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Fusion gene ID: 1583 |
FusionGeneSummary for AMBP_ORM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AMBP_ORM1 | Fusion gene ID: 1583 | Hgene | Tgene | Gene symbol | AMBP | ORM1 | Gene ID | 259 | 5004 |
| Gene name | alpha-1-microglobulin/bikunin precursor | orosomucoid 1 | |
| Synonyms | A1M|EDC1|HCP|HI30|IATIL|ITI|ITIL|ITILC|UTI | AGP-A|AGP1|HEL-S-153w|ORM | |
| Cytomap | 9q32 | 9q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein AMBPbikunincomplex-forming glycoprotein heterogeneous in chargegrowth-inhibiting protein 19inter-alpha-trypsin inhibitor light chainprotein HCtrypstatinuristatinuronic-acid-rich protein | alpha-1-acid glycoprotein 1AGP 1OMD 1epididymis secretory sperm binding protein Li 153w | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P02760 | P02763 | |
| Ensembl transtripts involved in fusion gene | ENST00000265132, | ENST00000259396, ENST00000538816, ENST00000477456, | |
| Fusion gene scores | * DoF score | 5 X 3 X 1=15 | 5 X 5 X 3=75 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/15*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AMBP [Title/Abstract] AND ORM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ORM1 | GO:0032715 | negative regulation of interleukin-6 production | 23973664 |
| Tgene | ORM1 | GO:0032720 | negative regulation of tumor necrosis factor production | 23973664 |
| Tgene | ORM1 | GO:0050716 | positive regulation of interleukin-1 secretion | 8774350 |
| Tgene | ORM1 | GO:0050718 | positive regulation of interleukin-1 beta secretion | 8774350 |
| Tgene | ORM1 | GO:1904469 | positive regulation of tumor necrosis factor secretion | 8774350 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-DD-A4NH-01A | AMBP | chr9 | 116835205 | - | ORM1 | chr9 | 117088572 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000265132 | ENST00000259396 | AMBP | chr9 | 116835205 | - | ORM1 | chr9 | 117088572 | + |
| 5CDS-intron | ENST00000265132 | ENST00000538816 | AMBP | chr9 | 116835205 | - | ORM1 | chr9 | 117088572 | + |
| 5CDS-intron | ENST00000265132 | ENST00000477456 | AMBP | chr9 | 116835205 | - | ORM1 | chr9 | 117088572 | + |
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FusionProtFeatures for AMBP_ORM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AMBP | ORM1 |
| Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin,and lysosomal granulocytic elastase. Inhibits calcium oxalatecrystallization. {ECO:0000269|PubMed:7676539}. Trypstatin is a trypsin inhibitor. {ECO:0000250}. | Functions as transport protein in the blood stream.Binds various ligands in the interior of its beta-barrel domain.Also binds synthetic drugs and influences their distribution andavailability in the body. Appears to function in modulating theactivity of the immune system during the acute-phase reaction.{ECO:0000269|PubMed:17008009, ECO:0000269|PubMed:17321687}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AMBP_ORM1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AMBP_ORM1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AMBP | AMBP, CD79A, FN1, A2M, ALB, GRB2, PIK3R3, PIK3CA, COX8A, ENO1, STAT3, DAAM1, FHL3 | ORM1 | SERPINE1, PIK3R3, GSDMB, TP63, TMEM37, BLVRB, GLUD1, GDPD1, DDX19B, ORM2, DDX31, SNX27, MAPK6, CDK15, PTGDS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AMBP_ORM1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | AMBP | P02760 | DB00062 | Human Serum Albumin | Protein AMBP | biotech | approved |
| Tgene | ORM1 | P02763 | DB00975 | Dipyridamole | Alpha-1-acid glycoprotein 1 | small molecule | approved |
| Tgene | ORM1 | P02763 | DB00497 | Oxycodone | Alpha-1-acid glycoprotein 1 | small molecule | approved|illicit|investigational |
| Tgene | ORM1 | P02763 | DB00276 | Amsacrine | Alpha-1-acid glycoprotein 1 | small molecule | approved|investigational |
| Tgene | ORM1 | P02763 | DB00477 | Chlorpromazine | Alpha-1-acid glycoprotein 1 | small molecule | approved|investigational|vet_approved |
| Tgene | ORM1 | P02763 | DB01041 | Thalidomide | Alpha-1-acid glycoprotein 1 | small molecule | approved|investigational|withdrawn |
| Tgene | ORM1 | P02763 | DB00281 | Lidocaine | Alpha-1-acid glycoprotein 1 | small molecule | approved|vet_approved |
| Tgene | ORM1 | P02763 | DB00396 | Progesterone | Alpha-1-acid glycoprotein 1 | small molecule | approved|vet_approved |
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RelatedDiseases for AMBP_ORM1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AMBP | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| Hgene | AMBP | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | AMBP | C2609414 | Acute kidney injury | 1 | CTD_human |
| Hgene | AMBP | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Tgene | ORM1 | C0085605 | Liver Failure | 1 | CTD_human |
| Tgene | ORM1 | C0344315 | Depressed mood | 1 | PSYGENET |
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