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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 15908

FusionGeneSummary for HCN1_SPEF2

check button Fusion gene summary
Fusion gene informationFusion gene name: HCN1_SPEF2
Fusion gene ID: 15908
HgeneTgene
Gene symbol

HCN1

SPEF2

Gene ID

348980

79925

Gene namehyperpolarization activated cyclic nucleotide gated potassium channel 1sperm flagellar 2
SynonymsBCNG-1|BCNG1|EIEE24|HAC-2CT122|KPL2
Cytomap

5p12

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionpotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1brain cyclic nucleotide-gated channel 1sperm flagellar protein 2cancer/testis antigen 122testis tissue sperm-binding protein Li 47a
Modification date2018052220180519
UniProtAcc

O60741

Q9C093

Ensembl transtripts involved in fusion geneENST00000303230, ENST00000282469, 
ENST00000509059, ENST00000356031, 
ENST00000440995, ENST00000303129, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 9 X 11=693
# samples 213
** MAII scorelog2(2/8*10)=1.32192809488736log2(13/693*10)=-2.41434372910876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HCN1 [Title/Abstract] AND SPEF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHCN1

GO:0051289

protein homotetramerization

28086084

HgeneHCN1

GO:0071320

cellular response to cAMP

22748890


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D3-A1Q3-06AHCN1chr5

45645287

-SPEF2chr5

35667174

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000303230ENST00000282469HCN1chr5

45645287

-SPEF2chr5

35667174

+
In-frameENST00000303230ENST00000509059HCN1chr5

45645287

-SPEF2chr5

35667174

+
In-frameENST00000303230ENST00000356031HCN1chr5

45645287

-SPEF2chr5

35667174

+
In-frameENST00000303230ENST00000440995HCN1chr5

45645287

-SPEF2chr5

35667174

+
5CDS-intronENST00000303230ENST00000303129HCN1chr5

45645287

-SPEF2chr5

35667174

+

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FusionProtFeatures for HCN1_SPEF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HCN1

O60741

SPEF2

Q9C093

Hyperpolarization-activated ion channel exhibiting weakselectivity for potassium over sodium ions (PubMed:28086084).Contributes to the native pacemaker currents in heart (If) and inneurons (Ih). May mediate responses to sour stimuli.{ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084}. Required for correct axoneme development. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-281_80283891Compositional biasNote=Gly-rich
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-281_93283891RegionIntrinsically disordered
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28165_173283891Topological domainExtracellular
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28195_215283891Topological domainCytoplasmic
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-281_142283891Topological domainCytoplasmic
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28237_260283891Topological domainExtracellular
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28143_164283891TransmembraneHelical%3B Name%3DSegment S1
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28174_194283891TransmembraneHelical%3B Name%3DSegment S2
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28216_236283891TransmembraneHelical%3B Name%3DSegment S3
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28261_281283891TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneSPEF2chr5:45645287chr5:35667174ENST00000282469+7101686_1712389515Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000282469+710732_758389515Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000282469+710871_909389515Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000303129+0131686_1712-75620Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000303129+013227_260-75620Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000303129+013321_396-75620Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000303129+013732_758-75620Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000303129+013871_909-75620Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000356031+7371686_17123891823Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000356031+737732_7583891823Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000356031+737871_9093891823Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000440995+7371686_17123891819Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000440995+737732_7583891819Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000440995+737871_9093891819Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000303129+0131_105-75620DomainCalponin-homology (CH)

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28726_756283891Compositional biasNote=Gln-rich
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28857_863283891Compositional biasNote=Poly-Pro
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28345_366283891IntramembranePore-forming%3B Name%3DSegment H5
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28358_362283891MotifSelectivity filter
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28539_542283891Nucleotide bindingcAMP
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28549_550283891Nucleotide bindingcAMP
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28590_593283891Nucleotide bindingcAMP
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28282_295283891Topological domainCytoplasmic
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28319_344283891Topological domainExtracellular
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28367_371283891Topological domainExtracellular
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28393_890283891Topological domainCytoplasmic
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28296_318283891TransmembraneHelical%3B Name%3DSegment S5
HgeneHCN1chr5:45645287chr5:35667174ENST00000303230-28372_392283891TransmembraneHelical%3B Name%3DSegment S6
TgeneSPEF2chr5:45645287chr5:35667174ENST00000282469+710227_260389515Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000282469+710321_396389515Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000356031+737227_2603891823Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000356031+737321_3963891823Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000440995+737227_2603891819Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000440995+737321_3963891819Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:45645287chr5:35667174ENST00000282469+7101_105389515DomainCalponin-homology (CH)
TgeneSPEF2chr5:45645287chr5:35667174ENST00000356031+7371_1053891823DomainCalponin-homology (CH)
TgeneSPEF2chr5:45645287chr5:35667174ENST00000440995+7371_1053891819DomainCalponin-homology (CH)


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FusionGeneSequence for HCN1_SPEF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_HCN1_ENST00000303230_chr5_45645287_-_SPEF2_ENST00000282469_chr5_35667174_+_409aa
MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGGGGGGEEPAGGFEDAEGPRRQ
YGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNV
ASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLR
LSRLIRYIHQWEEALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELF

>In-frame_HCN1_ENST00000303230_chr5_45645287_-_SPEF2_ENST00000509059_chr5_35667174_+_838aa
MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGGGGGGEEPAGGFEDAEGPRRQ
YGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNV
ASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLR
LSRLIRYIHQWEEALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELF
FNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELP
SFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSD
EVLPETEGANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEAL
TGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRD
QIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPE

>In-frame_HCN1_ENST00000303230_chr5_45645287_-_SPEF2_ENST00000356031_chr5_35667174_+_1717aa
MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGGGGGGEEPAGGFEDAEGPRRQ
YGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNV
ASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLR
LSRLIRYIHQWEEALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELF
FNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELP
SFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSD
EVLPETEGETMLSANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQL
LEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGD
QNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPP
APPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPK
PGSEEWVYVNEPVPEEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDDLW
DDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNK
RFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRL
MEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFR
LELIKTKALALLEDLVTKVVDVYKLMEKWLGERYLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGNIKVFPDPPPSIRPPPV
EKEEDGTLTIEQLDSLRDQFLDMAPKGIIGNKAFTDILIDLVTLNLGTNNFPSNWMHLTQPELQELTSLLTVNSEFVDWRKFLLVTSMPW
PIPLEEELLETLQKFKAVDKEQLGTITFEQYMQAGLWFTGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADYEKDPPQLDYTQMLLYFA
CHPDTVEGVYRALSVAVGTHVFQQVKASIPSAEKTSSTDAGPAEEFPEPEENAAREERKLKDDTEKREQKDEEIPENANNEKMSMETLLK
VFKGGSEAQDSNRFASHLKIENIYAEGFIKTFQDLGAKNLEPIEVAVLLKHPFIQDLISNYSDYKFPDIKIILQRSEHVQGSDGERSPSR

>In-frame_HCN1_ENST00000303230_chr5_45645287_-_SPEF2_ENST00000440995_chr5_35667174_+_1713aa
MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGGGGGGEEPAGGFEDAEGPRRQ
YGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNV
ASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLR
LSRLIRYIHQWEEALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELF
FNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELP
SFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSD
EVLPETEGANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEAL
TGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRD
QIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPE
PEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEE
WVYVNEPVPEEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDDLWDDEET
KAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRI
PLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEK
ENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFRLELIK
TKALALLEDLVTKVVDVYKLMEKWLGERYLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGNIKVFPDPPPSIRPPPVEKEED
GTLTIEQLDSLRDQFLDMAPKGIIGNKAFTDILIDLVTLNLGTNNFPSNWMHLTQPELQELTSLLTVNSEFVDWRKFLLVTSMPWPIPLE
EELLETLQKFKAVDKEQLGTITFEQYMQAGLWFTGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADYEKDPPQLDYTQMLLYFACHPDT
VEGVYRALSVAVGTHVFQQVKASIPSAEKTSSTDAGPAEEFPEPEENAAREERKLKDDTEKREQKDEEIPENANNEKMSMETLLKVFKGG
SEAQDSNRFASHLKIENIYAEGFIKTFQDLGAKNLEPIEVAVLLKHPFIQDLISNYSDYKFPVHIIYVVEMIVCAKGWAPLPSGKQCARW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_HCN1_ENST00000303230_chr5_45645287_-_SPEF2_ENST00000282469_chr5_35667174_+_1227nt
ATGGAAGGAGGCGGCAAGCCCAACTCTTCGTCTAACAGCCGGGACGATGGCAACAGCGTCTTCCCCGCCAAGGCGTCCGCGACGGGCGCG
GGGCCGGCCGCGGCCGAGAAGCGCCTGGGCACCCCGCCGGGGGGCGGCGGGGCCGGCGCGAAGGAGCACGGCAACTCCGTGTGCTTCAAG
GTGGACGGCGGTGGCGGCGGTGGCGGCGGCGGCGGCGGCGGCGAGGAGCCGGCGGGGGGCTTCGAAGACGCCGAGGGGCCCCGGCGGCAG
TACGGCTTCATGCAGAGGCAGTTCACCTCCATGCTGCAGCCCGGGGTCAACAAATTCTCCCTCCGCATGTTTGGGAGCCAGAAGGCGGTG
GAAAAGGAGCAGGAAAGGGTTAAAACTGCAGGCTTCTGGATTATCCACCCTTACAGTGATTTCAGGTTTTACTGGGATTTAATAATGCTT
ATAATGATGGTTGGAAATCTAGTCATCATACCAGTTGGAATCACATTCTTTACAGAGCAAACAACAACACCATGGATTATTTTCAATGTG
GCATCAGATACAGTTTTCCTATTGGACCTGATCATGAATTTTAGGACTGGGACTGTCAATGAAGACAGTTCTGAAATCATCCTGGACCCC
AAAGTGATCAAGATGAATTATTTAAAAAGCTGGTTTGTGGTTGACTTCATCTCATCCATCCCAGTGGATTATATCTTTCTTATTGTAGAA
AAAGGAATGGATTCTGAAGTTTACAAGACAGCCAGGGCACTTCGCATTGTGAGGTTTACAAAAATTCTCAGTCTCTTGCGTTTATTACGA
CTTTCAAGGTTAATTAGATACATACATCAATGGGAAGAGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAA
AAGAGATTTCATGATCAGATTGCTGTGGAAAGAGCTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATA
GTTGATTTGTCCACTAAAGTGGCAGACTATCGAATGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTT
TTTAATGCAAAACCCATATATGAACAAGCCTCTGTTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGG

>In-frame_HCN1_ENST00000303230_chr5_45645287_-_SPEF2_ENST00000509059_chr5_35667174_+_2514nt
ATGGAAGGAGGCGGCAAGCCCAACTCTTCGTCTAACAGCCGGGACGATGGCAACAGCGTCTTCCCCGCCAAGGCGTCCGCGACGGGCGCG
GGGCCGGCCGCGGCCGAGAAGCGCCTGGGCACCCCGCCGGGGGGCGGCGGGGCCGGCGCGAAGGAGCACGGCAACTCCGTGTGCTTCAAG
GTGGACGGCGGTGGCGGCGGTGGCGGCGGCGGCGGCGGCGGCGAGGAGCCGGCGGGGGGCTTCGAAGACGCCGAGGGGCCCCGGCGGCAG
TACGGCTTCATGCAGAGGCAGTTCACCTCCATGCTGCAGCCCGGGGTCAACAAATTCTCCCTCCGCATGTTTGGGAGCCAGAAGGCGGTG
GAAAAGGAGCAGGAAAGGGTTAAAACTGCAGGCTTCTGGATTATCCACCCTTACAGTGATTTCAGGTTTTACTGGGATTTAATAATGCTT
ATAATGATGGTTGGAAATCTAGTCATCATACCAGTTGGAATCACATTCTTTACAGAGCAAACAACAACACCATGGATTATTTTCAATGTG
GCATCAGATACAGTTTTCCTATTGGACCTGATCATGAATTTTAGGACTGGGACTGTCAATGAAGACAGTTCTGAAATCATCCTGGACCCC
AAAGTGATCAAGATGAATTATTTAAAAAGCTGGTTTGTGGTTGACTTCATCTCATCCATCCCAGTGGATTATATCTTTCTTATTGTAGAA
AAAGGAATGGATTCTGAAGTTTACAAGACAGCCAGGGCACTTCGCATTGTGAGGTTTACAAAAATTCTCAGTCTCTTGCGTTTATTACGA
CTTTCAAGGTTAATTAGATACATACATCAATGGGAAGAGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAA
AAGAGATTTCATGATCAGATTGCTGTGGAAAGAGCTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATA
GTTGATTTGTCCACTAAAGTGGCAGACTATCGAATGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTT
TTTAATGCAAAACCCATATATGAACAAGCCTCTGTTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGG
GACTTGCTAGATACCAATGATTATGAAGAATATAAGAACATGGTTGGAGAGTGGGCCTTACCAGAAGAAATGGTTGACAATTTACCACCC
TCCAACAATTGCATACTGGGCCATATTCTTCACAGGCTAGCTGAAAAATCTCTTCCTCCTCGAGCGGAATCAACAACACCTGAATTACCT
TCATTTGCTGTTAAAGGATGCTTATTGGGGAAAACATTAAGTGGAAAAACTACCATTTTAAGGTCTCTACAAAAAGACTTTCCTATACAG
ATACTTTCTATTGACACTCTTGTCCAAGAAGCTATCCAAGCATTTCATGACAATGAAAAAGTCAGTGAGGTTCTACCAATTCAGAAAAAT
GATGAAGAAGATGCTCTACCAGTTCTGCAAGAGGAGATTAAAGAAAGCCAGGATCCACAACATGTATTTTCAGCTGGTCCAGTTTCAGAT
GAAGTATTACCAGAAACAGAAGGTGCTAATGCTGATAAAACACCAAAAGCTGAAGAAGTCAAATCAAGTGATAGTTTCTTAAAACTCACT
ACACGTGCTCAGCTTGGTGCAAAATCAGAACAGTTGCTGAAGAAAGGAAAGAGCATTCCTGATGTGCTGCTTGTTGACATCATAGTAAAT
GCTATTAATGAGATACCTGTGAATCAAGACTGTATCCTAGATGGTTTTCCAATGACTTTAAACCAAGCACAGCTTCTGGAAGAAGCTCTT
ACAGGCTGCAATAGAAACCTCACAGAAGTGGAAAGAAAAAAAGCACAAAAATCCACATTGGCTATTGATCCTGCGACTTCCAAAGAAATA
CCTCTTCCCTCTCCTGCATTTGATTTTGTCATATTATTAGATGTTTCAGATACTTCCTCAATGAGTCGCATGAATGATATTATAGCTGAA
GAATTGTCCTATAAAACTGCTCACGAAGATATCAGTCAACGTGTAGCTGCTGAAAACCAAGATAAGGATGGAGACCAAAATTTAAGAGAC
CAGATACAACATAGAATTATAGGCTTCTTGGACAACTGGCCTTTATTGGAGCAATGGTTTTCAGAGCCAGAAAATATTTTGATAAAAATC
AATGCTGAAATAGATAAGGAATCTTTATGTGAAAAAGTAAAAGAAATTCTTACGACTGAAATAGCAAAAAAAAAGAATAAAGTTGAGAAG
AAATTAGAAGAAAAGGAAGCTGAGAAAAAAGCAGCAGCTTCCCTGGCTGAGCTTCCACTTCCTACACCTCCTCCTGCTCCTCCTCCTGAA

>In-frame_HCN1_ENST00000303230_chr5_45645287_-_SPEF2_ENST00000356031_chr5_35667174_+_5151nt
ATGGAAGGAGGCGGCAAGCCCAACTCTTCGTCTAACAGCCGGGACGATGGCAACAGCGTCTTCCCCGCCAAGGCGTCCGCGACGGGCGCG
GGGCCGGCCGCGGCCGAGAAGCGCCTGGGCACCCCGCCGGGGGGCGGCGGGGCCGGCGCGAAGGAGCACGGCAACTCCGTGTGCTTCAAG
GTGGACGGCGGTGGCGGCGGTGGCGGCGGCGGCGGCGGCGGCGAGGAGCCGGCGGGGGGCTTCGAAGACGCCGAGGGGCCCCGGCGGCAG
TACGGCTTCATGCAGAGGCAGTTCACCTCCATGCTGCAGCCCGGGGTCAACAAATTCTCCCTCCGCATGTTTGGGAGCCAGAAGGCGGTG
GAAAAGGAGCAGGAAAGGGTTAAAACTGCAGGCTTCTGGATTATCCACCCTTACAGTGATTTCAGGTTTTACTGGGATTTAATAATGCTT
ATAATGATGGTTGGAAATCTAGTCATCATACCAGTTGGAATCACATTCTTTACAGAGCAAACAACAACACCATGGATTATTTTCAATGTG
GCATCAGATACAGTTTTCCTATTGGACCTGATCATGAATTTTAGGACTGGGACTGTCAATGAAGACAGTTCTGAAATCATCCTGGACCCC
AAAGTGATCAAGATGAATTATTTAAAAAGCTGGTTTGTGGTTGACTTCATCTCATCCATCCCAGTGGATTATATCTTTCTTATTGTAGAA
AAAGGAATGGATTCTGAAGTTTACAAGACAGCCAGGGCACTTCGCATTGTGAGGTTTACAAAAATTCTCAGTCTCTTGCGTTTATTACGA
CTTTCAAGGTTAATTAGATACATACATCAATGGGAAGAGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAA
AAGAGATTTCATGATCAGATTGCTGTGGAAAGAGCTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATA
GTTGATTTGTCCACTAAAGTGGCAGACTATCGAATGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTT
TTTAATGCAAAACCCATATATGAACAAGCCTCTGTTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGG
GACTTGCTAGATACCAATGATTATGAAGAATATAAGAACATGGTTGGAGAGTGGGCCTTACCAGAAGAAATGGTTGACAATTTACCACCC
TCCAACAATTGCATACTGGGCCATATTCTTCACAGGCTAGCTGAAAAATCTCTTCCTCCTCGAGCGGAATCAACAACACCTGAATTACCT
TCATTTGCTGTTAAAGGATGCTTATTGGGGAAAACATTAAGTGGAAAAACTACCATTTTAAGGTCTCTACAAAAAGACTTTCCTATACAG
ATACTTTCTATTGACACTCTTGTCCAAGAAGCTATCCAAGCATTTCATGACAATGAAAAAGTCAGTGAGGTTCTACCAATTCAGAAAAAT
GATGAAGAAGATGCTCTACCAGTTCTGCAAGAGGAGATTAAAGAAAGCCAGGATCCACAACATGTATTTTCAGCTGGTCCAGTTTCAGAT
GAAGTATTACCAGAAACAGAAGGTGAAACAATGCTTAGTGCTAATGCTGATAAAACACCAAAAGCTGAAGAAGTCAAATCAAGTGATAGT
TTCTTAAAACTCACTACACGTGCTCAGCTTGGTGCAAAATCAGAACAGTTGCTGAAGAAAGGAAAGAGCATTCCTGATGTGCTGCTTGTT
GACATCATAGTAAATGCTATTAATGAGATACCTGTGAATCAAGACTGTATCCTAGATGGTTTTCCAATGACTTTAAACCAAGCACAGCTT
CTGGAAGAAGCTCTTACAGGCTGCAATAGAAACCTCACAGAAGTGGAAAGAAAAAAAGCACAAAAATCCACATTGGCTATTGATCCTGCG
ACTTCCAAAGAAATACCTCTTCCCTCTCCTGCATTTGATTTTGTCATATTATTAGATGTTTCAGATACTTCCTCAATGAGTCGCATGAAT
GATATTATAGCTGAAGAATTGTCCTATAAAACTGCTCACGAAGATATCAGTCAACGTGTAGCTGCTGAAAACCAAGATAAGGATGGAGAC
CAAAATTTAAGAGACCAGATACAACATAGAATTATAGGCTTCTTGGACAACTGGCCTTTATTGGAGCAATGGTTTTCAGAGCCAGAAAAT
ATTTTGATAAAAATCAATGCTGAAATAGATAAGGAATCTTTATGTGAAAAAGTAAAAGAAATTCTTACGACTGAAATAGCAAAAAAAAAG
AATAAAGTTGAGAAGAAATTAGAAGAAAAGGAAGCTGAGAAAAAAGCAGCAGCTTCCCTGGCTGAGCTTCCACTTCCTACACCTCCTCCT
GCTCCTCCTCCTGAACCAGAAAAAGAGAAGGAAATTCATCAAAGCCATGTGGCTTCAAAAACTCCTACTGCAAAAGGAAAACCTCAATCA
GAAGCCCCGCATGGTAAGCAAGAATCTCTTCAGGAAGGAAAAGGGAAGAAAGGTGAGACCGCACTCAAAAGAAAAGGTTCTCCTAAAGGA
AAATCATCAGGAGGAAAAGTACCAGTAAAGAAATCACCTGCTGACTCTACAGATACATCACCTGTTGCAATAGTGCCACAGCCACCTAAG
CCAGGATCAGAAGAATGGGTCTATGTGAATGAACCAGTTCCTGAGGAAATGCCTTTGTTTTTAGTACCTTACTGGGAACTAATAGAAAAT
TCCTATATAAACACCATCAAAACAGTACTCAGGCATCTGAGGGAAGACCAGCATACTGTGCTTGCTTACTTATATGAGATTAGAACAAGT
TTCCAGGAGTTTCTAAAGCGTCCGGATCACAAGCAAGATTTTGTAGCTCAATGGCAGGCTGATTTCAACTCCCTTCCTGATGACCTGTGG
GATGATGAGGAAACAAAGGCTGAACTACATCAACGAGTGAATGATCTGCGAGACCGCCTGTGGGACATTTGTGATGCCCGGAAGGAAGAG
GCGGAGCAGGAGCGGCTTGACATCATTAATGAGAGCTGGTTACAGGACACTCTTGGAATGACAATGAACCATTTCTTTTCCCTGATGCAG
GCAGAGCTGAACCGTTTCCAAGATACAAAGAGACTCCTTCAAGATTATTACTGGGGAATGGAAAGTAAAATCCCAGTAGAGGACAACAAG
AGATTTACTCGAATCCCTTTGGTCCAACTGGATAGTAAAGACAATTCTGAAAGCCAGCTTAGAATTCCTCTAGTTCCTCGAATATCCATT
TCTCTGGAAACAGTTACACCCAAACCAAAAACAAAATCAGTACTGAAGGGCAAGATGGATAACTCCCTAGAAAACGTTGAGTCCAACTTT
GAGGCCGATGAAAAGTTGGTCATGGACACCTGGCAGCAGGCTTCTTTAGCAGTATCTCACATGGTGGCTGCTGAAATTCATCAGAGGCTT
ATGGAAGAAGAAAAAGAAAACCAGCCAGCAGACCCCAAAGAAAAATCTCCTCAGATGGGTGCAAATAAAAAAGTCAAAAAGGAGCCACCC
AAGAAAAAACAGGAAGACAAAAAACCCAAAGGTAAATCACCACCTATGGCAGAAGCAACTCCTGTCATAGTAACAACAGAGGAAATTGCT
GAAATCAAAAGGAAAAATGAACTGAGGGTCAAAATAAAAGAAGAACACCTTGCTGCCTTGCAATTTGAAGAAATAGCCACGCAATTTCGA
CTTGAACTGATAAAGACAAAAGCATTGGCTCTTCTTGAAGATTTAGTAACAAAGGTGGTTGATGTATATAAACTCATGGAAAAATGGCTT
GGTGAGAGGTATTTGAATGAAATGGCCAGTACAGAAAAATTAACTGACGTAGCTCGCTATCACATTGAAACATCTACAAAAATTCAGAAT
GAACTTTATTTAAGCCAAGAAGACTTCTTCATTAATGGCAATATAAAAGTCTTCCCAGATCCTCCCCCATCAATACGTCCTCCACCTGTA
GAAAAGGAAGAAGATGGTACCCTGACCATTGAACAGCTTGACAGTCTTCGAGATCAGTTCTTAGATATGGCACCTAAAGGCATAATAGGA
AATAAAGCATTTACTGACATTCTGATCGATTTGGTGACCCTGAACCTTGGCACAAACAACTTTCCTAGTAATTGGATGCACCTTACCCAA
CCTGAATTACAGGAATTAACATCTTTATTAACAGTCAACTCCGAGTTCGTGGACTGGCGGAAGTTCCTGTTAGTAACCTCAATGCCTTGG
CCCATTCCCTTGGAGGAGGAGCTCCTTGAGACCCTTCAGAAGTTCAAGGCTGTGGATAAGGAGCAGTTGGGCACCATCACTTTTGAGCAG
TATATGCAGGCTGGTCTGTGGTTTACAGGAGATGAAGATATAAAAATTCCAGAAAATCCTCTTGAACCCCTTCCATTTAATAGGCAGGAG
CATCTTATAGAGTTTTTCTTTAGGCTATTTGCTGACTATGAGAAGGATCCACCCCAGCTTGACTACACACAGATGCTGCTTTACTTTGCT
TGCCACCCAGACACCGTGGAAGGAGTCTACAGGGCCCTCAGTGTGGCTGTTGGAACTCATGTCTTCCAACAAGTCAAAGCTTCCATTCCA
AGTGCAGAAAAGACCTCCTCAACTGATGCAGGTCCAGCTGAGGAATTTCCTGAACCTGAGGAAAATGCTGCAAGAGAAGAAAGGAAATTA
AAAGACGACACGGAGAAAAGGGAACAGAAGGATGAAGAAATCCCTGAAAATGCAAACAATGAAAAGATGTCCATGGAAACACTACTCAAA
GTGTTCAAAGGGGGAAGTGAAGCACAGGACTCCAATAGATTTGCCAGCCACCTAAAGATAGAGAACATTTATGCAGAGGGCTTCATAAAA
ACATTTCAAGACCTAGGTGCCAAGAACCTGGAGCCAATTGAAGTCGCTGTTCTCTTGAAGCATCCTTTTATTCAAGACCTGATTTCAAAT
TATTCAGACTATAAGTTTCCTGATATTAAAATAATTCTCCAAAGGAGTGAACATGTACAAGGAAGTGATGGAGAGAGATCACCTTCAAGA

>In-frame_HCN1_ENST00000303230_chr5_45645287_-_SPEF2_ENST00000440995_chr5_35667174_+_5139nt
ATGGAAGGAGGCGGCAAGCCCAACTCTTCGTCTAACAGCCGGGACGATGGCAACAGCGTCTTCCCCGCCAAGGCGTCCGCGACGGGCGCG
GGGCCGGCCGCGGCCGAGAAGCGCCTGGGCACCCCGCCGGGGGGCGGCGGGGCCGGCGCGAAGGAGCACGGCAACTCCGTGTGCTTCAAG
GTGGACGGCGGTGGCGGCGGTGGCGGCGGCGGCGGCGGCGGCGAGGAGCCGGCGGGGGGCTTCGAAGACGCCGAGGGGCCCCGGCGGCAG
TACGGCTTCATGCAGAGGCAGTTCACCTCCATGCTGCAGCCCGGGGTCAACAAATTCTCCCTCCGCATGTTTGGGAGCCAGAAGGCGGTG
GAAAAGGAGCAGGAAAGGGTTAAAACTGCAGGCTTCTGGATTATCCACCCTTACAGTGATTTCAGGTTTTACTGGGATTTAATAATGCTT
ATAATGATGGTTGGAAATCTAGTCATCATACCAGTTGGAATCACATTCTTTACAGAGCAAACAACAACACCATGGATTATTTTCAATGTG
GCATCAGATACAGTTTTCCTATTGGACCTGATCATGAATTTTAGGACTGGGACTGTCAATGAAGACAGTTCTGAAATCATCCTGGACCCC
AAAGTGATCAAGATGAATTATTTAAAAAGCTGGTTTGTGGTTGACTTCATCTCATCCATCCCAGTGGATTATATCTTTCTTATTGTAGAA
AAAGGAATGGATTCTGAAGTTTACAAGACAGCCAGGGCACTTCGCATTGTGAGGTTTACAAAAATTCTCAGTCTCTTGCGTTTATTACGA
CTTTCAAGGTTAATTAGATACATACATCAATGGGAAGAGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAA
AAGAGATTTCATGATCAGATTGCTGTGGAAAGAGCTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATA
GTTGATTTGTCCACTAAAGTGGCAGACTATCGAATGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTT
TTTAATGCAAAACCCATATATGAACAAGCCTCTGTTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGG
GACTTGCTAGATACCAATGATTATGAAGAATATAAGAACATGGTTGGAGAGTGGGCCTTACCAGAAGAAATGGTTGACAATTTACCACCC
TCCAACAATTGCATACTGGGCCATATTCTTCACAGGCTAGCTGAAAAATCTCTTCCTCCTCGAGCGGAATCAACAACACCTGAATTACCT
TCATTTGCTGTTAAAGGATGCTTATTGGGGAAAACATTAAGTGGAAAAACTACCATTTTAAGGTCTCTACAAAAAGACTTTCCTATACAG
ATACTTTCTATTGACACTCTTGTCCAAGAAGCTATCCAAGCATTTCATGACAATGAAAAAGTCAGTGAGGTTCTACCAATTCAGAAAAAT
GATGAAGAAGATGCTCTACCAGTTCTGCAAGAGGAGATTAAAGAAAGCCAGGATCCACAACATGTATTTTCAGCTGGTCCAGTTTCAGAT
GAAGTATTACCAGAAACAGAAGGTGCTAATGCTGATAAAACACCAAAAGCTGAAGAAGTCAAATCAAGTGATAGTTTCTTAAAACTCACT
ACACGTGCTCAGCTTGGTGCAAAATCAGAACAGTTGCTGAAGAAAGGAAAGAGCATTCCTGATGTGCTGCTTGTTGACATCATAGTAAAT
GCTATTAATGAGATACCTGTGAATCAAGACTGTATCCTAGATGGTTTTCCAATGACTTTAAACCAAGCACAGCTTCTGGAAGAAGCTCTT
ACAGGCTGCAATAGAAACCTCACAGAAGTGGAAAGAAAAAAAGCACAAAAATCCACATTGGCTATTGATCCTGCGACTTCCAAAGAAATA
CCTCTTCCCTCTCCTGCATTTGATTTTGTCATATTATTAGATGTTTCAGATACTTCCTCAATGAGTCGCATGAATGATATTATAGCTGAA
GAATTGTCCTATAAAACTGCTCACGAAGATATCAGTCAACGTGTAGCTGCTGAAAACCAAGATAAGGATGGAGACCAAAATTTAAGAGAC
CAGATACAACATAGAATTATAGGCTTCTTGGACAACTGGCCTTTATTGGAGCAATGGTTTTCAGAGCCAGAAAATATTTTGATAAAAATC
AATGCTGAAATAGATAAGGAATCTTTATGTGAAAAAGTAAAAGAAATTCTTACGACTGAAATAGCAAAAAAAAAGAATAAAGTTGAGAAG
AAATTAGAAGAAAAGGAAGCTGAGAAAAAAGCAGCAGCTTCCCTGGCTGAGCTTCCACTTCCTACACCTCCTCCTGCTCCTCCTCCTGAA
CCAGAAAAAGAGAAGGAAATTCATCAAAGCCATGTGGCTTCAAAAACTCCTACTGCAAAAGGAAAACCTCAATCAGAAGCCCCGCATGGT
AAGCAAGAATCTCTTCAGGAAGGAAAAGGGAAGAAAGGTGAGACCGCACTCAAAAGAAAAGGTTCTCCTAAAGGAAAATCATCAGGAGGA
AAAGTACCAGTAAAGAAATCACCTGCTGACTCTACAGATACATCACCTGTTGCAATAGTGCCACAGCCACCTAAGCCAGGATCAGAAGAA
TGGGTCTATGTGAATGAACCAGTTCCTGAGGAAATGCCTTTGTTTTTAGTACCTTACTGGGAACTAATAGAAAATTCCTATATAAACACC
ATCAAAACAGTACTCAGGCATCTGAGGGAAGACCAGCATACTGTGCTTGCTTACTTATATGAGATTAGAACAAGTTTCCAGGAGTTTCTA
AAGCGTCCGGATCACAAGCAAGATTTTGTAGCTCAATGGCAGGCTGATTTCAACTCCCTTCCTGATGACCTGTGGGATGATGAGGAAACA
AAGGCTGAACTACATCAACGAGTGAATGATCTGCGAGACCGCCTGTGGGACATTTGTGATGCCCGGAAGGAAGAGGCGGAGCAGGAGCGG
CTTGACATCATTAATGAGAGCTGGTTACAGGACACTCTTGGAATGACAATGAACCATTTCTTTTCCCTGATGCAGGCAGAGCTGAACCGT
TTCCAAGATACAAAGAGACTCCTTCAAGATTATTACTGGGGAATGGAAAGTAAAATCCCAGTAGAGGACAACAAGAGATTTACTCGAATC
CCTTTGGTCCAACTGGATAGTAAAGACAATTCTGAAAGCCAGCTTAGAATTCCTCTAGTTCCTCGAATATCCATTTCTCTGGAAACAGTT
ACACCCAAACCAAAAACAAAATCAGTACTGAAGGGCAAGATGGATAACTCCCTAGAAAACGTTGAGTCCAACTTTGAGGCCGATGAAAAG
TTGGTCATGGACACCTGGCAGCAGGCTTCTTTAGCAGTATCTCACATGGTGGCTGCTGAAATTCATCAGAGGCTTATGGAAGAAGAAAAA
GAAAACCAGCCAGCAGACCCCAAAGAAAAATCTCCTCAGATGGGTGCAAATAAAAAAGTCAAAAAGGAGCCACCCAAGAAAAAACAGGAA
GACAAAAAACCCAAAGGTAAATCACCACCTATGGCAGAAGCAACTCCTGTCATAGTAACAACAGAGGAAATTGCTGAAATCAAAAGGAAA
AATGAACTGAGGGTCAAAATAAAAGAAGAACACCTTGCTGCCTTGCAATTTGAAGAAATAGCCACGCAATTTCGACTTGAACTGATAAAG
ACAAAAGCATTGGCTCTTCTTGAAGATTTAGTAACAAAGGTGGTTGATGTATATAAACTCATGGAAAAATGGCTTGGTGAGAGGTATTTG
AATGAAATGGCCAGTACAGAAAAATTAACTGACGTAGCTCGCTATCACATTGAAACATCTACAAAAATTCAGAATGAACTTTATTTAAGC
CAAGAAGACTTCTTCATTAATGGCAATATAAAAGTCTTCCCAGATCCTCCCCCATCAATACGTCCTCCACCTGTAGAAAAGGAAGAAGAT
GGTACCCTGACCATTGAACAGCTTGACAGTCTTCGAGATCAGTTCTTAGATATGGCACCTAAAGGCATAATAGGAAATAAAGCATTTACT
GACATTCTGATCGATTTGGTGACCCTGAACCTTGGCACAAACAACTTTCCTAGTAATTGGATGCACCTTACCCAACCTGAATTACAGGAA
TTAACATCTTTATTAACAGTCAACTCCGAGTTCGTGGACTGGCGGAAGTTCCTGTTAGTAACCTCAATGCCTTGGCCCATTCCCTTGGAG
GAGGAGCTCCTTGAGACCCTTCAGAAGTTCAAGGCTGTGGATAAGGAGCAGTTGGGCACCATCACTTTTGAGCAGTATATGCAGGCTGGT
CTGTGGTTTACAGGAGATGAAGATATAAAAATTCCAGAAAATCCTCTTGAACCCCTTCCATTTAATAGGCAGGAGCATCTTATAGAGTTT
TTCTTTAGGCTATTTGCTGACTATGAGAAGGATCCACCCCAGCTTGACTACACACAGATGCTGCTTTACTTTGCTTGCCACCCAGACACC
GTGGAAGGAGTCTACAGGGCCCTCAGTGTGGCTGTTGGAACTCATGTCTTCCAACAAGTCAAAGCTTCCATTCCAAGTGCAGAAAAGACC
TCCTCAACTGATGCAGGTCCAGCTGAGGAATTTCCTGAACCTGAGGAAAATGCTGCAAGAGAAGAAAGGAAATTAAAAGACGACACGGAG
AAAAGGGAACAGAAGGATGAAGAAATCCCTGAAAATGCAAACAATGAAAAGATGTCCATGGAAACACTACTCAAAGTGTTCAAAGGGGGA
AGTGAAGCACAGGACTCCAATAGATTTGCCAGCCACCTAAAGATAGAGAACATTTATGCAGAGGGCTTCATAAAAACATTTCAAGACCTA
GGTGCCAAGAACCTGGAGCCAATTGAAGTCGCTGTTCTCTTGAAGCATCCTTTTATTCAAGACCTGATTTCAAATTATTCAGACTATAAG
TTTCCTGTACACATCATCTATGTAGTGGAAATGATAGTGTGTGCAAAAGGTTGGGCACCACTTCCATCAGGAAAACAGTGTGCAAGATGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_HCN1_ENST00000303230_chr5_45645287_-_SPEF2_ENST00000282469_chr5_35667174_+_2612nt
GGCGCCGGGCGGCCGGCGAGTCTGGAGCCCGCGCCGTCGCCGGCCGCGTCCTCCGGGCATGGAAGGAGGCGGCAAGCCCAACTCTTCGTC
TAACAGCCGGGACGATGGCAACAGCGTCTTCCCCGCCAAGGCGTCCGCGACGGGCGCGGGGCCGGCCGCGGCCGAGAAGCGCCTGGGCAC
CCCGCCGGGGGGCGGCGGGGCCGGCGCGAAGGAGCACGGCAACTCCGTGTGCTTCAAGGTGGACGGCGGTGGCGGCGGTGGCGGCGGCGG
CGGCGGCGGCGAGGAGCCGGCGGGGGGCTTCGAAGACGCCGAGGGGCCCCGGCGGCAGTACGGCTTCATGCAGAGGCAGTTCACCTCCAT
GCTGCAGCCCGGGGTCAACAAATTCTCCCTCCGCATGTTTGGGAGCCAGAAGGCGGTGGAAAAGGAGCAGGAAAGGGTTAAAACTGCAGG
CTTCTGGATTATCCACCCTTACAGTGATTTCAGGTTTTACTGGGATTTAATAATGCTTATAATGATGGTTGGAAATCTAGTCATCATACC
AGTTGGAATCACATTCTTTACAGAGCAAACAACAACACCATGGATTATTTTCAATGTGGCATCAGATACAGTTTTCCTATTGGACCTGAT
CATGAATTTTAGGACTGGGACTGTCAATGAAGACAGTTCTGAAATCATCCTGGACCCCAAAGTGATCAAGATGAATTATTTAAAAAGCTG
GTTTGTGGTTGACTTCATCTCATCCATCCCAGTGGATTATATCTTTCTTATTGTAGAAAAAGGAATGGATTCTGAAGTTTACAAGACAGC
CAGGGCACTTCGCATTGTGAGGTTTACAAAAATTCTCAGTCTCTTGCGTTTATTACGACTTTCAAGGTTAATTAGATACATACATCAATG
GGAAGAGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAG
AGCTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCG
AATGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTC
TGTTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATA
TAAGGTACCTACTGATATGAAATAATTAGAATGCTACATAATAAATCCTTTTTCTTTAACATTAATTTTGTGATATTCCTTATTTCATTT
CTACTAATAAAAATAGACATGTTTTGTTTGCATTTTCCCTTGTTTTAATTTGTATGTTTGTACTACTTTTTAGATGCTTAAACTATACAT
AAGCTATTATCTATTGTTCCTAGTAATCTTAGGGGAGTGGTCTGAAAAAACATCAAGCATAGTAATTGTCTGGGTAGACAGATTTCAGAA
TTTTTAAAATGCTTTAATTTATTTATTAGCATTTTTCTTTGTATGGGCTGTGTACTTTTGCTTCAAAAACCATTGTTAAAAAGTATTTCT
TTTGTAATCAATCTAAATAATAGACTTTTTTTACAGGCAAAATGAAAGAGGAGGAAGTCTGGGTTTTATGAATAGCATAGATTCAAACAA
TCTTTTATTCAAAGATTGAAATAAAAAGTATCGGGTGCCAACTGTGATTTTTAGAAGAACTGTTGTAAAGCCTTTGAGATTAGACAGACT
AGAGCTACATTACTGAAATTGCCAACTACTAACTGTGTGACCTTAGGTGACCAGTTCATTAAGGGCTAATAGATTTCCATTTTTCAATTA
ATGGAAAGGGAATGCTACTATACCTACTTCATTTAAAATAACATGAGTTAAACACTTAGCTGAGTGCACTTCATGTTGGATGCATATAAT
ACATATCCATTTCTTTCCTCACCATCCTACTCTCCCCATCCCACTCCATCTCACCCTTAGAAGTAAAGGTGTAACAATCATAGCTTTTGG
ATAGAAATTTTGAGTGGATCAACAGCAATGGAATGAGGAGTGAGGCTTTTTATTAGAAAAATTACAAAATGAGTCCCGGAAGGTCAGTAA
GTGCAACATGAAAAAAATCTATGAAAAGATTATTTGACCTAATTATTCACTGATAGTACATACTCAACAAAGGTTTGTGGGACAAAGGGT
GAATAAAATGAATGAATTACAATGAACAAAGAAAAGTGCAAAATAACACTAACAAGTAAATATTACAAGAAGATAACCTTGTGGTTAAAA
GATAAGGAAAAATATGAGATTATGAGAAATTAAATGTATACTATATTTTAATTAAATGAATCTGTATTTGTAGCACTAAGAGAATTATTA
TTAAGGATTGACTAGAACCTTAAAAGATATATGTGGATGTTTGTTTTGTACGGTTGTAAAATATACTAGACCTATTACATCCACCTAAAG
TATAATGCCATGTAAGAAAATGCTTTGACAGTATCAACCTGTGTTAAGGTATTTCTTTCCATTGTAAATTAAAAGTCATTTTATTTGACA

>In-frame_HCN1_ENST00000303230_chr5_45645287_-_SPEF2_ENST00000509059_chr5_35667174_+_4293nt
GGCGCCGGGCGGCCGGCGAGTCTGGAGCCCGCGCCGTCGCCGGCCGCGTCCTCCGGGCATGGAAGGAGGCGGCAAGCCCAACTCTTCGTC
TAACAGCCGGGACGATGGCAACAGCGTCTTCCCCGCCAAGGCGTCCGCGACGGGCGCGGGGCCGGCCGCGGCCGAGAAGCGCCTGGGCAC
CCCGCCGGGGGGCGGCGGGGCCGGCGCGAAGGAGCACGGCAACTCCGTGTGCTTCAAGGTGGACGGCGGTGGCGGCGGTGGCGGCGGCGG
CGGCGGCGGCGAGGAGCCGGCGGGGGGCTTCGAAGACGCCGAGGGGCCCCGGCGGCAGTACGGCTTCATGCAGAGGCAGTTCACCTCCAT
GCTGCAGCCCGGGGTCAACAAATTCTCCCTCCGCATGTTTGGGAGCCAGAAGGCGGTGGAAAAGGAGCAGGAAAGGGTTAAAACTGCAGG
CTTCTGGATTATCCACCCTTACAGTGATTTCAGGTTTTACTGGGATTTAATAATGCTTATAATGATGGTTGGAAATCTAGTCATCATACC
AGTTGGAATCACATTCTTTACAGAGCAAACAACAACACCATGGATTATTTTCAATGTGGCATCAGATACAGTTTTCCTATTGGACCTGAT
CATGAATTTTAGGACTGGGACTGTCAATGAAGACAGTTCTGAAATCATCCTGGACCCCAAAGTGATCAAGATGAATTATTTAAAAAGCTG
GTTTGTGGTTGACTTCATCTCATCCATCCCAGTGGATTATATCTTTCTTATTGTAGAAAAAGGAATGGATTCTGAAGTTTACAAGACAGC
CAGGGCACTTCGCATTGTGAGGTTTACAAAAATTCTCAGTCTCTTGCGTTTATTACGACTTTCAAGGTTAATTAGATACATACATCAATG
GGAAGAGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAG
AGCTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCG
AATGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTC
TGTTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATA
TAAGAACATGGTTGGAGAGTGGGCCTTACCAGAAGAAATGGTTGACAATTTACCACCCTCCAACAATTGCATACTGGGCCATATTCTTCA
CAGGCTAGCTGAAAAATCTCTTCCTCCTCGAGCGGAATCAACAACACCTGAATTACCTTCATTTGCTGTTAAAGGATGCTTATTGGGGAA
AACATTAAGTGGAAAAACTACCATTTTAAGGTCTCTACAAAAAGACTTTCCTATACAGATACTTTCTATTGACACTCTTGTCCAAGAAGC
TATCCAAGCATTTCATGACAATGAAAAAGTCAGTGAGGTTCTACCAATTCAGAAAAATGATGAAGAAGATGCTCTACCAGTTCTGCAAGA
GGAGATTAAAGAAAGCCAGGATCCACAACATGTATTTTCAGCTGGTCCAGTTTCAGATGAAGTATTACCAGAAACAGAAGGTGCTAATGC
TGATAAAACACCAAAAGCTGAAGAAGTCAAATCAAGTGATAGTTTCTTAAAACTCACTACACGTGCTCAGCTTGGTGCAAAATCAGAACA
GTTGCTGAAGAAAGGAAAGAGCATTCCTGATGTGCTGCTTGTTGACATCATAGTAAATGCTATTAATGAGATACCTGTGAATCAAGACTG
TATCCTAGATGGTTTTCCAATGACTTTAAACCAAGCACAGCTTCTGGAAGAAGCTCTTACAGGCTGCAATAGAAACCTCACAGAAGTGGA
AAGAAAAAAAGCACAAAAATCCACATTGGCTATTGATCCTGCGACTTCCAAAGAAATACCTCTTCCCTCTCCTGCATTTGATTTTGTCAT
ATTATTAGATGTTTCAGATACTTCCTCAATGAGTCGCATGAATGATATTATAGCTGAAGAATTGTCCTATAAAACTGCTCACGAAGATAT
CAGTCAACGTGTAGCTGCTGAAAACCAAGATAAGGATGGAGACCAAAATTTAAGAGACCAGATACAACATAGAATTATAGGCTTCTTGGA
CAACTGGCCTTTATTGGAGCAATGGTTTTCAGAGCCAGAAAATATTTTGATAAAAATCAATGCTGAAATAGATAAGGAATCTTTATGTGA
AAAAGTAAAAGAAATTCTTACGACTGAAATAGCAAAAAAAAAGAATAAAGTTGAGAAGAAATTAGAAGAAAAGGAAGCTGAGAAAAAAGC
AGCAGCTTCCCTGGCTGAGCTTCCACTTCCTACACCTCCTCCTGCTCCTCCTCCTGAACCAGAAAAAGAGAAGGAAATTCATCAAAGCCA
TGTGGCTTCAAAAACTCCTACTGCAAAAGGAAAACCTCAATCAGGTGATTGACAGAATGATTTATAATCCTGTTTTCAGTTTCTTATTTT
TACTCAGTAAAGAATTATAAATTATAGTCTATCTACATTCAGACTTTGGGCAACTTCAATCATATGAAACAAGGCTTTACACTCAGATGG
AAGTGGAAAAGCCCTCGGAGTAGCTAAAAGCGTAGTTGTTACAAAGCCCAACTTCTTTGCCATGTAGGAGGAGACATGGAGTCATCACAC
CTAGGTCTACTGATTAGAGTAAGACCACAGACGAGAAGAGGAAAAGGCACAGAGTAACAGGTAACTTCAGGCAGATCAAGAGGATACACG
TCTGTGTGCTGAACTATAGAGTTACATTTATGTAATGAGTAAGAACATCTTAATAAAATAAGAATGAGTATAGCTGGTTTTCCACCAGAA
TAAGGGAACAAATTAACAGCAACCATTAGAACTAGAATTTATATGTAATTGTAAATCTTCAGGACTATGTGATTATAAAAGTATAGAAAC
AAGCTCCTGCCATCTCAGTAAACATATATTTATGGACACAGAGATAAAGAGCCTAGATAGAGAACACTTTTAGTTTAAGTTTGTTCTAGA
TCCTTAACCGCTATGGACCATAAGTCTAGCATTAAGTGGCAGACAATGAATATAATGACAAAAGTGAAGTGCTTAATTGTTGTAATGCAT
GATATTGGTAGAGTGTCAGTATCCATTTGTGTGTGTATATAAAACAAATGAGGCTCTGGTTTCTAGTTTCAGCTTTATAAATGGCTGACT
GTGCAGTTACACCATGTCTACCTAAGTATCTTTGATACTGTGTCATGACCACATTTCTAAACTCTATAGTCTTTCTGCCTCACGGAGATT
TGAGATAGGTCTTAATTTTTAAAATTAAACTTATTCATATTAAACAAAGACATATGAAGACTTTAGTAAGATATATTATGATATATTAAA
GACCATTCTGCTCCAGGAAATTAGAAATTAACTACAGGCAAAATACACACATCCTAAAAAATGTTTTTATCATGTCAACAATAAAACACA
AAGACATGAATTAAACATACACCCTTTTCCCGCTGTCTCATTAGGAAATTAAAAAACAATTCAGAGGTCTGGAGGAAAATGGAAATATTT
AAAATGCTTTTTAGAACTGGGGAAGACAGGCCAAGCATGGTGGCTCATCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATC
ACCAGAAATCAGGAGTTCGAGACCCCGCTGGCCAACAGGGCAAAACCCATCTCTACCAAAAATACAAAAATTAGCTGGGCGTGGTGGCAG
GCACCTGTAATCCCAGCTGCTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGAGAGGCGGAGGTTGCAGTGAGCCGAGATTGCCCCA
CTGCACTCTAGCCTGGGGGATAGAGTGAAACTCTACCTCCAAAAAAAAGAAAAGAAAAATAACTGAGGAAGACAGTTTTCACAGTGGGTC
AGGTGAGCCTAGAATTATCGAATATCGTCCTTTAACCTATAGCTATGACTCTAGGTTAAAGCTCCTCCTCAGCTTGCTCCAGTCAAGAGT
ATCTATGTATTTGAGCCATTTCCTGAAACCAGACTCTAGTGTTTCTGATCAGACCAGCTCAGTCTTTAAGTTTCTGAAGTTTGTTTGCTA

>In-frame_HCN1_ENST00000303230_chr5_45645287_-_SPEF2_ENST00000356031_chr5_35667174_+_5267nt
GGCGCCGGGCGGCCGGCGAGTCTGGAGCCCGCGCCGTCGCCGGCCGCGTCCTCCGGGCATGGAAGGAGGCGGCAAGCCCAACTCTTCGTC
TAACAGCCGGGACGATGGCAACAGCGTCTTCCCCGCCAAGGCGTCCGCGACGGGCGCGGGGCCGGCCGCGGCCGAGAAGCGCCTGGGCAC
CCCGCCGGGGGGCGGCGGGGCCGGCGCGAAGGAGCACGGCAACTCCGTGTGCTTCAAGGTGGACGGCGGTGGCGGCGGTGGCGGCGGCGG
CGGCGGCGGCGAGGAGCCGGCGGGGGGCTTCGAAGACGCCGAGGGGCCCCGGCGGCAGTACGGCTTCATGCAGAGGCAGTTCACCTCCAT
GCTGCAGCCCGGGGTCAACAAATTCTCCCTCCGCATGTTTGGGAGCCAGAAGGCGGTGGAAAAGGAGCAGGAAAGGGTTAAAACTGCAGG
CTTCTGGATTATCCACCCTTACAGTGATTTCAGGTTTTACTGGGATTTAATAATGCTTATAATGATGGTTGGAAATCTAGTCATCATACC
AGTTGGAATCACATTCTTTACAGAGCAAACAACAACACCATGGATTATTTTCAATGTGGCATCAGATACAGTTTTCCTATTGGACCTGAT
CATGAATTTTAGGACTGGGACTGTCAATGAAGACAGTTCTGAAATCATCCTGGACCCCAAAGTGATCAAGATGAATTATTTAAAAAGCTG
GTTTGTGGTTGACTTCATCTCATCCATCCCAGTGGATTATATCTTTCTTATTGTAGAAAAAGGAATGGATTCTGAAGTTTACAAGACAGC
CAGGGCACTTCGCATTGTGAGGTTTACAAAAATTCTCAGTCTCTTGCGTTTATTACGACTTTCAAGGTTAATTAGATACATACATCAATG
GGAAGAGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAG
AGCTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCG
AATGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTC
TGTTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATA
TAAGAACATGGTTGGAGAGTGGGCCTTACCAGAAGAAATGGTTGACAATTTACCACCCTCCAACAATTGCATACTGGGCCATATTCTTCA
CAGGCTAGCTGAAAAATCTCTTCCTCCTCGAGCGGAATCAACAACACCTGAATTACCTTCATTTGCTGTTAAAGGATGCTTATTGGGGAA
AACATTAAGTGGAAAAACTACCATTTTAAGGTCTCTACAAAAAGACTTTCCTATACAGATACTTTCTATTGACACTCTTGTCCAAGAAGC
TATCCAAGCATTTCATGACAATGAAAAAGTCAGTGAGGTTCTACCAATTCAGAAAAATGATGAAGAAGATGCTCTACCAGTTCTGCAAGA
GGAGATTAAAGAAAGCCAGGATCCACAACATGTATTTTCAGCTGGTCCAGTTTCAGATGAAGTATTACCAGAAACAGAAGGTGAAACAAT
GCTTAGTGCTAATGCTGATAAAACACCAAAAGCTGAAGAAGTCAAATCAAGTGATAGTTTCTTAAAACTCACTACACGTGCTCAGCTTGG
TGCAAAATCAGAACAGTTGCTGAAGAAAGGAAAGAGCATTCCTGATGTGCTGCTTGTTGACATCATAGTAAATGCTATTAATGAGATACC
TGTGAATCAAGACTGTATCCTAGATGGTTTTCCAATGACTTTAAACCAAGCACAGCTTCTGGAAGAAGCTCTTACAGGCTGCAATAGAAA
CCTCACAGAAGTGGAAAGAAAAAAAGCACAAAAATCCACATTGGCTATTGATCCTGCGACTTCCAAAGAAATACCTCTTCCCTCTCCTGC
ATTTGATTTTGTCATATTATTAGATGTTTCAGATACTTCCTCAATGAGTCGCATGAATGATATTATAGCTGAAGAATTGTCCTATAAAAC
TGCTCACGAAGATATCAGTCAACGTGTAGCTGCTGAAAACCAAGATAAGGATGGAGACCAAAATTTAAGAGACCAGATACAACATAGAAT
TATAGGCTTCTTGGACAACTGGCCTTTATTGGAGCAATGGTTTTCAGAGCCAGAAAATATTTTGATAAAAATCAATGCTGAAATAGATAA
GGAATCTTTATGTGAAAAAGTAAAAGAAATTCTTACGACTGAAATAGCAAAAAAAAAGAATAAAGTTGAGAAGAAATTAGAAGAAAAGGA
AGCTGAGAAAAAAGCAGCAGCTTCCCTGGCTGAGCTTCCACTTCCTACACCTCCTCCTGCTCCTCCTCCTGAACCAGAAAAAGAGAAGGA
AATTCATCAAAGCCATGTGGCTTCAAAAACTCCTACTGCAAAAGGAAAACCTCAATCAGAAGCCCCGCATGGTAAGCAAGAATCTCTTCA
GGAAGGAAAAGGGAAGAAAGGTGAGACCGCACTCAAAAGAAAAGGTTCTCCTAAAGGAAAATCATCAGGAGGAAAAGTACCAGTAAAGAA
ATCACCTGCTGACTCTACAGATACATCACCTGTTGCAATAGTGCCACAGCCACCTAAGCCAGGATCAGAAGAATGGGTCTATGTGAATGA
ACCAGTTCCTGAGGAAATGCCTTTGTTTTTAGTACCTTACTGGGAACTAATAGAAAATTCCTATATAAACACCATCAAAACAGTACTCAG
GCATCTGAGGGAAGACCAGCATACTGTGCTTGCTTACTTATATGAGATTAGAACAAGTTTCCAGGAGTTTCTAAAGCGTCCGGATCACAA
GCAAGATTTTGTAGCTCAATGGCAGGCTGATTTCAACTCCCTTCCTGATGACCTGTGGGATGATGAGGAAACAAAGGCTGAACTACATCA
ACGAGTGAATGATCTGCGAGACCGCCTGTGGGACATTTGTGATGCCCGGAAGGAAGAGGCGGAGCAGGAGCGGCTTGACATCATTAATGA
GAGCTGGTTACAGGACACTCTTGGAATGACAATGAACCATTTCTTTTCCCTGATGCAGGCAGAGCTGAACCGTTTCCAAGATACAAAGAG
ACTCCTTCAAGATTATTACTGGGGAATGGAAAGTAAAATCCCAGTAGAGGACAACAAGAGATTTACTCGAATCCCTTTGGTCCAACTGGA
TAGTAAAGACAATTCTGAAAGCCAGCTTAGAATTCCTCTAGTTCCTCGAATATCCATTTCTCTGGAAACAGTTACACCCAAACCAAAAAC
AAAATCAGTACTGAAGGGCAAGATGGATAACTCCCTAGAAAACGTTGAGTCCAACTTTGAGGCCGATGAAAAGTTGGTCATGGACACCTG
GCAGCAGGCTTCTTTAGCAGTATCTCACATGGTGGCTGCTGAAATTCATCAGAGGCTTATGGAAGAAGAAAAAGAAAACCAGCCAGCAGA
CCCCAAAGAAAAATCTCCTCAGATGGGTGCAAATAAAAAAGTCAAAAAGGAGCCACCCAAGAAAAAACAGGAAGACAAAAAACCCAAAGG
TAAATCACCACCTATGGCAGAAGCAACTCCTGTCATAGTAACAACAGAGGAAATTGCTGAAATCAAAAGGAAAAATGAACTGAGGGTCAA
AATAAAAGAAGAACACCTTGCTGCCTTGCAATTTGAAGAAATAGCCACGCAATTTCGACTTGAACTGATAAAGACAAAAGCATTGGCTCT
TCTTGAAGATTTAGTAACAAAGGTGGTTGATGTATATAAACTCATGGAAAAATGGCTTGGTGAGAGGTATTTGAATGAAATGGCCAGTAC
AGAAAAATTAACTGACGTAGCTCGCTATCACATTGAAACATCTACAAAAATTCAGAATGAACTTTATTTAAGCCAAGAAGACTTCTTCAT
TAATGGCAATATAAAAGTCTTCCCAGATCCTCCCCCATCAATACGTCCTCCACCTGTAGAAAAGGAAGAAGATGGTACCCTGACCATTGA
ACAGCTTGACAGTCTTCGAGATCAGTTCTTAGATATGGCACCTAAAGGCATAATAGGAAATAAAGCATTTACTGACATTCTGATCGATTT
GGTGACCCTGAACCTTGGCACAAACAACTTTCCTAGTAATTGGATGCACCTTACCCAACCTGAATTACAGGAATTAACATCTTTATTAAC
AGTCAACTCCGAGTTCGTGGACTGGCGGAAGTTCCTGTTAGTAACCTCAATGCCTTGGCCCATTCCCTTGGAGGAGGAGCTCCTTGAGAC
CCTTCAGAAGTTCAAGGCTGTGGATAAGGAGCAGTTGGGCACCATCACTTTTGAGCAGTATATGCAGGCTGGTCTGTGGTTTACAGGAGA
TGAAGATATAAAAATTCCAGAAAATCCTCTTGAACCCCTTCCATTTAATAGGCAGGAGCATCTTATAGAGTTTTTCTTTAGGCTATTTGC
TGACTATGAGAAGGATCCACCCCAGCTTGACTACACACAGATGCTGCTTTACTTTGCTTGCCACCCAGACACCGTGGAAGGAGTCTACAG
GGCCCTCAGTGTGGCTGTTGGAACTCATGTCTTCCAACAAGTCAAAGCTTCCATTCCAAGTGCAGAAAAGACCTCCTCAACTGATGCAGG
TCCAGCTGAGGAATTTCCTGAACCTGAGGAAAATGCTGCAAGAGAAGAAAGGAAATTAAAAGACGACACGGAGAAAAGGGAACAGAAGGA
TGAAGAAATCCCTGAAAATGCAAACAATGAAAAGATGTCCATGGAAACACTACTCAAAGTGTTCAAAGGGGGAAGTGAAGCACAGGACTC
CAATAGATTTGCCAGCCACCTAAAGATAGAGAACATTTATGCAGAGGGCTTCATAAAAACATTTCAAGACCTAGGTGCCAAGAACCTGGA
GCCAATTGAAGTCGCTGTTCTCTTGAAGCATCCTTTTATTCAAGACCTGATTTCAAATTATTCAGACTATAAGTTTCCTGATATTAAAAT
AATTCTCCAAAGGAGTGAACATGTACAAGGAAGTGATGGAGAGAGATCACCTTCAAGACATACAGAGGAAAAGAAATGAAGACAAAAGAG

>In-frame_HCN1_ENST00000303230_chr5_45645287_-_SPEF2_ENST00000440995_chr5_35667174_+_5704nt
GGCGCCGGGCGGCCGGCGAGTCTGGAGCCCGCGCCGTCGCCGGCCGCGTCCTCCGGGCATGGAAGGAGGCGGCAAGCCCAACTCTTCGTC
TAACAGCCGGGACGATGGCAACAGCGTCTTCCCCGCCAAGGCGTCCGCGACGGGCGCGGGGCCGGCCGCGGCCGAGAAGCGCCTGGGCAC
CCCGCCGGGGGGCGGCGGGGCCGGCGCGAAGGAGCACGGCAACTCCGTGTGCTTCAAGGTGGACGGCGGTGGCGGCGGTGGCGGCGGCGG
CGGCGGCGGCGAGGAGCCGGCGGGGGGCTTCGAAGACGCCGAGGGGCCCCGGCGGCAGTACGGCTTCATGCAGAGGCAGTTCACCTCCAT
GCTGCAGCCCGGGGTCAACAAATTCTCCCTCCGCATGTTTGGGAGCCAGAAGGCGGTGGAAAAGGAGCAGGAAAGGGTTAAAACTGCAGG
CTTCTGGATTATCCACCCTTACAGTGATTTCAGGTTTTACTGGGATTTAATAATGCTTATAATGATGGTTGGAAATCTAGTCATCATACC
AGTTGGAATCACATTCTTTACAGAGCAAACAACAACACCATGGATTATTTTCAATGTGGCATCAGATACAGTTTTCCTATTGGACCTGAT
CATGAATTTTAGGACTGGGACTGTCAATGAAGACAGTTCTGAAATCATCCTGGACCCCAAAGTGATCAAGATGAATTATTTAAAAAGCTG
GTTTGTGGTTGACTTCATCTCATCCATCCCAGTGGATTATATCTTTCTTATTGTAGAAAAAGGAATGGATTCTGAAGTTTACAAGACAGC
CAGGGCACTTCGCATTGTGAGGTTTACAAAAATTCTCAGTCTCTTGCGTTTATTACGACTTTCAAGGTTAATTAGATACATACATCAATG
GGAAGAGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAG
AGCTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCG
AATGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTC
TGTTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATA
TAAGAACATGGTTGGAGAGTGGGCCTTACCAGAAGAAATGGTTGACAATTTACCACCCTCCAACAATTGCATACTGGGCCATATTCTTCA
CAGGCTAGCTGAAAAATCTCTTCCTCCTCGAGCGGAATCAACAACACCTGAATTACCTTCATTTGCTGTTAAAGGATGCTTATTGGGGAA
AACATTAAGTGGAAAAACTACCATTTTAAGGTCTCTACAAAAAGACTTTCCTATACAGATACTTTCTATTGACACTCTTGTCCAAGAAGC
TATCCAAGCATTTCATGACAATGAAAAAGTCAGTGAGGTTCTACCAATTCAGAAAAATGATGAAGAAGATGCTCTACCAGTTCTGCAAGA
GGAGATTAAAGAAAGCCAGGATCCACAACATGTATTTTCAGCTGGTCCAGTTTCAGATGAAGTATTACCAGAAACAGAAGGTGCTAATGC
TGATAAAACACCAAAAGCTGAAGAAGTCAAATCAAGTGATAGTTTCTTAAAACTCACTACACGTGCTCAGCTTGGTGCAAAATCAGAACA
GTTGCTGAAGAAAGGAAAGAGCATTCCTGATGTGCTGCTTGTTGACATCATAGTAAATGCTATTAATGAGATACCTGTGAATCAAGACTG
TATCCTAGATGGTTTTCCAATGACTTTAAACCAAGCACAGCTTCTGGAAGAAGCTCTTACAGGCTGCAATAGAAACCTCACAGAAGTGGA
AAGAAAAAAAGCACAAAAATCCACATTGGCTATTGATCCTGCGACTTCCAAAGAAATACCTCTTCCCTCTCCTGCATTTGATTTTGTCAT
ATTATTAGATGTTTCAGATACTTCCTCAATGAGTCGCATGAATGATATTATAGCTGAAGAATTGTCCTATAAAACTGCTCACGAAGATAT
CAGTCAACGTGTAGCTGCTGAAAACCAAGATAAGGATGGAGACCAAAATTTAAGAGACCAGATACAACATAGAATTATAGGCTTCTTGGA
CAACTGGCCTTTATTGGAGCAATGGTTTTCAGAGCCAGAAAATATTTTGATAAAAATCAATGCTGAAATAGATAAGGAATCTTTATGTGA
AAAAGTAAAAGAAATTCTTACGACTGAAATAGCAAAAAAAAAGAATAAAGTTGAGAAGAAATTAGAAGAAAAGGAAGCTGAGAAAAAAGC
AGCAGCTTCCCTGGCTGAGCTTCCACTTCCTACACCTCCTCCTGCTCCTCCTCCTGAACCAGAAAAAGAGAAGGAAATTCATCAAAGCCA
TGTGGCTTCAAAAACTCCTACTGCAAAAGGAAAACCTCAATCAGAAGCCCCGCATGGTAAGCAAGAATCTCTTCAGGAAGGAAAAGGGAA
GAAAGGTGAGACCGCACTCAAAAGAAAAGGTTCTCCTAAAGGAAAATCATCAGGAGGAAAAGTACCAGTAAAGAAATCACCTGCTGACTC
TACAGATACATCACCTGTTGCAATAGTGCCACAGCCACCTAAGCCAGGATCAGAAGAATGGGTCTATGTGAATGAACCAGTTCCTGAGGA
AATGCCTTTGTTTTTAGTACCTTACTGGGAACTAATAGAAAATTCCTATATAAACACCATCAAAACAGTACTCAGGCATCTGAGGGAAGA
CCAGCATACTGTGCTTGCTTACTTATATGAGATTAGAACAAGTTTCCAGGAGTTTCTAAAGCGTCCGGATCACAAGCAAGATTTTGTAGC
TCAATGGCAGGCTGATTTCAACTCCCTTCCTGATGACCTGTGGGATGATGAGGAAACAAAGGCTGAACTACATCAACGAGTGAATGATCT
GCGAGACCGCCTGTGGGACATTTGTGATGCCCGGAAGGAAGAGGCGGAGCAGGAGCGGCTTGACATCATTAATGAGAGCTGGTTACAGGA
CACTCTTGGAATGACAATGAACCATTTCTTTTCCCTGATGCAGGCAGAGCTGAACCGTTTCCAAGATACAAAGAGACTCCTTCAAGATTA
TTACTGGGGAATGGAAAGTAAAATCCCAGTAGAGGACAACAAGAGATTTACTCGAATCCCTTTGGTCCAACTGGATAGTAAAGACAATTC
TGAAAGCCAGCTTAGAATTCCTCTAGTTCCTCGAATATCCATTTCTCTGGAAACAGTTACACCCAAACCAAAAACAAAATCAGTACTGAA
GGGCAAGATGGATAACTCCCTAGAAAACGTTGAGTCCAACTTTGAGGCCGATGAAAAGTTGGTCATGGACACCTGGCAGCAGGCTTCTTT
AGCAGTATCTCACATGGTGGCTGCTGAAATTCATCAGAGGCTTATGGAAGAAGAAAAAGAAAACCAGCCAGCAGACCCCAAAGAAAAATC
TCCTCAGATGGGTGCAAATAAAAAAGTCAAAAAGGAGCCACCCAAGAAAAAACAGGAAGACAAAAAACCCAAAGGTAAATCACCACCTAT
GGCAGAAGCAACTCCTGTCATAGTAACAACAGAGGAAATTGCTGAAATCAAAAGGAAAAATGAACTGAGGGTCAAAATAAAAGAAGAACA
CCTTGCTGCCTTGCAATTTGAAGAAATAGCCACGCAATTTCGACTTGAACTGATAAAGACAAAAGCATTGGCTCTTCTTGAAGATTTAGT
AACAAAGGTGGTTGATGTATATAAACTCATGGAAAAATGGCTTGGTGAGAGGTATTTGAATGAAATGGCCAGTACAGAAAAATTAACTGA
CGTAGCTCGCTATCACATTGAAACATCTACAAAAATTCAGAATGAACTTTATTTAAGCCAAGAAGACTTCTTCATTAATGGCAATATAAA
AGTCTTCCCAGATCCTCCCCCATCAATACGTCCTCCACCTGTAGAAAAGGAAGAAGATGGTACCCTGACCATTGAACAGCTTGACAGTCT
TCGAGATCAGTTCTTAGATATGGCACCTAAAGGCATAATAGGAAATAAAGCATTTACTGACATTCTGATCGATTTGGTGACCCTGAACCT
TGGCACAAACAACTTTCCTAGTAATTGGATGCACCTTACCCAACCTGAATTACAGGAATTAACATCTTTATTAACAGTCAACTCCGAGTT
CGTGGACTGGCGGAAGTTCCTGTTAGTAACCTCAATGCCTTGGCCCATTCCCTTGGAGGAGGAGCTCCTTGAGACCCTTCAGAAGTTCAA
GGCTGTGGATAAGGAGCAGTTGGGCACCATCACTTTTGAGCAGTATATGCAGGCTGGTCTGTGGTTTACAGGAGATGAAGATATAAAAAT
TCCAGAAAATCCTCTTGAACCCCTTCCATTTAATAGGCAGGAGCATCTTATAGAGTTTTTCTTTAGGCTATTTGCTGACTATGAGAAGGA
TCCACCCCAGCTTGACTACACACAGATGCTGCTTTACTTTGCTTGCCACCCAGACACCGTGGAAGGAGTCTACAGGGCCCTCAGTGTGGC
TGTTGGAACTCATGTCTTCCAACAAGTCAAAGCTTCCATTCCAAGTGCAGAAAAGACCTCCTCAACTGATGCAGGTCCAGCTGAGGAATT
TCCTGAACCTGAGGAAAATGCTGCAAGAGAAGAAAGGAAATTAAAAGACGACACGGAGAAAAGGGAACAGAAGGATGAAGAAATCCCTGA
AAATGCAAACAATGAAAAGATGTCCATGGAAACACTACTCAAAGTGTTCAAAGGGGGAAGTGAAGCACAGGACTCCAATAGATTTGCCAG
CCACCTAAAGATAGAGAACATTTATGCAGAGGGCTTCATAAAAACATTTCAAGACCTAGGTGCCAAGAACCTGGAGCCAATTGAAGTCGC
TGTTCTCTTGAAGCATCCTTTTATTCAAGACCTGATTTCAAATTATTCAGACTATAAGTTTCCTGTACACATCATCTATGTAGTGGAAAT
GATAGTGTGTGCAAAAGGTTGGGCACCACTTCCATCAGGAAAACAGTGTGCAAGATGGAGAAACTAAGGACAAACCCCAGAGAAACTGGA
CAAACCCAGCAGAAGAAAGGAAGAACTGCAACTCAGAAATCACATAACCACCAAGCAGGTCTGGACCACACATGCTAAATGTGCATCCAC
TATGGCGAGTCCCAGGCCTTTAACAGCAGGGACTAAGGAGGGCAGAGGCTGACACCAACCCCCTTTCATACTGTAGCACTACATCCCTCT
CAGATACCAGTTTAACACGAAGTCTCCCTGTTTGACTCCTGTGAGTTGTGTATTGAACTACAAAGTGTTTGCTGAGTTGAAAATAAAAGC
GCTTTCACTTTGATAGAATGTAGATTGTGTATCTTGACTTCTCAATGATAGCAAGTTACATTTTGCAGTTTTCTTCCTATACCCACAAAT
GAAACTATTCAGACTTAAATATCTTCCTGTGTGCCTAAACGTTTTTGTTCTAAGTTGCTGATCCTTTTAAATATTAAATTATTAATTAAT


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FusionGenePPI for HCN1_SPEF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HCN1HCN2, HCN3, HCN4, HCN1, NEDD4LSPEF2APOA1, TSC22D2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HCN1_SPEF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HCN1_SPEF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHCN1C0011581Depressive disorder2PSYGENET
HgeneHCN1C0004134Ataxia1CTD_human
HgeneHCN1C0011570Mental Depression1PSYGENET
HgeneHCN1C0014544Epilepsy1CTD_human
HgeneHCN1C0036572Seizures1CTD_human
HgeneHCN1C3463992EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 11CTD_human
HgeneHCN1C4014531EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 241UNIPROT