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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15887

FusionGeneSummary for HBS1L_ARMC2

check button Fusion gene summary
Fusion gene informationFusion gene name: HBS1L_ARMC2
Fusion gene ID: 15887
HgeneTgene
Gene symbol

HBS1L

ARMC2

Gene ID

10767

84071

Gene nameHBS1 like translational GTPasearmadillo repeat containing 2
SynonymsEF-1a|ERFS|HBS1|HSPC276|eRF3cbA787I22.1
Cytomap

6q23.3

6q21

Type of geneprotein-codingprotein-coding
DescriptionHBS1-like proteinERF3-similar proteinHsp70 subfamily B suppressor 1-like proteineRF3 family memberarmadillo repeat-containing protein 2
Modification date2018052720180519
UniProtAcc

Q9Y450

Q8NEN0

Ensembl transtripts involved in fusion geneENST00000367837, ENST00000527578, 
ENST00000415177, ENST00000367826, 
ENST00000367824, ENST00000445176, 
ENST00000314674, ENST00000367822, 
ENST00000367820, ENST00000525067, 
ENST00000368972, ENST00000392644, 
ENST00000481850, 
Fusion gene scores* DoF score2 X 2 X 2=811 X 10 X 3=330
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/330*10)=-1.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HBS1L [Title/Abstract] AND ARMC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A1F0-01AHBS1Lchr6

135318535

-ARMC2chr6

109197346

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000367837ENST00000368972HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-5UTRENST00000367837ENST00000392644HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-intronENST00000367837ENST00000481850HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-5UTRENST00000527578ENST00000368972HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-5UTRENST00000527578ENST00000392644HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-intronENST00000527578ENST00000481850HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-5UTRENST00000415177ENST00000368972HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-5UTRENST00000415177ENST00000392644HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-intronENST00000415177ENST00000481850HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-5UTRENST00000367826ENST00000368972HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-5UTRENST00000367826ENST00000392644HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-intronENST00000367826ENST00000481850HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-5UTRENST00000367824ENST00000368972HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-5UTRENST00000367824ENST00000392644HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5CDS-intronENST00000367824ENST00000481850HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5UTR-5UTRENST00000445176ENST00000368972HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5UTR-5UTRENST00000445176ENST00000392644HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
5UTR-intronENST00000445176ENST00000481850HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
intron-5UTRENST00000314674ENST00000368972HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
intron-5UTRENST00000314674ENST00000392644HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
intron-intronENST00000314674ENST00000481850HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
intron-5UTRENST00000367822ENST00000368972HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
intron-5UTRENST00000367822ENST00000392644HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
intron-intronENST00000367822ENST00000481850HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
intron-5UTRENST00000367820ENST00000368972HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
intron-5UTRENST00000367820ENST00000392644HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
intron-intronENST00000367820ENST00000481850HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
intron-5UTRENST00000525067ENST00000368972HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
intron-5UTRENST00000525067ENST00000392644HBS1Lchr6

135318535

-ARMC2chr6

109197346

+
intron-intronENST00000525067ENST00000481850HBS1Lchr6

135318535

-ARMC2chr6

109197346

+

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FusionProtFeatures for HBS1L_ARMC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HBS1L

Q9Y450

ARMC2

Q8NEN0


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HBS1L_ARMC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HBS1L_ARMC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HBS1LCUL3, HTT, DIS3L, APP, CPLX1, LYN, UBE2G2, SRPK2, SRPK1, FANCI, PELO, MAP3K1, CACNG2, MSX2, EXOSC3, EXOSC7, EXOSC8, STK25, EIF2S3, RPS20, RPS5, NTRK1, CEP19, XPO1, EXOSC9, EXOSC6, EXOSC5, EXOSC4, EXOSC1, EIF1AD, ISOC2, RAB39B, JMJD6, UHRF1, LIN9, GCHFR, LAMP3ARMC2PYCARD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HBS1L_ARMC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HBS1L_ARMC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource