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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15712

FusionGeneSummary for GULP1_TFPI

check button Fusion gene summary
Fusion gene informationFusion gene name: GULP1_TFPI
Fusion gene ID: 15712
HgeneTgene
Gene symbol

GULP1

TFPI

Gene ID

51454

7035

Gene nameGULP, engulfment adaptor PTB domain containing 1tissue factor pathway inhibitor
SynonymsCED-6|CED6|GULPEPI|LACI|TFI|TFPI1
Cytomap

2q32.1-q32.2

2q32.1

Type of geneprotein-codingprotein-coding
DescriptionPTB domain-containing engulfment adapter protein 1PTB domain adapter protein CED-6PTB domain adaptor protein CED-6cell death protein 6 homologengulfment adapter proteintissue factor pathway inhibitoranti-convertinextrinsic pathway inhibitortissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Modification date2018051920180523
UniProtAcc

Q9UBP9

P10646

Ensembl transtripts involved in fusion geneENST00000409843, ENST00000409830, 
ENST00000410051, ENST00000479019, 
ENST00000409805, ENST00000359135, 
ENST00000409580, ENST00000409637, 
ENST00000409609, 		ENST00000392365, 
ENST00000233156, ENST00000409676, 
ENST00000339091, 
Fusion gene scores* DoF score6 X 5 X 4=1204 X 4 X 3=48
# samples 64
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GULP1 [Title/Abstract] AND TFPI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGULP1

GO:0006911

phagocytosis, engulfment

11729193

TgeneTFPI

GO:0030195

negative regulation of blood coagulation

21868574


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-M7-A724-01AGULP1chr2

189393922

+TFPIchr2

188394212

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000409843ENST00000392365GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409843ENST00000233156GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409843ENST00000409676GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409843ENST00000339091GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409830ENST00000392365GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409830ENST00000233156GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409830ENST00000409676GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409830ENST00000339091GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000410051ENST00000392365GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000410051ENST00000233156GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000410051ENST00000409676GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000410051ENST00000339091GULP1chr2

189393922

+TFPIchr2

188394212

-
3UTR-intronENST00000479019ENST00000392365GULP1chr2

189393922

+TFPIchr2

188394212

-
3UTR-intronENST00000479019ENST00000233156GULP1chr2

189393922

+TFPIchr2

188394212

-
3UTR-intronENST00000479019ENST00000409676GULP1chr2

189393922

+TFPIchr2

188394212

-
3UTR-intronENST00000479019ENST00000339091GULP1chr2

189393922

+TFPIchr2

188394212

-
intron-intronENST00000409805ENST00000392365GULP1chr2

189393922

+TFPIchr2

188394212

-
intron-intronENST00000409805ENST00000233156GULP1chr2

189393922

+TFPIchr2

188394212

-
intron-intronENST00000409805ENST00000409676GULP1chr2

189393922

+TFPIchr2

188394212

-
intron-intronENST00000409805ENST00000339091GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000359135ENST00000392365GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000359135ENST00000233156GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000359135ENST00000409676GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000359135ENST00000339091GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409580ENST00000392365GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409580ENST00000233156GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409580ENST00000409676GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409580ENST00000339091GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409637ENST00000392365GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409637ENST00000233156GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409637ENST00000409676GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409637ENST00000339091GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409609ENST00000392365GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409609ENST00000233156GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409609ENST00000409676GULP1chr2

189393922

+TFPIchr2

188394212

-
5CDS-intronENST00000409609ENST00000339091GULP1chr2

189393922

+TFPIchr2

188394212

-

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FusionProtFeatures for GULP1_TFPI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GULP1

Q9UBP9

TFPI

P10646

Inhibits factor X (X(a)) directly and, in a Xa-dependentway, inhibits VIIa/tissue factor activity, presumably by forming aquaternary Xa/LACI/VIIa/TF complex. It possesses an antithromboticaction and also the ability to associate with lipoproteins inplasma.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GULP1_TFPI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GULP1_TFPI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GULP1LRP1, SMC2, EPS8, CREB3L2, AP2M1, SNW1, CDC5L, MLLT6, CCDC102B, ANGPTL3TFPITHBS1, PRSS3, F10, ELAVL1, APP, SAP18, SRSF7, SMU1, SON, SRSF11, BCAS2, SF3B1, KCNIP4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GULP1_TFPI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTFPIP10646DB00036Coagulation factor VIIa Recombinant HumanTissue factor pathway inhibitorbiotechapproved
TgeneTFPIP10646DB06779DalteparinTissue factor pathway inhibitorsmall moleculeapproved

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RelatedDiseases for GULP1_TFPI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGULP1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneGULP1C0040128Thyroid Diseases1CTD_human
TgeneTFPIC0001883Airway Obstruction1CTD_human
TgeneTFPIC0034155Purpura, Thrombotic Thrombocytopenic1CTD_human
TgeneTFPIC0042487Venous Thrombosis1CTD_human
TgeneTFPIC0242184Hypoxia1CTD_human
TgeneTFPIC0600433Activated Protein C Resistance1CTD_human
TgeneTFPIC3495559Juvenile arthritis1CTD_human