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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15933

FusionGeneSummary for HDAC2_MATN2

check button Fusion gene summary
Fusion gene informationFusion gene name: HDAC2_MATN2
Fusion gene ID: 15933
HgeneTgene
Gene symbol

HDAC2

MATN2

Gene ID

3066

4147

Gene namehistone deacetylase 2matrilin 2
SynonymsHD2|RPD3|YAF1-
Cytomap

6q21

8q22.1-q22.2

Type of geneprotein-codingprotein-coding
Descriptionhistone deacetylase 2YY1-associated factor 1transcriptional regulator homolog RPD3matrilin-2testis tissue sperm-binding protein Li 94mP
Modification date2018052220180523
UniProtAcc

Q92769

O00339

Ensembl transtripts involved in fusion geneENST00000519065, ENST00000398283, 
ENST00000519108, ENST00000368632, 
ENST00000521689, ENST00000254898, 
ENST00000524308, ENST00000522025, 
ENST00000520016, ENST00000518238, 
Fusion gene scores* DoF score3 X 2 X 2=129 X 8 X 8=576
# samples 310
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/576*10)=-2.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HDAC2 [Title/Abstract] AND MATN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE150381HDAC2chr6

114268997

-MATN2chr8

98898618

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000519065ENST00000521689HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000519065ENST00000254898HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000519065ENST00000524308HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000519065ENST00000522025HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000519065ENST00000520016HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000519065ENST00000518238HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000398283ENST00000521689HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000398283ENST00000254898HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000398283ENST00000524308HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000398283ENST00000522025HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000398283ENST00000520016HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000398283ENST00000518238HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000519108ENST00000521689HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000519108ENST00000254898HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000519108ENST00000524308HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000519108ENST00000522025HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000519108ENST00000520016HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000519108ENST00000518238HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000368632ENST00000521689HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000368632ENST00000254898HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000368632ENST00000524308HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000368632ENST00000522025HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000368632ENST00000520016HDAC2chr6

114268997

-MATN2chr8

98898618

+
intron-intronENST00000368632ENST00000518238HDAC2chr6

114268997

-MATN2chr8

98898618

+

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FusionProtFeatures for HDAC2_MATN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HDAC2

Q92769

MATN2

O00339

Responsible for the deacetylation of lysine residues onthe N-terminal part of the core histones (H2A, H2B, H3 and H4).Histone deacetylation gives a tag for epigenetic repression andplays an important role in transcriptional regulation, cell cycleprogression and developmental events. Histone deacetylases act viathe formation of large multiprotein complexes. Formstranscriptional repressor complexes by associating with MAD, SIN3,YY1 and N-COR. Interacts in the late S-phase of DNA-replicationwith DNMT1 in the other transcriptional repressor complex composedof DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates itstranscriptional repressor activity. Component of aRCOR/GFI/KDM1A/HDAC complex that suppresses, via histonedeacetylase (HDAC) recruitment, a number of genes implicated inmultilineage blood cell development. May be involved in thetranscriptional repression of circadian target genes, such asPER1, mediated by CRY1 through histone deacetylation. Involved inMTA1-mediated transcriptional corepression of TFF1 and CDKN1A.{ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21965678}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HDAC2_MATN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HDAC2_MATN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HDAC2_MATN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHDAC2Q92769DB00277TheophyllineHistone deacetylase 2small moleculeapproved
HgeneHDAC2Q92769DB01223AminophyllineHistone deacetylase 2small moleculeapproved
HgeneHDAC2Q92769DB01303OxtriphyllineHistone deacetylase 2small moleculeapproved
HgeneHDAC2Q92769DB00227LovastatinHistone deacetylase 2small moleculeapproved|investigational
HgeneHDAC2Q92769DB00313Valproic AcidHistone deacetylase 2small moleculeapproved|investigational
HgeneHDAC2Q92769DB02546VorinostatHistone deacetylase 2small moleculeapproved|investigational
HgeneHDAC2Q92769DB06176RomidepsinHistone deacetylase 2small moleculeapproved|investigational
HgeneHDAC2Q92769DB09091TixocortolHistone deacetylase 2small moleculeapproved|withdrawn

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RelatedDiseases for HDAC2_MATN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHDAC2C0024117Chronic Obstructive Airway Disease2CTD_human
HgeneHDAC2C0525045Mood Disorders2PSYGENET
HgeneHDAC2C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneHDAC2C0007137Squamous cell carcinoma1CTD_human
HgeneHDAC2C0011570Mental Depression1PSYGENET
HgeneHDAC2C0014175Endometriosis1CTD_human
HgeneHDAC2C0018800Cardiomegaly1CTD_human
HgeneHDAC2C0023470Myeloid Leukemia1CTD_human
HgeneHDAC2C0025202melanoma1CTD_human
HgeneHDAC2C0033975Psychotic Disorders1PSYGENET
HgeneHDAC2C0036341Schizophrenia1PSYGENET
HgeneHDAC2C0349204Nonorganic psychosis1PSYGENET
HgeneHDAC2C0920269Microsatellite Instability1CTD_human