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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15706

FusionGeneSummary for GUK1_TPPP

check button Fusion gene summary
Fusion gene informationFusion gene name: GUK1_TPPP
Fusion gene ID: 15706
HgeneTgene
Gene symbol

GUK1

TPPP

Gene ID

2987

11076

Gene nameguanylate kinase 1tubulin polymerization promoting protein
SynonymsGMKTPPP/p25|TPPP1|p24|p25|p25alpha
Cytomap

1q42.13

5p15.33

Type of geneprotein-codingprotein-coding
Descriptionguanylate kinaseATP:GMP phosphotransferaseGMP kinasetubulin polymerization-promoting protein25 kDa brain-specific proteinbrain specific protein p25 alphaglycogen synthase kinase 3 (GSK3) inhibitor p24p25-alpha
Modification date2018052320180523
UniProtAcc

Q16774

O94811

Ensembl transtripts involved in fusion geneENST00000366730, ENST00000391865, 
ENST00000366726, ENST00000312726, 
ENST00000366728, ENST00000366723, 
ENST00000366722, ENST00000366721, 
ENST00000366718, ENST00000470040, 
ENST00000366716, 
ENST00000360578, 
Fusion gene scores* DoF score11 X 12 X 2=2644 X 2 X 3=24
# samples 134
** MAII scorelog2(13/264*10)=-1.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GUK1 [Title/Abstract] AND TPPP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGUK1

GO:0006163

purine nucleotide metabolic process

8663313

TgeneTPPP

GO:0001578

microtubule bundle formation

17105200

TgeneTPPP

GO:0032273

positive regulation of protein polymerization

15590652

TgeneTPPP

GO:0046785

microtubule polymerization

18028908


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-EW-A1PB-01AGUK1chr1

228333325

+TPPPchr5

678179

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000366730ENST00000360578GUK1chr1

228333325

+TPPPchr5

678179

-
5CDS-5UTRENST00000391865ENST00000360578GUK1chr1

228333325

+TPPPchr5

678179

-
5CDS-5UTRENST00000366726ENST00000360578GUK1chr1

228333325

+TPPPchr5

678179

-
5CDS-5UTRENST00000312726ENST00000360578GUK1chr1

228333325

+TPPPchr5

678179

-
5CDS-5UTRENST00000366728ENST00000360578GUK1chr1

228333325

+TPPPchr5

678179

-
5CDS-5UTRENST00000366723ENST00000360578GUK1chr1

228333325

+TPPPchr5

678179

-
5CDS-5UTRENST00000366722ENST00000360578GUK1chr1

228333325

+TPPPchr5

678179

-
5CDS-5UTRENST00000366721ENST00000360578GUK1chr1

228333325

+TPPPchr5

678179

-
5CDS-5UTRENST00000366718ENST00000360578GUK1chr1

228333325

+TPPPchr5

678179

-
3UTR-5UTRENST00000470040ENST00000360578GUK1chr1

228333325

+TPPPchr5

678179

-
5CDS-5UTRENST00000366716ENST00000360578GUK1chr1

228333325

+TPPPchr5

678179

-

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FusionProtFeatures for GUK1_TPPP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GUK1

Q16774

TPPP

O94811

Essential for recycling GMP and indirectly, cGMP. May play a role in the polymerization of tubulin intomicrotubules, microtubule bundling and the stabilization ofexisting microtubules, thus maintaining the integrity of themicrotubule network. May play a role in mitotic spindle assemblyand nuclear envelope breakdown. {ECO:0000269|PubMed:17105200,ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GUK1_TPPP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GUK1_TPPP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GUK1IQCB1, HNRNPD, MOV10, NXF1, DPY19L2, TTC19, TMEM97, NDUFA4, NLGN3TPPPHDAC6, SNCA, APP, CDK11B, HIST1H1A, C2orf27B, FADD, GRPEL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GUK1_TPPP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GUK1_TPPP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTPPPC3826462Depression in children1PSYGENET