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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15878

FusionGeneSummary for HBG2_ZEB2

check button Fusion gene summary
Fusion gene informationFusion gene name: HBG2_ZEB2
Fusion gene ID: 15878
HgeneTgene
Gene symbol

HBG2

ZEB2

Gene ID

3048

9839

Gene namehemoglobin subunit gamma 2zinc finger E-box binding homeobox 2
SynonymsHBG-T1|TNCYHSPC082|SIP-1|SIP1|SMADIP1|ZFHX1B
Cytomap

11p15.4

2q22.3

Type of geneprotein-codingprotein-coding
Descriptionhemoglobin subunit gamma-2G-gamma globin Pauliniaabnormal hemoglobingamma-2-globingamma-globin chainhb F Ggammahemoglobin gamma-2 chainhemoglobin gamma-G chainhemoglobin, gamma Gmethemoglobinzinc finger E-box-binding homeobox 2SMAD interacting protein 1Smad-interacting protein 1zinc finger homeobox 1b
Modification date2018052320180519
UniProtAcc

P69892

O60315

Ensembl transtripts involved in fusion geneENST00000380252, ENST00000380259, 
ENST00000336906, 		ENST00000558170, 
ENST00000409487, ENST00000303660, 
ENST00000539609, ENST00000493689, 
ENST00000470879, ENST00000465070, 
ENST00000462355, 
Fusion gene scores* DoF score4 X 4 X 2=324 X 4 X 2=32
# samples 44
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HBG2 [Title/Abstract] AND ZEB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZEB2

GO:0000122

negative regulation of transcription by RNA polymerase II

12837246|20516212


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK225738HBG2chr11

5529319

-ZEB2chr2

145222999

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000380252ENST00000558170HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380252ENST00000409487HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380252ENST00000303660HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380252ENST00000539609HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380252ENST00000493689HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380252ENST00000470879HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380252ENST00000465070HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380252ENST00000462355HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380259ENST00000558170HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380259ENST00000409487HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380259ENST00000303660HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380259ENST00000539609HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380259ENST00000493689HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380259ENST00000470879HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380259ENST00000465070HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000380259ENST00000462355HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000336906ENST00000558170HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000336906ENST00000409487HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000336906ENST00000303660HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000336906ENST00000539609HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000336906ENST00000493689HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000336906ENST00000470879HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000336906ENST00000465070HBG2chr11

5529319

-ZEB2chr2

145222999

+
intron-intronENST00000336906ENST00000462355HBG2chr11

5529319

-ZEB2chr2

145222999

+

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FusionProtFeatures for HBG2_ZEB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HBG2

P69892

ZEB2

O60315

Gamma chains make up the fetal hemoglobin F, incombination with alpha chains. Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. {ECO:0000269|PubMed:16061479}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HBG2_ZEB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HBG2_ZEB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HBG2_ZEB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HBG2_ZEB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHBG2C3151421CYANOSIS, TRANSIENT NEONATAL5ORPHANET;UNIPROT
HgeneHBG2C2609414Acute kidney injury2CTD_human
HgeneHBG2C0028961Oliguria1CTD_human
HgeneHBG2C0033578Prostatic Neoplasms1CTD_human
TgeneZEB2C1856113Mowat-Wilson syndrome5CTD_human;UNIPROT
TgeneZEB2C0007621Neoplastic Cell Transformation1CTD_human
TgeneZEB2C0018798Congenital Heart Defects1CTD_human
TgeneZEB2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneZEB2C0027626Neoplasm Invasiveness1CTD_human
TgeneZEB2C1458155Mammary Neoplasms1CTD_human