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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15729

FusionGeneSummary for GYG1_GYG1

check button Fusion gene summary
Fusion gene informationFusion gene name: GYG1_GYG1
Fusion gene ID: 15729
HgeneTgene
Gene symbol

GYG1

GYG1

Gene ID

2992

2992

Gene nameglycogenin 1glycogenin 1
SynonymsGSD15|GYGGSD15|GYG
Cytomap

3q24

3q24

Type of geneprotein-codingprotein-coding
Descriptionglycogenin-1GN-1glycogenin glucosyltransferaseglycogenin-1GN-1glycogenin glucosyltransferase
Modification date2018052220180522
UniProtAcc

P46976

P46976

Ensembl transtripts involved in fusion geneENST00000345003, ENST00000296048, 
ENST00000483267, ENST00000484197, 
ENST00000479119, 
ENST00000345003, 
ENST00000296048, ENST00000483267, 
ENST00000484197, ENST00000479119, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 4 X 3=60
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GYG1 [Title/Abstract] AND GYG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU677172GYG1chr3

148745192

-GYG1chr3

148745039

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000345003ENST00000345003GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-3UTRENST00000345003ENST00000296048GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-intronENST00000345003ENST00000483267GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-3UTRENST00000345003ENST00000484197GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-3UTRENST00000345003ENST00000479119GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-3UTRENST00000296048ENST00000345003GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-3UTRENST00000296048ENST00000296048GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-intronENST00000296048ENST00000483267GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-3UTRENST00000296048ENST00000484197GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-3UTRENST00000296048ENST00000479119GYG1chr3

148745192

-GYG1chr3

148745039

+
intron-3UTRENST00000483267ENST00000345003GYG1chr3

148745192

-GYG1chr3

148745039

+
intron-3UTRENST00000483267ENST00000296048GYG1chr3

148745192

-GYG1chr3

148745039

+
intron-intronENST00000483267ENST00000483267GYG1chr3

148745192

-GYG1chr3

148745039

+
intron-3UTRENST00000483267ENST00000484197GYG1chr3

148745192

-GYG1chr3

148745039

+
intron-3UTRENST00000483267ENST00000479119GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-3UTRENST00000484197ENST00000345003GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-3UTRENST00000484197ENST00000296048GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-intronENST00000484197ENST00000483267GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-3UTRENST00000484197ENST00000484197GYG1chr3

148745192

-GYG1chr3

148745039

+
3UTR-3UTRENST00000484197ENST00000479119GYG1chr3

148745192

-GYG1chr3

148745039

+
intron-3UTRENST00000479119ENST00000345003GYG1chr3

148745192

-GYG1chr3

148745039

+
intron-3UTRENST00000479119ENST00000296048GYG1chr3

148745192

-GYG1chr3

148745039

+
intron-intronENST00000479119ENST00000483267GYG1chr3

148745192

-GYG1chr3

148745039

+
intron-3UTRENST00000479119ENST00000484197GYG1chr3

148745192

-GYG1chr3

148745039

+
intron-3UTRENST00000479119ENST00000479119GYG1chr3

148745192

-GYG1chr3

148745039

+

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FusionProtFeatures for GYG1_GYG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GYG1

P46976

GYG1

P46976

Self-glucosylates, via an inter-subunit mechanism, toform an oligosaccharide primer that serves as substrate forglycogen synthase. Self-glucosylates, via an inter-subunit mechanism, toform an oligosaccharide primer that serves as substrate forglycogen synthase.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GYG1_GYG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GYG1_GYG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GYG1_GYG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GYG1_GYG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGYG1C0003811Cardiac Arrhythmia1CTD_human
HgeneGYG1C0017919Glycogen Storage Disease1CTD_human
HgeneGYG1C0151744Myocardial Ischemia1CTD_human
HgeneGYG1C0151786Muscle Weakness1CTD_human;HPO
HgeneGYG1C3150754GLYCOGEN STORAGE DISEASE XV1CTD_human;ORPHANET;UNIPROT
HgeneGYG1C4015452POLYGLUCOSAN BODY MYOPATHY 21ORPHANET;UNIPROT
TgeneGYG1C0003811Cardiac Arrhythmia1CTD_human
TgeneGYG1C0017919Glycogen Storage Disease1CTD_human
TgeneGYG1C0151744Myocardial Ischemia1CTD_human
TgeneGYG1C0151786Muscle Weakness1CTD_human;HPO
TgeneGYG1C3150754GLYCOGEN STORAGE DISEASE XV1CTD_human;ORPHANET;UNIPROT
TgeneGYG1C4015452POLYGLUCOSAN BODY MYOPATHY 21ORPHANET;UNIPROT