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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15827

FusionGeneSummary for HAPLN2_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: HAPLN2_MBP
Fusion gene ID: 15827
HgeneTgene
Gene symbol

HAPLN2

MBP

Gene ID

60484

5553

Gene namehyaluronan and proteoglycan link protein 2proteoglycan 2, pro eosinophil major basic protein
SynonymsBRAL1BMPG|MBP|MBP1|proMBP
Cytomap

1q23.1

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionhyaluronan and proteoglycan link protein 2brain link protein-1bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018052320180519
UniProtAcc

Q9GZV7

P02686

Ensembl transtripts involved in fusion geneENST00000255039, ENST00000494218, 
ENST00000382582, ENST00000355994, 
ENST00000397875, ENST00000397866, 
ENST00000397865, ENST00000527041, 
ENST00000359645, ENST00000528160, 
ENST00000397869, ENST00000354542, 
ENST00000526111, ENST00000580402, 
ENST00000579129, ENST00000578193, 
ENST00000397863, ENST00000397860, 
ENST00000487778, 
Fusion gene scores* DoF score2 X 2 X 1=426 X 20 X 3=1560
# samples 227
** MAII scorelog2(2/4*10)=2.32192809488736log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HAPLN2 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA270267HAPLN2chr1

156593369

+MBPchr18

74700872

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000255039ENST00000382582HAPLN2chr1

156593369

+MBPchr18

74700872

-
Frame-shitENST00000255039ENST00000355994HAPLN2chr1

156593369

+MBPchr18

74700872

-
Frame-shitENST00000255039ENST00000397875HAPLN2chr1

156593369

+MBPchr18

74700872

-
Frame-shitENST00000255039ENST00000397866HAPLN2chr1

156593369

+MBPchr18

74700872

-
Frame-shitENST00000255039ENST00000397865HAPLN2chr1

156593369

+MBPchr18

74700872

-
5CDS-intronENST00000255039ENST00000527041HAPLN2chr1

156593369

+MBPchr18

74700872

-
5CDS-intronENST00000255039ENST00000359645HAPLN2chr1

156593369

+MBPchr18

74700872

-
5CDS-intronENST00000255039ENST00000528160HAPLN2chr1

156593369

+MBPchr18

74700872

-
5CDS-intronENST00000255039ENST00000397869HAPLN2chr1

156593369

+MBPchr18

74700872

-
5CDS-intronENST00000255039ENST00000354542HAPLN2chr1

156593369

+MBPchr18

74700872

-
5CDS-intronENST00000255039ENST00000526111HAPLN2chr1

156593369

+MBPchr18

74700872

-
5CDS-intronENST00000255039ENST00000580402HAPLN2chr1

156593369

+MBPchr18

74700872

-
5CDS-intronENST00000255039ENST00000579129HAPLN2chr1

156593369

+MBPchr18

74700872

-
5CDS-intronENST00000255039ENST00000578193HAPLN2chr1

156593369

+MBPchr18

74700872

-
5CDS-intronENST00000255039ENST00000397863HAPLN2chr1

156593369

+MBPchr18

74700872

-
5CDS-intronENST00000255039ENST00000397860HAPLN2chr1

156593369

+MBPchr18

74700872

-
5CDS-intronENST00000255039ENST00000487778HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-3CDSENST00000494218ENST00000382582HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-3CDSENST00000494218ENST00000355994HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-3CDSENST00000494218ENST00000397875HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-3CDSENST00000494218ENST00000397866HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-3CDSENST00000494218ENST00000397865HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-intronENST00000494218ENST00000527041HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-intronENST00000494218ENST00000359645HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-intronENST00000494218ENST00000528160HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-intronENST00000494218ENST00000397869HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-intronENST00000494218ENST00000354542HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-intronENST00000494218ENST00000526111HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-intronENST00000494218ENST00000580402HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-intronENST00000494218ENST00000579129HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-intronENST00000494218ENST00000578193HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-intronENST00000494218ENST00000397863HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-intronENST00000494218ENST00000397860HAPLN2chr1

156593369

+MBPchr18

74700872

-
intron-intronENST00000494218ENST00000487778HAPLN2chr1

156593369

+MBPchr18

74700872

-

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FusionProtFeatures for HAPLN2_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HAPLN2

Q9GZV7

MBP

P02686

Mediates a firm binding of versican V2 to hyaluronicacid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) whichfacilitates neuronal conduction and general structuralstabilization. Binds to hyaluronic acid (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HAPLN2_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HAPLN2_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
HAPLN2MBPTRPM7, PRMT5, STK39, HLA-DRA, PLP1, TSSK6, IRAK4, PRKCA, PRKCI, PRKCZ, PPP2R5C, LIMK1, LIMK2, TBK1, IKBKE, STK3, APTX, ATN1, ATXN1, MAPK14, LRRK2, PRKDC, MAPK12, MAPK11, MAPK13, MAPK3, MAPK1, CDK1, CDK5, MAP3K5, TLK1, RPS6KA6, DDX58, MELK, CDK7, CDK8, CDK9, HIPK2, SQSTM1, PKN1, ULK1, PRKCB, MAP3K3, CTDSP1, ABL1, MUS81, RPS6KA5, MYH6, MAP3K1, MAPK8, CTDSPL, NLN, IDE, PTPRA, PRKCD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HAPLN2_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HAPLN2_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human