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Fusion gene ID: 15783 |
FusionGeneSummary for H3F3B_CCT5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: H3F3B_CCT5 | Fusion gene ID: 15783 | Hgene | Tgene | Gene symbol | H3F3B | CCT5 | Gene ID | 3021 | 22948 |
| Gene name | H3 histone family member 3B | chaperonin containing TCP1 subunit 5 | |
| Synonyms | H3.3B | CCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon | |
| Cytomap | 17q25.1 | 5p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone H3.3H3 histone, family 3B (H3.3B) | T-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P84243 | P48643 | |
| Ensembl transtripts involved in fusion gene | ENST00000254810, ENST00000593254, ENST00000592643, ENST00000591890, ENST00000587560, ENST00000589599, ENST00000586607, | ENST00000280326, ENST00000503026, ENST00000515390, ENST00000515676, ENST00000506600, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 49 X 6 X 16=4704 |
| # samples | 3 | 53 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(53/4704*10)=-3.1498237953858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: H3F3B [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | H3F3B | GO:0006334 | nucleosome assembly | 21636898 |
| Hgene | H3F3B | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-HT-A61C-01A | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000254810 | ENST00000280326 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000254810 | ENST00000503026 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000254810 | ENST00000515390 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000254810 | ENST00000515676 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000254810 | ENST00000506600 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000593254 | ENST00000280326 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000593254 | ENST00000503026 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000593254 | ENST00000515390 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000593254 | ENST00000515676 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000593254 | ENST00000506600 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000592643 | ENST00000280326 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000592643 | ENST00000503026 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000592643 | ENST00000515390 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000592643 | ENST00000515676 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000592643 | ENST00000506600 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000591890 | ENST00000280326 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000591890 | ENST00000503026 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000591890 | ENST00000515390 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000591890 | ENST00000515676 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000591890 | ENST00000506600 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000587560 | ENST00000280326 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000587560 | ENST00000503026 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000587560 | ENST00000515390 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000587560 | ENST00000515676 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000587560 | ENST00000506600 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000589599 | ENST00000280326 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000589599 | ENST00000503026 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000589599 | ENST00000515390 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000589599 | ENST00000515676 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000589599 | ENST00000506600 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000586607 | ENST00000280326 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000586607 | ENST00000503026 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000586607 | ENST00000515390 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000586607 | ENST00000515676 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000586607 | ENST00000506600 | H3F3B | chr17 | 73772517 | - | CCT5 | chr5 | 10250033 | + |
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FusionProtFeatures for H3F3B_CCT5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| H3F3B | CCT5 |
| Variant histone H3 which replaces conventional H3 in awide range of nucleosomes in active genes. Constitutes thepredominant form of histone H3 in non-dividing cells and isincorporated into chromatin independently of DNA synthesis.Deposited at sites of nucleosomal displacement throughouttranscribed genes, suggesting that it represents an epigeneticimprint of transcriptionally active chromatin. Nucleosomes wrapand compact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as a template. Histonesthereby play a central role in transcription regulation, DNArepair, DNA replication and chromosomal stability. DNAaccessibility is regulated via a complex set of post-translationalmodifications of histones, also called histone code, andnucleosome remodeling. {ECO:0000269|PubMed:14718166,ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}. | Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for H3F3B_CCT5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_H3F3B_ENST00000254810_chr17_73772517_-_CCT5_ENST00000280326_chr5_10250033_+_682aa KKKKNRKWVLPSSRSRSAKKXRNSALSQXIPPWDPLSRNYQWXRFKKXQIQSALDLCVLRFPLSVFKPPPPRLPGXXKFPKAADSRRYCL AXNXSQXKHKSRASCAARAQAFGPSREREVHSRFRSGLRRLGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMA AKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHP IRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLE DTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEA NHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKR SLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_H3F3B_ENST00000254810_chr17_73772517_-_CCT5_ENST00000280326_chr5_10250033_+_2046nt AAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATT CCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGA TTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTG GCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTG CATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCTTCGAT GAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCA GCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGGAGATGTGACTGTA ACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGAT GAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCA ATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAG GACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTGCTGTG AATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAG GACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATT CTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATAC GAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCA AATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGG ATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGGATAAA ATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGAAACGA TCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCC CTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATG GCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGC ATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_H3F3B_ENST00000254810_chr17_73772517_-_CCT5_ENST00000280326_chr5_10250033_+_6380nt GAGCGCAGAGCGGTTTGGTCGTTCGTTGGGCGGTGCTGGTTTTTCGCTCGTCGACTGCGGCTCTTCCTCGGGCAGCGGAAGCGGCGCGGC GGTCGGAGAAGTGGCCTAAAACTTCGGCGTTGGGTGAAAGAAAATGGCCCGAACCAAGCAGACTGCTCGTAAGTCCACCGGTGGGAAAGC CCCCCGCAAACAGCTGGCCACGAAAGCCGCCAGGAAAAGCGCTCCCTCTACCGGCGGGGTGAAGAAGCCTCATCGCTACAGGCCCGGGAC CGTGGCGCTTCGAGAGATTCGTCGTTATCAGAAGTCGACCGAGCTGCTCATCCGGAAGCTGCCCTTCCAGAGGTTGGTGAGGGAGATCGC GCAGGATTTCAAAACCGACCTGAGGTTTCAGAGCGCAGCCATCGGTGCGCTGCAGGAGGCTAGCGAAGCGTACCTGGTGGGTCTGTTCGA AGATACCAACCTGTGTGCCATCCACGCTAAGAGAGTCACCATCATGCCCAAAGACATCCAGTTGGCTCGCCGGATACGGGGAGAGAGAGC TTAAGTGAAGGCAGTTTTTATGGCGTTTTGTAGTAAATTCTGTAAAATACTTTGGTTTAATTTGTGACTTTTTTTGTAAGAAATTGTTTA TAATATGTTGCATTTGTACTTAAGTCATTCCATCTTTCACTCAGGATGAATGCGAAAAGTGACTGTTCACAGACCTCAGTGATGTGAGCA CTGTTGCTCAGGAGTGACAAGTTGCTAATATGCAGAAGGGATGGGTGATACTTCTTGCTTCTCATGATGCATGTTTCTGTATGTTAATGA CTTGTTGGGTAGCTATTAAGGTACTAGAGTTGATAAATGTGTACAGGGTCCTTTTGCAATAAAACTGGTTATGACTTGATCCAAGTGTTT AACAATTGGGGCTGTTAAGTCTGACCATACATCACTGTGATAGAATGTGGGCTTTTTCAAGGGTGAAGATACAAGTCTTAACCACAGTGT AACTTACAGTTTCCTTTAAAAAAAAAAAAAGTAAACCTGGCAGCTATAGAATACACTATGTGCATTTATAATAGCTATTTTATATATTGT AGTATCAACATTTTTAAATTAAATGTTTTACATTCACAAGTGGTGGGGAGTCTTGTCATTAAGGTGTGTGTAATTTAGAGTCCAGTTGGT TTTCTTCTGACTGCACTTGTTCTCATAGTAGTAAAATGCTATGCGCATTTATACCTTGCATAAGTCCTCATTCTACCACATGTTAACCCT CTAGCTGATAATGCAAACACTAACTGGGGGATTTTATTTATAAGGGCTCTAGAAAAAACGAGTTATTCACACCAGCATCATCTTAACTAA CATTCTGAACTAGTTAGTGCAGCTTTTCATTGTGTTGTGTGGTTGGTCTCATAACTAGGTTGAGTTTTTCTCCTCTGCTGAGGAAACAGT ACCGAAGTTCTTTTTCTTGTGGCATTTGTATTATAAAAACTTGGTGTGGGGGAGGAGCACAAAACTCCAGCCCACTGAACCTCTGCCAAT TAAGATGGTGTTGGGTTAGGTTACATCTGGTTACTGTCCTGGGAAAATCATTTTTATAGAGATGGCCTTCCAAGTGGTTTTAAAATTTAC TGAAGTTTTTAGGTCAATTATGTATGTTGACTAAATTTACAAATAAACTTGTTTATCCAACTAAGTGTCCAAAACCTAAATTGAATGTAC TAAGTTTTCACATGTCCCATTATCTAGGTCCTTGTATACTAATGTTTTGAACTTAGATCATTTCAGGTGTTGTTTGGTGGATAAAGGAAC CTTTTATTTATAAAGATACTGTAGAAAGCATGTGAACAGCTCTCTGCTTGATTAAGATGCCATAATAGTGCTGTATTTGCAGTGTGGGCT AAGACAAAGTATATTAATAAGCTTTTCAGCCCCCCCACTCCCGTTCCGTAGTGTAGAAGCCCACAGGTGTAGAACTCAGTCTTAAACTTC AGTATGAAACCAGTTTCCTTGTGCGATGATGGCCACTAAAGCATAGTACGTGGATGTCAGTGAGACAGCATGAGAGCCAGCAGTCATCAA AGCGTTCCACGTTTGAAGTTAGCAACTGCTTAAAGTTATACCCCATTAAAATTGCTTTCTCAAAAGTTTGGGTTAGTTTCAAATGTGATA TTTTGGAGGGAAGGTAAAGTAGGTATCTTTCAGGTCGTGATAATGAGCTCCTATGAAAGGATGCAATATAATGACCCGCTTTTCTAGAAA GTTCATAATCAGCTCTGGAACAAGCACACTTGATTCCTCACTGTGCTTCAGAATGAGATTAAGATCAGATGTTGGAACGTGCTATGCTGT AGCGTGTCTGGAAACAAAGTACACAAACCTGGCTACGGTGATGAGTTAGCTTCTGCTTACTACCTGTGACAACCCAAGTGGGTGACACTA GTGAACCTTCTCCAGTCTGCAGGCTGGCATAGAAGGCTCTTAGATTATATTGGGCAGCTTGCAATCTGCCGAAGCAGTGACTTGCATTTC CACACTTGGCTTGAGCACTCAACCCAGAAGGCGAAGATAGCTTTTGGTTGTAGGCGGCTTCCTGTATGGGATATCCCTCGGTAAGGGTAA AGGAGCAGAGGCAAAGGAGAAAAGCAGAAGTTGCAGCTGATGCAGGTATCCTATGCCCTTGATGGATGAGACTAAAATAAAATTTTTGAA GTTAAAAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAAT GAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCC TAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACT GTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGG AAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCT TCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAA TGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGGAGATGTGA CTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGG ATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTC ACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACA TAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTG CTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGC TGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTG CAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGA AATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATG AAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAG GGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGG ATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGA AACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCT GTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCC CCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTC TTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTC TTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGACATTGAGAAAACTATG TAGCAAGATCCACTTCTGTGATTAAGTAAATGGATGTCTCGTGATGCATCTACAGTTATTTATTGTTACATCCTTTTCCAGACACTGTAG ATGCTATAATAAAAATAGCTGTTTGGTAACCATAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATCTCAACTGCTTTTGTA TTCATTGTATTAAAAGAATCTGTTTAAACAACCTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGTAATTAAATGCTGCCT TAATTGAAGGGGTTTGGGTGGATTTTTTTTTCTCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAGCTCTCAAGATGCACT TTCATATTGAGAGGAATATGGGCTTGATCCTCTTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCACCACAGAATTATGGGA TGCCTTAAGTGCTGTTACTAGGTTGCTCACAGCCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGAGCCTTTGCTTTCCTC TGGCCCCGGCCCCACCCTGAACACAGCTCATACACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACAGGCTTAGGGCAGTTC AGAACCCACTTGTTTCCCTATCAGAGGGACACAGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAAATCTTGCAGTTACCA TGTTCAGATAGAGTGACTGAAATTAATTGTACTTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAGACGCTCCGAGAACTCTACCG GGATTGTCTGTTCTGACAACCCAGTGAGGCAGATACACTTTCTTACTGCTCACATCTTACAGGTGAGTACTCATAATTGGCCAGCATCTC ACCACCAGCAAGTAGTAGGGCCAGGTCAATCCCAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCTGTTATTTGCTTGTTA ATGATTCTCTAGATTTTCTAAAATAATGTTTCTTAGCATTGTGATGATAAAGCTCATGATGAACTTTATCACTAGTTATGCCACCTTAAC TAGTCAGATTTCCTAGAATTAGGAAATGGTGACTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTCTCATGTGAACCTGGA GATTCACCAGTCTTAACTTTTGGGTCATTGTGTTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATAACTCCTGTGGATTTAGGAAT GTGTGCTAATAGCAATCTTCCTAATTTTCATGTTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTGAGTTTATTTACAAGG ACTGAGTCTAGCCTACAGAGAACATACAGCAGCCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTATCAGAAGAGCCACTA AACCAATCCCCCTTTCCAAAATTGAACCTCACAGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACAGGAAGACTTAGAGAT |
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FusionGenePPI for H3F3B_CCT5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| H3F3B | EHMT2, ATRX, ARRB1, ITGA4, CD81, IGSF8, ICAM1, FUS, NASP, ESR1, SGOL2, LACC1, UNK, MCM2, MCM5, KIF3A, PDHA1 | CCT5 | XRN1, THEG, SSSCA1, HDAC3, ACTB, TBC1D17, IKBKAP, IMMT, TP53, PPP4C, CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, TRAF3IP3, PPP2CB, PPP2R2C, IGBP1, TCP1, ACTA2, ACTA1, GPN1, HNRNPH1, RPAP2, RPAP3, CDK9, RFWD2, SRRM2, SRRM1, WDR82, H2AFX, UBC, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, AGO4, HDAC5, PCK1, VHL, SIRT7, FBXO25, CUL3, CUL4A, CDK2, GNB5, GNB1, RGS7, PDCL, GRB2, PACRG, CCT2, CCT3, CCT8, CCT6A, CCT4, CCT7, CCT6B, AHCYL1, IARS, TARS, PSMA6, PSMB1, VCP, SSR1, XPO1, SLU7, TXNL1, SRSF2, ATXN2, TRIM28, FN1, VCAM1, ATF2, PEX14, NOS2, FAM86B2, METTL21B, ITGA4, PAN2, HDAC6, FBXW4, TERT, FBXO6, CDK5, ILK, CDC20, LGALS3BP, NEDD1, TUBG1, HUWE1, FUS, CUL7, OBSL1, RNF2, SIRT6, IKBKE, IRAK1, SGK2, TSSK6, TYK2, WDR76, POC1A, PEX7, RPS6KB2, DCAF7, UNK, ACTR2, AHNAK, HSPE1, PIN4, STUB1, NTRK1, BTRC, B9D1, MKS1, CETN2, CDK1, DDB2, HDAC1, PDK3, NSMAF, NIPSNAP1, PRPF4, BUB3, WRAP53, RFWD3, KIF21A, SEH1L, KBTBD7, TUBA1C, ARMC6, GAN, CRY2, ALKBH3, MCM2, SNW1, CDC5L, TTC27, NLE1, CDC73, CRBN, PPM1J, KLHDC8A, DNAI2, HCFC2, WDR77, DCAF11, KDM4B, KLHL33, KLHDC2, TXNDC9, WDR86, TBL1Y, DCAF8, THOC3, WDTC1, GANAB, ODF1, DCAF5, SEC31B, TSSC1, WDR83, CYLD, WDR92, TRIM25, MCPH1, HEY1, BRCA1, YAP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for H3F3B_CCT5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for H3F3B_CCT5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | H3F3B | C0008441 | Chondroblastoma | 1 | CTD_human |
| Hgene | H3F3B | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | H3F3B | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | CCT5 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | CCT5 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | CCT5 | C1850395 | Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive | 1 | CTD_human;ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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