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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15784

FusionGeneSummary for H3F3B_KCTD18

check button Fusion gene summary
Fusion gene informationFusion gene name: H3F3B_KCTD18
Fusion gene ID: 15784
HgeneTgene
Gene symbol

H3F3B

KCTD18

Gene ID

3021

130535

Gene nameH3 histone family member 3Bpotassium channel tetramerization domain containing 18
SynonymsH3.3B6530404F10Rik
Cytomap

17q25.1

2q33.1

Type of geneprotein-codingprotein-coding
Descriptionhistone H3.3H3 histone, family 3B (H3.3B)BTB/POZ domain-containing protein KCTD18potassium channel tetramerisation domain containing 18
Modification date2018052320180519
UniProtAcc

P84243

Q6PI47

Ensembl transtripts involved in fusion geneENST00000254810, ENST00000593254, 
ENST00000592643, ENST00000591890, 
ENST00000587560, ENST00000589599, 
ENST00000586607, 
ENST00000359878, 
ENST00000409157, ENST00000468413, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 4 X 3=48
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: H3F3B [Title/Abstract] AND KCTD18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneH3F3B

GO:0006334

nucleosome assembly

21636898

HgeneH3F3B

GO:0006336

DNA replication-independent nucleosome assembly

14718166


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE771697H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000254810ENST00000359878H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-3UTRENST00000254810ENST00000409157H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-intronENST00000254810ENST00000468413H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-3UTRENST00000593254ENST00000359878H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-3UTRENST00000593254ENST00000409157H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-intronENST00000593254ENST00000468413H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-3UTRENST00000592643ENST00000359878H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-3UTRENST00000592643ENST00000409157H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-intronENST00000592643ENST00000468413H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-3UTRENST00000591890ENST00000359878H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-3UTRENST00000591890ENST00000409157H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-intronENST00000591890ENST00000468413H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-3UTRENST00000587560ENST00000359878H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-3UTRENST00000587560ENST00000409157H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-intronENST00000587560ENST00000468413H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-3UTRENST00000589599ENST00000359878H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-3UTRENST00000589599ENST00000409157H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-intronENST00000589599ENST00000468413H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-3UTRENST00000586607ENST00000359878H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-3UTRENST00000586607ENST00000409157H3F3Bchr17

73774597

+KCTD18chr2

201354607

+
intron-intronENST00000586607ENST00000468413H3F3Bchr17

73774597

+KCTD18chr2

201354607

+

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FusionProtFeatures for H3F3B_KCTD18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
H3F3B

P84243

KCTD18

Q6PI47

Variant histone H3 which replaces conventional H3 in awide range of nucleosomes in active genes. Constitutes thepredominant form of histone H3 in non-dividing cells and isincorporated into chromatin independently of DNA synthesis.Deposited at sites of nucleosomal displacement throughouttranscribed genes, suggesting that it represents an epigeneticimprint of transcriptionally active chromatin. Nucleosomes wrapand compact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as a template. Histonesthereby play a central role in transcription regulation, DNArepair, DNA replication and chromosomal stability. DNAaccessibility is regulated via a complex set of post-translationalmodifications of histones, also called histone code, andnucleosome remodeling. {ECO:0000269|PubMed:14718166,ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for H3F3B_KCTD18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for H3F3B_KCTD18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for H3F3B_KCTD18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for H3F3B_KCTD18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneH3F3BC0008441Chondroblastoma1CTD_human
HgeneH3F3BC0024667Animal Mammary Neoplasms1CTD_human
HgeneH3F3BC0024668Mammary Neoplasms, Experimental1CTD_human