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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15937

FusionGeneSummary for HDAC3_S100B

check button Fusion gene summary
Fusion gene informationFusion gene name: HDAC3_S100B
Fusion gene ID: 15937
HgeneTgene
Gene symbol

HDAC3

S100B

Gene ID

8841

6285

Gene namehistone deacetylase 3S100 calcium binding protein B
SynonymsHD3|RPD3|RPD3-2NEF|S100|S100-B|S100beta
Cytomap

5q31.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionhistone deacetylase 3SMAP45protein S100-BS-100 calcium-binding protein, beta chainS-100 protein subunit betaS100 calcium-binding protein, beta (neural)
Modification date2018052020180522
UniProtAcc

O15379

P04271

Ensembl transtripts involved in fusion geneENST00000305264, ENST00000469207, 
ENST00000367071, ENST00000291700, 
ENST00000397648, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: HDAC3 [Title/Abstract] AND S100B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHDAC3

GO:0000122

negative regulation of transcription by RNA polymerase II

16569215|18417529|18854353

HgeneHDAC3

GO:0001934

positive regulation of protein phosphorylation

25190803

HgeneHDAC3

GO:0006476

protein deacetylation

17172643|21030595

HgeneHDAC3

GO:0031647

regulation of protein stability

25190803

HgeneHDAC3

GO:0042307

positive regulation of protein import into nucleus

25190803

HgeneHDAC3

GO:0045944

positive regulation of transcription by RNA polymerase II

25190803

HgeneHDAC3

GO:0071498

cellular response to fluid shear stress

25190803

TgeneS100B

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

15033494


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV717686HDAC3chr5

141000772

-S100Bchr21

48022311

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000305264ENST00000367071HDAC3chr5

141000772

-S100Bchr21

48022311

-
intron-3CDSENST00000305264ENST00000291700HDAC3chr5

141000772

-S100Bchr21

48022311

-
intron-3CDSENST00000305264ENST00000397648HDAC3chr5

141000772

-S100Bchr21

48022311

-
intron-3CDSENST00000469207ENST00000367071HDAC3chr5

141000772

-S100Bchr21

48022311

-
intron-3CDSENST00000469207ENST00000291700HDAC3chr5

141000772

-S100Bchr21

48022311

-
intron-3CDSENST00000469207ENST00000397648HDAC3chr5

141000772

-S100Bchr21

48022311

-

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FusionProtFeatures for HDAC3_S100B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HDAC3

O15379

S100B

P04271

Responsible for the deacetylation of lysine residues onthe N-terminal part of the core histones (H2A, H2B, H3 and H4),and some other non-histone substrates. Histone deacetylation givesa tag for epigenetic repression and plays an important role intranscriptional regulation, cell cycle progression anddevelopmental events. Histone deacetylases act via the formationof large multiprotein complexes. Participates in the BCL6transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300acetyltransferase activity and repressing proximal geneexpression. Probably participates in the regulation oftranscription through its binding to the zinc-finger transcriptionfactor YY1; increases YY1 repression activity. Required to represstranscription of the POU1F1 transcription factor. Acts as amolecular chaperone for shuttling phosphorylated NR2C1 to PMLbodies for sumoylation (PubMed:21444723, PubMed:23911289).Contributes, together with XBP1 isoform 1, to the activation ofNFE2L2-mediated HMOX1 transcription factor gene expression in aPI(3)K/mTORC2/Akt-dependent signaling pathway leading toendothelial cell (EC) survival under disturbed flow/oxidativestress (PubMed:25190803). {ECO:0000269|PubMed:21444723,ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:25190803}. Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for bothions on each monomer. Physiological concentrations of potassiumion antagonize the binding of both divalent cations, especiallyaffecting high-affinity calcium-binding sites. Binds to andinitiates the activation of STK38 by releasing autoinhibitoryintramolecular interactions within the kinase. Interaction withAGER after myocardial infarction may play a role in myocyteapoptosis by activating ERK1/2 and p53/TP53 signaling. Couldassist ATAD3A cytoplasmic processing, preventing aggregation andfavoring mitochondrial localization. May mediate calcium-dependentregulation on many physiological processes by interacting withother proteins, such as TPR-containing proteins, and modulatingtheir activity. {ECO:0000269|PubMed:20351179,ECO:0000269|PubMed:22399290}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HDAC3_S100B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HDAC3_S100B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HDAC3_S100B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHDAC3O15379DB02546VorinostatHistone deacetylase 3small moleculeapproved|investigational
TgeneS100BP04271DB00768OlopatadineProtein S100-Bsmall moleculeapproved
TgeneS100BP04271DB11093Calcium CitrateProtein S100-Bsmall moleculeapproved
TgeneS100BP04271DB11348Calcium PhosphateProtein S100-Bsmall moleculeapproved
TgeneS100BP04271DB01373CalciumProtein S100-Bsmall moleculeapproved|nutraceutical

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RelatedDiseases for HDAC3_S100B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHDAC3C0036341Schizophrenia4PSYGENET
HgeneHDAC3C0018799Heart Diseases1CTD_human
TgeneS100BC0005586Bipolar Disorder6CTD_human;PSYGENET
TgeneS100BC0011570Mental Depression5PSYGENET
TgeneS100BC0011581Depressive disorder5PSYGENET
TgeneS100BC0041696Unipolar Depression4PSYGENET
TgeneS100BC1269683Major Depressive Disorder4PSYGENET
TgeneS100BC0036341Schizophrenia3PSYGENET
TgeneS100BC0525045Mood Disorders2PSYGENET
TgeneS100BC0013080Down Syndrome1CTD_human
TgeneS100BC0018944Hematoma1CTD_human
TgeneS100BC0027051Myocardial Infarction1CTD_human
TgeneS100BC0033975Psychotic Disorders1PSYGENET
TgeneS100BC0221480Recurrent depression1PSYGENET
TgeneS100BC0236964Attention Deficit and Disruptive Behavior Disorders1CTD_human
TgeneS100BC0751895Vasospasm, Intracranial1CTD_human
TgeneS100BC1527311Brain Edema1CTD_human
TgeneS100BC2937358Cerebral Hemorrhage1CTD_human