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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15913

FusionGeneSummary for HCP5_NCR3

check button Fusion gene summary
Fusion gene informationFusion gene name: HCP5_NCR3
Fusion gene ID: 15913
HgeneTgene
Gene symbol

HCP5

NCR3

Gene ID

10866

259197

Gene nameHLA complex P5natural cytotoxicity triggering receptor 3
Synonyms6S2650E|D6S2650E|P5-11C7|CD337|LY117|MALS|NKp30
Cytomap

6p21.33

6p21.33

Type of genencRNAprotein-coding
DescriptionHLA class I histocompatibility antigen protein P5HLA complex P5 (non-protein coding)HLA complex protein P5MHC class I region ORFnatural cytotoxicity triggering receptor 3NK-p30activating NK-A1 receptoractivating natural killer receptor p30lymphocyte antigen 117natural killer cell p30-related protein
Modification date2018051920180523
UniProtAcc

O14931

Ensembl transtripts involved in fusion geneENST00000414046, ENST00000419355, 
ENST00000457127, ENST00000423496, 
ENST00000491161, ENST00000376073, 
ENST00000340027, ENST00000376072, 
ENST00000376071, ENST00000497117, 
ENST00000420556, ENST00000432392, 
ENST00000457547, ENST00000419728, 
ENST00000498490, ENST00000433654, 
ENST00000447248, ENST00000418936, 
ENST00000420485, ENST00000491762, 
ENST00000439584, ENST00000415123, 
ENST00000436623, ENST00000455448, 
ENST00000459657, ENST00000455825, 
ENST00000435674, ENST00000412603, 
ENST00000438663, ENST00000495500, 
ENST00000383478, ENST00000383477, 
ENST00000383476, ENST00000400241, 
ENST00000494590, ENST00000430599, 
ENST00000446756, ENST00000441372, 
ENST00000453657, ENST00000489751, 
ENST00000437517, ENST00000436253, 
ENST00000452296, ENST00000419086, 
Fusion gene scores* DoF score3 X 1 X 3=96 X 3 X 5=90
# samples 36
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HCP5 [Title/Abstract] AND NCR3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNCR3

GO:0002429

immune response-activating cell surface receptor signaling pathway

18852879

TgeneNCR3

GO:0030101

natural killer cell activation

18852879


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDMESOTCGA-XT-AASU-01AHCP5chr6

31368540

+NCR3chr6

31557676

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000414046ENST00000491161HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-5UTRENST00000414046ENST00000376073HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-5UTRENST00000414046ENST00000340027HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-5UTRENST00000414046ENST00000376072HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-5UTRENST00000414046ENST00000376071HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000497117HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000420556HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000432392HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000457547HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000419728HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000498490HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000433654HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000447248HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000418936HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000420485HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000491762HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000439584HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000415123HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000436623HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000455448HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000459657HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000455825HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000435674HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000412603HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000438663HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000495500HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000383478HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000383477HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000383476HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000400241HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000494590HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000430599HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000446756HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000441372HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000453657HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000489751HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000437517HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000436253HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000452296HCP5chr6

31368540

+NCR3chr6

31557676

-
3UTR-intronENST00000414046ENST00000419086HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000419355ENST00000491161HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000419355ENST00000376073HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000419355ENST00000340027HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000419355ENST00000376072HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000419355ENST00000376071HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000497117HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000420556HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000432392HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000457547HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000419728HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000498490HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000433654HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000447248HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000418936HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000420485HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000491762HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000439584HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000415123HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000436623HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000455448HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000459657HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000455825HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000435674HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000412603HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000438663HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000495500HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000383478HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000383477HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000383476HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000400241HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000494590HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000430599HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000446756HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000441372HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000453657HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000489751HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000437517HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000436253HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000452296HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000419355ENST00000419086HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000457127ENST00000491161HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000457127ENST00000376073HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000457127ENST00000340027HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000457127ENST00000376072HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000457127ENST00000376071HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000497117HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000420556HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000432392HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000457547HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000419728HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000498490HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000433654HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000447248HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000418936HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000420485HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000491762HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000439584HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000415123HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000436623HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000455448HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000459657HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000455825HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000435674HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000412603HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000438663HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000495500HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000383478HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000383477HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000383476HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000400241HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000494590HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000430599HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000446756HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000441372HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000453657HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000489751HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000437517HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000436253HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000452296HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000457127ENST00000419086HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000423496ENST00000491161HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000423496ENST00000376073HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000423496ENST00000340027HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000423496ENST00000376072HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-5UTRENST00000423496ENST00000376071HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000497117HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000420556HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000432392HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000457547HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000419728HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000498490HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000433654HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000447248HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000418936HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000420485HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000491762HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000439584HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000415123HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000436623HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000455448HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000459657HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000455825HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000435674HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000412603HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000438663HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000495500HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000383478HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000383477HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000383476HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000400241HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000494590HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000430599HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000446756HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000441372HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000453657HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000489751HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000437517HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000436253HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000452296HCP5chr6

31368540

+NCR3chr6

31557676

-
intron-intronENST00000423496ENST00000419086HCP5chr6

31368540

+NCR3chr6

31557676

-

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FusionProtFeatures for HCP5_NCR3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HCP5

NCR3

O14931

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HCP5_NCR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HCP5_NCR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HCP5APPNCR3CD59, BAG6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HCP5_NCR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HCP5_NCR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource