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Fusion gene ID: 15706 |
FusionGeneSummary for GUK1_TPPP |
Fusion gene summary |
Fusion gene information | Fusion gene name: GUK1_TPPP | Fusion gene ID: 15706 | Hgene | Tgene | Gene symbol | GUK1 | TPPP | Gene ID | 2987 | 11076 |
Gene name | guanylate kinase 1 | tubulin polymerization promoting protein | |
Synonyms | GMK | TPPP/p25|TPPP1|p24|p25|p25alpha | |
Cytomap | 1q42.13 | 5p15.33 | |
Type of gene | protein-coding | protein-coding | |
Description | guanylate kinaseATP:GMP phosphotransferaseGMP kinase | tubulin polymerization-promoting protein25 kDa brain-specific proteinbrain specific protein p25 alphaglycogen synthase kinase 3 (GSK3) inhibitor p24p25-alpha | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q16774 | O94811 | |
Ensembl transtripts involved in fusion gene | ENST00000366730, ENST00000391865, ENST00000366726, ENST00000312726, ENST00000366728, ENST00000366723, ENST00000366722, ENST00000366721, ENST00000366718, ENST00000470040, ENST00000366716, | ENST00000360578, | |
Fusion gene scores | * DoF score | 11 X 12 X 2=264 | 4 X 2 X 3=24 |
# samples | 13 | 4 | |
** MAII score | log2(13/264*10)=-1.02202630633 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: GUK1 [Title/Abstract] AND TPPP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GUK1 | GO:0006163 | purine nucleotide metabolic process | 8663313 |
Tgene | TPPP | GO:0001578 | microtubule bundle formation | 17105200 |
Tgene | TPPP | GO:0032273 | positive regulation of protein polymerization | 15590652 |
Tgene | TPPP | GO:0046785 | microtubule polymerization | 18028908 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-EW-A1PB-01A | GUK1 | chr1 | 228333325 | + | TPPP | chr5 | 678179 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000366730 | ENST00000360578 | GUK1 | chr1 | 228333325 | + | TPPP | chr5 | 678179 | - |
5CDS-5UTR | ENST00000391865 | ENST00000360578 | GUK1 | chr1 | 228333325 | + | TPPP | chr5 | 678179 | - |
5CDS-5UTR | ENST00000366726 | ENST00000360578 | GUK1 | chr1 | 228333325 | + | TPPP | chr5 | 678179 | - |
5CDS-5UTR | ENST00000312726 | ENST00000360578 | GUK1 | chr1 | 228333325 | + | TPPP | chr5 | 678179 | - |
5CDS-5UTR | ENST00000366728 | ENST00000360578 | GUK1 | chr1 | 228333325 | + | TPPP | chr5 | 678179 | - |
5CDS-5UTR | ENST00000366723 | ENST00000360578 | GUK1 | chr1 | 228333325 | + | TPPP | chr5 | 678179 | - |
5CDS-5UTR | ENST00000366722 | ENST00000360578 | GUK1 | chr1 | 228333325 | + | TPPP | chr5 | 678179 | - |
5CDS-5UTR | ENST00000366721 | ENST00000360578 | GUK1 | chr1 | 228333325 | + | TPPP | chr5 | 678179 | - |
5CDS-5UTR | ENST00000366718 | ENST00000360578 | GUK1 | chr1 | 228333325 | + | TPPP | chr5 | 678179 | - |
3UTR-5UTR | ENST00000470040 | ENST00000360578 | GUK1 | chr1 | 228333325 | + | TPPP | chr5 | 678179 | - |
5CDS-5UTR | ENST00000366716 | ENST00000360578 | GUK1 | chr1 | 228333325 | + | TPPP | chr5 | 678179 | - |
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FusionProtFeatures for GUK1_TPPP |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
GUK1 | TPPP |
Essential for recycling GMP and indirectly, cGMP. | May play a role in the polymerization of tubulin intomicrotubules, microtubule bundling and the stabilization ofexisting microtubules, thus maintaining the integrity of themicrotubule network. May play a role in mitotic spindle assemblyand nuclear envelope breakdown. {ECO:0000269|PubMed:17105200,ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GUK1_TPPP |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GUK1_TPPP |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GUK1 | IQCB1, HNRNPD, MOV10, NXF1, DPY19L2, TTC19, TMEM97, NDUFA4, NLGN3 | TPPP | HDAC6, SNCA, APP, CDK11B, HIST1H1A, C2orf27B, FADD, GRPEL1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GUK1_TPPP |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GUK1_TPPP |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TPPP | C3826462 | Depression in children | 1 | PSYGENET |