FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 15834

FusionGeneSummary for HARS_FAM53C

check button Fusion gene summary
Fusion gene informationFusion gene name: HARS_FAM53C
Fusion gene ID: 15834
HgeneTgene
Gene symbol

HARS

FAM53C

Gene ID

3035

51307

Gene namehistidyl-tRNA synthetasefamily with sequence similarity 53 member C
SynonymsCMT2W|HRS|USH3BC5orf6
Cytomap

5q31.3

5q31.2

Type of geneprotein-codingprotein-coding
Descriptionhistidine--tRNA ligase, cytoplasmicHisRShistidine translaseprotein FAM53Cputative nuclear protein
Modification date2018052320180519
UniProtAcc

P12081

Q9NYF3

Ensembl transtripts involved in fusion geneENST00000504156, ENST00000457527, 
ENST00000431330, ENST00000504366, 
ENST00000448240, ENST00000307633, 
ENST00000438307, ENST00000415192, 
ENST00000434981, ENST00000507506, 
ENST00000239906, ENST00000513056, 
Fusion gene scores* DoF score4 X 3 X 3=363 X 3 X 2=18
# samples 44
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HARS [Title/Abstract] AND FAM53C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E9-A1RC-01AHARSchr5

140070440

-FAM53Cchr5

137676873

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000504156ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-intronENST00000504156ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000504156ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000504156ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000457527ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-intronENST00000457527ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000457527ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000457527ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000431330ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-intronENST00000431330ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000431330ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000431330ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
intron-5UTRENST00000504366ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
intron-intronENST00000504366ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
intron-5UTRENST00000504366ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
intron-5UTRENST00000504366ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
5UTR-5UTRENST00000448240ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5UTR-intronENST00000448240ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5UTR-5UTRENST00000448240ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5UTR-5UTRENST00000448240ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000307633ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-intronENST00000307633ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000307633ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000307633ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000438307ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-intronENST00000438307ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000438307ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000438307ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000415192ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-intronENST00000415192ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000415192ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000415192ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+

Top

FusionProtFeatures for HARS_FAM53C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HARS

P12081

FAM53C

Q9NYF3

Cytoplasmic histidine--tRNA ligase (Probable). Plays arole in axon guidance. {ECO:0000269|PubMed:26072516, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for HARS_FAM53C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for HARS_FAM53C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HARSEEF1G, EEF1B2, TNIK, EIF2D, ANXA5, G6PD, PI4KA, AARSD1, CALU, EFTUD2, FEN1, ACBD3, ELAC2, GTF2E1, NSUN2, SHMT1, TTC1, XPO5, IPO7, PFDN1, RPUSD2, SNF8, THG1L, MOV10, NXF1, SGCZ, CKAP5, DTD1, GCN1L1, C9orf78, DHRS11, GARS, KIAA0101, MARS, PAPOLG, SARS, SNW1, SPDL1, THUMPD1, WDR5, HNRNPF, PLS3, PRRC1, WARS, NTRK1, PSMC5, MCM2, PTPDC1, PTPN2, HARS2, MTNR1BFAM53CYWHAZ, YWHAG, YWHAE, DYRK1B, DYRK1A, SFN, NCK2, PLK1, FNTB, TRAF3, XPO1, DCAF7, KSR1, EIF4E2, SH3PXD2A, CDC25B, DENND1A, ZNF638, CDK16, RAB3IP, LRFN1, SRSF12, USP21, FAM110A, FAM110B, MAGI1, TESK2, LIMA1, DCLK1, TBC1D25, ZBTB21, GIGYF1, SRGAP2, ANKRD34A, SYDE1, AGAP1, KCTD3, SIPA1L1, KIF13B, MAPKAP1, PPM1H, MAST3, RTKN, DENND4C, HDAC4, PHLDB2, TIAM1, GAB2, NADK, KIAA1804, MLLT4, SH3BP4, MELK, DEPDC1B, RASAL2, PLEKHA7, NF1, CBY1, KIF1C


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for HARS_FAM53C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for HARS_FAM53C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHARSC4225265CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2W2UNIPROT
HgeneHARSC0004364Autoimmune Diseases1CTD_human
HgeneHARSC0007134Renal Cell Carcinoma1CTD_human
HgeneHARSC0024115Lung diseases1CTD_human
HgeneHARSC3281066USHER SYNDROME, TYPE IIIB1UNIPROT