	FusionGeneSummary
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Fusion gene ID: 15966

FusionGeneSummary for HDAC9_C8orf34

Fusion gene summary

Fusion gene information	Fusion gene name: HDAC9_C8orf34
	Fusion gene ID: 15966
		Hgene	Tgene
	Gene symbol	HDAC9	C8orf34
	Gene ID	9734	116328
	Gene name	histone deacetylase 9	chromosome 8 open reading frame 34
	Synonyms	HD7\|HD7b\|HD9\|HDAC\|HDAC7\|HDAC7B\|HDAC9B\|HDAC9FL\|HDRP\|MITR	VEST-1\|VEST1
	Cytomap	7p21.1	8q13.2
	Type of gene	protein-coding	protein-coding
	Description	histone deacetylase 9MEF-2 interacting transcription repressor (MITR) proteinhistone deacetylase 4/5-related proteinhistone deacetylase 7B	uncharacterized protein C8orf34protein VEST-1vestibule-1 protein
	Modification date	20180519	20180519
	UniProtAcc	Q9UKV0	Q49A92
	Ensembl transtripts involved in fusion gene	ENST00000406451, ENST00000401921, ENST00000432645, ENST00000441542, ENST00000417496, ENST00000476135, ENST00000405010, ENST00000428307, ENST00000406072, ENST00000456174, ENST00000524023,	ENST00000539993, ENST00000518698, ENST00000349492, ENST00000523686, ENST00000348340, ENST00000337103, ENST00000325233,
Fusion gene scores	* DoF score	6 X 6 X 6=216	11 X 8 X 9=792
	# samples	6	10
	** MAII score	log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/792*10)=-2.98550043030489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HDAC9 [Title/Abstract] AND C8orf34 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HDAC9	GO:0000122	negative regulation of transcription by RNA polymerase II	10655483\|11535832
Hgene	HDAC9	GO:0016575	histone deacetylation	11535832
Hgene	HDAC9	GO:0032869	cellular response to insulin stimulus	19303849
Hgene	HDAC9	GO:0034983	peptidyl-lysine deacetylation	11535832
Hgene	HDAC9	GO:0045892	negative regulation of transcription, DNA-templated	11535832
Hgene	HDAC9	GO:0070932	histone H3 deacetylation	12590135
Hgene	HDAC9	GO:0070933	histone H4 deacetylation	12590135

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUSC	TCGA-68-A59I-01A	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000406451	ENST00000539993	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000406451	ENST00000518698	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000406451	ENST00000349492	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000406451	ENST00000523686	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000406451	ENST00000348340	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000406451	ENST00000337103	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000406451	ENST00000325233	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000401921	ENST00000539993	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000401921	ENST00000518698	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000401921	ENST00000349492	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000401921	ENST00000523686	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000401921	ENST00000348340	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000401921	ENST00000337103	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000401921	ENST00000325233	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000432645	ENST00000539993	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000432645	ENST00000518698	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000432645	ENST00000349492	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000432645	ENST00000523686	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000432645	ENST00000348340	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000432645	ENST00000337103	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000432645	ENST00000325233	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000441542	ENST00000539993	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000441542	ENST00000518698	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000441542	ENST00000349492	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000441542	ENST00000523686	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000441542	ENST00000348340	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000441542	ENST00000337103	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000441542	ENST00000325233	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000417496	ENST00000539993	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000417496	ENST00000518698	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000417496	ENST00000349492	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000417496	ENST00000523686	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000417496	ENST00000348340	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000417496	ENST00000337103	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000417496	ENST00000325233	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
intron-3CDS	ENST00000476135	ENST00000539993	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
intron-3CDS	ENST00000476135	ENST00000518698	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
intron-intron	ENST00000476135	ENST00000349492	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
intron-intron	ENST00000476135	ENST00000523686	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
intron-intron	ENST00000476135	ENST00000348340	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
intron-intron	ENST00000476135	ENST00000337103	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
intron-intron	ENST00000476135	ENST00000325233	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000405010	ENST00000539993	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000405010	ENST00000518698	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000405010	ENST00000349492	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000405010	ENST00000523686	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000405010	ENST00000348340	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000405010	ENST00000337103	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000405010	ENST00000325233	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000428307	ENST00000539993	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000428307	ENST00000518698	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000428307	ENST00000349492	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000428307	ENST00000523686	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000428307	ENST00000348340	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000428307	ENST00000337103	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000428307	ENST00000325233	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000406072	ENST00000539993	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000406072	ENST00000518698	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000406072	ENST00000349492	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000406072	ENST00000523686	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000406072	ENST00000348340	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000406072	ENST00000337103	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000406072	ENST00000325233	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000456174	ENST00000539993	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000456174	ENST00000518698	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000456174	ENST00000349492	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000456174	ENST00000523686	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000456174	ENST00000348340	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000456174	ENST00000337103	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000456174	ENST00000325233	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000524023	ENST00000539993	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
Frame-shift	ENST00000524023	ENST00000518698	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000524023	ENST00000349492	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000524023	ENST00000523686	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000524023	ENST00000348340	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000524023	ENST00000337103	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+
5CDS-intron	ENST00000524023	ENST00000325233	HDAC9	chr7	18688306	+	C8orf34	chr8	69552611	+

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FusionProtFeatures for HDAC9_C8orf34

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HDAC9 Q9UKV0	C8orf34 Q49A92

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for HDAC9_C8orf34

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HDAC9_C8orf34

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
HDAC9	CTBP1, SIN3A, MORF4L2, HIST4H4, HIST2H3A, HDAC3, SIN3B, NCOR1, ETV6, HDAC4, MEF2A, HDAC1, HEY2, FOXP3, YWHAE, YWHAZ, MEF2C, ESR1, MAPK8, MAPK9, MAPK10, JUN, NUP214, SYK, RFXANK, ANKRA2, PKD1, MEF2B, HDAC9, SFN, CAMK1, H3F3A, CEBPB, PARP1, SMARCA4, MAML1, TRIM29, TP53, BCL6, HINT1, MKI67, TOP1, ADAR, EIF6, H1FX, TMPO, NUP93, TPR, FIP1L1, CCAR2, NOP2, RCC1, RBM14, SMC3, TPX2, ZC3H11A	C8orf34	UBC, MCM7, MTUS2, C8orf34, ASB7, CNDP2

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for HDAC9_C8orf34

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	HDAC9	Q9UKV0	DB00313	Valproic Acid	Histone deacetylase 9	small molecule	approved\|investigational

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RelatedDiseases for HDAC9_C8orf34

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HDAC9	C0011570	Mental Depression	2	PSYGENET
Hgene	HDAC9	C0036341	Schizophrenia	2	PSYGENET
Hgene	HDAC9	C0011581	Depressive disorder	1	PSYGENET
Hgene	HDAC9	C0038454	Cerebrovascular accident	1	CTD_human
Hgene	HDAC9	C0041696	Unipolar Depression	1	PSYGENET

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Fusion gene ID: 15966

FusionGeneSummary for HDAC9_C8orf34

FusionProtFeatures for HDAC9_C8orf34

FusionGeneSequence for HDAC9_C8orf34

FusionGenePPI for HDAC9_C8orf34

RelatedDrugs for HDAC9_C8orf34

RelatedDiseases for HDAC9_C8orf34