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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15802

FusionGeneSummary for HACL1_ZZEF1

check button Fusion gene summary
Fusion gene informationFusion gene name: HACL1_ZZEF1
Fusion gene ID: 15802
HgeneTgene
Gene symbol

HACL1

ZZEF1

Gene ID

26061

23140

Gene name2-hydroxyacyl-CoA lyase 1zinc finger ZZ-type and EF-hand domain containing 1
Synonyms2-HPCL|HPCL|HPCL2|PHYH2ZZZ4
Cytomap

3p25.1

17p13.2

Type of geneprotein-codingprotein-coding
Description2-hydroxyacyl-CoA lyase 11600020H07Rik2-hydroxyphytanol-CoA lyase2-hydroxyphytanoyl-CoA lyasephytanoyl-CoA 2-hydroxylase 2phytanoyl-CoA hydroxylase 2zinc finger ZZ-type and EF-hand domain-containing protein 1zinc finger, ZZ-type with EF hand domain 1
Modification date2018052320180519
UniProtAcc

Q9UJ83

O43149

Ensembl transtripts involved in fusion geneENST00000321169, ENST00000435217, 
ENST00000451445, ENST00000456194, 
ENST00000457447, 
ENST00000381638, 
ENST00000574474, 
Fusion gene scores* DoF score4 X 4 X 2=329 X 11 X 5=495
# samples 514
** MAII scorelog2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(14/495*10)=-1.82200169802201
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HACL1 [Title/Abstract] AND ZZEF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHACL1

GO:0001561

fatty acid alpha-oxidation

10468558

HgeneHACL1

GO:0051259

protein complex oligomerization

21708296


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI969337HACL1chr3

15604937

+ZZEF1chr17

3926423

+
ChiTaRS3.1BE501084HACL1chr3

15604937

+ZZEF1chr17

3926423

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000321169ENST00000381638HACL1chr3

15604937

+ZZEF1chr17

3926423

+
intron-intronENST00000321169ENST00000574474HACL1chr3

15604937

+ZZEF1chr17

3926423

+
intron-intronENST00000435217ENST00000381638HACL1chr3

15604937

+ZZEF1chr17

3926423

+
intron-intronENST00000435217ENST00000574474HACL1chr3

15604937

+ZZEF1chr17

3926423

+
intron-intronENST00000451445ENST00000381638HACL1chr3

15604937

+ZZEF1chr17

3926423

+
intron-intronENST00000451445ENST00000574474HACL1chr3

15604937

+ZZEF1chr17

3926423

+
intron-intronENST00000456194ENST00000381638HACL1chr3

15604937

+ZZEF1chr17

3926423

+
intron-intronENST00000456194ENST00000574474HACL1chr3

15604937

+ZZEF1chr17

3926423

+
intron-intronENST00000457447ENST00000381638HACL1chr3

15604937

+ZZEF1chr17

3926423

+
intron-intronENST00000457447ENST00000574474HACL1chr3

15604937

+ZZEF1chr17

3926423

+

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FusionProtFeatures for HACL1_ZZEF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HACL1

Q9UJ83

ZZEF1

O43149

Catalyzes a carbon-carbon cleavage reaction; cleaves a2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branchedfatty aldehyde.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for HACL1_ZZEF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for HACL1_ZZEF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for HACL1_ZZEF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HACL1_ZZEF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHACL1C0008370Cholestasis1CTD_human
HgeneHACL1C4277682Chemical and Drug Induced Liver Injury1CTD_human