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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15941

FusionGeneSummary for HDAC4_PDE11A

check button Fusion gene summary
Fusion gene informationFusion gene name: HDAC4_PDE11A
Fusion gene ID: 15941
HgeneTgene
Gene symbol

HDAC4

PDE11A

Gene ID

9759

50940

Gene namehistone deacetylase 4phosphodiesterase 11A
SynonymsAHO3|BDMR|HA6116|HD4|HDAC-4|HDAC-A|HDACAPPNAD2
Cytomap

2q37.3

2q31.2

Type of geneprotein-codingprotein-coding
Descriptionhistone deacetylase 4histone deacetylase Adual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AcAMP and cGMP cyclic nucleotide phosphodiesterase 11A
Modification date2018052220180329
UniProtAcc

P56524

Q9HCR9

Ensembl transtripts involved in fusion geneENST00000345617, ENST00000543185, 
ENST00000541256, ENST00000553145, 
ENST00000286063, ENST00000358450, 
ENST00000450799, ENST00000409504, 
ENST00000389683, ENST00000449286, 
ENST00000497003, 
Fusion gene scores* DoF score8 X 5 X 7=2808 X 4 X 6=192
# samples 88
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HDAC4 [Title/Abstract] AND PDE11A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHDAC4

GO:0000122

negative regulation of transcription by RNA polymerase II

10869435|16236793

HgeneHDAC4

GO:0006338

chromatin remodeling

18850004

HgeneHDAC4

GO:0006476

protein deacetylation

27708256

HgeneHDAC4

GO:0016575

histone deacetylation

10869435

HgeneHDAC4

GO:0033235

positive regulation of protein sumoylation

17696781

HgeneHDAC4

GO:0034983

peptidyl-lysine deacetylation

18614528

HgeneHDAC4

GO:0045892

negative regulation of transcription, DNA-templated

10869435

HgeneHDAC4

GO:0070932

histone H3 deacetylation

12590135

HgeneHDAC4

GO:0070933

histone H4 deacetylation

12590135


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-GN-A264-06AHDAC4chr2

240274373

-PDE11Achr2

178769914

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000345617ENST00000286063HDAC4chr2

240274373

-PDE11Achr2

178769914

-
Frame-shitENST00000345617ENST00000358450HDAC4chr2

240274373

-PDE11Achr2

178769914

-
5CDS-intronENST00000345617ENST00000450799HDAC4chr2

240274373

-PDE11Achr2

178769914

-
5CDS-5UTRENST00000345617ENST00000409504HDAC4chr2

240274373

-PDE11Achr2

178769914

-
5CDS-intronENST00000345617ENST00000389683HDAC4chr2

240274373

-PDE11Achr2

178769914

-
5CDS-5UTRENST00000345617ENST00000449286HDAC4chr2

240274373

-PDE11Achr2

178769914

-
5CDS-5UTRENST00000345617ENST00000497003HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-3CDSENST00000543185ENST00000286063HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-3CDSENST00000543185ENST00000358450HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-intronENST00000543185ENST00000450799HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-5UTRENST00000543185ENST00000409504HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-intronENST00000543185ENST00000389683HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-5UTRENST00000543185ENST00000449286HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-5UTRENST00000543185ENST00000497003HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-3CDSENST00000541256ENST00000286063HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-3CDSENST00000541256ENST00000358450HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-intronENST00000541256ENST00000450799HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-5UTRENST00000541256ENST00000409504HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-intronENST00000541256ENST00000389683HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-5UTRENST00000541256ENST00000449286HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-5UTRENST00000541256ENST00000497003HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-3CDSENST00000553145ENST00000286063HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-3CDSENST00000553145ENST00000358450HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-intronENST00000553145ENST00000450799HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-5UTRENST00000553145ENST00000409504HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-intronENST00000553145ENST00000389683HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-5UTRENST00000553145ENST00000449286HDAC4chr2

240274373

-PDE11Achr2

178769914

-
intron-5UTRENST00000553145ENST00000497003HDAC4chr2

240274373

-PDE11Achr2

178769914

-

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FusionProtFeatures for HDAC4_PDE11A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HDAC4

P56524

PDE11A

Q9HCR9

Responsible for the deacetylation of lysine residues onthe N-terminal part of the core histones (H2A, H2B, H3 and H4).Histone deacetylation gives a tag for epigenetic repression andplays an important role in transcriptional regulation, cell cycleprogression and developmental events. Histone deacetylases act viathe formation of large multiprotein complexes. Involved in musclematuration via its interaction with the myocyte enhancer factorssuch as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediatedepigenetic regulation of ESR1 expression in breast cancer.Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to theirpreferential binding to co-chaperone STUB1 (PubMed:27708256).{ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532,ECO:0000269|PubMed:27708256}. Plays a role in signal transduction by regulating theintracellular concentration of cyclic nucleotides cAMP and cGMP.Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. {ECO:0000269|PubMed:10725373,ECO:0000269|PubMed:10906126, ECO:0000269|PubMed:11050148}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HDAC4_PDE11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HDAC4_PDE11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HDAC4ZBTB16, SFN, CTBP1, GATA1, RARA, RXRA, NR2C1, NR2C2, AR, PPARD, PPARG, IKZF2, ZNF354A, HDAC9, MEF2A, MEF2C, MEF2D, HDAC4, RBBP4, HDAC3, NCOR1, NCOR2, YWHAE, YWHAG, YWHAZ, BCL6, BCOR, IKZF1, IKZF3, IKZF4, YWHAB, MECOM, SUV39H1, UBE2I, MAPK3, MAPK1, FOXP3, DNAJB6, DNAJB8, ATF2, MORC2, RUNX2, SENP1, CDK5, PARK2, NR1H2, SIN3A, HIF1A, CAMK2D, ESR1, YY1, LZTR1, SS18L1, SP1, REST, MARK3, GATA3, CAMK1, GCM1, NUP214, DNAJB5, SYK, ESCO2, GNB1, CTNNB1, TP53BP1, SRF, SIRT1, LCOR, HNF4A, CDKN1A, RANBP2, SMAD3, YWHAQ, ANKRA2, ATRX, REV3L, MAP1S, RFXANK, CIITA, RFX5, RFXAP, IFRD1, PPP2CA, NFKBIA, NFKBIE, HDAC5, CAMK4, CSRP3, HDAC7, PPP2R4, AHRR, CEBPD, BCORL1, NUP155, ACTA1, NPPB, CACNA1C, ATXN1, HIC1, NFKB1, SF1, KDM5B, ELAVL1, PPP2R1A, STAT1, ZEB2, NFATC1, BRMS1, NACC1, JDP2, ATF3, APP, ZBTB7B, YWHAH, TBL1XR1, MIF4GD, GSK3B, CDR2, GOLGA2, KRT31, KRT38, PNMA1, MTUS2, LDOC1, EFEMP2, RINT1, CCDC136, KRT40, CUL7, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, CGN, DENND1A, SH3PXD2A, SRGAP2, RTKN, EIF4E2, MAST3, SIPA1L1, PPM1H, DENND4C, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, SYDE1, MAPKAP1, NF1, AGAP1, CBY1, CDC25B, CDK16, NADK, CDC25C, FAM110B, USP21, GIGYF2, CAMSAP2, FAM53C, ANKRD34A, LPIN3, TIAM1, KIAA1804, RASAL2, PHLDB2, RALGPS2, FAM110A, PLEKHA7, KIF1C, GAB2, NAV1, MELK, SH3RF3, PTPN14, STARD13, DENND4A, OSBPL6, INPP5E, NR1H3PDE11A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HDAC4_PDE11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHDAC4P56524DB01593ZincHistone deacetylase 4small moleculeapproved|investigational
HgeneHDAC4P56524DB06176RomidepsinHistone deacetylase 4small moleculeapproved|investigational
TgenePDE11AQ9HCR9DB00820TadalafilDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11Asmall moleculeapproved|investigational

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RelatedDiseases for HDAC4_PDE11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHDAC4C0036341Schizophrenia2PSYGENET
HgeneHDAC4C0005695Bladder Neoplasm1CTD_human
HgeneHDAC4C0011570Mental Depression1PSYGENET
HgeneHDAC4C0011616Contact Dermatitis1CTD_human
HgeneHDAC4C0221357Brachydactyly1CTD_human;HPO
HgeneHDAC4C0236736Cocaine-Related Disorders1CTD_human
HgeneHDAC4C0340543Familial primary pulmonary hypertension1CTD_human
HgeneHDAC4C0345967Malignant mesothelioma1CTD_human
HgeneHDAC4C0525045Mood Disorders1PSYGENET
HgeneHDAC4C1862102BRACHYDACTYLY, TYPE E11CTD_human
HgeneHDAC4C2931817Chromosome 2q37 deletion syndrome1CTD_human;ORPHANET
HgeneHDAC4C3714756Intellectual Disability1CTD_human;HPO
TgenePDE11AC0041696Unipolar Depression1PSYGENET
TgenePDE11AC1269683Major Depressive Disorder1PSYGENET