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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15981

FusionGeneSummary for HDGF_RRNAD1

check button Fusion gene summary
Fusion gene informationFusion gene name: HDGF_RRNAD1
Fusion gene ID: 15981
HgeneTgene
Gene symbol

HDGF

RRNAD1

Gene ID

3068

51093

Gene nameheparin binding growth factorribosomal RNA adenine dimethylase domain containing 1
SynonymsHMG1L2C1orf66|CGI-41|METTL25B
Cytomap

1q23.1

1q23.1

Type of geneprotein-codingprotein-coding
Descriptionhepatoma-derived growth factorhepatoma derived growth factorhigh mobility group protein 1-like 2protein RRNAD1ribosomal RNA adenine dimethylase domain-containing protein 1
Modification date2018052220180519
UniProtAcc

P51858

Q96FB5

Ensembl transtripts involved in fusion geneENST00000357325, ENST00000537739, 
ENST00000368209, ENST00000465180, 
ENST00000416666, ENST00000368206, 
ENST00000368218, ENST00000368216, 
ENST00000524343, ENST00000476229, 
ENST00000481920, 
Fusion gene scores* DoF score4 X 5 X 2=403 X 3 X 3=27
# samples 53
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HDGF [Title/Abstract] AND RRNAD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHDGF

GO:0000122

negative regulation of transcription by RNA polymerase II

19162039


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0FJ-01AHDGFchr1

156714800

-RRNAD1chr1

156706424

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000357325ENST00000368218HDGFchr1

156714800

-RRNAD1chr1

156706424

+
Frame-shiftENST00000357325ENST00000368216HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000357325ENST00000524343HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000357325ENST00000476229HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000357325ENST00000481920HDGFchr1

156714800

-RRNAD1chr1

156706424

+
Frame-shiftENST00000537739ENST00000368218HDGFchr1

156714800

-RRNAD1chr1

156706424

+
In-frameENST00000537739ENST00000368216HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000537739ENST00000524343HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000537739ENST00000476229HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000537739ENST00000481920HDGFchr1

156714800

-RRNAD1chr1

156706424

+
Frame-shiftENST00000368209ENST00000368218HDGFchr1

156714800

-RRNAD1chr1

156706424

+
Frame-shiftENST00000368209ENST00000368216HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000368209ENST00000524343HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000368209ENST00000476229HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000368209ENST00000481920HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5UTR-3CDSENST00000465180ENST00000368218HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5UTR-3CDSENST00000465180ENST00000368216HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5UTR-intronENST00000465180ENST00000524343HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5UTR-intronENST00000465180ENST00000476229HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5UTR-intronENST00000465180ENST00000481920HDGFchr1

156714800

-RRNAD1chr1

156706424

+
Frame-shiftENST00000416666ENST00000368218HDGFchr1

156714800

-RRNAD1chr1

156706424

+
In-frameENST00000416666ENST00000368216HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000416666ENST00000524343HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000416666ENST00000476229HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000416666ENST00000481920HDGFchr1

156714800

-RRNAD1chr1

156706424

+
Frame-shiftENST00000368206ENST00000368218HDGFchr1

156714800

-RRNAD1chr1

156706424

+
Frame-shiftENST00000368206ENST00000368216HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000368206ENST00000524343HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000368206ENST00000476229HDGFchr1

156714800

-RRNAD1chr1

156706424

+
5CDS-intronENST00000368206ENST00000481920HDGFchr1

156714800

-RRNAD1chr1

156706424

+

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FusionProtFeatures for HDGF_RRNAD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HDGF

P51858

RRNAD1

Q96FB5

Heparin-binding protein, with mitogenic activity forfibroblasts. Acts as a transcriptional repressor.{ECO:0000269|PubMed:17974029}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HDGF_RRNAD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HDGF_RRNAD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HDGFXBP1, EMD, KAT5, KAT2A, ABCF1, ATAD3A, BMS1, BRIX1, ASUN, VWA9, C7orf26, C7orf50, C8orf33, CDK1, CDC5L, DDX1, DDX17, DDX21, DDX47, DDX5, DDX50, DHX15, DHX30, DHX9, DIMT1, EBNA1BP2, EFTUD2, EIF2S1, EIF2S3, EIF5B, EXOSC10, EXOSC2, EXOSC3, EXOSC6, FARSB, FBL, GNL3, GRWD1, GTPBP1, H1FX, HDAC1, HDAC2, HIST1H1E, HIST1H2BK, HIST1H3A, HIST1H3D, HIST1H3C, HIST1H3E, HIST1H3I, HIST1H3G, HIST1H3J, HIST1H3H, HIST1H3B, HIST1H3F, HIST1H4I, HIST1H4A, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4J, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, HIST4H4, HIST2H4B, HNRNPA2B1, HNRNPA3, HNRNPU, INTS10, KIF2A, KPNA2, LRRC59, MRTO4, MYBBP1A, NACA, NCL, NOP2, PARP1, PGAM5, POLDIP3, POLRMT, PRKDC, PSIP1, PWP2, RBBP4, RBM39, RCC2, RFC1, RFC4, RFC5, RPA1, RPL17, RPL19, RPL22, RPL32, RPL34, RPL35, RPL35A, RPS11, RPS15A, RPS23, RRP1B, RSL1D1, SRSF1, SRSF2, SRSF3, SRSF5, SRSF7, SLC25A3, SLC25A5, SMC3, SNRPD1, SRPK1, SSR1, SSRP1, STAU1, SUB1, SUPT16H, ALYREF, TMPO, TOP1, TSR1, U2AF1, WDR36, WDR5, XRCC5, XRCC6, ZC3HAV1, RNA28S5, RNA18S5, ACTL6A, BAZ1B, BUB3, CBX3, CKAP4, DEK, DNAJA1, DRG1, EEF2, EIF2AK2, EIF2S2, H1F0, H2AFY, H2AFY2, HIST1H1D, HIST1H1C, HIST1H2BD, HIST1H2BG, HIST1H2BF, HIST1H2BE, HIST1H2BI, HIST1H2BC, HMGA2, HMGN1, HP1BP3, HSD17B10, HSPA9, LYAR, MAGEB2, MAP4, MAPK14, MPG, MRPS22, MRPS27, NUDC, PHF6, PLS3, RAN, RBMX, RCC1, RCL1, RFC3, TRMT10C, RPL10, RPP38, RUVBL1, SMARCA5, SRP68, SRP72, SSB, THOC3, U2AF2, UBA52, ZRANB2, KRT1, KRT10, KRT2, PRMT5, PRSS3, HIST2H2BE, JUN, PARK2, ASB6, AHCY, CROCC, MCTS1, OLA1, SH2D4A, UBR7, SNRPF, ENO1, MOV10, NXF1, NTRK1, MSH6, PSME3, APP, EWSR1, EGFR, EGFL6, CPNE2, FOXA1RRNAD1ELAVL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HDGF_RRNAD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HDGF_RRNAD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHDGFC0019693HIV Infections1CTD_human