FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 15721

FusionGeneSummary for GUSBP1_MAP4

check button Fusion gene summary
Fusion gene informationFusion gene name: GUSBP1_MAP4
Fusion gene ID: 15721
HgeneTgene
Gene symbol

GUSBP1

MAP4

Gene ID

728411

4134

Gene nameglucuronidase, beta pseudogene 1microtubule associated protein 4
Synonyms--
Cytomap

5p14.3

3p21.31

Type of genepseudoprotein-coding
DescriptionPutative beta-glucuronidase-like protein MGC87375microtubule-associated protein 4MAP-4
Modification date2018051920180523
UniProtAcc

P27816

Ensembl transtripts involved in fusion geneENST00000607545, ENST00000383737, 
ENST00000395734, ENST00000426837, 
ENST00000360240, ENST00000439356, 
ENST00000264724, ENST00000420772, 
ENST00000441748, ENST00000462206, 
ENST00000434267, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 10 X 3=210
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GUSBP1 [Title/Abstract] AND MAP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF740993GUSBP1chr5

21346603

-MAP4chr3

47952887

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000607545ENST00000383737GUSBP1chr5

21346603

-MAP4chr3

47952887

-
intron-intronENST00000607545ENST00000395734GUSBP1chr5

21346603

-MAP4chr3

47952887

-
intron-intronENST00000607545ENST00000426837GUSBP1chr5

21346603

-MAP4chr3

47952887

-
intron-intronENST00000607545ENST00000360240GUSBP1chr5

21346603

-MAP4chr3

47952887

-
intron-intronENST00000607545ENST00000439356GUSBP1chr5

21346603

-MAP4chr3

47952887

-
intron-intronENST00000607545ENST00000264724GUSBP1chr5

21346603

-MAP4chr3

47952887

-
intron-intronENST00000607545ENST00000420772GUSBP1chr5

21346603

-MAP4chr3

47952887

-
intron-intronENST00000607545ENST00000441748GUSBP1chr5

21346603

-MAP4chr3

47952887

-
intron-intronENST00000607545ENST00000462206GUSBP1chr5

21346603

-MAP4chr3

47952887

-
intron-intronENST00000607545ENST00000434267GUSBP1chr5

21346603

-MAP4chr3

47952887

-

Top

FusionProtFeatures for GUSBP1_MAP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GUSBP1

MAP4

P27816

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Non-neuronal microtubule-associated protein. Promotesmicrotubule assembly. {ECO:0000269|PubMed:10791892}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GUSBP1_MAP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GUSBP1_MAP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GUSBP1_MAP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMAP4P27816DB01248DocetaxelMicrotubule-associated protein 4small moleculeapproved|investigational
TgeneMAP4P27816DB11638ArtenimolMicrotubule-associated protein 4small moleculeapproved|investigational
TgeneMAP4P27816DB01229PaclitaxelMicrotubule-associated protein 4small moleculeapproved|vet_approved

Top

RelatedDiseases for GUSBP1_MAP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMAP4C0043094Weight Gain1CTD_human