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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15850

FusionGeneSummary for HAUS6_SLC39A8

check button Fusion gene summary
Fusion gene informationFusion gene name: HAUS6_SLC39A8
Fusion gene ID: 15850
HgeneTgene
Gene symbol

HAUS6

SLC39A8

Gene ID

54801

64116

Gene nameHAUS augmin like complex subunit 6solute carrier family 39 member 8
SynonymsDgt6|FAM29ABIGM103|CDG2N|LZT-Hs6|PP3105|ZIP8
Cytomap

9p22.1

4q24

Type of geneprotein-codingprotein-coding
DescriptionHAUS augmin-like complex subunit 6dim gamma-tubulin homologfamily with sequence similarity 29, member Azinc transporter ZIP8BCG induced integral membrane protein BIGM103BCG-induced integral membrane protein in monocyte clone 103 proteinLIV-1 subfamily of ZIP zinc transporter 6ZIP-8Zrt- and Irt-like protein 8solute carrier family 39 (metal ion transpo
Modification date2018051920180523
UniProtAcc

Q7Z4H7

Q9C0K1

Ensembl transtripts involved in fusion geneENST00000380502, ENST00000380496, 
ENST00000424970, ENST00000394833, 
ENST00000356736, ENST00000510255, 
Fusion gene scores* DoF score4 X 4 X 6=961 X 1 X 1=1
# samples 61
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: HAUS6 [Title/Abstract] AND SLC39A8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB128514HAUS6chr9

19063654

-SLC39A8chr4

103226183

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000380502ENST00000424970HAUS6chr9

19063654

-SLC39A8chr4

103226183

-
intron-3CDSENST00000380502ENST00000394833HAUS6chr9

19063654

-SLC39A8chr4

103226183

-
intron-3CDSENST00000380502ENST00000356736HAUS6chr9

19063654

-SLC39A8chr4

103226183

-
intron-5UTRENST00000380502ENST00000510255HAUS6chr9

19063654

-SLC39A8chr4

103226183

-
intron-3CDSENST00000380496ENST00000424970HAUS6chr9

19063654

-SLC39A8chr4

103226183

-
intron-3CDSENST00000380496ENST00000394833HAUS6chr9

19063654

-SLC39A8chr4

103226183

-
intron-3CDSENST00000380496ENST00000356736HAUS6chr9

19063654

-SLC39A8chr4

103226183

-
intron-5UTRENST00000380496ENST00000510255HAUS6chr9

19063654

-SLC39A8chr4

103226183

-

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FusionProtFeatures for HAUS6_SLC39A8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HAUS6

Q7Z4H7

SLC39A8

Q9C0K1

Acts as a manganese and zinc influx transporter(PubMed:12504855, PubMed:26637978). Plays a role in manganesereabsorption in the proximal tubule of the kidney and in manganeseuptake into the brain (PubMed:26637978).{ECO:0000269|PubMed:12504855, ECO:0000305|PubMed:26637978}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HAUS6_SLC39A8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HAUS6_SLC39A8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HAUS6_SLC39A8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HAUS6_SLC39A8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC39A8C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSLC39A8C4225234CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIn1ORPHANET;UNIPROT