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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15833

FusionGeneSummary for HARS_DUSP6

check button Fusion gene summary
Fusion gene informationFusion gene name: HARS_DUSP6
Fusion gene ID: 15833
HgeneTgene
Gene symbol

HARS

DUSP6

Gene ID

3035

1848

Gene namehistidyl-tRNA synthetasedual specificity phosphatase 6
SynonymsCMT2W|HRS|USH3BHH19|MKP3|PYST1
Cytomap

5q31.3

12q21.33

Type of geneprotein-codingprotein-coding
Descriptionhistidine--tRNA ligase, cytoplasmicHisRShistidine translasedual specificity protein phosphatase 6MAP kinase phosphatase 3dual specificity protein phosphatase PYST1mitogen-activated protein kinase phosphatase 3serine/threonine specific protein phosphatase
Modification date2018052320180527
UniProtAcc

P12081

Q16828

Ensembl transtripts involved in fusion geneENST00000504156, ENST00000457527, 
ENST00000431330, ENST00000504366, 
ENST00000448240, ENST00000307633, 
ENST00000438307, ENST00000415192, 
ENST00000279488, ENST00000308385, 
ENST00000547291, ENST00000547140, 
Fusion gene scores* DoF score4 X 3 X 3=361 X 1 X 1=1
# samples 41
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: HARS [Title/Abstract] AND DUSP6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDUSP6

GO:0000188

inactivation of MAPK activity

8670865

TgeneDUSP6

GO:0035335

peptidyl-tyrosine dephosphorylation

8670865

TgeneDUSP6

GO:0043065

positive regulation of apoptotic process

10846176


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA527301HARSchr5

140062885

-DUSP6chr12

89746181

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000504156ENST00000279488HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000504156ENST00000308385HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000504156ENST00000547291HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000504156ENST00000547140HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000457527ENST00000279488HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000457527ENST00000308385HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000457527ENST00000547291HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000457527ENST00000547140HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000431330ENST00000279488HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000431330ENST00000308385HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000431330ENST00000547291HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000431330ENST00000547140HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000504366ENST00000279488HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000504366ENST00000308385HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000504366ENST00000547291HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000504366ENST00000547140HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000448240ENST00000279488HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000448240ENST00000308385HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000448240ENST00000547291HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000448240ENST00000547140HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000307633ENST00000279488HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000307633ENST00000308385HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000307633ENST00000547291HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000307633ENST00000547140HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000438307ENST00000279488HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000438307ENST00000308385HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000438307ENST00000547291HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000438307ENST00000547140HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000415192ENST00000279488HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-5UTRENST00000415192ENST00000308385HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000415192ENST00000547291HARSchr5

140062885

-DUSP6chr12

89746181

-
intron-intronENST00000415192ENST00000547140HARSchr5

140062885

-DUSP6chr12

89746181

-

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FusionProtFeatures for HARS_DUSP6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HARS

P12081

DUSP6

Q16828

Cytoplasmic histidine--tRNA ligase (Probable). Plays arole in axon guidance. {ECO:0000269|PubMed:26072516, ECO:0000305}. Inactivates MAP kinases. Has a specificity for the ERKfamily (PubMed:9858808). Plays an important role in alleviatingchronic postoperative pain. Necessary for the normaldephosphorylation of the long-lasting phosphorylated forms ofspinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery,which drives the resolution of acute postoperative allodynia (Bysimilarity). Also important for dephosphorylation of MAPK1/3 inlocal wound tissue, which further contributes to resolution ofacute pain (By similarity). {ECO:0000250|UniProtKB:Q9DBB1,ECO:0000269|PubMed:8670865}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HARS_DUSP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HARS_DUSP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HARS_DUSP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HARS_DUSP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHARSC4225265CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2W2UNIPROT
HgeneHARSC0004364Autoimmune Diseases1CTD_human
HgeneHARSC0007134Renal Cell Carcinoma1CTD_human
HgeneHARSC0024115Lung diseases1CTD_human
HgeneHARSC3281066USHER SYNDROME, TYPE IIIB1UNIPROT
TgeneDUSP6C0005586Bipolar Disorder3PSYGENET
TgeneDUSP6C0011570Mental Depression1PSYGENET
TgeneDUSP6C0011581Depressive disorder1HPO;PSYGENET
TgeneDUSP6C0017636Glioblastoma1CTD_human
TgeneDUSP6C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneDUSP6C0024667Animal Mammary Neoplasms1CTD_human
TgeneDUSP6C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneDUSP6C0036341Schizophrenia1PSYGENET
TgeneDUSP6C0151744Myocardial Ischemia1CTD_human
TgeneDUSP6C0525045Mood Disorders1PSYGENET
TgeneDUSP6C3808981HYPOGONADOTROPIC HYPOGONADISM 19 WITH OR WITHOUT ANOSMIA1UNIPROT