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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15851

FusionGeneSummary for HAUS7_H19

check button Fusion gene summary
Fusion gene informationFusion gene name: HAUS7_H19
Fusion gene ID: 15851
HgeneTgene
Gene symbol

HAUS7

H19

Gene ID

55559

283120

Gene nameHAUS augmin like complex subunit 7H19, imprinted maternally expressed transcript
SynonymsUCHL5IP|UIP1ASM|ASM1|BWS|D11S813E|LINC00008|NCRNA00008|WT2
Cytomap

Xq28

11p15.5

Type of geneprotein-codingncRNA
DescriptionHAUS augmin-like complex subunit 726S proteasome-associated UCH37-interacting protein 1UCHL5 interacting proteinX-linked protein STS1769H19, imprinted maternally expressed transcript (non-protein coding)H19, imprinted maternally expressed untranslated mRNAlong intergenic non-protein coding RNA 8
Modification date2018051920180527
UniProtAcc

Q99871

Ensembl transtripts involved in fusion geneENST00000370211, ENST00000484394, 
ENST00000421080, ENST00000370212, 
ENST00000370210, 
ENST00000390168, 
Fusion gene scores* DoF score1 X 1 X 1=125 X 28 X 3=2100
# samples 131
** MAII scorelog2(1/1*10)=3.32192809488736log2(31/2100*10)=-2.76004920727925
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HAUS7 [Title/Abstract] AND H19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA451864HAUS7chrX

152770780

+H19chr11

2018816

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000370211ENST00000390168HAUS7chrX

152770780

+H19chr11

2018816

-
intron-intronENST00000484394ENST00000390168HAUS7chrX

152770780

+H19chr11

2018816

-
intron-intronENST00000421080ENST00000390168HAUS7chrX

152770780

+H19chr11

2018816

-
intron-intronENST00000370212ENST00000390168HAUS7chrX

152770780

+H19chr11

2018816

-
intron-intronENST00000370210ENST00000390168HAUS7chrX

152770780

+H19chr11

2018816

-

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FusionProtFeatures for HAUS7_H19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HAUS7

Q99871

H19

Contributes to mitotic spindle assembly, maintenance ofcentrosome integrity and completion of cytokinesis as part of theHAUS augmin-like complex. {ECO:0000269|PubMed:19369198,ECO:0000269|PubMed:19427217}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HAUS7_H19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HAUS7_H19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HAUS7_H19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HAUS7_H19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneH19C0019188Hepatitis, Animal1CTD_human
TgeneH19C0023904Liver Neoplasms, Experimental1CTD_human
TgeneH19C0175693Russell-Silver syndrome1CTD_human