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Fusion gene ID: 15850 |
FusionGeneSummary for HAUS6_SLC39A8 |
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Fusion gene information | Fusion gene name: HAUS6_SLC39A8 | Fusion gene ID: 15850 | Hgene | Tgene | Gene symbol | HAUS6 | SLC39A8 | Gene ID | 54801 | 64116 |
Gene name | HAUS augmin like complex subunit 6 | solute carrier family 39 member 8 | |
Synonyms | Dgt6|FAM29A | BIGM103|CDG2N|LZT-Hs6|PP3105|ZIP8 | |
Cytomap | 9p22.1 | 4q24 | |
Type of gene | protein-coding | protein-coding | |
Description | HAUS augmin-like complex subunit 6dim gamma-tubulin homologfamily with sequence similarity 29, member A | zinc transporter ZIP8BCG induced integral membrane protein BIGM103BCG-induced integral membrane protein in monocyte clone 103 proteinLIV-1 subfamily of ZIP zinc transporter 6ZIP-8Zrt- and Irt-like protein 8solute carrier family 39 (metal ion transpo | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q7Z4H7 | Q9C0K1 | |
Ensembl transtripts involved in fusion gene | ENST00000380502, ENST00000380496, | ENST00000424970, ENST00000394833, ENST00000356736, ENST00000510255, | |
Fusion gene scores | * DoF score | 4 X 4 X 6=96 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: HAUS6 [Title/Abstract] AND SLC39A8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB128514 | HAUS6 | chr9 | 19063654 | - | SLC39A8 | chr4 | 103226183 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000380502 | ENST00000424970 | HAUS6 | chr9 | 19063654 | - | SLC39A8 | chr4 | 103226183 | - |
intron-3CDS | ENST00000380502 | ENST00000394833 | HAUS6 | chr9 | 19063654 | - | SLC39A8 | chr4 | 103226183 | - |
intron-3CDS | ENST00000380502 | ENST00000356736 | HAUS6 | chr9 | 19063654 | - | SLC39A8 | chr4 | 103226183 | - |
intron-5UTR | ENST00000380502 | ENST00000510255 | HAUS6 | chr9 | 19063654 | - | SLC39A8 | chr4 | 103226183 | - |
intron-3CDS | ENST00000380496 | ENST00000424970 | HAUS6 | chr9 | 19063654 | - | SLC39A8 | chr4 | 103226183 | - |
intron-3CDS | ENST00000380496 | ENST00000394833 | HAUS6 | chr9 | 19063654 | - | SLC39A8 | chr4 | 103226183 | - |
intron-3CDS | ENST00000380496 | ENST00000356736 | HAUS6 | chr9 | 19063654 | - | SLC39A8 | chr4 | 103226183 | - |
intron-5UTR | ENST00000380496 | ENST00000510255 | HAUS6 | chr9 | 19063654 | - | SLC39A8 | chr4 | 103226183 | - |
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FusionProtFeatures for HAUS6_SLC39A8 |
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Hgene | Tgene |
HAUS6 | SLC39A8 |
Acts as a manganese and zinc influx transporter(PubMed:12504855, PubMed:26637978). Plays a role in manganesereabsorption in the proximal tubule of the kidney and in manganeseuptake into the brain (PubMed:26637978).{ECO:0000269|PubMed:12504855, ECO:0000305|PubMed:26637978}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HAUS6_SLC39A8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HAUS6_SLC39A8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HAUS6_SLC39A8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HAUS6_SLC39A8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SLC39A8 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | SLC39A8 | C4225234 | CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIn | 1 | ORPHANET;UNIPROT |