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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15936

FusionGeneSummary for HDAC3_NSL1

check button Fusion gene summary
Fusion gene informationFusion gene name: HDAC3_NSL1
Fusion gene ID: 15936
HgeneTgene
Gene symbol

HDAC3

NSL1

Gene ID

8841

284058

Gene namehistone deacetylase 3KAT8 regulatory NSL complex subunit 1
SynonymsHD3|RPD3|RPD3-2CENP-36|KDVS|KIAA1267|MSL1v1|NSL1|hMSL1v1
Cytomap

5q31.3

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionhistone deacetylase 3SMAP45KAT8 regulatory NSL complex subunit 1MLL1/MLL complex subunit KANSL1MSL1 homolog 1NSL complex protein NSL1centromere protein 36male-specific lethal 1 homolognon-specific lethal 1 homolog
Modification date2018052020180523
UniProtAcc

O15379

Q96IY1

Ensembl transtripts involved in fusion geneENST00000305264, ENST00000469207, 
ENST00000366978, ENST00000366977, 
ENST00000422588, ENST00000366975, 
ENST00000366976, ENST00000473995, 
Fusion gene scores* DoF score2 X 2 X 1=46 X 6 X 3=108
# samples 26
** MAII scorelog2(2/4*10)=2.32192809488736log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HDAC3 [Title/Abstract] AND NSL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHDAC3

GO:0000122

negative regulation of transcription by RNA polymerase II

16569215|18417529|18854353

HgeneHDAC3

GO:0001934

positive regulation of protein phosphorylation

25190803

HgeneHDAC3

GO:0006476

protein deacetylation

17172643|21030595

HgeneHDAC3

GO:0031647

regulation of protein stability

25190803

HgeneHDAC3

GO:0042307

positive regulation of protein import into nucleus

25190803

HgeneHDAC3

GO:0045944

positive regulation of transcription by RNA polymerase II

25190803

HgeneHDAC3

GO:0071498

cellular response to fluid shear stress

25190803

TgeneNSL1

GO:0043981

histone H4-K5 acetylation

20018852

TgeneNSL1

GO:0043982

histone H4-K8 acetylation

20018852

TgeneNSL1

GO:0043984

histone H4-K16 acetylation

20018852


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF871741HDAC3chr5

141005639

+NSL1chr1

212923269

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000305264ENST00000366978HDAC3chr5

141005639

+NSL1chr1

212923269

-
intron-intronENST00000305264ENST00000366977HDAC3chr5

141005639

+NSL1chr1

212923269

-
intron-intronENST00000305264ENST00000422588HDAC3chr5

141005639

+NSL1chr1

212923269

-
intron-intronENST00000305264ENST00000366975HDAC3chr5

141005639

+NSL1chr1

212923269

-
intron-intronENST00000305264ENST00000366976HDAC3chr5

141005639

+NSL1chr1

212923269

-
intron-intronENST00000305264ENST00000473995HDAC3chr5

141005639

+NSL1chr1

212923269

-
intron-intronENST00000469207ENST00000366978HDAC3chr5

141005639

+NSL1chr1

212923269

-
intron-intronENST00000469207ENST00000366977HDAC3chr5

141005639

+NSL1chr1

212923269

-
intron-intronENST00000469207ENST00000422588HDAC3chr5

141005639

+NSL1chr1

212923269

-
intron-intronENST00000469207ENST00000366975HDAC3chr5

141005639

+NSL1chr1

212923269

-
intron-intronENST00000469207ENST00000366976HDAC3chr5

141005639

+NSL1chr1

212923269

-
intron-intronENST00000469207ENST00000473995HDAC3chr5

141005639

+NSL1chr1

212923269

-

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FusionProtFeatures for HDAC3_NSL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HDAC3

O15379

NSL1

Q96IY1

Responsible for the deacetylation of lysine residues onthe N-terminal part of the core histones (H2A, H2B, H3 and H4),and some other non-histone substrates. Histone deacetylation givesa tag for epigenetic repression and plays an important role intranscriptional regulation, cell cycle progression anddevelopmental events. Histone deacetylases act via the formationof large multiprotein complexes. Participates in the BCL6transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300acetyltransferase activity and repressing proximal geneexpression. Probably participates in the regulation oftranscription through its binding to the zinc-finger transcriptionfactor YY1; increases YY1 repression activity. Required to represstranscription of the POU1F1 transcription factor. Acts as amolecular chaperone for shuttling phosphorylated NR2C1 to PMLbodies for sumoylation (PubMed:21444723, PubMed:23911289).Contributes, together with XBP1 isoform 1, to the activation ofNFE2L2-mediated HMOX1 transcription factor gene expression in aPI(3)K/mTORC2/Akt-dependent signaling pathway leading toendothelial cell (EC) survival under disturbed flow/oxidativestress (PubMed:25190803). {ECO:0000269|PubMed:21444723,ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:25190803}. Part of the MIS12 complex which is required for normalchromosome alignment and segregation and kinetochore formationduring mitosis. {ECO:0000269|PubMed:16585270}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HDAC3_NSL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HDAC3_NSL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HDAC3_NSL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHDAC3O15379DB02546VorinostatHistone deacetylase 3small moleculeapproved|investigational

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RelatedDiseases for HDAC3_NSL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHDAC3C0036341Schizophrenia4PSYGENET
HgeneHDAC3C0018799Heart Diseases1CTD_human