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Fusion gene ID: 15824 |
FusionGeneSummary for HAPLN1_EDIL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HAPLN1_EDIL3 | Fusion gene ID: 15824 | Hgene | Tgene | Gene symbol | HAPLN1 | EDIL3 | Gene ID | 1404 | 10085 |
| Gene name | hyaluronan and proteoglycan link protein 1 | EGF like repeats and discoidin domains 3 | |
| Synonyms | CRT1|CRTL1 | DEL1 | |
| Cytomap | 5q14.3 | 5q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | hyaluronan and proteoglycan link protein 1Cartilage link proteincartilage-link proteincartilage-linking protein 1proteoglycan link protein | EGF-like repeat and discoidin I-like domain-containing protein 3EGF-like repeats and discoidin I-like domains 3developmental endothelial locus-1developmentally-regulated endothelial cell locus 1 proteinintegrin-binding protein DEL1 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P10915 | O43854 | |
| Ensembl transtripts involved in fusion gene | ENST00000274341, ENST00000514416, | ENST00000296591, ENST00000380138, ENST00000510271, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 4=64 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HAPLN1 [Title/Abstract] AND EDIL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-DA-A1I7-06A | HAPLN1 | chr5 | 83016608 | - | EDIL3 | chr5 | 83239387 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000274341 | ENST00000296591 | HAPLN1 | chr5 | 83016608 | - | EDIL3 | chr5 | 83239387 | - |
| 5UTR-3CDS | ENST00000274341 | ENST00000380138 | HAPLN1 | chr5 | 83016608 | - | EDIL3 | chr5 | 83239387 | - |
| 5UTR-intron | ENST00000274341 | ENST00000510271 | HAPLN1 | chr5 | 83016608 | - | EDIL3 | chr5 | 83239387 | - |
| intron-3CDS | ENST00000514416 | ENST00000296591 | HAPLN1 | chr5 | 83016608 | - | EDIL3 | chr5 | 83239387 | - |
| intron-3CDS | ENST00000514416 | ENST00000380138 | HAPLN1 | chr5 | 83016608 | - | EDIL3 | chr5 | 83239387 | - |
| intron-intron | ENST00000514416 | ENST00000510271 | HAPLN1 | chr5 | 83016608 | - | EDIL3 | chr5 | 83239387 | - |
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FusionProtFeatures for HAPLN1_EDIL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HAPLN1 | EDIL3 |
| Stabilizes the aggregates of proteoglycan monomers withhyaluronic acid in the extracellular cartilage matrix. | Promotes adhesion of endothelial cells throughinteraction with the alpha-v/beta-3 integrin receptor. Inhibitsformation of vascular-like structures. May be involved inregulation of vascular morphogenesis of remodeling in embryonicdevelopment. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for HAPLN1_EDIL3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for HAPLN1_EDIL3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| HAPLN1 | VCAN, APP | EDIL3 | CDKL1, CCDC8, HAX1, NUFIP1, DGUOK, TF, ITGB5, LPHN1, ZNF496, ITGAV |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for HAPLN1_EDIL3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | HAPLN1 | P10915 | DB08818 | Hyaluronic acid | Hyaluronan and proteoglycan link protein 1 | small molecule | approved|vet_approved |
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RelatedDiseases for HAPLN1_EDIL3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HAPLN1 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Hgene | HAPLN1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | HAPLN1 | C0013336 | Dwarfism | 1 | CTD_human |
| Hgene | HAPLN1 | C0206762 | Limb Deformities, Congenital | 1 | CTD_human |
| Hgene | HAPLN1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Tgene | EDIL3 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
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