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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15733

FusionGeneSummary for GYS1_EML2

check button Fusion gene summary
Fusion gene informationFusion gene name: GYS1_EML2
Fusion gene ID: 15733
HgeneTgene
Gene symbol

GYS1

EML2

Gene ID

2997

24139

Gene nameglycogen synthase 1echinoderm microtubule associated protein like 2
SynonymsGSY|GYSELP70|EMAP-2|EMAP2
Cytomap

19q13.33

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionglycogen [starch] synthase, muscleglycogen synthase 1 (muscle)echinoderm microtubule-associated protein-like 2echinoderm MT-associated protein (EMAP)-like protein 70microtubule-associated protein like echinoderm EMAP
Modification date2018052320180523
UniProtAcc

P13807

O95834

Ensembl transtripts involved in fusion geneENST00000323798, ENST00000263276, 
ENST00000541188, ENST00000544287, 
ENST00000540532, ENST00000457974, 
ENST00000589876, ENST00000245925, 
ENST00000536630, ENST00000587152, 
ENST00000586902, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 4 X 3=48
# samples 44
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GYS1 [Title/Abstract] AND EML2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGYS1

GO:0005978

glycogen biosynthetic process

16275910

TgeneEML2

GO:0010968

regulation of microtubule nucleation

11694528

TgeneEML2

GO:0031115

negative regulation of microtubule polymerization

11694528


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A1F6-01AGYS1chr19

49485512

-EML2chr19

46116929

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000323798ENST00000589876GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000323798ENST00000245925GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000323798ENST00000536630GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000323798ENST00000587152GYS1chr19

49485512

-EML2chr19

46116929

-
5CDS-intronENST00000323798ENST00000586902GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000263276ENST00000589876GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000263276ENST00000245925GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000263276ENST00000536630GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000263276ENST00000587152GYS1chr19

49485512

-EML2chr19

46116929

-
5CDS-intronENST00000263276ENST00000586902GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000541188ENST00000589876GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000541188ENST00000245925GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000541188ENST00000536630GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000541188ENST00000587152GYS1chr19

49485512

-EML2chr19

46116929

-
5CDS-intronENST00000541188ENST00000586902GYS1chr19

49485512

-EML2chr19

46116929

-
5UTR-3CDSENST00000544287ENST00000589876GYS1chr19

49485512

-EML2chr19

46116929

-
5UTR-3CDSENST00000544287ENST00000245925GYS1chr19

49485512

-EML2chr19

46116929

-
5UTR-3CDSENST00000544287ENST00000536630GYS1chr19

49485512

-EML2chr19

46116929

-
5UTR-3CDSENST00000544287ENST00000587152GYS1chr19

49485512

-EML2chr19

46116929

-
5UTR-intronENST00000544287ENST00000586902GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000540532ENST00000589876GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000540532ENST00000245925GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000540532ENST00000536630GYS1chr19

49485512

-EML2chr19

46116929

-
Frame-shiftENST00000540532ENST00000587152GYS1chr19

49485512

-EML2chr19

46116929

-
5CDS-intronENST00000540532ENST00000586902GYS1chr19

49485512

-EML2chr19

46116929

-
intron-3CDSENST00000457974ENST00000589876GYS1chr19

49485512

-EML2chr19

46116929

-
intron-3CDSENST00000457974ENST00000245925GYS1chr19

49485512

-EML2chr19

46116929

-
intron-3CDSENST00000457974ENST00000536630GYS1chr19

49485512

-EML2chr19

46116929

-
intron-3CDSENST00000457974ENST00000587152GYS1chr19

49485512

-EML2chr19

46116929

-
intron-intronENST00000457974ENST00000586902GYS1chr19

49485512

-EML2chr19

46116929

-

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FusionProtFeatures for GYS1_EML2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GYS1

P13807

EML2

O95834

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Tubulin binding protein that inhibits microtubulenucleation and growth, resulting in shorter microtubules.{ECO:0000269|PubMed:11694528}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GYS1_EML2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GYS1_EML2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GYS1GYG1, GYG2, PRKAB1, SIRT2, OTUD5, GABARAPL1, PRKAA2, PRKAB2, NHLRC1, CUL1, COPS5, GRK5, GSK3B, APP, AIMP2, CCDC36, PPP1R3B, PPP1R3C, PPP1CC, PPP1CA, STBD1, ZFP41, NTRK1, CEP290, CEP152, CEP135, EVC2, XPO1, WWP2, GBE1, PPP1R7EML2NEK6, ELAVL1, REL, EXD1, TUBB2A, TUBB2B, GNAS, NHP2L1, TTC38, TUBA1C, EML3, TUBB3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GYS1_EML2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GYS1_EML2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource