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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15731

FusionGeneSummary for GYPC_GYPC

check button Fusion gene summary
Fusion gene informationFusion gene name: GYPC_GYPC
Fusion gene ID: 15731
HgeneTgene
Gene symbol

GYPC

GYPC

Gene ID

2995

2995

Gene nameglycophorin C (Gerbich blood group)glycophorin C (Gerbich blood group)
SynonymsCD236|CD236R|GE|GE:GPC:GPD:GYPD|GPC|GPD|GYPD|PAS-2|PAS-2'CD236|CD236R|GE|GE:GPC:GPD:GYPD|GPC|GPD|GYPD|PAS-2|PAS-2'
Cytomap

2q14.3

2q14.3

Type of geneprotein-codingprotein-coding
Descriptionglycophorin-Cglycoconnectinglycophorin-Dglycoprotein betasialoglycoprotein Dglycophorin-Cglycoconnectinglycophorin-Dglycoprotein betasialoglycoprotein D
Modification date2018052220180522
UniProtAcc

P04921

P04921

Ensembl transtripts involved in fusion geneENST00000259254, ENST00000356887, 
ENST00000409836, ENST00000464053, 
ENST00000259254, ENST00000356887, 
ENST00000409836, ENST00000464053, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 1=9
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GYPC [Title/Abstract] AND GYPC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG431197GYPCchr2

127453995

+GYPCchr2

127413824

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000259254ENST00000259254GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-5UTRENST00000259254ENST00000356887GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-5UTRENST00000259254ENST00000409836GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-3UTRENST00000259254ENST00000464053GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-5UTRENST00000356887ENST00000259254GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-5UTRENST00000356887ENST00000356887GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-5UTRENST00000356887ENST00000409836GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-3UTRENST00000356887ENST00000464053GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-5UTRENST00000409836ENST00000259254GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-5UTRENST00000409836ENST00000356887GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-5UTRENST00000409836ENST00000409836GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-3UTRENST00000409836ENST00000464053GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-5UTRENST00000464053ENST00000259254GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-5UTRENST00000464053ENST00000356887GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-5UTRENST00000464053ENST00000409836GYPCchr2

127453995

+GYPCchr2

127413824

+
3UTR-3UTRENST00000464053ENST00000464053GYPCchr2

127453995

+GYPCchr2

127413824

+

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FusionProtFeatures for GYPC_GYPC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GYPC

P04921

GYPC

P04921

This protein is a minor sialoglycoprotein in humanerythrocyte membranes. The blood group Gerbich antigens andreceptors for Plasmodium falciparum merozoites are most likelylocated within the extracellular domain. Glycophorin-C plays animportant role in regulating the stability of red cells. This protein is a minor sialoglycoprotein in humanerythrocyte membranes. The blood group Gerbich antigens andreceptors for Plasmodium falciparum merozoites are most likelylocated within the extracellular domain. Glycophorin-C plays animportant role in regulating the stability of red cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GYPC_GYPC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GYPC_GYPC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GYPC_GYPC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GYPC_GYPC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource