Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+2024387_440709761Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+2024462_634709761Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+2024656_699709761Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+19231_199709761Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+1923221_272709761Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+1923294_365709761Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+1923387_440709761Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+1923462_634709761Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+1923656_699709761Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+16201_199709761Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+1620221_272709761Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+1620294_365709761Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+1620387_440709761Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+1620462_634709761Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+1620656_699709761Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+2024200_220709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+2024273_293709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+2024366_386709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+2024441_461709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+2024635_655709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000297784+2024700_720709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+1923200_220709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+1923273_293709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+1923366_386709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+1923441_461709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+1923635_655709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000340019+1923700_720709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+1620200_220709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+1620273_293709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+1620366_386709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+1620441_461709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+1620635_655709761TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST00000396237+1620700_720709761TransmembraneHelical


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FusionGeneSequence for HDLBP_TMC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HDLBP_ENST00000391976_chr2_242186471_-_TMC1_ENST00000297784_chr9_75445367_+_657aa
MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYK
DMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKT
ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVF
TGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAK
ANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHL
IGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV
IINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGSESGSQKED

>In-frame_HDLBP_ENST00000391976_chr2_242186471_-_TMC1_ENST00000340019_chr9_75445367_+_657aa
MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYK
DMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKT
ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVF
TGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAK
ANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHL
IGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV
IINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGSESGSQKED

>In-frame_HDLBP_ENST00000391976_chr2_242186471_-_TMC1_ENST00000396237_chr9_75445367_+_657aa
MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYK
DMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKT
ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVF
TGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAK
ANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHL
IGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV
IINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGSESGSQKED

>In-frame_HDLBP_ENST00000310931_chr2_242186471_-_TMC1_ENST00000297784_chr9_75445367_+_657aa
MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYK
DMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKT
ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVF
TGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAK
ANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHL
IGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV
IINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGSESGSQKED

>In-frame_HDLBP_ENST00000310931_chr2_242186471_-_TMC1_ENST00000340019_chr9_75445367_+_657aa
MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYK
DMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKT
ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVF
TGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAK
ANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHL
IGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV
IINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGSESGSQKED

>In-frame_HDLBP_ENST00000310931_chr2_242186471_-_TMC1_ENST00000396237_chr9_75445367_+_657aa
MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYK
DMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKT
ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVF
TGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAK
ANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHL
IGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV
IINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGSESGSQKED

>In-frame_HDLBP_ENST00000427183_chr2_242186471_-_TMC1_ENST00000297784_chr9_75445367_+_624aa
MHLAERDRWLFVATVMMHFVSIKSGFPGLCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACL
ESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIV
ARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFH
PFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQ
MPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRI
EGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKM

>In-frame_HDLBP_ENST00000427183_chr2_242186471_-_TMC1_ENST00000340019_chr9_75445367_+_624aa
MHLAERDRWLFVATVMMHFVSIKSGFPGLCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACL
ESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIV
ARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFH
PFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQ
MPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRI
EGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKM

>In-frame_HDLBP_ENST00000427183_chr2_242186471_-_TMC1_ENST00000396237_chr9_75445367_+_624aa
MHLAERDRWLFVATVMMHFVSIKSGFPGLCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACL
ESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIV
ARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFH
PFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQ
MPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRI
EGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKM


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HDLBP_ENST00000391976_chr2_242186471_-_TMC1_ENST00000297784_chr9_75445367_+_1972nt
ATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAACAAATCAAAGTTGCCACTCTAAAT
TCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTTGCCTGGAAAGTGCCCAGGAACCC
TCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTACCCCTGGAGGAGAGAAAATACAAG
GATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCACTTGGAGCTGTCTTTGGCC
AAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACATTGTTGCTAGACTGCAGACTCAG
GCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAAGACTTGGAGCTAAAAACT
GCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGCATCGAGAAAGCTCGCCAT
GAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCACCCCTTCATCGCTGGGCCG
TATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAACCGGACAGAGATTGTCTTC
ACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGAAAAAGAAGACTACAACCATTGCAGTG
GAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGCAGGAGATCCTTGAGAGAACTGGAGTTTCCGTTGAG
ATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAAAGTTAGGTCAGGCGTTGACTGAAGTCTATGCCAAG
GCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGCCAAAATC
ACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAATGTGGCC
CAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAGTTCCACAGGCACCTC
ATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAGCAATTTG
ATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAAAATGAGCGTACCAAG
GATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGACAAATTCCCAGAGGTC
ATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAAATACATG
CAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGGGAAAGGA
GGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGATCTCAAAAAGAAGAT

>In-frame_HDLBP_ENST00000391976_chr2_242186471_-_TMC1_ENST00000340019_chr9_75445367_+_1972nt
ATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAACAAATCAAAGTTGCCACTCTAAAT
TCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTTGCCTGGAAAGTGCCCAGGAACCC
TCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTACCCCTGGAGGAGAGAAAATACAAG
GATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCACTTGGAGCTGTCTTTGGCC
AAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACATTGTTGCTAGACTGCAGACTCAG
GCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAAGACTTGGAGCTAAAAACT
GCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGCATCGAGAAAGCTCGCCAT
GAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCACCCCTTCATCGCTGGGCCG
TATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAACCGGACAGAGATTGTCTTC
ACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGAAAAAGAAGACTACAACCATTGCAGTG
GAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGCAGGAGATCCTTGAGAGAACTGGAGTTTCCGTTGAG
ATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAAAGTTAGGTCAGGCGTTGACTGAAGTCTATGCCAAG
GCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGCCAAAATC
ACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAATGTGGCC
CAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAGTTCCACAGGCACCTC
ATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAGCAATTTG
ATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAAAATGAGCGTACCAAG
GATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGACAAATTCCCAGAGGTC
ATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAAATACATG
CAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGGGAAAGGA
GGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGATCTCAAAAAGAAGAT

>In-frame_HDLBP_ENST00000391976_chr2_242186471_-_TMC1_ENST00000396237_chr9_75445367_+_1972nt
ATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAACAAATCAAAGTTGCCACTCTAAAT
TCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTTGCCTGGAAAGTGCCCAGGAACCC
TCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTACCCCTGGAGGAGAGAAAATACAAG
GATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCACTTGGAGCTGTCTTTGGCC
AAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACATTGTTGCTAGACTGCAGACTCAG
GCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAAGACTTGGAGCTAAAAACT
GCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGCATCGAGAAAGCTCGCCAT
GAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCACCCCTTCATCGCTGGGCCG
TATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAACCGGACAGAGATTGTCTTC
ACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGAAAAAGAAGACTACAACCATTGCAGTG
GAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGCAGGAGATCCTTGAGAGAACTGGAGTTTCCGTTGAG
ATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAAAGTTAGGTCAGGCGTTGACTGAAGTCTATGCCAAG
GCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGCCAAAATC
ACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAATGTGGCC
CAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAGTTCCACAGGCACCTC
ATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAGCAATTTG
ATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAAAATGAGCGTACCAAG
GATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGACAAATTCCCAGAGGTC
ATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAAATACATG
CAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGGGAAAGGA
GGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGATCTCAAAAAGAAGAT

>In-frame_HDLBP_ENST00000310931_chr2_242186471_-_TMC1_ENST00000297784_chr9_75445367_+_1972nt
ATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAACAAATCAAAGTTGCCACTCTAAAT
TCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTTGCCTGGAAAGTGCCCAGGAACCC
TCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTACCCCTGGAGGAGAGAAAATACAAG
GATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCACTTGGAGCTGTCTTTGGCC
AAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACATTGTTGCTAGACTGCAGACTCAG
GCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAAGACTTGGAGCTAAAAACT
GCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGCATCGAGAAAGCTCGCCAT
GAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCACCCCTTCATCGCTGGGCCG
TATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAACCGGACAGAGATTGTCTTC
ACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGAAAAAGAAGACTACAACCATTGCAGTG
GAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGCAGGAGATCCTTGAGAGAACTGGAGTTTCCGTTGAG
ATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAAAGTTAGGTCAGGCGTTGACTGAAGTCTATGCCAAG
GCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGCCAAAATC
ACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAATGTGGCC
CAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAGTTCCACAGGCACCTC
ATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAGCAATTTG
ATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAAAATGAGCGTACCAAG
GATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGACAAATTCCCAGAGGTC
ATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAAATACATG
CAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGGGAAAGGA
GGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGATCTCAAAAAGAAGAT

>In-frame_HDLBP_ENST00000310931_chr2_242186471_-_TMC1_ENST00000340019_chr9_75445367_+_1972nt
ATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAACAAATCAAAGTTGCCACTCTAAAT
TCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTTGCCTGGAAAGTGCCCAGGAACCC
TCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTACCCCTGGAGGAGAGAAAATACAAG
GATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCACTTGGAGCTGTCTTTGGCC
AAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACATTGTTGCTAGACTGCAGACTCAG
GCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAAGACTTGGAGCTAAAAACT
GCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGCATCGAGAAAGCTCGCCAT
GAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCACCCCTTCATCGCTGGGCCG
TATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAACCGGACAGAGATTGTCTTC
ACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGAAAAAGAAGACTACAACCATTGCAGTG
GAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGCAGGAGATCCTTGAGAGAACTGGAGTTTCCGTTGAG
ATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAAAGTTAGGTCAGGCGTTGACTGAAGTCTATGCCAAG
GCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGCCAAAATC
ACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAATGTGGCC
CAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAGTTCCACAGGCACCTC
ATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAGCAATTTG
ATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAAAATGAGCGTACCAAG
GATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGACAAATTCCCAGAGGTC
ATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAAATACATG
CAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGGGAAAGGA
GGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGATCTCAAAAAGAAGAT

>In-frame_HDLBP_ENST00000310931_chr2_242186471_-_TMC1_ENST00000396237_chr9_75445367_+_1972nt
ATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAACAAATCAAAGTTGCCACTCTAAAT
TCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTTGCCTGGAAAGTGCCCAGGAACCC
TCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTACCCCTGGAGGAGAGAAAATACAAG
GATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCACTTGGAGCTGTCTTTGGCC
AAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACATTGTTGCTAGACTGCAGACTCAG
GCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAAGACTTGGAGCTAAAAACT
GCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGCATCGAGAAAGCTCGCCAT
GAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCACCCCTTCATCGCTGGGCCG
TATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAACCGGACAGAGATTGTCTTC
ACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGAAAAAGAAGACTACAACCATTGCAGTG
GAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGCAGGAGATCCTTGAGAGAACTGGAGTTTCCGTTGAG
ATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAAAGTTAGGTCAGGCGTTGACTGAAGTCTATGCCAAG
GCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGCCAAAATC
ACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAATGTGGCC
CAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAGTTCCACAGGCACCTC
ATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAGCAATTTG
ATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAAAATGAGCGTACCAAG
GATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGACAAATTCCCAGAGGTC
ATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAAATACATG
CAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGGGAAAGGA
GGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGATCTCAAAAAGAAGAT

>In-frame_HDLBP_ENST00000427183_chr2_242186471_-_TMC1_ENST00000297784_chr9_75445367_+_1873nt
ATGCACCTTGCAGAGAGAGACCGCTGGCTTTTTGTAGCAACTGTCATGATGCATTTTGTAAGCATTAAGAGTGGTTTTCCCGGATTGTGT
GTAGGTGTGAGATCAACCATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAACAAATC
AAAGTTGCCACTCTAAATTCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTTGCCTG
GAAAGTGCCCAGGAACCCTCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTACCCCTG
GAGGAGAGAAAATACAAGGATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCAC
TTGGAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACATTGTT
GCTAGACTGCAGACTCAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAA
GACTTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGC
ATCGAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCAC
CCCTTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAAC
CGGACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGGCCAATAGC
TTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGCCAAAATCACTCAGCAG
ATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAATGTGGCCCAGGAACAG
ATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAGTTCCACAGGCACCTCATTGGGAAG
AGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAGCAATTTGATCCGCATC
GAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAAAATGAGCGTACCAAGGATCTAATC
ATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGACAAATTCCCAGAGGTCATCATTAAC
TTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAAATACATGCAGAAGATG
GTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGGGAAAGGAGGCGCAAAC
ATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGATCTCAAAAAGAAGATGAAAATGCA

>In-frame_HDLBP_ENST00000427183_chr2_242186471_-_TMC1_ENST00000340019_chr9_75445367_+_1873nt
ATGCACCTTGCAGAGAGAGACCGCTGGCTTTTTGTAGCAACTGTCATGATGCATTTTGTAAGCATTAAGAGTGGTTTTCCCGGATTGTGT
GTAGGTGTGAGATCAACCATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAACAAATC
AAAGTTGCCACTCTAAATTCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTTGCCTG
GAAAGTGCCCAGGAACCCTCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTACCCCTG
GAGGAGAGAAAATACAAGGATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCAC
TTGGAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACATTGTT
GCTAGACTGCAGACTCAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAA
GACTTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGC
ATCGAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCAC
CCCTTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAAC
CGGACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGGCCAATAGC
TTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGCCAAAATCACTCAGCAG
ATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAATGTGGCCCAGGAACAG
ATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAGTTCCACAGGCACCTCATTGGGAAG
AGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAGCAATTTGATCCGCATC
GAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAAAATGAGCGTACCAAGGATCTAATC
ATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGACAAATTCCCAGAGGTCATCATTAAC
TTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAAATACATGCAGAAGATG
GTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGGGAAAGGAGGCGCAAAC
ATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGATCTCAAAAAGAAGATGAAAATGCA

>In-frame_HDLBP_ENST00000427183_chr2_242186471_-_TMC1_ENST00000396237_chr9_75445367_+_1873nt
ATGCACCTTGCAGAGAGAGACCGCTGGCTTTTTGTAGCAACTGTCATGATGCATTTTGTAAGCATTAAGAGTGGTTTTCCCGGATTGTGT
GTAGGTGTGAGATCAACCATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAACAAATC
AAAGTTGCCACTCTAAATTCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTTGCCTG
GAAAGTGCCCAGGAACCCTCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTACCCCTG
GAGGAGAGAAAATACAAGGATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCAC
TTGGAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACATTGTT
GCTAGACTGCAGACTCAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAA
GACTTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGC
ATCGAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCAC
CCCTTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAAC
CGGACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGGCCAATAGC
TTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGCCAAAATCACTCAGCAG
ATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAATGTGGCCCAGGAACAG
ATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAGTTCCACAGGCACCTCATTGGGAAG
AGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAGCAATTTGATCCGCATC
GAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAAAATGAGCGTACCAAGGATCTAATC
ATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGACAAATTCCCAGAGGTCATCATTAAC
TTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAAATACATGCAGAAGATG
GTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGGGAAAGGAGGCGCAAAC
ATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGATCTCAAAAAGAAGATGAAAATGCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_HDLBP_ENST00000391976_chr2_242186471_-_TMC1_ENST00000297784_chr9_75445367_+_2643nt
GATCGGGGGGCCTCTCTGGGATTGGCTGCGCGCACGTCACGTGGGGCCGACGGGCCCTGCGCAGACCATCGAGTCGGGCGTCCCTCCCCG
GGGACGTGGCCTTCCTGTGCCCGGGCTGGGGCCCGCCGCCCCGCGGGGGAGGGCGGAGCTGGCGCGGCCCCTAGCTTTCTCCTTCTGGTG
TGGGGCCCGAGCAAAAGCTGGCAGGCTGACAGAGGCGGCCTCAGGACGGACCTTCTGGCTACTGACCGTTTTGCTGTGGTTTTCCCGGAT
TGTGTGTAGGTGTGAGATCAACCATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAAC
AAATCAAAGTTGCCACTCTAAATTCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTT
GCCTGGAAAGTGCCCAGGAACCCTCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTAC
CCCTGGAGGAGAGAAAATACAAGGATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTG
CTCACTTGGAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACA
TTGTTGCTAGACTGCAGACTCAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAAC
TGCAAGACTTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAG
AGGGCATCGAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCAT
TCCACCCCTTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCG
TGAACCGGACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGAAAA
AGAAGACTACAACCATTGCAGTGGAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGCAGGAGATCCTTG
AGAGAACTGGAGTTTCCGTTGAGATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAAAGTTAGGTCAGG
CGTTGACTGAAGTCTATGCCAAGGCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGA
AAGGGCAGAACCTGGCCAAAATCACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCC
CTACAGAGGATGTCAATGTGGCCCAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCG
ACCACAAGTTCCACAGGCACCTCATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTC
CTGACAGTGAGAAGAGCAATTTGATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTC
GCATGGAAAATGAGCGTACCAAGGATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAA
TTCGTGACAAATTCCCAGAGGTCATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGG
TGGAAAAATGCACAAAATACATGCAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTC
ACAAGAATATCATTGGGAAAGGAGGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCG
AATCTGGATCTCAAAAAGAAGATGAAAATGCAAGCTTTGGAGAACAAAATGCGAAACAAGAAAATGGCAGCTGCACGAGCAGCTGCAGCT
GCTGGTCGCCAGTAATAAGTATCCTGAGAGCCCAGAAAAGGTACACTTTGCCTTGCTGTTTAAAAGTAATGCAATATGTGAACGCCCAGA
GAACAAGCACTGTGGAACTGCTATTTTCCTGTTCTACCCTTGATGGATTTTCAAGGTCATGCTGGCCAATTAAGGCATCATCAGTCCTAC
CTGAGCAACAAGAATCTAAACTTTATTCCAAGTCAGAAACTGTTTCTGCAGAGCCACTCTCTCCCCTGCTCCATTTCGTGACTTTTTTTT
TTTTTTTAACAAATTGAGTTTAGAAGTGAGTGTAATCCAGCAATACAGTTTACTGGTTTAGTTGGTGGGTTAATTAAAAAAAATTTGCTC

>In-frame_HDLBP_ENST00000391976_chr2_242186471_-_TMC1_ENST00000340019_chr9_75445367_+_2643nt
GATCGGGGGGCCTCTCTGGGATTGGCTGCGCGCACGTCACGTGGGGCCGACGGGCCCTGCGCAGACCATCGAGTCGGGCGTCCCTCCCCG
GGGACGTGGCCTTCCTGTGCCCGGGCTGGGGCCCGCCGCCCCGCGGGGGAGGGCGGAGCTGGCGCGGCCCCTAGCTTTCTCCTTCTGGTG
TGGGGCCCGAGCAAAAGCTGGCAGGCTGACAGAGGCGGCCTCAGGACGGACCTTCTGGCTACTGACCGTTTTGCTGTGGTTTTCCCGGAT
TGTGTGTAGGTGTGAGATCAACCATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAAC
AAATCAAAGTTGCCACTCTAAATTCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTT
GCCTGGAAAGTGCCCAGGAACCCTCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTAC
CCCTGGAGGAGAGAAAATACAAGGATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTG
CTCACTTGGAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACA
TTGTTGCTAGACTGCAGACTCAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAAC
TGCAAGACTTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAG
AGGGCATCGAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCAT
TCCACCCCTTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCG
TGAACCGGACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGAAAA
AGAAGACTACAACCATTGCAGTGGAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGCAGGAGATCCTTG
AGAGAACTGGAGTTTCCGTTGAGATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAAAGTTAGGTCAGG
CGTTGACTGAAGTCTATGCCAAGGCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGA
AAGGGCAGAACCTGGCCAAAATCACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCC
CTACAGAGGATGTCAATGTGGCCCAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCG
ACCACAAGTTCCACAGGCACCTCATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTC
CTGACAGTGAGAAGAGCAATTTGATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTC
GCATGGAAAATGAGCGTACCAAGGATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAA
TTCGTGACAAATTCCCAGAGGTCATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGG
TGGAAAAATGCACAAAATACATGCAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTC
ACAAGAATATCATTGGGAAAGGAGGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCG
AATCTGGATCTCAAAAAGAAGATGAAAATGCAAGCTTTGGAGAACAAAATGCGAAACAAGAAAATGGCAGCTGCACGAGCAGCTGCAGCT
GCTGGTCGCCAGTAATAAGTATCCTGAGAGCCCAGAAAAGGTACACTTTGCCTTGCTGTTTAAAAGTAATGCAATATGTGAACGCCCAGA
GAACAAGCACTGTGGAACTGCTATTTTCCTGTTCTACCCTTGATGGATTTTCAAGGTCATGCTGGCCAATTAAGGCATCATCAGTCCTAC
CTGAGCAACAAGAATCTAAACTTTATTCCAAGTCAGAAACTGTTTCTGCAGAGCCACTCTCTCCCCTGCTCCATTTCGTGACTTTTTTTT
TTTTTTTAACAAATTGAGTTTAGAAGTGAGTGTAATCCAGCAATACAGTTTACTGGTTTAGTTGGTGGGTTAATTAAAAAAAATTTGCTC

>In-frame_HDLBP_ENST00000391976_chr2_242186471_-_TMC1_ENST00000396237_chr9_75445367_+_2353nt
GATCGGGGGGCCTCTCTGGGATTGGCTGCGCGCACGTCACGTGGGGCCGACGGGCCCTGCGCAGACCATCGAGTCGGGCGTCCCTCCCCG
GGGACGTGGCCTTCCTGTGCCCGGGCTGGGGCCCGCCGCCCCGCGGGGGAGGGCGGAGCTGGCGCGGCCCCTAGCTTTCTCCTTCTGGTG
TGGGGCCCGAGCAAAAGCTGGCAGGCTGACAGAGGCGGCCTCAGGACGGACCTTCTGGCTACTGACCGTTTTGCTGTGGTTTTCCCGGAT
TGTGTGTAGGTGTGAGATCAACCATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAAC
AAATCAAAGTTGCCACTCTAAATTCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTT
GCCTGGAAAGTGCCCAGGAACCCTCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTAC
CCCTGGAGGAGAGAAAATACAAGGATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTG
CTCACTTGGAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACA
TTGTTGCTAGACTGCAGACTCAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAAC
TGCAAGACTTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAG
AGGGCATCGAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCAT
TCCACCCCTTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCG
TGAACCGGACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGAAAA
AGAAGACTACAACCATTGCAGTGGAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGCAGGAGATCCTTG
AGAGAACTGGAGTTTCCGTTGAGATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAAAGTTAGGTCAGG
CGTTGACTGAAGTCTATGCCAAGGCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGA
AAGGGCAGAACCTGGCCAAAATCACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCC
CTACAGAGGATGTCAATGTGGCCCAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCG
ACCACAAGTTCCACAGGCACCTCATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTC
CTGACAGTGAGAAGAGCAATTTGATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTC
GCATGGAAAATGAGCGTACCAAGGATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAA
TTCGTGACAAATTCCCAGAGGTCATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGG
TGGAAAAATGCACAAAATACATGCAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTC
ACAAGAATATCATTGGGAAAGGAGGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCG
AATCTGGATCTCAAAAAGAAGATGAAAATGCAAGCTTTGGAGAACAAAATGCGAAACAAGAAAATGGCAGCTGCACGAGCAGCTGCAGCT
GCTGGTCGCCAGTAATAAGTATCCTGAGAGCCCAGAAAAGGTACACTTTGCCTTGCTGTTTAAAAGTAATGCAATATGTGAACGCCCAGA

>In-frame_HDLBP_ENST00000310931_chr2_242186471_-_TMC1_ENST00000297784_chr9_75445367_+_2725nt
TTTGCCAACTGCTTCCTGGCTCAGTGCGACCTGGCCTTCTTCCCCTCCCCCATGCGGCCGGCTTCCGAGTGCGCAAGCCCAGAGTCGTCC
GCGTTGTCCGCCTCTGCGCAAGCGCCGTGCTCCTCCCACGGCAGTTGGCCATATAGAGGCTGGGGGTGGGGGGGGAGGTCAAGCGTAGCC
TCTTCTCCTTTACCAAGATGGCGGCTTGTCCCTGTTTCGCCACAGTTCCTACCTTATGAGCTCGGTTTTCTTATGCTTATAAGAGTGGAA
CAGCAAAAGCTGGCAGGCTGACAGAGGCGGCCTCAGGACGGACCTTCTGGCTACTGACCGTTTTGCTGTGGTTTTCCCGGATTGTGTGTA
GGTGTGAGATCAACCATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAACAAATCAAA
GTTGCCACTCTAAATTCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTTGCCTGGAA
AGTGCCCAGGAACCCTCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTACCCCTGGAG
GAGAGAAAATACAAGGATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCACTTG
GAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACATTGTTGCT
AGACTGCAGACTCAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAAGAC
TTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGCATC
GAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCACCCC
TTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAACCGG
ACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGAAAAAGAAGACT
ACAACCATTGCAGTGGAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGCAGGAGATCCTTGAGAGAACT
GGAGTTTCCGTTGAGATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAAAGTTAGGTCAGGCGTTGACT
GAAGTCTATGCCAAGGCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAG
AACCTGGCCAAAATCACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAG
GATGTCAATGTGGCCCAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAG
TTCCACAGGCACCTCATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGT
GAGAAGAGCAATTTGATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAA
AATGAGCGTACCAAGGATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGAC
AAATTCCCAGAGGTCATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAA
TGCACAAAATACATGCAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAAT
ATCATTGGGAAAGGAGGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGA
TCTCAAAAAGAAGATGAAAATGCAAGCTTTGGAGAACAAAATGCGAAACAAGAAAATGGCAGCTGCACGAGCAGCTGCAGCTGCTGGTCG
CCAGTAATAAGTATCCTGAGAGCCCAGAAAAGGTACACTTTGCCTTGCTGTTTAAAAGTAATGCAATATGTGAACGCCCAGAGAACAAGC
ACTGTGGAACTGCTATTTTCCTGTTCTACCCTTGATGGATTTTCAAGGTCATGCTGGCCAATTAAGGCATCATCAGTCCTACCTGAGCAA
CAAGAATCTAAACTTTATTCCAAGTCAGAAACTGTTTCTGCAGAGCCACTCTCTCCCCTGCTCCATTTCGTGACTTTTTTTTTTTTTTTA
ACAAATTGAGTTTAGAAGTGAGTGTAATCCAGCAATACAGTTTACTGGTTTAGTTGGTGGGTTAATTAAAAAAAATTTGCTCATATGAAC

>In-frame_HDLBP_ENST00000310931_chr2_242186471_-_TMC1_ENST00000340019_chr9_75445367_+_2725nt
TTTGCCAACTGCTTCCTGGCTCAGTGCGACCTGGCCTTCTTCCCCTCCCCCATGCGGCCGGCTTCCGAGTGCGCAAGCCCAGAGTCGTCC
GCGTTGTCCGCCTCTGCGCAAGCGCCGTGCTCCTCCCACGGCAGTTGGCCATATAGAGGCTGGGGGTGGGGGGGGAGGTCAAGCGTAGCC
TCTTCTCCTTTACCAAGATGGCGGCTTGTCCCTGTTTCGCCACAGTTCCTACCTTATGAGCTCGGTTTTCTTATGCTTATAAGAGTGGAA
CAGCAAAAGCTGGCAGGCTGACAGAGGCGGCCTCAGGACGGACCTTCTGGCTACTGACCGTTTTGCTGTGGTTTTCCCGGATTGTGTGTA
GGTGTGAGATCAACCATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAACAAATCAAA
GTTGCCACTCTAAATTCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTTGCCTGGAA
AGTGCCCAGGAACCCTCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTACCCCTGGAG
GAGAGAAAATACAAGGATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCACTTG
GAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACATTGTTGCT
AGACTGCAGACTCAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAAGAC
TTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGCATC
GAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCACCCC
TTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAACCGG
ACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGAAAAAGAAGACT
ACAACCATTGCAGTGGAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGCAGGAGATCCTTGAGAGAACT
GGAGTTTCCGTTGAGATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAAAGTTAGGTCAGGCGTTGACT
GAAGTCTATGCCAAGGCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAG
AACCTGGCCAAAATCACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAG
GATGTCAATGTGGCCCAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAG
TTCCACAGGCACCTCATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGT
GAGAAGAGCAATTTGATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAA
AATGAGCGTACCAAGGATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGAC
AAATTCCCAGAGGTCATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAA
TGCACAAAATACATGCAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAAT
ATCATTGGGAAAGGAGGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGA
TCTCAAAAAGAAGATGAAAATGCAAGCTTTGGAGAACAAAATGCGAAACAAGAAAATGGCAGCTGCACGAGCAGCTGCAGCTGCTGGTCG
CCAGTAATAAGTATCCTGAGAGCCCAGAAAAGGTACACTTTGCCTTGCTGTTTAAAAGTAATGCAATATGTGAACGCCCAGAGAACAAGC
ACTGTGGAACTGCTATTTTCCTGTTCTACCCTTGATGGATTTTCAAGGTCATGCTGGCCAATTAAGGCATCATCAGTCCTACCTGAGCAA
CAAGAATCTAAACTTTATTCCAAGTCAGAAACTGTTTCTGCAGAGCCACTCTCTCCCCTGCTCCATTTCGTGACTTTTTTTTTTTTTTTA
ACAAATTGAGTTTAGAAGTGAGTGTAATCCAGCAATACAGTTTACTGGTTTAGTTGGTGGGTTAATTAAAAAAAATTTGCTCATATGAAC

>In-frame_HDLBP_ENST00000310931_chr2_242186471_-_TMC1_ENST00000396237_chr9_75445367_+_2435nt
TTTGCCAACTGCTTCCTGGCTCAGTGCGACCTGGCCTTCTTCCCCTCCCCCATGCGGCCGGCTTCCGAGTGCGCAAGCCCAGAGTCGTCC
GCGTTGTCCGCCTCTGCGCAAGCGCCGTGCTCCTCCCACGGCAGTTGGCCATATAGAGGCTGGGGGTGGGGGGGGAGGTCAAGCGTAGCC
TCTTCTCCTTTACCAAGATGGCGGCTTGTCCCTGTTTCGCCACAGTTCCTACCTTATGAGCTCGGTTTTCTTATGCTTATAAGAGTGGAA
CAGCAAAAGCTGGCAGGCTGACAGAGGCGGCCTCAGGACGGACCTTCTGGCTACTGACCGTTTTGCTGTGGTTTTCCCGGATTGTGTGTA
GGTGTGAGATCAACCATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCTGGTTCCGCAACAAATCAAA
GTTGCCACTCTAAATTCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGAGAAAGCTGCTTGCCTGGAA
AGTGCCCAGGAACCCTCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGTGTTCCATGTACCCCTGGAG
GAGAGAAAATACAAGGATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCAGAGAACTGGTGCTCACTTG
GAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGCTCGGAAGGACATTGTTGCT
AGACTGCAGACTCAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAATGGAGAGAAACTGCAAGAC
TTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCACTGGCACCAAAGAGGGCATC
GAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGTAGAAAAGGCATTCCACCCC
TTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCCCCCACCCAGCGTGAACCGG
ACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGAGGAGAAGAAAAAGAAGACT
ACAACCATTGCAGTGGAAGTGAAGAAATCCCAACACAAGTATGTCATTGGGCCCAAGGGCAATTCATTGCAGGAGATCCTTGAGAGAACT
GGAGTTTCCGTTGAGATCCCACCCTCAGACAGCATCTCTGAGACTGTAATACTTCGAGGCGAACCTGAAAAGTTAGGTCAGGCGTTGACT
GAAGTCTATGCCAAGGCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAG
AACCTGGCCAAAATCACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAG
GATGTCAATGTGGCCCAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAG
TTCCACAGGCACCTCATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGT
GAGAAGAGCAATTTGATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAA
AATGAGCGTACCAAGGATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGAC
AAATTCCCAGAGGTCATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAA
TGCACAAAATACATGCAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAAT
ATCATTGGGAAAGGAGGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGA
TCTCAAAAAGAAGATGAAAATGCAAGCTTTGGAGAACAAAATGCGAAACAAGAAAATGGCAGCTGCACGAGCAGCTGCAGCTGCTGGTCG
CCAGTAATAAGTATCCTGAGAGCCCAGAAAAGGTACACTTTGCCTTGCTGTTTAAAAGTAATGCAATATGTGAACGCCCAGAGAACAAGC

>In-frame_HDLBP_ENST00000427183_chr2_242186471_-_TMC1_ENST00000297784_chr9_75445367_+_2447nt
GGAGCGTCCCGGCTTCTCCCGCGCGGGGGGCGAGTAAGCCAGCGGCAGGACCAGCGGGCGGGGGCCCACGACAAAAGCTGGCAGGCTGAC
AGAGGCGGCCTCAGGACGGACCTTCTGGCTACTGACCGTTTTGCTGCTACCACTTATAACCACCTGGTTAAGTCGAGATTTGGAGGTGGT
TTAGTTTGGGGCCTGGATGCACCTTGCAGAGAGAGACCGCTGGCTTTTTGTAGCAACTGTCATGATGCATTTTGTAAGCATTAAGAGTGG
TTTTCCCGGATTGTGTGTAGGTGTGAGATCAACCATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCT
GGTTCCGCAACAAATCAAAGTTGCCACTCTAAATTCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGA
GAAAGCTGCTTGCCTGGAAAGTGCCCAGGAACCCTCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGT
GTTCCATGTACCCCTGGAGGAGAGAAAATACAAGGATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCA
GAGAACTGGTGCTCACTTGGAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGC
TCGGAAGGACATTGTTGCTAGACTGCAGACTCAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAA
TGGAGAGAAACTGCAAGACTTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCAC
TGGCACCAAAGAGGGCATCGAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGT
AGAAAAGGCATTCCACCCCTTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCC
CCCACCCAGCGTGAACCGGACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGA
GGAGAAGGCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGC
CAAAATCACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAA
TGTGGCCCAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAGTTCCACAG
GCACCTCATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAG
CAATTTGATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAAAATGAGCG
TACCAAGGATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGACAAATTCCC
AGAGGTCATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAA
ATACATGCAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGG
GAAAGGAGGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGATCTCAAAA
AGAAGATGAAAATGCAAGCTTTGGAGAACAAAATGCGAAACAAGAAAATGGCAGCTGCACGAGCAGCTGCAGCTGCTGGTCGCCAGTAAT
AAGTATCCTGAGAGCCCAGAAAAGGTACACTTTGCCTTGCTGTTTAAAAGTAATGCAATATGTGAACGCCCAGAGAACAAGCACTGTGGA
ACTGCTATTTTCCTGTTCTACCCTTGATGGATTTTCAAGGTCATGCTGGCCAATTAAGGCATCATCAGTCCTACCTGAGCAACAAGAATC
TAAACTTTATTCCAAGTCAGAAACTGTTTCTGCAGAGCCACTCTCTCCCCTGCTCCATTTCGTGACTTTTTTTTTTTTTTTAACAAATTG
AGTTTAGAAGTGAGTGTAATCCAGCAATACAGTTTACTGGTTTAGTTGGTGGGTTAATTAAAAAAAATTTGCTCATATGAACTTTCATTT

>In-frame_HDLBP_ENST00000427183_chr2_242186471_-_TMC1_ENST00000340019_chr9_75445367_+_2447nt
GGAGCGTCCCGGCTTCTCCCGCGCGGGGGGCGAGTAAGCCAGCGGCAGGACCAGCGGGCGGGGGCCCACGACAAAAGCTGGCAGGCTGAC
AGAGGCGGCCTCAGGACGGACCTTCTGGCTACTGACCGTTTTGCTGCTACCACTTATAACCACCTGGTTAAGTCGAGATTTGGAGGTGGT
TTAGTTTGGGGCCTGGATGCACCTTGCAGAGAGAGACCGCTGGCTTTTTGTAGCAACTGTCATGATGCATTTTGTAAGCATTAAGAGTGG
TTTTCCCGGATTGTGTGTAGGTGTGAGATCAACCATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCT
GGTTCCGCAACAAATCAAAGTTGCCACTCTAAATTCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGA
GAAAGCTGCTTGCCTGGAAAGTGCCCAGGAACCCTCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGT
GTTCCATGTACCCCTGGAGGAGAGAAAATACAAGGATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCA
GAGAACTGGTGCTCACTTGGAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGC
TCGGAAGGACATTGTTGCTAGACTGCAGACTCAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAA
TGGAGAGAAACTGCAAGACTTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCAC
TGGCACCAAAGAGGGCATCGAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGT
AGAAAAGGCATTCCACCCCTTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCC
CCCACCCAGCGTGAACCGGACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGA
GGAGAAGGCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGC
CAAAATCACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAA
TGTGGCCCAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAGTTCCACAG
GCACCTCATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAG
CAATTTGATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAAAATGAGCG
TACCAAGGATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGACAAATTCCC
AGAGGTCATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAA
ATACATGCAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGG
GAAAGGAGGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGATCTCAAAA
AGAAGATGAAAATGCAAGCTTTGGAGAACAAAATGCGAAACAAGAAAATGGCAGCTGCACGAGCAGCTGCAGCTGCTGGTCGCCAGTAAT
AAGTATCCTGAGAGCCCAGAAAAGGTACACTTTGCCTTGCTGTTTAAAAGTAATGCAATATGTGAACGCCCAGAGAACAAGCACTGTGGA
ACTGCTATTTTCCTGTTCTACCCTTGATGGATTTTCAAGGTCATGCTGGCCAATTAAGGCATCATCAGTCCTACCTGAGCAACAAGAATC
TAAACTTTATTCCAAGTCAGAAACTGTTTCTGCAGAGCCACTCTCTCCCCTGCTCCATTTCGTGACTTTTTTTTTTTTTTTAACAAATTG
AGTTTAGAAGTGAGTGTAATCCAGCAATACAGTTTACTGGTTTAGTTGGTGGGTTAATTAAAAAAAATTTGCTCATATGAACTTTCATTT

>In-frame_HDLBP_ENST00000427183_chr2_242186471_-_TMC1_ENST00000396237_chr9_75445367_+_2157nt
GGAGCGTCCCGGCTTCTCCCGCGCGGGGGGCGAGTAAGCCAGCGGCAGGACCAGCGGGCGGGGGCCCACGACAAAAGCTGGCAGGCTGAC
AGAGGCGGCCTCAGGACGGACCTTCTGGCTACTGACCGTTTTGCTGCTACCACTTATAACCACCTGGTTAAGTCGAGATTTGGAGGTGGT
TTAGTTTGGGGCCTGGATGCACCTTGCAGAGAGAGACCGCTGGCTTTTTGTAGCAACTGTCATGATGCATTTTGTAAGCATTAAGAGTGG
TTTTCCCGGATTGTGTGTAGGTGTGAGATCAACCATGAGTTCCGTTGCAGTTTTGACCCAAGAGAGTTTTGCTGAACACCGAAGTGGGCT
GGTTCCGCAACAAATCAAAGTTGCCACTCTAAATTCAGAAGAGGAGAGCGACCCTCCAACCTACAAGGATGCCTTCCCTCCACTTCCTGA
GAAAGCTGCTTGCCTGGAAAGTGCCCAGGAACCCTCTGGAGCCTGGGGGAACAAGATCCGACCCATCAAGGCTTCTGTCATCACTCAGGT
GTTCCATGTACCCCTGGAGGAGAGAAAATACAAGGATATGAACCAGTTTGGAGAAGGTGAACAAGCAAAAATCTGCCTTGAGATCATGCA
GAGAACTGGTGCTCACTTGGAGCTGTCTTTGGCCAAAGACCAAGGCCTCTCCATCATGGTGTCAGGAAAGCTGGATGCTGTCATGAAAGC
TCGGAAGGACATTGTTGCTAGACTGCAGACTCAGGCCTCAGCAACTGTTGCCATTCCCAAAGAACACCATCGCTTTGTTATTGGCAAAAA
TGGAGAGAAACTGCAAGACTTGGAGCTAAAAACTGCAACCAAAATCCAGATCCCACGCCCAGATGACCCCAGCAATCAGATCAAGATCAC
TGGCACCAAAGAGGGCATCGAGAAAGCTCGCCATGAAGTCTTACTCATCTCTGCCGAGCAGGACAAACGTGCTGTGGAGAGGCTAGAAGT
AGAAAAGGCATTCCACCCCTTCATCGCTGGGCCGTATAATAGACTGGTTGGCGAGATCATGCAGGAGACAGGCACGCGCATCAACATCCC
CCCACCCAGCGTGAACCGGACAGAGATTGTCTTCACTGGAGAGAAGGAACAGTTGGCTCAGGCTGTGGCTCGCATCAAGAAGATTTATGA
GGAGAAGGCCAATAGCTTCACCGTCTCCTCTGTCGCCGCCCCTTCCTGGCTTCACCGTTTCATCATTGGCAAGAAAGGGCAGAACCTGGC
CAAAATCACTCAGCAGATGCCAAAGGTTCACATCGAGTTCACAGAGGGCGAAGACAAGATCACCCTGGAGGGCCCTACAGAGGATGTCAA
TGTGGCCCAGGAACAGATAGAAGGCATGGTCAAAGATTTGATTAACCGGATGGACTATGTGGAGATCAACATCGACCACAAGTTCCACAG
GCACCTCATTGGGAAGAGCGGTGCCAACATAAACAGAATCAAAGACCAGTACAAGGTGTCCGTGCGCATCCCTCCTGACAGTGAGAAGAG
CAATTTGATCCGCATCGAGGGGGACCCACAGGGCGTGCAGCAGGCCAAGCGAGAGCTGCTGGAGCTTGCATCTCGCATGGAAAATGAGCG
TACCAAGGATCTAATCATTGAGCAAAGATTTCATCGCACAATCATTGGGCAGAAGGGTGAACGGATCCGTGAAATTCGTGACAAATTCCC
AGAGGTCATCATTAACTTTCCAGACCCAGCACAAAAAAGTGACATTGTCCAGCTCAGAGGACCTAAGAATGAGGTGGAAAAATGCACAAA
ATACATGCAGAAGATGGTGGCAGATCTGGTGGAAAATAGCTATTCAATTTCTGTTCCGATCTTCAAACAGTTTCACAAGAATATCATTGG
GAAAGGAGGCGCAAACATTAAAAAGTTTGGCCATCTATTATCTCAATGCTACTGCCAAGGGCCAGAAGGCAGCGAATCTGGATCTCAAAA
AGAAGATGAAAATGCAAGCTTTGGAGAACAAAATGCGAAACAAGAAAATGGCAGCTGCACGAGCAGCTGCAGCTGCTGGTCGCCAGTAAT


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FusionGenePPI for HDLBP_TMC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HDLBPAKTIP, MAGEA6, XPOT, XRCC5, PRKDC, ADAR, DHX9, SOS1, SUV39H1, CBX5, ARRB1, SIRT7, CDK2, COPS5, PSMD12, VPS35, S100A11, VPS29, UPF1, VPS26A, VPS36, UBA6, VPS25, TTC4, TYRO3, UBE2A, PLAUR, TOPBP1, TTK, ATP6V1B2, S100A10, ZW10, UBE4B, ZNF598, VCP, CSNK2A1, SMAD4, FAM46A, DYNLL1, EIF2A, FAU, KCMF1, IKBKG, WWOX, LGR4, OBSL1, CCDC8, ESR1, SERPINB5, BPGM, TMEM171, PTCRA, ZCCHC7, SERPINB3, ACTL6A, CYP1A1, HSPB1, CLUH, DDX43, GLMN, SMS, SAC3D1, NTRK1, SCARNA22, ERBB2, KIF11, MLH1, YBX1, SNW1, CDC5L, CDH1, STYX, WDR59, SERPINB2, CCDC102B, GTF2E2, HDHD2, SNRNP27, FGB, HSPA8, IL20RA, USP47, SYNCRIP, DLD, PDHA1, SDHATMC1COPS5, CAND1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HDLBP_TMC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HDLBP_TMC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHDLBPC0004352Autistic Disorder1CTD_human
HgeneHDLBPC2931817Chromosome 2q37 deletion syndrome1CTD_human
TgeneTMC1C1832978Deafness, Autosomal Recessive 71CTD_human;UNIPROT
TgeneTMC1C1847626Deafness, Autosomal Dominant 361CTD_human;UNIPROT